GB2321244B - Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents - Google Patents

Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents

Info

Publication number
GB2321244B
GB2321244B GB9701116A GB9701116A GB2321244B GB 2321244 B GB2321244 B GB 2321244B GB 9701116 A GB9701116 A GB 9701116A GB 9701116 A GB9701116 A GB 9701116A GB 2321244 B GB2321244 B GB 2321244B
Authority
GB
United Kingdom
Prior art keywords
antiproliferative
analogues
vitamin
preparing
antitumour agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9701116A
Other versions
GB2321244A (en
GB9701116D0 (en
Inventor
Achille Panzeri
Nicola Mongelli
Enzo Santaniello
Patrizia Ferraboschi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Priority to GB9701116A priority Critical patent/GB2321244B/en
Publication of GB9701116D0 publication Critical patent/GB9701116D0/en
Publication of GB2321244A publication Critical patent/GB2321244A/en
Application granted granted Critical
Publication of GB2321244B publication Critical patent/GB2321244B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0007—Androstane derivatives not substituted in position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
GB9701116A 1997-01-20 1997-01-20 Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents Expired - Fee Related GB2321244B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9701116A GB2321244B (en) 1997-01-20 1997-01-20 Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9701116A GB2321244B (en) 1997-01-20 1997-01-20 Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents

Publications (3)

Publication Number Publication Date
GB9701116D0 GB9701116D0 (en) 1997-03-12
GB2321244A GB2321244A (en) 1998-07-22
GB2321244B true GB2321244B (en) 2000-11-22

Family

ID=10806285

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9701116A Expired - Fee Related GB2321244B (en) 1997-01-20 1997-01-20 Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents

Country Status (1)

Country Link
GB (1) GB2321244B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
ATE341539T1 (en) 2001-01-26 2006-10-15 Chugai Pharmaceutical Co Ltd MALONYL COA-DECARBOXYLASE INHIBITORS AS METABOLISM MODULATORS
WO2002058690A2 (en) 2001-01-26 2002-08-01 Chugai Seiyaku Kabushiki Kaisha Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors
WO2002058698A2 (en) 2001-01-26 2002-08-01 Chugai Seiyaku Kabushiki Kaisha Malonyl-coa decarboxylase inhibitors useful as metabolic modulators
US7709510B2 (en) 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
EP1379243B1 (en) 2001-02-20 2009-09-09 Chugai Seiyaku Kabushiki Kaisha Methods for treating metabolic diseases using malonyl-coa decarboxylase inhibitors
EP2208495B1 (en) 2003-08-01 2011-12-14 Chugai Seiyaku Kabushiki Kaisha Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors
JP4727578B2 (en) 2003-08-01 2011-07-20 中外製薬株式会社 Heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors
EP1653957B1 (en) 2003-08-01 2008-07-09 Chugai Seiyaku Kabushiki Kaisha Piperidine compounds useful as malonyl-coa decarboxylase inhibitors
WO2005011812A1 (en) 2003-08-01 2005-02-10 Chugai Seiyaku Kabushiki Kaisha Cyanoamide compounds useful as malonyl-coa decarboxylase inhibithors
CN115536717B (en) * 2022-10-10 2023-11-24 浙江仙居君业药业有限公司 Synthesis method of androstane-4, 16-diene-3-ketone

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003994A1 (en) * 1994-08-02 1996-02-15 The Johns-Hopkins University 20(s)-22-oxa vitamin d3 analogues
EP0712843A1 (en) * 1994-06-07 1996-05-22 Teijin Limited Vitamin d3 derivative and process for producing the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0712843A1 (en) * 1994-06-07 1996-05-22 Teijin Limited Vitamin d3 derivative and process for producing the same
WO1996003994A1 (en) * 1994-08-02 1996-02-15 The Johns-Hopkins University 20(s)-22-oxa vitamin d3 analogues

Also Published As

Publication number Publication date
GB2321244A (en) 1998-07-22
GB9701116D0 (en) 1997-03-12

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20060120