ATE407673T1 - Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer - Google Patents

Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer

Info

Publication number
ATE407673T1
ATE407673T1 AT04816789T AT04816789T ATE407673T1 AT E407673 T1 ATE407673 T1 AT E407673T1 AT 04816789 T AT04816789 T AT 04816789T AT 04816789 T AT04816789 T AT 04816789T AT E407673 T1 ATE407673 T1 AT E407673T1
Authority
AT
Austria
Prior art keywords
malonyl
prophylaxis
management
cyanoguanidine
treatment
Prior art date
Application number
AT04816789T
Other languages
English (en)
Inventor
Jie Cheng
Bin Liu
Thomas Arrhenius
Mark Wilson
Alex Nadzan
Gary Lopaschuk
Jason R Dyck
Rossy Serafimov
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE407673T1 publication Critical patent/ATE407673T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04816789T 2003-08-01 2004-07-28 Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer ATE407673T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49203103P 2003-08-01 2003-08-01

Publications (1)

Publication Number Publication Date
ATE407673T1 true ATE407673T1 (de) 2008-09-15

Family

ID=34465060

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04816789T ATE407673T1 (de) 2003-08-01 2004-07-28 Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer
AT08163168T ATE536872T1 (de) 2003-08-01 2004-07-28 Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT08163168T ATE536872T1 (de) 2003-08-01 2004-07-28 Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer

Country Status (8)

Country Link
US (1) US7786145B2 (de)
EP (2) EP1658071B1 (de)
JP (1) JP4773960B2 (de)
AT (2) ATE407673T1 (de)
CA (1) CA2533881C (de)
DE (1) DE602004016530D1 (de)
ES (2) ES2378418T3 (de)
WO (1) WO2005037258A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7709510B2 (en) * 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
ATE442141T1 (de) * 2001-02-20 2009-09-15 Chugai Pharmaceutical Co Ltd Verfahren zur behandlung von stoffwechselerkrankungen mit malonyl-coa- decarboxylase-hemmern
WO2004071458A2 (en) 2003-02-13 2004-08-26 Albert Einstein College Of Medicine Of Yeshiva University REGULATION OF FOOD INTAKE AND GLUCOSE PRODUCTION BY MODULATION OF LONG-CHAIN FATTY ACYL-CoA LEVELS IN THE HYPOTHALAMUS
ES2309563T3 (es) * 2003-08-01 2008-12-16 Chugai Seiyaku Kabushiki Kaisha Compuestos de piperidina utiles como inhibidores de malonil coenzima a descarboxilasa.
ES2353306T3 (es) * 2003-08-01 2011-03-01 Chugai Seiyaku Kabushiki Kaisha Compuestos heterocíclicos útiles como inhibidores de la malonil-coa-descarboxilasa.
WO2006041922A2 (en) * 2004-10-08 2006-04-20 Dara Biosciences, Inc. Agents and methods for administration to the central nervous system
WO2006088875A2 (en) * 2005-02-14 2006-08-24 Albert Einstein College Of Medicine Of Yeshiva University Intranasal administration of modulators of hypothalamic atp-sensitive potassium channels

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863874A (en) * 1955-05-26 1958-12-09 Goodrich Co B F Process of preparing 2-aminothiazoles
US3728455A (en) * 1971-06-24 1973-04-17 American Cyanamid Co Novel compositions of matter
US4499103A (en) * 1983-03-17 1985-02-12 Merck & Co., Inc. Benzothiazole-2-sulfonamide derivatives for the topical treatment of elevated intraocular pressure
EP0144101B1 (de) 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bizyklisches Heterozyklyl aufveisende N-(bizyklisches Heterozyklyl-4-piperidinamine
JPS60202872A (ja) * 1984-03-27 1985-10-14 Kaken Pharmaceut Co Ltd ベンゾフラン誘導体、その製法およびそれを有効成分とする降圧剤
CA1281325C (en) 1984-06-20 1991-03-12 Patrice C. Belanger Benzofuran derivatives
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
GB8714537D0 (en) 1987-06-22 1987-07-29 Ici Plc Pyrazine derivatives
EP0733366B1 (de) 1988-01-07 1998-04-01 E.I. Du Pont De Nemours And Company Angiotensin II-Rezeptor blockierende Imidazole und Diuretika enthaltende pharmazeutische Zusammensetzungen
EP0331279A3 (de) * 1988-02-15 1989-09-20 Zeneca Limited Verbindungen und ihre Verwendung
JP2568315B2 (ja) 1989-06-30 1997-01-08 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 縮合環アリール置換イミダゾール
DE69025473T2 (de) 1989-06-30 1996-10-17 Du Pont Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin ii
SU1681502A1 (ru) 1989-07-26 1994-06-15 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе Гидрохлорид 3-(2,5- диметоксибензоил) -4- диметиламинометил -5-окси-6- бромбензофурана, обладающий анальгетическим, местноанестезирующим, противосудорожным, противоаритмическим, стимулирующим коронарный, мозговой и почечный кровоток действиями
RU1743153C (ru) 1990-06-04 1995-02-27 ВНИИ химических средств защиты растений N-[4-2'-гидроксигексафторизопропил)фенил] -n-этил-n'-фенилмочевина, обладающая рострегулирующим и антидотным действием
DK0533840T3 (da) 1990-06-22 1996-12-30 Du Pont Behandling af kronisk nyresvigt med imidazol-angiotensin-II-receptor-antagonister
CA2053216C (en) * 1990-10-12 2003-04-08 Michel L. Belley Saturated hydroxyalkylquinoline acids as leukotriene antagonists
US5470975A (en) * 1990-10-16 1995-11-28 E.R. Squibb & Sons, Inc. Dihydropyrimidine derivatives
CA2053148A1 (en) 1990-10-16 1992-04-17 Karnail Atwal Dihydropyrimidine derivatives
US5374615A (en) * 1990-10-31 1994-12-20 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
SU1825496A3 (ru) 1991-04-04 1994-12-30 Всесоюзный научно-исследовательский институт химических средств защиты растений Производные n-[4-(1-гидрокси-1-трифторметил-2,2,2-трифторэтил)фенил]мочевины, обладающие антидотной активностью к 2-хлор-n-[(4-метокси-6-метил-1,3,5-триазин-2-ил)аминокарбонил] бензолсульфамиду в посевах льна
JPH05124925A (ja) 1991-04-09 1993-05-21 Sansho Seiyaku Co Ltd メラニン生成抑制外用剤
US5190942A (en) * 1991-04-22 1993-03-02 E. R. Squibb & Sons, Inc. Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives
US5256695A (en) * 1991-07-24 1993-10-26 E. R. Squibb & Sons, Inc. Acyl amidine and acyl guanidine substituted biphenyl derivatives
US5177097A (en) * 1991-07-24 1993-01-05 E. R. Squibb & Sons, Inc. Acyl amidine and acyl, guanidine substituted biphenyl derivatives
CZ36394A3 (en) * 1991-08-19 1994-07-13 Du Pont Substituted imidazilonone derivatives and pharmaceutical preparations based thereon
US5350752A (en) 1991-12-16 1994-09-27 E. R. Squibb & Sons, Inc. Dihydropyrimidine derivatives
US5212177A (en) * 1991-12-16 1993-05-18 E. R. Squibb & Sons, Inc. Indole and benzimidazole-substituted dihydropyrimidine derivatives
US5225408A (en) * 1991-12-20 1993-07-06 E. R. Squibb & Sons, Inc. Biphenyl oxadiazinone angiotensin II inhibitors
TW297025B (de) 1992-02-14 1997-02-01 Squibb & Sons Inc
US5208235A (en) * 1992-03-10 1993-05-04 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole derivatives
US5208234A (en) * 1992-03-10 1993-05-04 E. R. Squibb & Sons, Inc. Substituted imidazole phosphonic and phosphinic acid derivatives
AU3884893A (en) 1992-04-10 1993-11-18 Merck Frosst Canada Inc. Thiazole-substituted benzyl alcohols as leukotriene antagonists
US5506227A (en) 1992-04-13 1996-04-09 Merck Frosst Canada, Inc. Pyridine-substituted benzyl alcohols as leukotriene antagonists
US5378704A (en) * 1992-04-15 1995-01-03 E. R. Squibb & Sons, Inc. Non-peptidic angiotensin-II-receptor-antagonists
US5534347A (en) * 1992-09-04 1996-07-09 Eastman Kodak Company Fusing roll having a fluorocarbon-silicone barrier layer
RU2106710C1 (ru) 1992-10-30 1998-03-10 Лорд Корпорейшн Магнитореологический материал
GB9226860D0 (en) 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Novel treatment
WO1994015932A1 (en) 1993-01-15 1994-07-21 G.D. Searle & Co. Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US5521037A (en) 1993-02-03 1996-05-28 Toray Industries, Inc. Intermediate transfer material, and an image forming method using it
DE4306152A1 (de) * 1993-02-27 1994-09-01 Hoechst Ag Positiv arbeitendes strahlungsempfindliches Gemisch und damit hergestelltes Aufzeichnungsmaterial
JPH07188227A (ja) 1993-12-24 1995-07-25 Japan Tobacco Inc チアゾリジン誘導体及びオキサゾール誘導体
JPH09509156A (ja) * 1994-02-03 1997-09-16 ケンブリッジ・ニューロサイエンス・インコーポレーテッド 治療用グアニジン類
US5519040A (en) 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
US5637599A (en) 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
JPH10503176A (ja) 1994-06-17 1998-03-24 コーバス インターナショナル， インコーポレイテッド 酵素インヒビターとしての３−アミノ−２−オキソ−１−ピペリジン酢酸誘導体
US5932733A (en) 1994-06-17 1999-08-03 Corvas International, Inc. 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
US5519143A (en) * 1994-09-19 1996-05-21 The Du Pont Merck Pharmaceutical Company Process for the isolation and purification of an imidazole stereoisomer from a mixture of stereoisomers by selective precipitation
US5552437A (en) 1994-10-27 1996-09-03 Merck Frosst Canada, Inc. Bisarylcarbinol derivatives as inhibitors of leukotriene biosynthesis
US5527827A (en) 1994-10-27 1996-06-18 Merck Frosst Canada, Inc. Bisarylcarbinol cinnamic acids as inhibitors of leukotriene biosynthesis
US5674876A (en) * 1995-01-20 1997-10-07 Research Development Foundation ρ-heteroatom-substituted phenols and uses thereof
JPH08311036A (ja) 1995-03-14 1996-11-26 Takeda Chem Ind Ltd ピラゾール誘導体、その用途
IL117534A0 (en) 1995-03-24 1996-07-23 Rhone Poulenc Agrochimie Reagent and process which are useful for grafting a substituted difluoromethyl group onto a compound containing at least one electrophilic function
JPH0912585A (ja) 1995-06-30 1997-01-14 Ube Ind Ltd 高配位典型元素錯体
ATE203234T1 (de) 1995-08-30 2001-08-15 Searle & Co Meta-guanidine, harnstoff, thioharnstoff oder azacyklische aminobenzoesäure-derivate als integrin antagonisten
JPH09124632A (ja) 1995-10-31 1997-05-13 Sankyo Co Ltd ベンゾヘテロ環誘導体
FR2756825B1 (fr) 1996-12-10 1999-01-08 Adir Nouveaux derives [3h]-benzoxazole-2-thiones et [3h]- benzothiazole-2-thiones substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB2321244B (en) 1997-01-20 2000-11-22 Pharmacia & Upjohn Spa Vitamin D3 analogues,process for preparing them,and their use as antiproliferative and antitumour agents
DE19716231A1 (de) 1997-04-18 1998-10-22 Studiengesellschaft Kohle Mbh Olefinmetathese in komprimiertem Kohlendioxid
DE19722952A1 (de) 1997-05-31 1998-12-03 Huels Chemische Werke Ag Verwendung von Polymeren zur Inhibierung der Denaturierung von adsorbierten Eiweißstoffen
US5895771A (en) * 1997-06-05 1999-04-20 Akzo Nobel Nv Fluorinated alkoxy and/or aryloxy aluminates as cocatalysts for metallocene-catalyzed olefin polymerizations
US5977413A (en) * 1997-08-04 1999-11-02 Nippon Kayaku Kabushiki Kaisha Method for producing bis(3-amino-4-hydroxyphenyl) compounds
KR20010086196A (ko) 1997-09-11 2001-09-10 추후보정 폴리플루오로알콕사이드 리간드를 함유한 약한 배위결합음이온
EP1071648A2 (de) 1998-03-13 2001-01-31 Merck Frosst Canada & Co. CARBONSÄUREN UND ACYLSULFONAMIDE, SOLCHE VERBINDUNGEN ENTHALTENDE Gemenge UND BEHANDLUNGSVERFAHREN
GB2337701A (en) 1998-05-26 1999-12-01 United Medical And Dental Schools Of Guys St Thomas Hospitals Treatment of ischemia with an angiotensin II antagonist
DE19825182A1 (de) 1998-06-05 1999-12-09 Agfa Gevaert Ag Reifung von Silberhalogenidemulsionen
EP1087951B9 (de) 1998-06-18 2006-09-13 Bristol-Myers Squibb Company Durch kohlenstoff substituierte aminothiazole als inhibitoren von zyclin-abhägigen kinasen
WO2000009710A2 (en) 1998-08-11 2000-02-24 The Governors Of The University Of Alberta Compositions and methods for identifying mammalian malonyl coa decarboxylase inhibitors, agonists and antagonists
FR2784114B1 (fr) 1998-09-18 2001-02-02 Thomson Csf Materiaux polymeres absorbant les composes organophosphores. procede de synthese de ces materiaux. capteurs chimiques comprenant ces materiaux
CN1249105C (zh) 1998-10-05 2006-04-05 普罗米鲁斯有限责任公司 环烯烃聚合催化剂及聚合方法
JP2000128878A (ja) 1998-10-28 2000-05-09 Teijin Ltd ベンゾフリル−α−ピリドン誘導体
KR100739482B1 (ko) 1998-12-09 2007-07-13 스미토모 베이클라이트 가부시키가이샤 제 10족 금속 착물을 사용하는 노르보르넨형 단량체의 몰드내 첨가 중합반응
JP2002533318A (ja) 1998-12-22 2002-10-08 ニューロサーチ、アクティーゼルスカブ イオンチャネル調節剤
US20030144175A1 (en) * 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
CN1253441C (zh) 1998-12-23 2006-04-26 史密丝克莱恩比彻姆公司 蛋白酶抑制剂
CA2362401A1 (en) 1999-02-04 2000-08-10 Paul Fleming G-protein coupled heptahelical receptor binding compounds and methods of use thereof
JP2002536411A (ja) * 1999-02-09 2002-10-29 ブリストル−マイヤーズ スクイブ カンパニー Ｘａ因子のラクタム系阻害剤および方法
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6316503B1 (en) 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
CZ20013767A3 (cs) 1999-05-17 2002-04-17 Novo Nordisk A/S Sloučenina, farmaceutický prostředek, pouľití sloučeniny a způsob léčení
US6503949B1 (en) * 1999-05-17 2003-01-07 Noro Nordisk A/S Glucagon antagonists/inverse agonists
EP1212065A4 (de) 1999-07-08 2004-02-11 Tularik Inc Zusammenstellungen und methoden zur erhöhung des hdl cholesterolspiegels
EP1215203B1 (de) 1999-09-24 2005-02-16 Ono Pharmaceutical Co., Ltd. Hydroxamsäurederivate, verfahren zu ihrer herstellung und medikamente die diese als aktiven wirkstoff enthalten
IL153421A0 (en) 2000-06-14 2003-07-06 Smithkline Beecham Corp Protease inhibitors
HU227197B1 (en) * 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
ES2274005T3 (es) 2001-01-26 2007-05-16 Chugai Seiyaku Kabushiki Kaisha Inhibidores de malonyl-coa decarboxilasa usados como moduladores metabolicos.
EP1353662B1 (de) 2001-01-26 2007-04-18 Chugai Seiyaku Kabushiki Kaisha Verfahren zur behandlung von erkrankungen mit malonyl coa-decarboxylase-inhibitoren
CN101596191B (zh) 2001-01-26 2011-06-15 中外制药株式会社 用作代谢调节剂的丙二酰基辅酶a脱羧酶抑制剂
ATE442141T1 (de) 2001-02-20 2009-09-15 Chugai Pharmaceutical Co Ltd Verfahren zur behandlung von stoffwechselerkrankungen mit malonyl-coa- decarboxylase-hemmern
US7709510B2 (en) * 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
JP2004359546A (ja) 2001-03-15 2004-12-24 Ono Pharmaceut Co Ltd ヒドロキサム酸誘導体、それらの非毒性塩およびそれらのプロドラッグ体を有効成分として含有する、固形癌の予防および／または治療剤
ES2278016T3 (es) * 2001-04-09 2007-08-01 Novartis Vaccines And Diagnostics, Inc. Compuestos guanidino como agonistas del receptor de melanocortina 4 (mc4-r).
ES2353306T3 (es) * 2003-08-01 2011-03-01 Chugai Seiyaku Kabushiki Kaisha Compuestos heterocíclicos útiles como inhibidores de la malonil-coa-descarboxilasa.
ES2309563T3 (es) * 2003-08-01 2008-12-16 Chugai Seiyaku Kabushiki Kaisha Compuestos de piperidina utiles como inhibidores de malonil coenzima a descarboxilasa.
CA2533763C (en) * 2003-08-01 2012-11-20 Chugai Seiyaku Kabushiki Kaisha Cyanoamide compounds useful as malonyl-coa decarboxylase inhibitors

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US7786145B2 (en) 2010-08-31
EP2208495A1 (de) 2010-07-21
DE602004016530D1 (de) 2008-10-23
CA2533881C (en) 2012-07-10
ES2378418T3 (es) 2012-04-12
EP2208495B1 (de) 2011-12-14
JP2007501237A (ja) 2007-01-25
EP1658071A2 (de) 2006-05-24
ATE536872T1 (de) 2011-12-15
ES2314491T3 (es) 2009-03-16
WO2005037258A2 (en) 2005-04-28
WO2005037258A3 (en) 2005-09-15
EP1658071B1 (de) 2008-09-10
JP4773960B2 (ja) 2011-09-14
US20050032824A1 (en) 2005-02-10

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