ATE388147T1 - Thiazolderivate als a2b-antagonisten - Google Patents
Thiazolderivate als a2b-antagonistenInfo
- Publication number
- ATE388147T1 ATE388147T1 AT05706936T AT05706936T ATE388147T1 AT E388147 T1 ATE388147 T1 AT E388147T1 AT 05706936 T AT05706936 T AT 05706936T AT 05706936 T AT05706936 T AT 05706936T AT E388147 T1 ATE388147 T1 AT E388147T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- alkoxy
- hydrogen
- haloalkyl
- cyano
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 150000007979 thiazole derivatives Chemical class 0.000 title 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 cyano, hydroxy Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0401336.3A GB0401336D0 (en) | 2004-01-21 | 2004-01-21 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE388147T1 true ATE388147T1 (de) | 2008-03-15 |
Family
ID=31971241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05706936T ATE388147T1 (de) | 2004-01-21 | 2005-01-20 | Thiazolderivate als a2b-antagonisten |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090233938A1 (de) |
| EP (1) | EP1709036B1 (de) |
| JP (1) | JP2007518767A (de) |
| KR (1) | KR20060129276A (de) |
| CN (1) | CN1910178B (de) |
| AT (1) | ATE388147T1 (de) |
| AU (1) | AU2005206290B2 (de) |
| BR (1) | BRPI0506927A (de) |
| CA (1) | CA2553010A1 (de) |
| DE (1) | DE602005005161T2 (de) |
| ES (1) | ES2300985T3 (de) |
| GB (1) | GB0401336D0 (de) |
| PL (1) | PL1709036T3 (de) |
| PT (1) | PT1709036E (de) |
| RU (1) | RU2374242C2 (de) |
| WO (1) | WO2005070926A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2270715B1 (es) | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| NZ566036A (en) | 2005-09-13 | 2010-06-25 | Janssen Pharmaceutica Nv | 2-Aniline-4-aryl substituted thiazole derivatives that modulate the alpha7 nicotinic receptor |
| ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| RU2457842C2 (ru) * | 2006-03-17 | 2012-08-10 | Гайлид Пало Альто, Инк. | Способ предотвращения и лечения болезни печени с использованием антагонистов рецептора аденозина a2b |
| WO2007134958A1 (en) * | 2006-05-18 | 2007-11-29 | F. Hoffmann-La Roche Ag | Thiazolo-pyramidine / pyridine urea derivatives as adenosine a2b receptor antagonists |
| JP2011500625A (ja) | 2007-10-18 | 2011-01-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トリ置換された１，２，４−トリアゾール |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| MY152486A (en) | 2008-03-19 | 2014-10-15 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4 - triazoles as nicotinic acetylcholine receptor modulators |
| WO2009135944A1 (en) | 2008-05-09 | 2009-11-12 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
| US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
| ES2580702B1 (es) | 2015-02-25 | 2017-06-08 | Palobiofarma, S.L. | Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina |
| CN109293652B (zh) * | 2017-07-24 | 2021-10-22 | 四川科伦博泰生物医药股份有限公司 | 一种取代的噻唑衍生物及其用途 |
| WO2019072143A1 (zh) * | 2017-10-11 | 2019-04-18 | 上海迪诺医药科技有限公司 | 4-氨基吡啶衍生物、其药物组合物、制备方法及应用 |
| CN112955441B (zh) | 2018-10-24 | 2024-06-18 | 里德埃克斯普洛股份公司 | 官能化氨基三嗪 |
| CN113727999A (zh) | 2019-01-11 | 2021-11-30 | 奥默罗斯公司 | 用于治疗癌症的方法和组合物 |
| BR112022022437A2 (pt) | 2020-05-07 | 2023-01-03 | Adorx Therapeutics Ltd | Antagonistas do receptor a2a de adenosina |
| WO2023139132A1 (en) * | 2022-01-19 | 2023-07-27 | Leadxpro Ag | Functionalized aminothiazoles |
| GB2615307A (en) * | 2022-01-28 | 2023-08-09 | Adorx Therapeutics Ltd | Antagonist compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2677356B1 (fr) * | 1991-06-05 | 1995-03-17 | Sanofi Sa | Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant. |
| WO1999064418A1 (en) * | 1998-06-05 | 1999-12-16 | Novartis Ag | Aryl pyridinyl thiazoles |
| JP2000281685A (ja) * | 1999-01-28 | 2000-10-10 | Takeda Chem Ind Ltd | チアゾロピリミジン化合物、その製造法および用途 |
| AU7922900A (en) * | 1999-10-27 | 2001-05-08 | Novartis Ag | Thiazole and imidazo (4,5-b) pyridine compounds and their pharmaceutical use |
| GB0028383D0 (en) * | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
| JP2002302445A (ja) * | 2001-02-02 | 2002-10-18 | Takeda Chem Ind Ltd | Ｊｎｋ阻害剤 |
| GB0123589D0 (en) * | 2001-10-01 | 2001-11-21 | Syngenta Participations Ag | Organic compounds |
| EP1441732A2 (de) * | 2001-11-08 | 2004-08-04 | Fujisawa Pharmaceutical Co., Ltd. | Thiazolderivat und seine pharmazeutische anwendung |
-
2004
- 2004-01-21 GB GBGB0401336.3A patent/GB0401336D0/en not_active Ceased
-
2005
- 2005-01-20 BR BRPI0506927-0A patent/BRPI0506927A/pt not_active IP Right Cessation
- 2005-01-20 DE DE602005005161T patent/DE602005005161T2/de not_active Expired - Lifetime
- 2005-01-20 RU RU2006130002/04A patent/RU2374242C2/ru not_active IP Right Cessation
- 2005-01-20 CN CN2005800026886A patent/CN1910178B/zh not_active Expired - Fee Related
- 2005-01-20 CA CA002553010A patent/CA2553010A1/en not_active Abandoned
- 2005-01-20 JP JP2006550041A patent/JP2007518767A/ja active Pending
- 2005-01-20 WO PCT/EP2005/000542 patent/WO2005070926A1/en not_active Ceased
- 2005-01-20 AU AU2005206290A patent/AU2005206290B2/en not_active Ceased
- 2005-01-20 ES ES05706936T patent/ES2300985T3/es not_active Expired - Lifetime
- 2005-01-20 KR KR1020067014629A patent/KR20060129276A/ko not_active Ceased
- 2005-01-20 PL PL05706936T patent/PL1709036T3/pl unknown
- 2005-01-20 AT AT05706936T patent/ATE388147T1/de not_active IP Right Cessation
- 2005-01-20 EP EP05706936A patent/EP1709036B1/de not_active Expired - Lifetime
- 2005-01-20 PT PT05706936T patent/PT1709036E/pt unknown
- 2005-01-20 US US10/585,614 patent/US20090233938A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005206290B2 (en) | 2008-12-04 |
| BRPI0506927A (pt) | 2007-06-05 |
| EP1709036B1 (de) | 2008-03-05 |
| RU2006130002A (ru) | 2008-02-27 |
| ES2300985T3 (es) | 2008-06-16 |
| GB0401336D0 (en) | 2004-02-25 |
| PL1709036T3 (pl) | 2008-08-29 |
| PT1709036E (pt) | 2008-05-28 |
| US20090233938A1 (en) | 2009-09-17 |
| RU2374242C2 (ru) | 2009-11-27 |
| AU2005206290A1 (en) | 2005-08-04 |
| CN1910178B (zh) | 2010-06-02 |
| JP2007518767A (ja) | 2007-07-12 |
| CN1910178A (zh) | 2007-02-07 |
| CA2553010A1 (en) | 2005-08-04 |
| KR20060129276A (ko) | 2006-12-15 |
| EP1709036A1 (de) | 2006-10-11 |
| WO2005070926A1 (en) | 2005-08-04 |
| DE602005005161D1 (de) | 2008-04-17 |
| DE602005005161T2 (de) | 2009-03-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1709036 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |