BR0114073A - Derivados de piridina com atividade inibidora ikb-cinase (ikk-beta) - Google Patents

Derivados de piridina com atividade inibidora ikb-cinase (ikk-beta)

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Publication number
BR0114073A
BR0114073A BR0114073-6A BR0114073A BR0114073A BR 0114073 A BR0114073 A BR 0114073A BR 0114073 A BR0114073 A BR 0114073A BR 0114073 A BR0114073 A BR 0114073A
Authority
BR
Brazil
Prior art keywords
ikk
beta
alkylamino
pyridine derivatives
inhibitory activity
Prior art date
Application number
BR0114073-6A
Other languages
English (en)
Inventor
Timothy B Lowinger
Toshiki Murata
Masaomi Umeda
Sachiko Sakakibara
Takashi Yoshino
Hiroki Sato
Tsutomu Masuda
Yuji Koriyama
Mitsuyuki Shimada
Takuya Shintani
Hiroshi Kadono
Karl B Ziegelbauer
Kinji Fuchikami
Hiroshi Komura
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BR0114073A publication Critical patent/BR0114073A/pt

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/08—Preparation by ring-closure
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Hydrogenated Pyridines (AREA)

Abstract

"DERIVADOS DE PIRIDINA COM ATIVIDADE INIBIDORA IKB-CINASE (IKK-BETA)". Compostos piridínicos de fórmula geral (I) em que -R^ 1^ representa, ou no qual R^ 11^ é hidrogênio, C~ 1-6~ alquila, halogênio, hidróxi, C~ 1-12~ alcóxi, nitro, amino, C~ 1-6~ alquilsulfonilamino, C~ 1-6~ alcoxicarbonila, C~ 1-6~ alquilamino, di(C~ 1-6~ alquil)amino, C~ 1-6~ alcanoilamino, fenil C~ 1-6~ alquilamino, fenilsulfonilamino, ou -O-(CH~ 2~)~ n~-R^ 111^; R^ 2^ representa hidrogênio ou halogênio; R^ 3^ representa hidrogênio, -CR^ 31^R^ 32^R^ 33^, ou -NR^ 34^R^ 35^; R~ 4~ é hidrogênio, carbamoíla, CN, carboxila, etc.; R^ 5^ é amino, C~ 1-6~ alquilamino, di C~ 1-6~ alquilamino, etc. ou sal do mesmo. O composto possui excelente atividade antiinflamatória, e outras atividades biológicas.
BR0114073-6A 2000-09-22 2001-09-10 Derivados de piridina com atividade inibidora ikb-cinase (ikk-beta) BR0114073A (pt)

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JP2000289173A JP4272338B2 (ja) 2000-09-22 2000-09-22 ピリジン誘導体
PCT/EP2001/010405 WO2002024679A1 (en) 2000-09-22 2001-09-10 PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-β) INHIBITING ACTIVITY

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ATE381556T1 (de) 2008-01-15
PL361811A1 (en) 2004-10-04
SV2002000637A (es) 2002-12-02
EP1326856B1 (en) 2007-12-19
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CN1476442A (zh) 2004-02-18
GT200100189A (es) 2002-05-16
KR20030030030A (ko) 2003-04-16
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