ATE375810T1 - Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer - Google Patents

Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer

Info

Publication number
ATE375810T1
ATE375810T1 AT04779377T AT04779377T ATE375810T1 AT E375810 T1 ATE375810 T1 AT E375810T1 AT 04779377 T AT04779377 T AT 04779377T AT 04779377 T AT04779377 T AT 04779377T AT E375810 T1 ATE375810 T1 AT E375810T1
Authority
AT
Austria
Prior art keywords
compounds
malonyl
useful
prophylaxis
management
Prior art date
Application number
AT04779377T
Other languages
English (en)
Inventor
Mark Kafka
Mark Wilson
Anna Russell
Gary Lopaschuk
Jason Dyck
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE375810T1 publication Critical patent/ATE375810T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT04779377T 2003-08-01 2004-07-28 Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer ATE375810T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49210003P 2003-08-01 2003-08-01

Publications (1)

Publication Number Publication Date
ATE375810T1 true ATE375810T1 (de) 2007-11-15

Family

ID=34115594

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04779377T ATE375810T1 (de) 2003-08-01 2004-07-28 Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer

Country Status (8)

Country Link
US (2) US7285562B2 (de)
EP (1) EP1648564B1 (de)
JP (1) JP4727579B2 (de)
AT (1) ATE375810T1 (de)
CA (1) CA2533763C (de)
DE (1) DE602004009582T2 (de)
ES (1) ES2295930T3 (de)
WO (1) WO2005011812A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7709510B2 (en) * 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
EP1370260B1 (de) * 2001-02-20 2010-11-24 Chugai Seiyaku Kabushiki Kaisha Azole als malonyl-coa decarboxylase hemmer verwendbar als modulatoren des metabolismus
EP1594439A2 (de) * 2003-02-13 2005-11-16 Albert Einstein College Of Medicine Of Yeshiva University Regulierung der nahrungsaufnahme und glukoseproduktion durch modulation der spiegel von langkettigem fettsäureacyl-coa im hypothalamus
US7449482B2 (en) * 2003-08-01 2008-11-11 Chugai Seiyaku Kabushiki Kaisha Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors
ATE487475T1 (de) * 2003-08-01 2010-11-15 Chugai Pharmaceutical Co Ltd Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer
CA2533763C (en) * 2003-08-01 2012-11-20 Chugai Seiyaku Kabushiki Kaisha Cyanoamide compounds useful as malonyl-coa decarboxylase inhibitors
ATE536872T1 (de) * 2003-08-01 2011-12-15 Chugai Pharmaceutical Co Ltd Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer
WO2006041922A2 (en) * 2004-10-08 2006-04-20 Dara Biosciences, Inc. Agents and methods for administration to the central nervous system
WO2006088875A2 (en) * 2005-02-14 2006-08-24 Albert Einstein College Of Medicine Of Yeshiva University Intranasal administration of modulators of hypothalamic atp-sensitive potassium channels
ATE485804T1 (de) * 2007-03-15 2010-11-15 Ivoclar Vivadent Ag Dentalmaterialien auf der basis von radikalisch polymerisationsfähigen, n,o-funktionalisierten acrylsäure-hydroxamiden
BR112012011528A2 (pt) 2009-11-16 2019-09-24 Univ California métodos para inibir uma proteína quinase e para tratar uma doença associada com atividade de quinase, e, composto
JP6068451B2 (ja) * 2011-05-17 2017-01-25 ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・カリフオルニア キナーゼ阻害剤
WO2012158795A1 (en) 2011-05-17 2012-11-22 Principia Biopharma Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
US8962831B2 (en) 2011-05-17 2015-02-24 Principia Biopharma Inc. Tyrosine kinase inhibitors
RS58956B1 (sr) 2012-09-10 2019-08-30 Principia Biopharma Inc Jedinjenja pirazolopirimidina kao inhibitori kinaze
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
MX372673B (es) 2014-02-21 2020-03-25 Principia Biopharma Inc Un inhibidor de btk para usarse en el tratamiento de penfigo y sales y formas sólidas del mismo.
CN105461722B (zh) * 2014-09-04 2019-05-10 欣凯医药化工中间体（上海）有限公司 一种脱氮嘌呤类化合物及其衍生物及其制备方法和应用
ES2843323T3 (es) 2014-12-18 2021-07-16 Principia Biopharma Inc Tratamiento de pénfigo
EP3313839A1 (de) 2015-06-24 2018-05-02 Principia Biopharma Inc. Tyrosin-kinase-inhibitoren
US20190231784A1 (en) 2016-06-29 2019-08-01 Principia Biopharma Inc. Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
KR20220080179A (ko) 2019-10-14 2022-06-14 프린시피아 바이오파마, 인코퍼레이티드 (R)-2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴을 투여하여 면역 혈소판 감소증을 치료하는 방법
TW202140484A (zh) 2020-01-22 2021-11-01 美商普林斯匹亞生物製藥公司 ２－［３－［４－胺基－３－（２－氟－４－苯氧基－苯基）－１Ｈ－吡唑并［３，４－ｄ］嘧啶－１－基］哌啶－１－羰基］－４－甲基－４－［４－（氧環丁烷－３－基）哌𠯤－１－基］戊－２－烯腈之晶形
KR20220163285A (ko) 2021-06-01 2022-12-09 주식회사 에즈큐리스 Il-33단백질 저해용 화합물의 스크리닝 방법 및 상기 화합물을 포함하는 알러지성 질환 치료용 약학조성물

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3728455A (en) * 1971-06-24 1973-04-17 American Cyanamid Co Novel compositions of matter
DE3484096D1 (de) 1983-11-30 1991-03-14 Janssen Pharmaceutica Nv Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine.
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
GB8714537D0 (en) 1987-06-22 1987-07-29 Ici Plc Pyrazine derivatives
EP0733366B1 (de) 1988-01-07 1998-04-01 E.I. Du Pont De Nemours And Company Angiotensin II-Rezeptor blockierende Imidazole und Diuretika enthaltende pharmazeutische Zusammensetzungen
ATE134368T1 (de) 1989-06-30 1996-03-15 Du Pont Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin ii
WO1991000281A2 (en) 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Fused-ring aryl substituted imidazoles
RU1743153C (ru) 1990-06-04 1995-02-27 ВНИИ химических средств защиты растений N-[4-2'-гидроксигексафторизопропил)фенил] -n-этил-n'-фенилмочевина, обладающая рострегулирующим и антидотным действием
EP0533840B1 (de) 1990-06-22 1996-12-11 E.I. Du Pont De Nemours And Company Behandlung des chronischen nierenversagens mit imidazol-angiotensin-ii-rezeptorantagonisten
EP0480716A1 (de) * 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Gesättigte Hydroxyalkylchinolinsäuren zur Verwendung als Leukotrien-Antagonisten
CA2053148A1 (en) 1990-10-16 1992-04-17 Karnail Atwal Dihydropyrimidine derivatives
US5470975A (en) * 1990-10-16 1995-11-28 E.R. Squibb & Sons, Inc. Dihydropyrimidine derivatives
US5374615A (en) * 1990-10-31 1994-12-20 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
SU1825496A3 (ru) 1991-04-04 1994-12-30 Всесоюзный научно-исследовательский институт химических средств защиты растений Производные n-[4-(1-гидрокси-1-трифторметил-2,2,2-трифторэтил)фенил]мочевины, обладающие антидотной активностью к 2-хлор-n-[(4-метокси-6-метил-1,3,5-триазин-2-ил)аминокарбонил] бензолсульфамиду в посевах льна
JPH05124925A (ja) 1991-04-09 1993-05-21 Sansho Seiyaku Co Ltd メラニン生成抑制外用剤
US5190942A (en) * 1991-04-22 1993-03-02 E. R. Squibb & Sons, Inc. Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives
US5256695A (en) * 1991-07-24 1993-10-26 E. R. Squibb & Sons, Inc. Acyl amidine and acyl guanidine substituted biphenyl derivatives
US5177097A (en) * 1991-07-24 1993-01-05 E. R. Squibb & Sons, Inc. Acyl amidine and acyl, guanidine substituted biphenyl derivatives
JPH06510763A (ja) * 1991-08-19 1994-12-01 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー アンジオテンシン２受容体遮断イミダゾリノン誘導体
US5212177A (en) * 1991-12-16 1993-05-18 E. R. Squibb & Sons, Inc. Indole and benzimidazole-substituted dihydropyrimidine derivatives
US5350752A (en) 1991-12-16 1994-09-27 E. R. Squibb & Sons, Inc. Dihydropyrimidine derivatives
US5225408A (en) * 1991-12-20 1993-07-06 E. R. Squibb & Sons, Inc. Biphenyl oxadiazinone angiotensin II inhibitors
TW297025B (de) 1992-02-14 1997-02-01 Squibb & Sons Inc
US5208234A (en) * 1992-03-10 1993-05-04 E. R. Squibb & Sons, Inc. Substituted imidazole phosphonic and phosphinic acid derivatives
US5208235A (en) * 1992-03-10 1993-05-04 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole derivatives
CA2132724A1 (en) 1992-04-10 1993-10-28 Robert Zamboni Thiazole-substituted benzyl alcohols as leukotriene antagonists
US5506227A (en) 1992-04-13 1996-04-09 Merck Frosst Canada, Inc. Pyridine-substituted benzyl alcohols as leukotriene antagonists
US5378704A (en) * 1992-04-15 1995-01-03 E. R. Squibb & Sons, Inc. Non-peptidic angiotensin-II-receptor-antagonists
US5534347A (en) * 1992-09-04 1996-07-09 Eastman Kodak Company Fusing roll having a fluorocarbon-silicone barrier layer
EP0672293A4 (de) 1992-10-30 1996-04-17 Lord Corp Niederviskose magnetorheologische materialien.
GB9226860D0 (en) 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Novel treatment
ES2111288T3 (es) 1993-01-15 1998-03-01 Searle & Co Nuevos 3,4-diaril tiofenos y analogos de los mismos utiles como agentes antiinflamatorios.
DE4302681A1 (de) 1993-02-01 1994-08-04 Hoechst Ag Sulfonsäureester, damit hergestellte strahlungsempfindliche Gemische und deren Verwendung
DE4306152A1 (de) * 1993-02-27 1994-09-01 Hoechst Ag Positiv arbeitendes strahlungsempfindliches Gemisch und damit hergestelltes Aufzeichnungsmaterial
US5519040A (en) 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
US5932733A (en) 1994-06-17 1999-08-03 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
JPH10503176A (ja) 1994-06-17 1998-03-24 コーバス インターナショナル， インコーポレイテッド 酵素インヒビターとしての３−アミノ−２−オキソ−１−ピペリジン酢酸誘導体
US5637599A (en) 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
US5519143A (en) * 1994-09-19 1996-05-21 The Du Pont Merck Pharmaceutical Company Process for the isolation and purification of an imidazole stereoisomer from a mixture of stereoisomers by selective precipitation
US5527827A (en) 1994-10-27 1996-06-18 Merck Frosst Canada, Inc. Bisarylcarbinol cinnamic acids as inhibitors of leukotriene biosynthesis
US5552437A (en) 1994-10-27 1996-09-03 Merck Frosst Canada, Inc. Bisarylcarbinol derivatives as inhibitors of leukotriene biosynthesis
JPH08311036A (ja) 1995-03-14 1996-11-26 Takeda Chem Ind Ltd ピラゾール誘導体、その用途
IL117534A0 (en) 1995-03-24 1996-07-23 Rhone Poulenc Agrochimie Reagent and process which are useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function
JPH0912585A (ja) 1995-06-30 1997-01-14 Ube Ind Ltd 高配位典型元素錯体
AU5459498A (en) 1996-12-09 1998-07-03 Warner-Lambert Company Microorganism capable of producing compounds where pyrrole is fused with 4-oxo-1,3-benzoxazine and method of use as antibacterial and antifungal
FR2756825B1 (fr) 1996-12-10 1999-01-08 Adir Nouveaux derives [3h]-benzoxazole-2-thiones et [3h]- benzothiazole-2-thiones substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB2321244B (en) 1997-01-20 2000-11-22 Pharmacia & Upjohn Spa Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents
DE19716231A1 (de) 1997-04-18 1998-10-22 Studiengesellschaft Kohle Mbh Olefinmetathese in komprimiertem Kohlendioxid
DE19722952A1 (de) 1997-05-31 1998-12-03 Huels Chemische Werke Ag Verwendung von Polymeren zur Inhibierung der Denaturierung von adsorbierten Eiweißstoffen
US5895771A (en) * 1997-06-05 1999-04-20 Akzo Nobel Nv Fluorinated alkoxy and/or aryloxy aluminates as cocatalysts for metallocene-catalyzed olefin polymerizations
US5977413A (en) * 1997-08-04 1999-11-02 Nippon Kayaku Kabushiki Kaisha Method for producing bis(3-amino-4-hydroxyphenyl) compounds
ATE285413T1 (de) 1997-09-11 2005-01-15 Univ Colorado State Res Found Schwach koordinierende, polyfluoralkoxid-liganden enthaltende anionen
WO1999047497A2 (en) 1998-03-13 1999-09-23 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
GB2337701A (en) 1998-05-26 1999-12-01 United Medical And Dental Schools Of Guys St Thomas Hospitals Treatment of ischemia with an angiotensin II antagonist
ES2237919T4 (es) 1998-06-18 2007-05-01 Bristol-Myers Squibb Company Inhibidores aminotiazol sustituidos con carbono de quinasas dependientes de ciclina.
WO2000009710A2 (en) 1998-08-11 2000-02-24 The Governors Of The University Of Alberta Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists
FR2784114B1 (fr) 1998-09-18 2001-02-02 Thomson Csf Materiaux polymeres absorbant les composes organophosphores. procede de synthese de ces materiaux. capteurs chimiques comprenant ces materiaux
CN1249105C (zh) 1998-10-05 2006-04-05 普罗米鲁斯有限责任公司 环烯烃聚合催化剂及聚合方法
ATE298352T1 (de) 1998-12-09 2005-07-15 Sumitomo Bakelite Co Additionspolymerisation in einer form unter benutzung von polymeren des norbornentyps mit gruppe-3-metallkomplexen
AU1857600A (en) 1998-12-22 2000-07-12 Neurosearch A/S Ion channel modulating agents
AU2871900A (en) 1999-02-04 2000-08-25 Millennium Pharmaceuticals, Inc. G-protein coupled heptahelical receptor binding compounds and methods of use thereof
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6316503B1 (en) 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
JP2002544254A (ja) 1999-05-17 2002-12-24 ノボ ノルディスク アクティーゼルスカブ グルカゴンアンタゴニスト／逆アゴニスト
WO2001003705A1 (en) 1999-07-08 2001-01-18 Tularik Inc. Compositions and methods for raising hdl cholesterol levels
JP4503232B2 (ja) 2001-01-26 2010-07-14 中外製薬株式会社 マロニル−ＣｏＡ脱炭酸酵素阻害剤を用いた疾患の治療法
WO2002064136A2 (en) 2001-01-26 2002-08-22 Chugai Seiyaku Kabushiki Kaisha Malonyl-coa decarboxylase inhibitors useful as metabolic modulators
WO2002058698A2 (en) * 2001-01-26 2002-08-01 Chugai Seiyaku Kabushiki Kaisha Malonyl-coa decarboxylase inhibitors useful as metabolic modulators
EP1370260B1 (de) * 2001-02-20 2010-11-24 Chugai Seiyaku Kabushiki Kaisha Azole als malonyl-coa decarboxylase hemmer verwendbar als modulatoren des metabolismus
DK1385823T3 (da) * 2001-04-09 2007-03-26 Novartis Vaccines & Diagnostic Guanidinoforbindelser som melanocortin-4-receptor- (MC4-R) -agonister
CA2533763C (en) * 2003-08-01 2012-11-20 Chugai Seiyaku Kabushiki Kaisha Cyanoamide compounds useful as malonyl-coa decarboxylase inhibitors

Also Published As

Publication number Publication date
DE602004009582T2 (de) 2009-01-02
WO2005011812A1 (en) 2005-02-10
US20050026945A1 (en) 2005-02-03
CA2533763A1 (en) 2005-02-10
ES2295930T3 (es) 2008-04-16
JP4727579B2 (ja) 2011-07-20
US7285562B2 (en) 2007-10-23
JP2007501233A (ja) 2007-01-25
CA2533763C (en) 2012-11-20
US20080161358A1 (en) 2008-07-03
DE602004009582D1 (de) 2007-11-29
US7897615B2 (en) 2011-03-01
EP1648564A1 (de) 2006-04-26
EP1648564B1 (de) 2007-10-17

Similar Documents

Publication Publication Date Title
ATE375810T1 (de) Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer
ATE487475T1 (de) Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer
ATE400272T1 (de) Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer
ATE509014T1 (de) Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren
UA100007C2 (ru) Гетероциклические ингибиторы мек, их применение и фармацевтическая композиция, которая их содержит
WO2009114725A3 (en) Mobilization op hematopoietic stem cells using cdc42 inhibitors
EA200870019A1 (ru) Лактамовые соединения и способы их применения
EA201170508A1 (ru) Производные 1-амино-2-циклобутилэтилбороновой кислоты
NO20042596L (no) Inbibitorer av 11-beta-hydroksy steroid dehydrogenase type 1
EA200870216A1 (ru) Амидо соединения и их применение в качестве лекарственных средств
EA200970791A1 (ru) N-АДАМАНТИЛБЕНЗАМИДЫ В КАЧЕСТВЕ ИНГИБИТОРОВ 11-β-ГИДРОКСИСТЕРОИДДЕГИДРОГЕНАЗЫ
EA200970337A1 (ru) Ингибиторы котранспортера натрий-глюкозы 2 и способы их применения
MX342423B (es) Metodos para usar inhibidores de cotransportadores 1 y 2 de glucosa y sodio.
ATE423087T1 (de) Proteasome inhibitoren und deren verwendung
ATE341539T1 (de) Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren
DK1370260T3 (da) Azoler, som malonyl-coa-decarboxylaseinhibitorer anvendelige som mataboliske modulatorer
NO20062739L (no) Kontrollert frigivining av topirimat i flytende doseringsform
DE602005010876D1 (de) Neuartige biaromatische ppar-rezeptoren aktivierende zusammensetzungen und ihre verwendung in kosmetischen oder pharmazeutischen zusammensetzungen
ATE536872T1 (de) Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer
WO2006108680A3 (en) Substances and pharmaceutical compositions for the inhibition of glyoxalases and their use against protozoa and helminthes
ATE462703T1 (de) Bicyclononen-derivate als renin-inhibitoren
IL191670A0 (en) Compounds for the inhibition of apoptosis
ATE531703T1 (de) Benzochromenderivate
ATE453614T1 (de) Sphingolipiden
CY1107277T1 (el) Βενζισοξαζολες

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties