DK0984936T3 - Cyanoguanidiner som celleproliferationsinhibitorer - Google Patents
Cyanoguanidiner som celleproliferationsinhibitorerInfo
- Publication number
- DK0984936T3 DK0984936T3 DK98924052T DK98924052T DK0984936T3 DK 0984936 T3 DK0984936 T3 DK 0984936T3 DK 98924052 T DK98924052 T DK 98924052T DK 98924052 T DK98924052 T DK 98924052T DK 0984936 T3 DK0984936 T3 DK 0984936T3
- Authority
- DK
- Denmark
- Prior art keywords
- stands
- cyanoguanidines
- alkoxycarbonyl
- carboxy
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9711123.1A GB9711123D0 (en) | 1997-05-29 | 1997-05-29 | Novel cyanoguanidines |
| PCT/DK1998/000193 WO1998054141A1 (en) | 1997-05-29 | 1998-05-15 | Cyanoguanidines as cell proliferation inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0984936T3 true DK0984936T3 (da) | 2004-01-05 |
Family
ID=10813253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98924052T DK0984936T3 (da) | 1997-05-29 | 1998-05-15 | Cyanoguanidiner som celleproliferationsinhibitorer |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6346520B1 (da) |
| EP (1) | EP0984936B1 (da) |
| JP (1) | JP4349476B2 (da) |
| KR (1) | KR100549631B1 (da) |
| CN (1) | CN1121389C (da) |
| AT (1) | ATE248819T1 (da) |
| AU (1) | AU733000B2 (da) |
| CA (1) | CA2292775C (da) |
| CZ (1) | CZ293275B6 (da) |
| DE (1) | DE69817810T2 (da) |
| DK (1) | DK0984936T3 (da) |
| ES (1) | ES2206931T3 (da) |
| GB (1) | GB9711123D0 (da) |
| HK (1) | HK1027568A1 (da) |
| HU (1) | HUP0003823A3 (da) |
| NZ (1) | NZ501266A (da) |
| PL (1) | PL190249B1 (da) |
| PT (1) | PT984936E (da) |
| RO (1) | RO119880B1 (da) |
| RU (1) | RU2194697C2 (da) |
| WO (1) | WO1998054141A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4080300A (en) | 1999-04-09 | 2000-11-14 | Shionogi Bioresearch Corp. | Cyanoguanidine compounds |
| AU1494702A (en) | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
| BR0209930A (pt) * | 2001-05-24 | 2004-03-30 | Leo Pharma As | Composto, composição farmacêutica, método para tratar doenças proliferativas, e, uso de um composto |
| US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
| US7253193B2 (en) | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| JP5189367B2 (ja) | 2004-12-22 | 2013-04-24 | レオ ファーマ アクティーゼルスカブ | 新規シアノグアニジン化合物 |
| EP2197443A4 (en) | 2007-09-26 | 2014-01-01 | Gemin X Pharmaceuticals Canada Inc | COMPOSITIONS AND METHODS FOR INFLUENCING NAD + CONTENT USING A NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE INHIBITOR |
| US8173677B2 (en) | 2007-09-26 | 2012-05-08 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| AU2010210248B2 (en) * | 2009-02-06 | 2012-08-16 | Tianjin Hemay Bio-Tech Co., Ltd. | Pharmaceutical compositions comprising pyridyl cyanoguanidine, process for preparing the same and use thereof |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| WO2012055346A1 (zh) | 2010-10-26 | 2012-05-03 | 天津和美生物技术有限公司 | N-(6-(4-氯苯氧基)己基)-n'-氰基-n''-(4-吡啶基)胍的多晶型物及其制备和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9219472D0 (en) * | 1992-09-15 | 1992-10-28 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| AU1494702A (en) * | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
-
1997
- 1997-05-29 GB GBGB9711123.1A patent/GB9711123D0/en active Pending
-
1998
- 1998-05-15 KR KR1019997011148A patent/KR100549631B1/ko not_active IP Right Cessation
- 1998-05-15 CA CA002292775A patent/CA2292775C/en not_active Expired - Lifetime
- 1998-05-15 DK DK98924052T patent/DK0984936T3/da active
- 1998-05-15 CZ CZ19994240A patent/CZ293275B6/cs not_active IP Right Cessation
- 1998-05-15 PT PT98924052T patent/PT984936E/pt unknown
- 1998-05-15 PL PL98337059A patent/PL190249B1/pl not_active IP Right Cessation
- 1998-05-15 AU AU76383/98A patent/AU733000B2/en not_active Expired
- 1998-05-15 JP JP50011199A patent/JP4349476B2/ja not_active Expired - Lifetime
- 1998-05-15 WO PCT/DK1998/000193 patent/WO1998054141A1/en not_active Application Discontinuation
- 1998-05-15 NZ NZ501266A patent/NZ501266A/en not_active IP Right Cessation
- 1998-05-15 ES ES98924052T patent/ES2206931T3/es not_active Expired - Lifetime
- 1998-05-15 DE DE69817810T patent/DE69817810T2/de not_active Expired - Lifetime
- 1998-05-15 HU HU0003823A patent/HUP0003823A3/hu unknown
- 1998-05-15 US US09/424,631 patent/US6346520B1/en not_active Expired - Lifetime
- 1998-05-15 RU RU99128101/04A patent/RU2194697C2/ru active
- 1998-05-15 RO RO99-01253A patent/RO119880B1/ro unknown
- 1998-05-15 CN CN98805591A patent/CN1121389C/zh not_active Expired - Lifetime
- 1998-05-15 AT AT98924052T patent/ATE248819T1/de not_active IP Right Cessation
- 1998-05-15 EP EP98924052A patent/EP0984936B1/en not_active Expired - Lifetime
-
2000
- 2000-10-23 HK HK00106694A patent/HK1027568A1/xx not_active IP Right Cessation
-
2002
- 2002-02-04 US US10/061,204 patent/US6646129B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0984936B1 (en) | 2003-09-03 |
| EP0984936A1 (en) | 2000-03-15 |
| CN1121389C (zh) | 2003-09-17 |
| GB9711123D0 (en) | 1997-07-23 |
| WO1998054141A1 (en) | 1998-12-03 |
| US6646129B2 (en) | 2003-11-11 |
| KR100549631B1 (ko) | 2006-02-08 |
| CZ9904240A3 (cs) | 2001-01-17 |
| ATE248819T1 (de) | 2003-09-15 |
| CZ293275B6 (cs) | 2004-03-17 |
| CN1258277A (zh) | 2000-06-28 |
| HK1027568A1 (en) | 2001-01-19 |
| JP4349476B2 (ja) | 2009-10-21 |
| PL190249B1 (pl) | 2005-11-30 |
| KR20010013164A (ko) | 2001-02-26 |
| HUP0003823A3 (en) | 2001-09-28 |
| PL337059A1 (en) | 2000-07-31 |
| US6346520B1 (en) | 2002-02-12 |
| DE69817810T2 (de) | 2004-07-01 |
| CA2292775C (en) | 2009-10-13 |
| AU7638398A (en) | 1998-12-30 |
| CA2292775A1 (en) | 1998-12-03 |
| NZ501266A (en) | 2001-09-28 |
| DE69817810D1 (de) | 2003-10-09 |
| HUP0003823A2 (en) | 2001-03-28 |
| ES2206931T3 (es) | 2004-05-16 |
| RO119880B1 (ro) | 2005-05-30 |
| RU2194697C2 (ru) | 2002-12-20 |
| US20020107400A1 (en) | 2002-08-08 |
| JP2001526692A (ja) | 2001-12-18 |
| AU733000B2 (en) | 2001-05-03 |
| PT984936E (pt) | 2004-02-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE0202463D0 (sv) | Novel compounds | |
| DK0984938T3 (da) | Cyanoguanidiner som celleproliferationsinhibitorer | |
| NO20066055L (no) | Pyridinderivater | |
| HK1080470A1 (en) | Heterocyclic compounds | |
| DE60226469D1 (de) | Biphenylkarbonsäureamidderivate als p38 kinase-inhibitoren | |
| ATE253545T1 (de) | Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren | |
| EP1248612A4 (en) | NEW SUBSTANCES AND COMPOUNDS AS PROTEASE INHIBITORS | |
| DE69928697D1 (de) | Sulfohydroxamsäure and sulfohydroxamate und ihre verwendung als mek-inhibitoren | |
| HK1053463A1 (en) | Aminobenzophenones as inhibitors of il-1B and TNF-a. | |
| IL166271A0 (en) | Pyrrolidinedione substituted piperidine phthalazone derivatives and pharmaceutical compositions containing the same | |
| NO20044731L (no) | Kinolin- og isokinolinderivater fremgangsmate for fremstilling derav og anvendelse derav som betennelseshemmere | |
| DE60334536D1 (de) | Furylverbindungen | |
| DE60333746D1 (de) | Thienylverbindungen | |
| ATE416157T1 (de) | Inhibitoren von integrin alpha-v-beta-6 | |
| DK0984936T3 (da) | Cyanoguanidiner som celleproliferationsinhibitorer | |
| BRPI0407841A (pt) | inibidores heterocìclicos de quinase | |
| BG103867A (en) | Cyanoguanidines as cell proliferation inhibitors | |
| SE0302756D0 (sv) | Novel Compounds | |
| NO20072078L (no) | Indolderivater som inhibitorer av loselig adenylsyklase | |
| NO20055749L (no) | Sulfamat benzotiofenderivater som steroid sulfatase inhibitorer | |
| EA200600100A1 (ru) | Производные никотинамида, полезные в качестве ингибиторов pde4 | |
| ATE333457T1 (de) | Zyklische gmp-spezifische phosphodiesteraseinhibitoren | |
| ATE419242T1 (de) | Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren | |
| SE0202461D0 (sv) | Novel compounds | |
| ATE246174T1 (de) | Tosylprolin-derivate als thymidylat-synthase inhibitoren |