CY1111868T1 - Παραγωγα ιμιδαζο[1,2-α] πυριδινο-2-καρβοξαμιδιων η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη - Google Patents

Παραγωγα ιμιδαζο[1,2-α] πυριδινο-2-καρβοξαμιδιων η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη

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Publication number
CY1111868T1
CY1111868T1 CY20111100038T CY111100038T CY1111868T1 CY 1111868 T1 CY1111868 T1 CY 1111868T1 CY 20111100038 T CY20111100038 T CY 20111100038T CY 111100038 T CY111100038 T CY 111100038T CY 1111868 T1 CY1111868 T1 CY 1111868T1
Authority
CY
Cyprus
Prior art keywords
group
alkoxy
alkyl
optionally substituted
cycloalkyl
Prior art date
Application number
CY20111100038T
Other languages
English (en)
Inventor
Youssef El-Ahmad
Anne Olivier
Jean-François Peyronel
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of CY1111868T1 publication Critical patent/CY1111868T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Η εφεύρεση αφορά τα παράγωγα ιμιδαζοπυριδινο 2-καρβοξαμίδιων, του γενικού τύπου (I), με το Χ να δηλώνει μία από τις ακόλουθες ομάδες : μια ομάδα φαινυλίου ενδεχομένως υποκαθιστούμενη, το R1 δηλώνει ένα άτομο υδρογόνου, ένα αλογόνο, μια ομάδα (C1-C6)άλκοξυ, μια ομάδα (C1-C6)αλκυλίου, μια ομάδα (C3-C7)κυκλοαλκυλο (C1-C6)αλκυλίου, μια ομάδα (C3-C7)κυκλοαλκυλο (C1-C6)άλκοξυ, ένα αμίνιο, μια ομάδα NRcRd, με τις ομάδες αλκυλίων και αλκοξέος να μπορούν ενδεχομένως να υποκαθίστανται. To R2 δηλώνει μία από τις ακόλουθες ομάδες : ένα άτομο υδρογόνου, μια ομάδα(C1-C6)αλκυλίου ενδεχομένως υποκαθιστούμενη, μια ομάδα (C1-C6)άλκοξυ ενδεχομένως υποκαθιστούμενη, μια ομάδα (C3-C7)κυκλοαλκυλο (C1-C6)αλκυλίου, μια ομάδα (C3-C7)κυκλοαλκυλο (C1-C6)άλκοξυ, μια ομάδα (C2-C6)αλκενυλίου, μια ομάδα (C2-C6)αλκυνυλίου, μια ομάδα -CO-R5 μια ομάδα -CO-NR6R7 μια ομάδα -CO-O-R8 μια ομάδα -NR9-CO-R10, μια ομάδα -NR11R12 ένα άτομο αλογόνου, μια ομάδα κυανό, μια ομάδα φαινυλίου ενδεχομένως υποκαθιστούμενη, το R3 δηλώνει ένα άτομο υδρογόνου, μια ομάδα (C1-C6)αλκυλίου, μια ομάδα (C1-C6)άλκοξυ, ή ένα άτομο αλογόνου, το R4 δηλώνει ένα άτομο υδρογόνου μια ομάδα (C1-C4)αλκυλίου, μια ομάδα (C1-C4)άλκοξυ ή ένα άτομο φθορίου. Διαδικασία παρασκευής και εφαρμογή στη θεραπευτική πρακτική.
CY20111100038T 2006-07-03 2011-01-12 Παραγωγα ιμιδαζο[1,2-α] πυριδινο-2-καρβοξαμιδιων η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη CY1111868T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0606012A FR2903107B1 (fr) 2006-07-03 2006-07-03 Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique
EP07803833A EP2041133B1 (fr) 2006-07-03 2007-07-03 Dérivés d'imidazo[1,2-a]pyridine-2-carboxamides leur préparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
CY1111868T1 true CY1111868T1 (el) 2015-11-04

Family

ID=37775231

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100038T CY1111868T1 (el) 2006-07-03 2011-01-12 Παραγωγα ιμιδαζο[1,2-α] πυριδινο-2-καρβοξαμιδιων η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη

Country Status (24)

Country Link
US (2) US7704989B2 (el)
EP (1) EP2041133B1 (el)
JP (1) JP5259587B2 (el)
KR (1) KR20090024776A (el)
CN (1) CN101484453B (el)
AT (1) ATE484504T1 (el)
AU (1) AU2007271008B2 (el)
BR (1) BRPI0714320A2 (el)
CA (1) CA2655713C (el)
CY (1) CY1111868T1 (el)
DE (1) DE602007009839D1 (el)
DK (1) DK2041133T3 (el)
ES (1) ES2354482T3 (el)
FR (1) FR2903107B1 (el)
HK (1) HK1135964A1 (el)
HR (1) HRP20110015T1 (el)
IL (1) IL195891A0 (el)
MX (1) MX2008016546A (el)
PL (1) PL2041133T3 (el)
PT (1) PT2041133E (el)
RS (1) RS51652B (el)
RU (1) RU2441003C2 (el)
SI (1) SI2041133T1 (el)
WO (1) WO2008003856A1 (el)

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FR2903108B1 (fr) * 2006-07-03 2008-08-29 Sanofi Aventis Sa Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique.
TW200911798A (en) 2007-08-02 2009-03-16 Amgen Inc PI3 kinase modulators and methods of use
EP2231661A1 (en) * 2007-12-19 2010-09-29 Amgen, Inc. Inhibitors of pi3 kinase
FR2925901B1 (fr) * 2008-01-02 2011-03-04 Sanofi Aventis DERIVES DE N-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2925905B1 (fr) 2008-01-02 2010-11-05 Sanofi Aventis DERIVES DE 2-BENZOYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2925903B1 (fr) 2008-01-02 2011-01-21 Sanofi Aventis DERIVES 6-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2925900B1 (fr) 2008-01-02 2011-03-04 Sanofi Aventis DERIVES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2925906B1 (fr) * 2008-01-02 2010-08-20 Sanofi Aventis COMPOSES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2928921B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique
FR2928923B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
FR2928924B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
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FR2933609B1 (fr) 2008-07-10 2010-08-27 Fournier Lab Sa Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson.
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FR2955110A1 (fr) 2010-01-08 2011-07-15 Fournier Lab Sa Nouveaux derives de type pyrrolopyridine benzoique
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Also Published As

Publication number Publication date
EP2041133A1 (fr) 2009-04-01
US20100168155A1 (en) 2010-07-01
JP5259587B2 (ja) 2013-08-07
BRPI0714320A2 (pt) 2014-06-24
RS51652B (en) 2011-10-31
WO2008003856A1 (fr) 2008-01-10
HK1135964A1 (en) 2010-06-18
FR2903107A1 (fr) 2008-01-04
DK2041133T3 (da) 2011-02-07
IL195891A0 (en) 2009-09-01
CN101484453A (zh) 2009-07-15
PT2041133E (pt) 2011-01-10
EP2041133B1 (fr) 2010-10-13
US7704989B2 (en) 2010-04-27
US20090149441A1 (en) 2009-06-11
SI2041133T1 (sl) 2011-02-28
JP2009541471A (ja) 2009-11-26
MX2008016546A (es) 2009-02-06
KR20090024776A (ko) 2009-03-09
ATE484504T1 (de) 2010-10-15
DE602007009839D1 (de) 2010-11-25
HRP20110015T1 (hr) 2011-02-28
CA2655713A1 (fr) 2008-01-10
PL2041133T3 (pl) 2011-04-29
CA2655713C (fr) 2015-05-05
CN101484453B (zh) 2012-07-04
FR2903107B1 (fr) 2008-08-22
US8404848B2 (en) 2013-03-26
ES2354482T3 (es) 2011-03-15
AU2007271008A1 (en) 2008-01-10
RU2009103307A (ru) 2010-08-10
RU2441003C2 (ru) 2012-01-27
AU2007271008B2 (en) 2012-10-11

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