ATE341539T1 - Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren - Google Patents
Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatorenInfo
- Publication number
- ATE341539T1 ATE341539T1 AT02707566T AT02707566T ATE341539T1 AT E341539 T1 ATE341539 T1 AT E341539T1 AT 02707566 T AT02707566 T AT 02707566T AT 02707566 T AT02707566 T AT 02707566T AT E341539 T1 ATE341539 T1 AT E341539T1
- Authority
- AT
- Austria
- Prior art keywords
- malonyl
- decarboxylase
- malonyl coa
- decarboxylase inhibitors
- compounds
- Prior art date
Links
- 108010081805 Malonyl-CoA decarboxylase Proteins 0.000 title abstract 4
- 102100029461 Malonyl-CoA decarboxylase, mitochondrial Human genes 0.000 title abstract 3
- 239000003954 decarboxylase inhibitor Substances 0.000 title 1
- 230000004060 metabolic process Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 208000010444 Acidosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 230000007950 acidosis Effects 0.000 abstract 1
- 208000026545 acidosis disease Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000007726 management method Methods 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/415—1,2-Diazoles
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- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
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- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
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- C07F9/22—Amides of acids of phosphorus
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- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/247—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aromatic amines (N-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4021—Esters of aromatic acids (P-C aromatic linkage)
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US26538001P | 2001-01-26 | 2001-01-26 |
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ATE341539T1 true ATE341539T1 (de) | 2006-10-15 |
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AT02707566T ATE341539T1 (de) | 2001-01-26 | 2002-01-22 | Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren |
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US (2) | US7279477B2 (de) |
EP (1) | EP1377290B1 (de) |
JP (2) | JP4267920B2 (de) |
AT (1) | ATE341539T1 (de) |
AU (1) | AU2002241966A1 (de) |
DE (1) | DE60215139T2 (de) |
ES (1) | ES2274005T3 (de) |
WO (1) | WO2002064136A2 (de) |
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CA2735267C (en) | 2001-01-26 | 2013-05-07 | Chugai Seiyaku Kabushiki Kaisha | Malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
JP4503232B2 (ja) * | 2001-01-26 | 2010-07-14 | 中外製薬株式会社 | マロニル−CoA脱炭酸酵素阻害剤を用いた疾患の治療法 |
US7709510B2 (en) | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
PT1370260E (pt) | 2001-02-20 | 2011-02-01 | Chugai Pharmaceutical Co Ltd | Azóis como inibidores da malonil-coa-descarboxilase úteis como moduladores metabólicos |
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WO2003090869A1 (en) * | 2002-04-23 | 2003-11-06 | Chugai Seiyaku Kabushiki Kaisha | Lxr modulators |
AU2003223684A1 (en) * | 2002-04-23 | 2003-11-10 | Chugai Seiyaku Kabushiki Kaisha | Lxr modulators for the treatment of cardiovascular diseases |
EP1658071B1 (de) | 2003-08-01 | 2008-09-10 | Chugai Seiyaku Kabushiki Kaisha | Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer |
CA2533749C (en) | 2003-08-01 | 2012-07-10 | Chugai Seiyaku Kabushiki Kaisha | Piperidine compounds useful as malonyl-coa decarboxylase inhibitors |
EP1653944B1 (de) | 2003-08-01 | 2010-11-10 | Chugai Seiyaku Kabushiki Kaisha | Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer |
US7285562B2 (en) | 2003-08-01 | 2007-10-23 | Chugai Seiyaku Kabushiki Kaisha | Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors |
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UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
AU2017329090B9 (en) | 2016-09-19 | 2019-09-05 | Novartis Ag | Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor |
JP7309614B2 (ja) | 2017-05-02 | 2023-07-18 | ノバルティス アーゲー | 組み合わせ療法 |
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-
2002
- 2002-01-22 US US10/466,926 patent/US7279477B2/en not_active Expired - Fee Related
- 2002-01-22 AT AT02707566T patent/ATE341539T1/de not_active IP Right Cessation
- 2002-01-22 ES ES02707566T patent/ES2274005T3/es not_active Expired - Lifetime
- 2002-01-22 EP EP02707566A patent/EP1377290B1/de not_active Expired - Lifetime
- 2002-01-22 JP JP2002563930A patent/JP4267920B2/ja not_active Expired - Fee Related
- 2002-01-22 AU AU2002241966A patent/AU2002241966A1/en not_active Abandoned
- 2002-01-22 WO PCT/US2002/002179 patent/WO2002064136A2/en active IP Right Grant
- 2002-01-22 DE DE60215139T patent/DE60215139T2/de not_active Expired - Lifetime
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2007
- 2007-09-14 US US11/855,984 patent/US20080070869A1/en not_active Abandoned
- 2007-10-15 JP JP2007267407A patent/JP4855368B2/ja not_active Expired - Fee Related
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WO2002064136A3 (en) | 2003-10-30 |
EP1377290A2 (de) | 2004-01-07 |
DE60215139T2 (de) | 2007-08-16 |
WO2002064136A2 (en) | 2002-08-22 |
EP1377290B1 (de) | 2006-10-04 |
JP4267920B2 (ja) | 2009-05-27 |
ES2274005T3 (es) | 2007-05-16 |
US7279477B2 (en) | 2007-10-09 |
AU2002241966A1 (en) | 2002-08-28 |
JP2008100998A (ja) | 2008-05-01 |
US20080070869A1 (en) | 2008-03-20 |
JP2004523542A (ja) | 2004-08-05 |
JP4855368B2 (ja) | 2012-01-18 |
US20040063671A1 (en) | 2004-04-01 |
DE60215139D1 (en) | 2006-11-16 |
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