MX2009013667A - Inhibidores triciclicos de hidroxiesteroide deshidrogenasas. - Google Patents

Inhibidores triciclicos de hidroxiesteroide deshidrogenasas.

Info

Publication number
MX2009013667A
MX2009013667A MX2009013667A MX2009013667A MX2009013667A MX 2009013667 A MX2009013667 A MX 2009013667A MX 2009013667 A MX2009013667 A MX 2009013667A MX 2009013667 A MX2009013667 A MX 2009013667A MX 2009013667 A MX2009013667 A MX 2009013667A
Authority
MX
Mexico
Prior art keywords
hydroxysteroid dehydrogenases
tricyclic inhibitors
compounds
hydroxysteroid
treatment
Prior art date
Application number
MX2009013667A
Other languages
English (en)
Inventor
Jay P Powers
Lisa Julian
Daqing Sun
Xuelei Yan
Felix Gonzalez Lopez De Turiso
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2009013667A publication Critical patent/MX2009013667A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members

Abstract

La presente invención provee compuestos tricíclicos de conformidad con la fórmula (I), en la cual R1, R2, R3, W, X, Y, Z, m, n y p son como se definen en la descripción; así como composiciones farmacéuticas que comprenden a los mismos, métodos de uso de los compuestos y composiciones de la invención para el tratamiento de condiciones asociadas con hidroxiesteroide deshidrogenasas (por ejemplo, 11ß-HSD1), y el uso de los compuestos de la invención en la preparación de medicamentos para el tratamiento de condiciones asociadas con hidroxiesteroide deshidrogenasa.
MX2009013667A 2007-06-14 2008-06-11 Inhibidores triciclicos de hidroxiesteroide deshidrogenasas. MX2009013667A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92913207P 2007-06-14 2007-06-14
PCT/US2008/007269 WO2008156601A1 (en) 2007-06-14 2008-06-11 Tricyclic inhibitors of hydroxysteroid dehydrogenases

Publications (1)

Publication Number Publication Date
MX2009013667A true MX2009013667A (es) 2010-03-22

Family

ID=39638695

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013667A MX2009013667A (es) 2007-06-14 2008-06-11 Inhibidores triciclicos de hidroxiesteroide deshidrogenasas.

Country Status (7)

Country Link
US (1) US8765788B2 (es)
EP (1) EP2162439A1 (es)
JP (1) JP2010529192A (es)
AU (1) AU2008267017A1 (es)
CA (1) CA2691309A1 (es)
MX (1) MX2009013667A (es)
WO (1) WO2008156601A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140057953A1 (en) * 2011-03-03 2014-02-27 Rolf Hartmann Biaryl derivatives as selective 17beta-hydroxysteroid dehydrogenase type 2 inhibitors
CN105481844A (zh) * 2015-12-08 2016-04-13 梁彦云 一种治疗高血压的药物组合物
EP3235813A1 (en) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Aza-tetra-cyclo derivatives
CN109134222B (zh) * 2018-09-14 2022-01-21 上海博栋化学科技有限公司 一种2-羟基异丙基取代的苯乙酮的制备方法
US20220325171A1 (en) 2021-03-31 2022-10-13 Hoya Lens Thailand Ltd. Photochromic compound, photochromic article and eyeglasses

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2636819B2 (ja) 1994-12-20 1997-07-30 日本たばこ産業株式会社 オキサゾール系複素環式芳香族化合物
EP0816362A4 (en) 1995-03-22 1998-07-08 Taisho Pharmaceutical Co Ltd THIAZOLE DERIVATIVES
JPH1149762A (ja) 1997-08-08 1999-02-23 Japan Tobacco Inc チアゾール化合物
WO2001027094A1 (fr) 1999-10-12 2001-04-19 Japan Tobacco Inc. Remede anti-hypertriglyceridemie et anti-obesite
ATE341539T1 (de) * 2001-01-26 2006-10-15 Chugai Pharmaceutical Co Ltd Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren
CA2568186C (en) 2004-05-24 2011-11-15 Amgen Inc. Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
JP2008001596A (ja) * 2004-09-03 2008-01-10 Astellas Pharma Inc ナトリウムチャネル阻害剤
EP1951696A2 (en) 2005-11-22 2008-08-06 Amgen Inc. Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

Also Published As

Publication number Publication date
WO2008156601A1 (en) 2008-12-24
CA2691309A1 (en) 2008-12-24
EP2162439A1 (en) 2010-03-17
JP2010529192A (ja) 2010-08-26
US20100280073A1 (en) 2010-11-04
US8765788B2 (en) 2014-07-01
AU2008267017A1 (en) 2008-12-24

Similar Documents

Publication Publication Date Title
MX2010001754A (es) Derivados de azepina como inhibidores de gamma secretasa.
TW201129565A (en) Tricyclic heterocyclic compounds, compositions and methods of use thereof
MY147994A (en) Azabiphenylaminobenzoic acid derivatives as dhodh inhibitors
MX336381B (es) Boronatos como inhibidores de arginasa.
TW200745067A (en) Novel compounds
MY148634A (en) Pyridazinone derivatives
UA98804C2 (ru) Катехоламиновые производные и фармацевтическая композиция на их основе
MA33803B1 (fr) Inhibiteur de bromodomaine de benzodiazépine
MX2012007175A (es) Derivados de imidazopiridina como inhibidores de jak.
GEP20125652B (en) cMET INHIBITORS
NZ577916A (en) Cyclopamine analogs
TW200801003A (en) Novel compounds
MX2010009022A (es) Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.
MY153921A (en) Aminopyrazole derivatives
MX2009011205A (es) Derivados de 2-iminoisotiazol como ligandos del receptor canabinoide.
TW200745084A (en) Novel compounds
JO2682B1 (en) Derivatives of alkynil-8.1-naphthayridone, preparations thereof and therapeutic use thereof
MX2009007713A (es) Derivados de piridazina, procedimientos para su preparacion y su uso como fungicidas.
MY186599A (en) Substituted pyridopyrazines as novel syk inhibitors
MX2010005649A (es) Compuestos novedosos como ligandos del receptor canabinoide y sus usos.
JO2673B1 (en) Diosmetin compounds, method of preparation and pharmaceutical compositions
MX2012006805A (es) Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa.
IL205696A0 (en) Heterocyclic derivatives, compositions comprising the same and uses thereof
TW200738627A (en) Trialkylsilyl-indoles
SG158091A1 (en) Imidazoazepinone compounds

Legal Events

Date Code Title Description
FA Abandonment or withdrawal