DE69817810D1 - Cyanoguanidine als zellproliferation inhibitoren - Google Patents

Cyanoguanidine als zellproliferation inhibitoren

Info

Publication number
DE69817810D1
DE69817810D1 DE69817810T DE69817810T DE69817810D1 DE 69817810 D1 DE69817810 D1 DE 69817810D1 DE 69817810 T DE69817810 T DE 69817810T DE 69817810 T DE69817810 T DE 69817810T DE 69817810 D1 DE69817810 D1 DE 69817810D1
Authority
DE
Germany
Prior art keywords
stands
cyanoguanidine
alkoxycarbonyl
carboxy
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69817810T
Other languages
English (en)
Other versions
DE69817810T2 (de
Inventor
Charlotte Schou
Rytter Ottosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharma AS
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma AS, Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharma AS
Publication of DE69817810D1 publication Critical patent/DE69817810D1/de
Application granted granted Critical
Publication of DE69817810T2 publication Critical patent/DE69817810T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69817810T 1997-05-29 1998-05-15 Cyanoguanidine als zellproliferation inhibitoren Expired - Lifetime DE69817810T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9711123 1997-05-29
GBGB9711123.1A GB9711123D0 (en) 1997-05-29 1997-05-29 Novel cyanoguanidines
PCT/DK1998/000193 WO1998054141A1 (en) 1997-05-29 1998-05-15 Cyanoguanidines as cell proliferation inhibitors

Publications (2)

Publication Number Publication Date
DE69817810D1 true DE69817810D1 (de) 2003-10-09
DE69817810T2 DE69817810T2 (de) 2004-07-01

Family

ID=10813253

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69817810T Expired - Lifetime DE69817810T2 (de) 1997-05-29 1998-05-15 Cyanoguanidine als zellproliferation inhibitoren

Country Status (21)

Country Link
US (2) US6346520B1 (de)
EP (1) EP0984936B1 (de)
JP (1) JP4349476B2 (de)
KR (1) KR100549631B1 (de)
CN (1) CN1121389C (de)
AT (1) ATE248819T1 (de)
AU (1) AU733000B2 (de)
CA (1) CA2292775C (de)
CZ (1) CZ293275B6 (de)
DE (1) DE69817810T2 (de)
DK (1) DK0984936T3 (de)
ES (1) ES2206931T3 (de)
GB (1) GB9711123D0 (de)
HK (1) HK1027568A1 (de)
HU (1) HUP0003823A3 (de)
NZ (1) NZ501266A (de)
PL (1) PL190249B1 (de)
PT (1) PT984936E (de)
RO (1) RO119880B1 (de)
RU (1) RU2194697C2 (de)
WO (1) WO1998054141A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061561A1 (en) 1999-04-09 2000-10-19 Shionogi Bioresearch Corp. Cyanoguanidine compounds
AU1494702A (en) 2000-11-21 2002-06-03 Leo Pharma As Cyanoguanidine prodrugs
US20030045515A1 (en) * 2001-05-24 2003-03-06 Lise Binderup Combination medicament for treatment of neoplastic diseases
HUP0400021A3 (en) 2001-05-24 2008-03-28 Leo Pharma As Novel pyridyl cyanoguanidine derivatives and pharmaceutical compositions containing them
US7253193B2 (en) 2002-05-17 2007-08-07 Leo Pharma A/S Cyanoguanidine prodrugs
JP5189367B2 (ja) 2004-12-22 2013-04-24 レオ ファーマ アクティーゼルスカブ 新規シアノグアニジン化合物
EP2197443A4 (de) 2007-09-26 2014-01-01 Gemin X Pharmaceuticals Canada Inc Zusammensetzungen und verfahren zur herbeiführung von nad+-spiegeln mithilfe eines nicotinamid-phosphoribosyl-transferase-hemmers
US8173677B2 (en) 2007-09-26 2012-05-08 Gemin X Pharmaceuticals Canada Inc. Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor
EP2394649A4 (de) 2009-02-06 2012-08-15 Tianjin Hemay Bio Tech Co Ltd Pharmazeutische zusammensetzungen mit pyridylcyanoguanidinen, herstellungsverfahren dafür und ihre verwendung
US8912184B1 (en) 2010-03-01 2014-12-16 Alzheimer's Institute Of America, Inc. Therapeutic and diagnostic methods
JP2013540781A (ja) 2010-10-26 2013-11-07 ティエンジン ホーメイ バイオ−テック カンパニー， リミテッド Ｎ−（６−（４−クロロフェノキシ）ヘキシル）−ｎ’−シアノ−ｎ’’−（４−ピリジル）グアニジンの結晶多形とその製造及び使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9219472D0 (en) * 1992-09-15 1992-10-28 Leo Pharm Prod Ltd Chemical compounds
GB9711125D0 (en) * 1997-05-29 1997-07-23 Leo Pharm Prod Ltd Novel cyanoguanidines
AU1494702A (en) * 2000-11-21 2002-06-03 Leo Pharma As Cyanoguanidine prodrugs

Also Published As

Publication number Publication date
JP2001526692A (ja) 2001-12-18
GB9711123D0 (en) 1997-07-23
US20020107400A1 (en) 2002-08-08
HUP0003823A2 (en) 2001-03-28
DK0984936T3 (da) 2004-01-05
WO1998054141A1 (en) 1998-12-03
PT984936E (pt) 2004-02-27
US6646129B2 (en) 2003-11-11
HUP0003823A3 (en) 2001-09-28
ES2206931T3 (es) 2004-05-16
CZ9904240A3 (cs) 2001-01-17
EP0984936A1 (de) 2000-03-15
CN1121389C (zh) 2003-09-17
RU2194697C2 (ru) 2002-12-20
AU7638398A (en) 1998-12-30
CN1258277A (zh) 2000-06-28
KR20010013164A (ko) 2001-02-26
CZ293275B6 (cs) 2004-03-17
CA2292775A1 (en) 1998-12-03
EP0984936B1 (de) 2003-09-03
RO119880B1 (ro) 2005-05-30
CA2292775C (en) 2009-10-13
JP4349476B2 (ja) 2009-10-21
NZ501266A (en) 2001-09-28
PL337059A1 (en) 2000-07-31
KR100549631B1 (ko) 2006-02-08
PL190249B1 (pl) 2005-11-30
ATE248819T1 (de) 2003-09-15
US6346520B1 (en) 2002-02-12
HK1027568A1 (en) 2001-01-19
AU733000B2 (en) 2001-05-03
DE69817810T2 (de) 2004-07-01

Similar Documents

Publication Publication Date Title
SE0202463D0 (sv) Novel compounds
DE60226469D1 (de) Biphenylkarbonsäureamidderivate als p38 kinase-inhibitoren
DE69928697D1 (de) Sulfohydroxamsäure and sulfohydroxamate und ihre verwendung als mek-inhibitoren
ATE253545T1 (de) Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren
DK0984938T3 (da) Cyanoguanidiner som celleproliferationsinhibitorer
HK1080470A1 (en) Heterocyclic compounds
DE69719350T2 (de) 2-pyrimidinamin derivaten und verfahrens zu deren herstellung
IL166271A0 (en) Pyrrolidinedione substituted piperidine phthalazone derivatives and pharmaceutical compositions containing the same
ATE465146T1 (de) 1h-indolderivate als hochselektive cyclooxygenase-2-inhibitoren
NO20044996L (no) Furylforbindelser
DE60230127D1 (de) Inhibitoren von integrin alpha-v-beta-6
DE69817810D1 (de) Cyanoguanidine als zellproliferation inhibitoren
DE60112306D1 (de) Kondensierte pyrazindionderivate als pde5 inhibitore
BRPI0407841A (pt) inibidores heterocìclicos de quinase
BG103867A (en) Cyanoguanidines as cell proliferation inhibitors
HUP0003942A2 (hu) Helyettesített 3,3-diamino-2-propén-nitrilek, előállításuk és alkalmazásuk
ATE333457T1 (de) Zyklische gmp-spezifische phosphodiesteraseinhibitoren
MXPA06001039A (es) Derivados de nicotinamida utiles como inhibidores de pde4.
ATE419242T1 (de) Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren
DE60110124D1 (de) Kondensierte pyrazindionderivate als pde inhibitoren
ATE348800T1 (de) 4'-methansulfonylbiphenylderivate als hochselektive cyclooxygenase-2-inhibitoren
ATE337320T1 (de) Indolderivate als pde5-inhibitoren
SE0202461D0 (sv) Novel compounds
ATE246174T1 (de) Tosylprolin-derivate als thymidylat-synthase inhibitoren
MXPA03000887A (es) Derivados heterociclicos fusionados como inhibidores de fosfodiesterasa.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition