ATE400272T1 - Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer - Google Patents
Piperidin-verbindungen als malonyl-coa decarboxylase-hemmerInfo
- Publication number
- ATE400272T1 ATE400272T1 AT04779398T AT04779398T ATE400272T1 AT E400272 T1 ATE400272 T1 AT E400272T1 AT 04779398 T AT04779398 T AT 04779398T AT 04779398 T AT04779398 T AT 04779398T AT E400272 T1 ATE400272 T1 AT E400272T1
- Authority
- AT
- Austria
- Prior art keywords
- malonyl
- prophylaxis
- management
- treatment
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49212203P | 2003-08-01 | 2003-08-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE400272T1 true ATE400272T1 (de) | 2008-07-15 |
Family
ID=34115600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04779398T ATE400272T1 (de) | 2003-08-01 | 2004-07-28 | Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer |
Country Status (8)
Country | Link |
---|---|
US (2) | US7449482B2 (de) |
EP (1) | EP1653957B1 (de) |
JP (1) | JP4648317B2 (de) |
AT (1) | ATE400272T1 (de) |
CA (1) | CA2533749C (de) |
DE (1) | DE602004014937D1 (de) |
ES (1) | ES2309563T3 (de) |
WO (1) | WO2005011693A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002066034A1 (en) * | 2001-02-20 | 2002-08-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for treating metabolic diseases using malonyl-coa decarboxylase inhibitors |
US7709510B2 (en) * | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
CA2515368A1 (en) * | 2003-02-13 | 2004-08-26 | Luciano Rossetti | Regulation of food intake and glucose production by modulation of long-chain fatty acyl-coa levels in the hypothalamus |
JP4727578B2 (ja) | 2003-08-01 | 2011-07-20 | 中外製薬株式会社 | マロニル−CoAデカルボキシラーゼ阻害剤として有用な複素環式化合物 |
US7449482B2 (en) * | 2003-08-01 | 2008-11-11 | Chugai Seiyaku Kabushiki Kaisha | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors |
US7786145B2 (en) * | 2003-08-01 | 2010-08-31 | Chugai Seiyaku Kabushiki Kaisha | Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors |
TW200630337A (en) * | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
US20070026079A1 (en) * | 2005-02-14 | 2007-02-01 | Louis Herlands | Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels |
WO2007110449A1 (en) | 2006-03-29 | 2007-10-04 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use |
WO2007118854A1 (en) | 2006-04-13 | 2007-10-25 | Euro-Celtique S.A. | Benzenesulfonamide compounds and the use thereof |
US8791264B2 (en) | 2006-04-13 | 2014-07-29 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use as blockers of calcium channels |
WO2008001883A1 (fr) * | 2006-06-29 | 2008-01-03 | Nissan Chemical Industries, Ltd. | DÉRIVÉ D'ACIDE α-AMINÉ ET PRODUIT PHARMACEUTIQUE QUI LE COMPREND EN TANT QUE MATIÈRE ACTIVE |
TW200838851A (en) * | 2007-01-29 | 2008-10-01 | Arete Therapeutics Inc | Processes for the preparation of piperidinyl-substituted urea compounds |
WO2008124118A1 (en) * | 2007-04-09 | 2008-10-16 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use therof |
WO2009040659A2 (en) | 2007-09-28 | 2009-04-02 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
EP2566853B1 (de) | 2010-05-05 | 2017-01-25 | Infinity Pharmaceuticals, Inc. | Tetrazolone als fettsäuresynthasehemmer |
US9393221B2 (en) | 2011-07-20 | 2016-07-19 | The General Hospital Corporation | Methods and compounds for reducing intracellular lipid storage |
Family Cites Families (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2863874A (en) * | 1955-05-26 | 1958-12-09 | Goodrich Co B F | Process of preparing 2-aminothiazoles |
US3728455A (en) | 1971-06-24 | 1973-04-17 | American Cyanamid Co | Novel compositions of matter |
US4499103A (en) * | 1983-03-17 | 1985-02-12 | Merck & Co., Inc. | Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure |
EP0144101B1 (de) | 1983-11-30 | 1991-02-06 | Janssen Pharmaceutica N.V. | Bizyklisches Heterozyklyl aufveisende N-(bizyklisches Heterozyklyl-4-piperidinamine |
JPS60202872A (ja) * | 1984-03-27 | 1985-10-14 | Kaken Pharmaceut Co Ltd | ベンゾフラン誘導体、その製法およびそれを有効成分とする降圧剤 |
CA1281325C (en) | 1984-06-20 | 1991-03-12 | Patrice C. Belanger | Benzofuran derivatives |
US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
GB8714537D0 (en) | 1987-06-22 | 1987-07-29 | Ici Plc | Pyrazine derivatives |
EP0733366B1 (de) | 1988-01-07 | 1998-04-01 | E.I. Du Pont De Nemours And Company | Angiotensin II-Rezeptor blockierende Imidazole und Diuretika enthaltende pharmazeutische Zusammensetzungen |
SG52709A1 (en) | 1989-06-30 | 1998-09-28 | Du Pont | Substituted imidazoles |
JP2568315B2 (ja) | 1989-06-30 | 1997-01-08 | イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー | 縮合環アリール置換イミダゾール |
SU1681502A1 (ru) | 1989-07-26 | 1994-06-15 | Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе | Гидрохлорид 3-(2,5- диметоксибензоил) -4- диметиламинометил -5-окси-6- бромбензофурана, обладающий анальгетическим, местноанестезирующим, противосудорожным, противоаритмическим, стимулирующим коронарный, мозговой и почечный кровоток действиями |
RU1743153C (ru) | 1990-06-04 | 1995-02-27 | ВНИИ химических средств защиты растений | N-[4-2'-гидроксигексафторизопропил)фенил] -n-этил-n'-фенилмочевина, обладающая рострегулирующим и антидотным действием |
EP0533840B1 (de) | 1990-06-22 | 1996-12-11 | E.I. Du Pont De Nemours And Company | Behandlung des chronischen nierenversagens mit imidazol-angiotensin-ii-rezeptorantagonisten |
HUT61980A (en) | 1990-10-12 | 1993-03-29 | Merck Frosst Canada Inc | Process for producing saturated hydroxyalkylquinoline acids and pharmaceutical compositions comprising such compounds as active ingredient |
US5470975A (en) | 1990-10-16 | 1995-11-28 | E.R. Squibb & Sons, Inc. | Dihydropyrimidine derivatives |
CA2053148A1 (en) | 1990-10-16 | 1992-04-17 | Karnail Atwal | Dihydropyrimidine derivatives |
US5374615A (en) | 1990-10-31 | 1994-12-20 | E. R. Squibb & Sons, Inc. | Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives |
SU1825496A3 (ru) | 1991-04-04 | 1994-12-30 | Всесоюзный научно-исследовательский институт химических средств защиты растений | Производные n-[4-(1-гидрокси-1-трифторметил-2,2,2-трифторэтил)фенил]мочевины, обладающие антидотной активностью к 2-хлор-n-[(4-метокси-6-метил-1,3,5-триазин-2-ил)аминокарбонил] бензолсульфамиду в посевах льна |
JPH05124925A (ja) | 1991-04-09 | 1993-05-21 | Sansho Seiyaku Co Ltd | メラニン生成抑制外用剤 |
US5190942A (en) | 1991-04-22 | 1993-03-02 | E. R. Squibb & Sons, Inc. | Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives |
US5256695A (en) | 1991-07-24 | 1993-10-26 | E. R. Squibb & Sons, Inc. | Acyl amidine and acyl guanidine substituted biphenyl derivatives |
US5177097A (en) | 1991-07-24 | 1993-01-05 | E. R. Squibb & Sons, Inc. | Acyl amidine and acyl, guanidine substituted biphenyl derivatives |
EP0601039A1 (de) | 1991-08-19 | 1994-06-15 | E.I. Du Pont De Nemours And Company | Imidazolinon derivate mit angiotensin ii rezeptor blockierungswirkung |
US5212177A (en) | 1991-12-16 | 1993-05-18 | E. R. Squibb & Sons, Inc. | Indole and benzimidazole-substituted dihydropyrimidine derivatives |
US5350752A (en) | 1991-12-16 | 1994-09-27 | E. R. Squibb & Sons, Inc. | Dihydropyrimidine derivatives |
US5225408A (en) | 1991-12-20 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Biphenyl oxadiazinone angiotensin II inhibitors |
TW297025B (de) | 1992-02-14 | 1997-02-01 | Squibb & Sons Inc | |
US5208234A (en) | 1992-03-10 | 1993-05-04 | E. R. Squibb & Sons, Inc. | Substituted imidazole phosphonic and phosphinic acid derivatives |
US5208235A (en) | 1992-03-10 | 1993-05-04 | E. R. Squibb & Sons, Inc. | Indole- and benzimidazole-substituted imidazole derivatives |
CA2132724A1 (en) | 1992-04-10 | 1993-10-28 | Robert Zamboni | Thiazole-substituted benzyl alcohols as leukotriene antagonists |
US5506227A (en) | 1992-04-13 | 1996-04-09 | Merck Frosst Canada, Inc. | Pyridine-substituted benzyl alcohols as leukotriene antagonists |
US5378704A (en) | 1992-04-15 | 1995-01-03 | E. R. Squibb & Sons, Inc. | Non-peptidic angiotensin-II-receptor-antagonists |
US5534347A (en) | 1992-09-04 | 1996-07-09 | Eastman Kodak Company | Fusing roll having a fluorocarbon-silicone barrier layer |
JP3323500B2 (ja) | 1992-10-30 | 2002-09-09 | ロード・コーポレーション | 低粘度磁気レオロジー材料 |
GB9226860D0 (en) | 1992-12-23 | 1993-02-17 | Leo Pharm Prod Ltd | Novel treatment |
DK0679157T3 (da) | 1993-01-15 | 1998-07-27 | Searle & Co | Nye 3,4-diarylthiophener og analoge deraf til anvendelse som antiinflammatoriske midler |
DE4302681A1 (de) | 1993-02-01 | 1994-08-04 | Hoechst Ag | Sulfonsäureester, damit hergestellte strahlungsempfindliche Gemische und deren Verwendung |
DE4306152A1 (de) | 1993-02-27 | 1994-09-01 | Hoechst Ag | Positiv arbeitendes strahlungsempfindliches Gemisch und damit hergestelltes Aufzeichnungsmaterial |
JPH07188227A (ja) | 1993-12-24 | 1995-07-25 | Japan Tobacco Inc | チアゾリジン誘導体及びオキサゾール誘導体 |
KR100423272B1 (ko) * | 1994-02-03 | 2004-09-01 | 캠브리지 뉴로사이언스, 인코포레이티드 | 신경전달물질의방출을조절하는화합물,이의약학적으로허용가능한염및이를포함하는약학조성물 |
US5519040A (en) | 1994-04-29 | 1996-05-21 | Allergan | Substituted thiazole sulfonamides as antiglaucoma agents |
US5932733A (en) | 1994-06-17 | 1999-08-03 | Corvas International, Inc. | 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors |
US5637599A (en) | 1994-06-17 | 1997-06-10 | Corvas International, Inc. | Arginine mimic derivatives as enzyme inhibitors |
JPH10503176A (ja) | 1994-06-17 | 1998-03-24 | コーバス インターナショナル, インコーポレイテッド | 酵素インヒビターとしての3−アミノ−2−オキソ−1−ピペリジン酢酸誘導体 |
US5519143A (en) | 1994-09-19 | 1996-05-21 | The Du Pont Merck Pharmaceutical Company | Process for the isolation and purification of an imidazole stereoisomer from a mixture of stereoisomers by selective precipitation |
US5552437A (en) | 1994-10-27 | 1996-09-03 | Merck Frosst Canada, Inc. | Bisarylcarbinol derivatives as inhibitors of leukotriene biosynthesis |
US5527827A (en) | 1994-10-27 | 1996-06-18 | Merck Frosst Canada, Inc. | Bisarylcarbinol cinnamic acids as inhibitors of leukotriene biosynthesis |
US5674876A (en) * | 1995-01-20 | 1997-10-07 | Research Development Foundation | ρ-heteroatom-substituted phenols and uses thereof |
JPH08311036A (ja) | 1995-03-14 | 1996-11-26 | Takeda Chem Ind Ltd | ピラゾール誘導体、その用途 |
IL117534A0 (en) | 1995-03-24 | 1996-07-23 | Rhone Poulenc Agrochimie | Reagent and process which are useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function |
JPH0912585A (ja) | 1995-06-30 | 1997-01-14 | Ube Ind Ltd | 高配位典型元素錯体 |
ATE203234T1 (de) | 1995-08-30 | 2001-08-15 | Searle & Co | Meta-guanidine, harnstoff, thioharnstoff oder azacyklische aminobenzoesäure-derivate als integrin antagonisten |
JPH09124632A (ja) | 1995-10-31 | 1997-05-13 | Sankyo Co Ltd | ベンゾヘテロ環誘導体 |
FR2756825B1 (fr) | 1996-12-10 | 1999-01-08 | Adir | Nouveaux derives [3h]-benzoxazole-2-thiones et [3h]- benzothiazole-2-thiones substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
GB2321244B (en) | 1997-01-20 | 2000-11-22 | Pharmacia & Upjohn Spa | Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents |
DE19716231A1 (de) | 1997-04-18 | 1998-10-22 | Studiengesellschaft Kohle Mbh | Olefinmetathese in komprimiertem Kohlendioxid |
DE19722952A1 (de) | 1997-05-31 | 1998-12-03 | Huels Chemische Werke Ag | Verwendung von Polymeren zur Inhibierung der Denaturierung von adsorbierten Eiweißstoffen |
US5895771A (en) | 1997-06-05 | 1999-04-20 | Akzo Nobel Nv | Fluorinated alkoxy and/or aryloxy aluminates as cocatalysts for metallocene-catalyzed olefin polymerizations |
US5977413A (en) | 1997-08-04 | 1999-11-02 | Nippon Kayaku Kabushiki Kaisha | Method for producing bis(3-amino-4-hydroxyphenyl) compounds |
KR20010086196A (ko) | 1997-09-11 | 2001-09-10 | 추후보정 | 폴리플루오로알콕사이드 리간드를 함유한 약한 배위결합음이온 |
WO1999047497A2 (en) | 1998-03-13 | 1999-09-23 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
GB2337701A (en) | 1998-05-26 | 1999-12-01 | United Medical And Dental Schools Of Guys St Thomas Hospitals | Treatment of ischemia with an angiotensin II antagonist |
DE19825182A1 (de) | 1998-06-05 | 1999-12-09 | Agfa Gevaert Ag | Reifung von Silberhalogenidemulsionen |
EP1087951B9 (de) | 1998-06-18 | 2006-09-13 | Bristol-Myers Squibb Company | Durch kohlenstoff substituierte aminothiazole als inhibitoren von zyclin-abhägigen kinasen |
EP1127139A2 (de) | 1998-08-11 | 2001-08-29 | The Governors Of The University Of Alberta | Zusamensetzungen und methode zur identifizierung von inhibitoren, agonisten und antagonisten der malonyl coa-decarboxylase von säugertieren |
FR2784114B1 (fr) | 1998-09-18 | 2001-02-02 | Thomson Csf | Materiaux polymeres absorbant les composes organophosphores. procede de synthese de ces materiaux. capteurs chimiques comprenant ces materiaux |
DE69923156T2 (de) | 1998-10-05 | 2005-12-29 | Promerus Llc, Brecksville | Katalysator und verfahren zur polymerisation von cycloolefinen |
JP2000128878A (ja) | 1998-10-28 | 2000-05-09 | Teijin Ltd | ベンゾフリル−α−ピリドン誘導体 |
CN1554680A (zh) | 1998-12-09 | 2004-12-15 | ס�ѵ�ľ��ʽ���� | 降冰片烯型单体的模内加成聚合用反应物组合物,及其交联加成聚合物 |
AU1857600A (en) | 1998-12-22 | 2000-07-12 | Neurosearch A/S | Ion channel modulating agents |
US20030144175A1 (en) * | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
CN1253441C (zh) | 1998-12-23 | 2006-04-26 | 史密丝克莱恩比彻姆公司 | 蛋白酶抑制剂 |
EP1150955A2 (de) | 1999-02-04 | 2001-11-07 | Millennium Pharmaceuticals, Inc. | G-protein-gekoppelte heptahelikale rezeptor-verbindungen und entspechende anwendungen |
WO2000047207A1 (en) | 1999-02-09 | 2000-08-17 | Bristol-Myers Squibb Company | LACTAM INHIBITORS OF FXa AND METHOD |
GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
US6316503B1 (en) | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
US6503949B1 (en) * | 1999-05-17 | 2003-01-07 | Noro Nordisk A/S | Glucagon antagonists/inverse agonists |
KR20020014797A (ko) | 1999-05-17 | 2002-02-25 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 글루카곤 길항제/역 아고니스트 |
AU6074700A (en) | 1999-07-08 | 2001-01-30 | Tularik Inc. | Compositions and methods for raising hdl cholesterol levels |
ATE289291T1 (de) | 1999-09-24 | 2005-03-15 | Ono Pharmaceutical Co | Hydroxamsäurederivate, verfahren zu ihrer herstellung und medikamente die diese als aktiven wirkstoff enthalten |
OA12288A (en) | 2000-06-14 | 2003-12-12 | Smithkline Beecham Corp | Protease inhibitors. |
HU227197B1 (en) * | 2000-10-24 | 2010-10-28 | Richter Gedeon Nyrt | Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them |
ATE341539T1 (de) | 2001-01-26 | 2006-10-15 | Chugai Pharmaceutical Co Ltd | Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren |
JP4503232B2 (ja) | 2001-01-26 | 2010-07-14 | 中外製薬株式会社 | マロニル−CoA脱炭酸酵素阻害剤を用いた疾患の治療法 |
KR100637564B1 (ko) | 2001-01-26 | 2006-10-20 | 추가이 세이야쿠 가부시키가이샤 | 대사 조절자로서 유용한 말로닐-코에이 데카르복실라제억제제 |
WO2002066034A1 (en) * | 2001-02-20 | 2002-08-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for treating metabolic diseases using malonyl-coa decarboxylase inhibitors |
US7709510B2 (en) * | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
ATE375810T1 (de) * | 2003-08-01 | 2007-11-15 | Chugai Pharmaceutical Co Ltd | Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer |
US7449482B2 (en) * | 2003-08-01 | 2008-11-11 | Chugai Seiyaku Kabushiki Kaisha | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors |
JP4727578B2 (ja) * | 2003-08-01 | 2011-07-20 | 中外製薬株式会社 | マロニル−CoAデカルボキシラーゼ阻害剤として有用な複素環式化合物 |
US7786145B2 (en) * | 2003-08-01 | 2010-08-31 | Chugai Seiyaku Kabushiki Kaisha | Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors |
-
2004
- 2004-07-28 US US10/900,705 patent/US7449482B2/en not_active Expired - Fee Related
- 2004-07-28 JP JP2006522612A patent/JP4648317B2/ja not_active Expired - Fee Related
- 2004-07-28 ES ES04779398T patent/ES2309563T3/es active Active
- 2004-07-28 EP EP04779398A patent/EP1653957B1/de active Active
- 2004-07-28 CA CA2533749A patent/CA2533749C/en not_active Expired - Fee Related
- 2004-07-28 WO PCT/US2004/024332 patent/WO2005011693A1/en active Application Filing
- 2004-07-28 AT AT04779398T patent/ATE400272T1/de not_active IP Right Cessation
- 2004-07-28 DE DE602004014937T patent/DE602004014937D1/de active Active
-
2008
- 2008-10-03 US US12/245,558 patent/US8080665B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE602004014937D1 (de) | 2008-08-21 |
CA2533749A1 (en) | 2005-02-10 |
EP1653957A1 (de) | 2006-05-10 |
WO2005011693A1 (en) | 2005-02-10 |
JP4648317B2 (ja) | 2011-03-09 |
CA2533749C (en) | 2012-07-10 |
JP2007501234A (ja) | 2007-01-25 |
US20050032828A1 (en) | 2005-02-10 |
US8080665B2 (en) | 2011-12-20 |
US20090124660A1 (en) | 2009-05-14 |
EP1653957B1 (de) | 2008-07-09 |
ES2309563T3 (es) | 2008-12-16 |
US7449482B2 (en) | 2008-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE375810T1 (de) | Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer | |
ATE487475T1 (de) | Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer | |
ATE400272T1 (de) | Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer | |
UA100007C2 (ru) | Гетероциклические ингибиторы мек, их применение и фармацевтическая композиция, которая их содержит | |
EA200870019A1 (ru) | Лактамовые соединения и способы их применения | |
EA200870216A1 (ru) | Амидо соединения и их применение в качестве лекарственных средств | |
EA201290389A8 (ru) | Применение 1,3-дифенилпроп-2-ен-1-оновых производных для лечения заболеваний печени | |
EA200700118A1 (ru) | Амидосоединения и их применение в качестве лекарственных средств | |
BR0214343A (pt) | Inibidores de 11 - beta - hidroxi esteróide desidrogenase tipo 1 | |
EA201170508A1 (ru) | Производные 1-амино-2-циклобутилэтилбороновой кислоты | |
DE602005010876D1 (de) | Neuartige biaromatische ppar-rezeptoren aktivierende zusammensetzungen und ihre verwendung in kosmetischen oder pharmazeutischen zusammensetzungen | |
IL181271A0 (en) | Triazolophthalazine derivatives and pharmaceutical compositions containing the same | |
NO20062739L (no) | Kontrollert frigivining av topirimat i flytende doseringsform | |
MY143568A (en) | 11b-hsd1 inhibitors for the treatment of diabetes | |
EA200802223A1 (ru) | 1,5-дифенилпиразолы ii в качестве ингибиторов hsp90 | |
DK1730147T3 (da) | Substituerede 1,4,8-triazaspiro[4.5]decan-2-on-forbindelser til behandling af fedme | |
DK1370260T3 (da) | Azoler, som malonyl-coa-decarboxylaseinhibitorer anvendelige som mataboliske modulatorer | |
ATE341539T1 (de) | Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren | |
CY1109366T1 (el) | Υποκατεστημενες ενωσεις 1,4,8-τριαζασπειρο[4.5]δεκαν-2-ονης | |
WO2006108680A3 (en) | Substances and pharmaceutical compositions for the inhibition of glyoxalases and their use against protozoa and helminthes | |
ATE462703T1 (de) | Bicyclononen-derivate als renin-inhibitoren | |
NO20080650L (no) | Forbindelser omfattende DMXAA for behandling av kreft | |
EP2077719A4 (de) | Piperidin- und pyrrolidin-beta-secretase-hemmer zur behandlung von alzheimer-krankheit | |
ATE536872T1 (de) | Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer | |
ATE453614T1 (de) | Sphingolipiden |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |