HUP0003942A2 - Helyettesített 3,3-diamino-2-propén-nitrilek, előállításuk és alkalmazásuk - Google Patents

Helyettesített 3,3-diamino-2-propén-nitrilek, előállításuk és alkalmazásuk

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Publication number
HUP0003942A2
HUP0003942A2 HU0003942A HUP0003942A HUP0003942A2 HU P0003942 A2 HUP0003942 A2 HU P0003942A2 HU 0003942 A HU0003942 A HU 0003942A HU P0003942 A HUP0003942 A HU P0003942A HU P0003942 A2 HUP0003942 A2 HU P0003942A2
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HU
Hungary
Prior art keywords
group
compounds
optionally substituted
aryl
amino
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Application number
HU0003942A
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English (en)
Inventor
Florenzio Zaragoza Dörwald
John Bondo Hansen
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Novo Nordisk A/S
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Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of HUP0003942A2 publication Critical patent/HUP0003942A2/hu

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/06—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms of an acyclic and unsaturated carbon skeleton
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    • C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
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    • C07C317/00—Sulfones; Sulfoxides
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)

Abstract

A találmány tárgyát az (I) általános képletű, káliumcsatorna-megnyitóaktivitással rendelkező vegyületek, ahol R1 jelentése adott esetben helyettesített alkilcsoport,aralkilcsoport, adott esetben helyettesített arilcsoport vagy adottesetben helyettesített heteroarilcsoport, R2 és R3 jelentése egymástól függetlenül hidrogénatom, adott esetbenhelyettesített alkilcsoport, adott esetben helyettesített arilcsoport,adott esetben helyettesített heteroarilcsoport, vagy R2-t és R3-at egy -(CH2)n- csoport kapcsolja össze, ahol n értéke 4-7,azzal a feltétellel, hogy R2 és R3 egyszerre nem lehet hidrogénatom, Z jelentése hidrogénatom, ciano-, alkoxi-karbonil-, adott esetbenhelyettesített amino-karbonil-, adott esetben alkil-, aril- vagyheteroarilcsoporttal, halogénatommal, alkoxi-, aril-oxi-, dialkil-amino-, alkil-aril-amino-, diaril-amino-, nitro-, alkil-szulfonil-,aril-szulfonil-, ciano-, alkoxi-karbonil- vagy amino-karbonil-csoporttal helyettesített alkil-szulfonil- vagy aril-szulfonil-csoport, valamint ezen vegyületek gyógyászatilag elfogadható sóiképezik. Szintén a találmány tárgyát képezik a (II) általános képletűvegyületek, ahol Su jelentése szubsztrát, L jelentése kémiai kötés vagy linkercsoport, és R1, R2 és R3 jelentése a fentiekben megadott. A találmány tárgyátképezi továbbá ezen vegyületek, illetve az ezeket a vegyületekettartalmazó elrendezések előállítása, illetve ezen vegyületek, illetveaz ezeket a vegyületeket tartalmazó elrendezések alkalmazásaspecifikus receptorokkal, illetve enzimekkel szemben.<$TSize=2;SpAbove=1;SpBelow=0;SpInterLn=310;SpInterPar=0;ULineHt=13;ULineSh=35;DULineHt=13;DULineSh=70;StrikeHt=13;StrikeSh=69;OverscHt=13;OverscSh=207;SupSize=1;SupSh=120;SubSize=;SubSh=38;AltSize=1;> Ó
HU0003942A 1997-05-07 1998-05-06 Helyettesített 3,3-diamino-2-propén-nitrilek, előállításuk és alkalmazásuk HUP0003942A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK53397 1997-05-07
PCT/DK1998/000176 WO1998050344A1 (en) 1997-05-07 1998-05-06 Substituted 3,3-diamino-2-propenenitriles, their preparation and use

Publications (1)

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HUP0003942A2 true HUP0003942A2 (hu) 2001-04-28

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HU0003942A HUP0003942A2 (hu) 1997-05-07 1998-05-06 Helyettesített 3,3-diamino-2-propén-nitrilek, előállításuk és alkalmazásuk

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EP (1) EP0998451B1 (hu)
JP (1) JP2002500641A (hu)
KR (1) KR20010012326A (hu)
CN (1) CN1259119A (hu)
AT (1) ATE237585T1 (hu)
AU (1) AU7331098A (hu)
BR (1) BR9809234A (hu)
CA (1) CA2289099A1 (hu)
DE (1) DE69813565T2 (hu)
HU (1) HUP0003942A2 (hu)
IL (1) IL132599A0 (hu)
NO (1) NO995431L (hu)
PL (1) PL336640A1 (hu)
WO (1) WO1998050344A1 (hu)
ZA (1) ZA983851B (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6152966A (en) * 1998-05-13 2000-11-28 Novo Nordisk A/S Treatment of cork with a phenol oxidizing enzyme
AU6327199A (en) 1998-11-05 2000-05-29 Novo Nordisk A/S Substituted 3,3-diamino-2-propenenitriles, their preparation and use
US6362205B2 (en) 1998-11-05 2002-03-26 Novo Nordisk A/S Substituted 3,3-diamino-2-propenenitriles, their preparation and use
US20030004337A1 (en) * 2000-05-04 2003-01-02 Jung Kyung Woon Efficient lactam synthesis
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ATE237585T1 (de) 2003-05-15
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EP0998451B1 (en) 2003-04-16
ZA983851B (en) 1998-11-13
KR20010012326A (ko) 2001-02-15
PL336640A1 (en) 2000-07-03
NO995431D0 (no) 1999-11-05
WO1998050344A1 (en) 1998-11-12
DE69813565D1 (de) 2003-05-22
EP0998451A1 (en) 2000-05-10
NO995431L (no) 1999-11-05
BR9809234A (pt) 2000-06-27
IL132599A0 (en) 2001-03-19
CN1259119A (zh) 2000-07-05
DE69813565T2 (de) 2004-03-04
CA2289099A1 (en) 1998-11-12

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