TR200400185T4 - PDE 5 inhibitörleri olarak, 8-kuinolinkisantin ve 8-izokuinolinkisantin türevleri. - Google Patents

PDE 5 inhibitörleri olarak, 8-kuinolinkisantin ve 8-izokuinolinkisantin türevleri.

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Publication number
TR200400185T4
TR200400185T4 TR2004/00185T TR200400185T TR200400185T4 TR 200400185 T4 TR200400185 T4 TR 200400185T4 TR 2004/00185 T TR2004/00185 T TR 2004/00185T TR 200400185 T TR200400185 T TR 200400185T TR 200400185 T4 TR200400185 T4 TR 200400185T4
Authority
TR
Turkey
Prior art keywords
alkyl
hydroxy
hydrogen
alkoxy
optionally
Prior art date
Application number
TR2004/00185T
Other languages
English (en)
Inventor
Bhalay Gurdip
Paul Collingwood Stephen
Alec Fairhurst Robin
Felicite Gomez Sylvie
Naef Reto
Andrew Sandham David
Original Assignee
Novartis Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag. filed Critical Novartis Ag.
Publication of TR200400185T4 publication Critical patent/TR200400185T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
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    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/16—Otologicals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Serbest veya tuz formundaki formül (I)'deki bir bilesik olup, söz konusu formül içerisindeki R1; hidrojen veya hidroksi, alkoksi, veya alkiltiyo ile istege bagli olarak substitüsyonlu alkildir. R2; hidrojen, alkil, hidroksialkil, alkilkarboniloksialkil, alkoksialkil, alkiltiyoalkil, alkenil, sikloalkilalkil, heterosiklialkil, aralkil olup, içerisinde bulunan bunlarin aril halkasi, istege bagli olarak bir 5-elemanli heterosiklik gruba birlesiktir veya istege bagli olarak alkoksi, amino, alkilamino, dialkilamino, asilamino, halojen, hidroksi, aminosülfonil, alkilaminosülfonil, dialkilaminosülfonil, alkilsülfonilamino veya dialkilaminosülfonilaminodan seçilen bir veya daha fazla substitüent ile substitüsyonludur. R3; hidrojen veya istege bagli olarak hidroksi, alkoksi, veya alkiltiyo ile substitüsyonlu alkildir. R4; hidrojen veya alkildir, R5; istege bagli olarak bir 5-elemanli heterosiklik gruba birlesik ve istege bagli olarak halojen, siyano, hidroksi, alkil,... DEVAMI VAR.
TR2004/00185T 2000-04-07 2001-04-05 PDE 5 inhibitörleri olarak, 8-kuinolinkisantin ve 8-izokuinolinkisantin türevleri. TR200400185T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0008694.2A GB0008694D0 (en) 2000-04-07 2000-04-07 Organic compounds

Publications (1)

Publication Number Publication Date
TR200400185T4 true TR200400185T4 (tr) 2004-03-22

Family

ID=9889516

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/00185T TR200400185T4 (tr) 2000-04-07 2001-04-05 PDE 5 inhibitörleri olarak, 8-kuinolinkisantin ve 8-izokuinolinkisantin türevleri.

Country Status (29)

Country Link
US (1) US20030171384A1 (tr)
EP (1) EP1268480B1 (tr)
JP (1) JP3869725B2 (tr)
KR (1) KR100526094B1 (tr)
CN (1) CN1176922C (tr)
AR (1) AR028531A1 (tr)
AT (1) ATE253576T1 (tr)
AU (2) AU7392101A (tr)
BR (1) BR0109855A (tr)
CA (1) CA2403514C (tr)
CZ (1) CZ20023305A3 (tr)
DE (1) DE60101158T2 (tr)
DK (1) DK1268480T3 (tr)
ES (1) ES2210169T3 (tr)
GB (1) GB0008694D0 (tr)
HU (1) HUP0300565A3 (tr)
IL (1) IL152078A0 (tr)
MX (1) MXPA02009903A (tr)
MY (1) MY119238A (tr)
NO (1) NO20024741D0 (tr)
NZ (1) NZ521361A (tr)
PE (1) PE20020228A1 (tr)
PL (1) PL212407B1 (tr)
PT (1) PT1268480E (tr)
RU (1) RU2269529C2 (tr)
SK (1) SK14282002A3 (tr)
TR (1) TR200400185T4 (tr)
WO (1) WO2001077110A1 (tr)
ZA (1) ZA200207956B (tr)

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KR20020081590A (ko) 2002-10-28
RU2269529C2 (ru) 2006-02-10
PL358205A1 (en) 2004-08-09
AR028531A1 (es) 2003-05-14
CZ20023305A3 (cs) 2003-01-15
WO2001077110A1 (en) 2001-10-18
JP2003530398A (ja) 2003-10-14
EP1268480B1 (en) 2003-11-05
ES2210169T3 (es) 2004-07-01
KR100526094B1 (ko) 2005-11-08
MY119238A (en) 2005-04-30
GB0008694D0 (en) 2000-05-31
RU2002129557A (ru) 2004-03-27
BR0109855A (pt) 2003-06-03
PL212407B1 (pl) 2012-09-28
ZA200207956B (en) 2003-07-16
CN1420887A (zh) 2003-05-28
AU7392101A (en) 2001-10-23
NZ521361A (en) 2004-05-28
DE60101158D1 (en) 2003-12-11
CA2403514A1 (en) 2001-10-18
HUP0300565A2 (hu) 2003-07-28
HUP0300565A3 (en) 2004-10-28
AU2001273921B2 (en) 2005-05-05
CA2403514C (en) 2010-01-12
EP1268480A1 (en) 2003-01-02
CN1176922C (zh) 2004-11-24
PE20020228A1 (es) 2002-03-28
US20030171384A1 (en) 2003-09-11
PT1268480E (pt) 2004-03-31
MXPA02009903A (es) 2003-03-27
NO20024741L (no) 2002-10-02
IL152078A0 (en) 2003-05-29
DE60101158T2 (de) 2004-08-26
ATE253576T1 (de) 2003-11-15
NO20024741D0 (no) 2002-10-02
SK14282002A3 (sk) 2003-04-01
JP3869725B2 (ja) 2007-01-17
DK1268480T3 (da) 2004-03-15

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