UY31193A1 - Derivados de 6-cicloamino-3-(piridin-4-il)imidazo[1,2-b]-piridazina, su preparasción y su aplicación en terapéutica - Google Patents
Derivados de 6-cicloamino-3-(piridin-4-il)imidazo[1,2-b]-piridazina, su preparasción y su aplicación en terapéuticaInfo
- Publication number
- UY31193A1 UY31193A1 UY31193A UY31193A UY31193A1 UY 31193 A1 UY31193 A1 UY 31193A1 UY 31193 A UY31193 A UY 31193A UY 31193 A UY31193 A UY 31193A UY 31193 A1 UY31193 A1 UY 31193A1
- Authority
- UY
- Uruguay
- Prior art keywords
- imidazo
- therapeutics
- derivatives
- preparation
- application
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La invención se refiere a derivados de 6-cicloamino-3-(piridin-4-il)imidazo[1,2-b]piridazina, que respoden a la fórmula general (I) en la que los radicales (R2, R3, R7, y R8) y sustituyentes (A,B y L) tienen el significado especificado en la memoria descriptiva y en las reivindicaciones. Se describen los Procedimientos de preparación de los productos intermedios, composiciones farmacéuticas y medicamentos, y se describe su aplicación en terapéutica en el tratamiento o prevención de enfermedades que implican caseína quinasa 1 epsilon y/o caseína quinasa 1 delta.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94678507P | 2007-06-28 | 2007-06-28 | |
FR0704661A FR2918061B1 (fr) | 2007-06-28 | 2007-06-28 | Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique. |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31193A1 true UY31193A1 (es) | 2009-01-30 |
Family
ID=39203151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY31193A UY31193A1 (es) | 2007-06-28 | 2008-06-27 | Derivados de 6-cicloamino-3-(piridin-4-il)imidazo[1,2-b]-piridazina, su preparasción y su aplicación en terapéutica |
Country Status (22)
Country | Link |
---|---|
US (2) | US8354405B2 (es) |
EP (1) | EP2170889B1 (es) |
JP (1) | JP5537424B2 (es) |
KR (1) | KR20100050492A (es) |
CN (1) | CN101765602A (es) |
AR (1) | AR069269A1 (es) |
AU (1) | AU2008281662A1 (es) |
BR (1) | BRPI0814807A2 (es) |
CA (1) | CA2691866A1 (es) |
CL (1) | CL2008001932A1 (es) |
CO (1) | CO6251269A2 (es) |
EA (1) | EA201070072A1 (es) |
FR (1) | FR2918061B1 (es) |
MA (1) | MA31572B1 (es) |
MX (1) | MX2009013948A (es) |
NZ (1) | NZ582677A (es) |
PA (1) | PA8786101A1 (es) |
PE (1) | PE20090556A1 (es) |
TW (1) | TW200911812A (es) |
UY (1) | UY31193A1 (es) |
WO (1) | WO2009016286A2 (es) |
ZA (1) | ZA200909186B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7868001B2 (en) * | 2007-11-02 | 2011-01-11 | Hutchison Medipharma Enterprises Limited | Cytokine inhibitors |
US8507488B2 (en) | 2008-05-13 | 2013-08-13 | Irm Llc | Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors |
FR2934994B1 (fr) * | 2008-08-12 | 2010-09-17 | Sanofi Aventis | Derives de 2-alkyl-6cycloamino-3-(pyridin-4-yl)imidaz°1,2-b! pyridazine, leur preparation et leur application en therapeutique |
FR2939134A1 (fr) * | 2008-12-01 | 2010-06-04 | Sanofi Aventis | Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique |
FR2940285A1 (fr) * | 2008-12-19 | 2010-06-25 | Sanofi Aventis | Derives de 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo °1,2-b!-pyridazine et 6-cycloamino-2-furanyl-3- (pyridin-4-yl)imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique |
FR2940284B1 (fr) * | 2008-12-19 | 2011-02-18 | Sanofi Aventis | Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique |
JP5759470B2 (ja) * | 2009-10-23 | 2015-08-05 | ヤンセン ファーマシューティカ エヌ.ベー. | オレキシン受容体調節因子としての二置換オクタヒドロピロロ[3,4−c]ピロール |
US8680275B2 (en) | 2009-10-23 | 2014-03-25 | Janssen Pharmaceutica Nv | Fused heterocyclic compounds as orexin receptor modulators |
JP5848251B2 (ja) | 2009-10-23 | 2016-01-27 | ヤンセン ファーマシューティカ エヌ.ベー. | オレキシン受容体調節因子としての縮合複素環式化合物 |
MX2012004990A (es) | 2009-10-30 | 2012-06-12 | Janssen Pharmaceutica Nv | Deribados de imidazo [1,2-b] pirimideazina y su uso como inhibidores de la enzima fosfodiesterasa 10. |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
CA2795765C (en) | 2010-04-06 | 2020-07-07 | Fred Hutchinson Cancer Research Center | Methods for identifying and using inhibitors of casein kinase 1 epsilon isoform for inhibiting the growth and/or proliferation of myc-driven tumor cells |
US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
CA2818903C (en) | 2010-12-14 | 2021-03-23 | Electrophoretics Limited | 5-(1,3-benzoxazol-2-yl)-4-(pyridin-4-yl)pyrimidin-2-amine and its use as a casein kinase 1delta inhibitor |
TWI617559B (zh) * | 2010-12-22 | 2018-03-11 | 江蘇恆瑞醫藥股份有限公司 | 2-芳基咪唑并[1,2-b]嗒.2-苯基咪唑并[1,2-a]吡啶,和2-苯基咪唑并[1,2-a]吡衍生物 |
US9586962B2 (en) | 2011-04-20 | 2017-03-07 | Janssen Pharmaceutica Nv | Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators |
BR112013033375B1 (pt) | 2011-06-27 | 2022-05-10 | Janssen Pharmaceutica N.V | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário |
EP3778896A1 (en) | 2011-08-09 | 2021-02-17 | Fred Hutchinson Cancer Research Center | Methods and compositions for inhibiting the growth and/or proliferation of myc-driven tumor cells |
CN104411312B (zh) | 2012-06-26 | 2018-03-06 | 詹森药业有限公司 | 包括pde2抑制剂例如1‑芳基‑4‑甲基‑[1,2,4]三唑[4,3‑a]‑喹喔啉化合物和pde10抑制剂的用于在治疗神经病学障碍或代谢障碍中使用的组合 |
UA116541C2 (uk) | 2012-06-27 | 2018-04-10 | 4Ск Діскавері Гмбх | Біфтордіоксаланамінобензімідазольні інгібітори кінази для лікування злоякісного новоутворення, аутоімунного запалення і порушень цнс |
MX362197B (es) | 2012-07-09 | 2019-01-08 | Janssen Pharmaceutica Nv | Derivados de imidazo[1,2-b]piridazina e imidazo[1,2-a]pirazina como inhibidores de la fosfodiesterasa 10; y el uso de los mismos en el tratamiento de trastornos neurológicos, psiquiátricos y metabólicos. |
CZ2012538A3 (cs) * | 2012-08-08 | 2014-02-19 | Masarykova Univerzita | Inhibitory pro léčbu B-buněčné chronické lymfocytární leukémie |
US10676746B2 (en) | 2013-11-22 | 2020-06-09 | Fred Hutchinson Cancer Research Center | Methods for identifying therapeutic targets and treating monitoring cancers |
MX2016008968A (es) * | 2014-01-09 | 2016-10-26 | Intra-Cellular Therapies Inc | Compuestos organicos. |
JP2017506259A (ja) * | 2014-02-03 | 2017-03-02 | イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム・リミテッドYissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | 幹細胞を枯渇させるためのカゼインキナーゼi阻害剤の使用 |
HRP20220642T1 (hr) | 2016-03-10 | 2022-06-24 | Janssen Pharmaceutica Nv | Postupci za liječenje depresije uporabom antagonista receptora oreksina 2 |
EP3597648B1 (en) * | 2017-03-14 | 2023-06-07 | Daiichi Sankyo Company, Limited | METHOD FOR PRODUCING 3, 6-DISUBSTITUTED IMIDAZO[1, 2-b]PYRIDAZINE DERIVATIVE |
CN109311897B (zh) | 2017-03-20 | 2021-07-20 | 福马治疗股份有限公司 | 作为丙酮酸激酶(pkr)活化剂的吡咯并吡咯组合物 |
US10973820B2 (en) | 2017-12-13 | 2021-04-13 | Facio Intellectual Property B.V. | Compounds for treatment of diseases related to DUX4 expression |
US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
US20230055923A1 (en) | 2018-09-19 | 2023-02-23 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
WO2020151682A1 (zh) * | 2019-01-23 | 2020-07-30 | 成都先导药物开发股份有限公司 | 一种大环类免疫调节剂 |
TW202112368A (zh) * | 2019-06-13 | 2021-04-01 | 荷蘭商法西歐知識產權股份有限公司 | 用於治療有關dux4表現之疾病的抑制劑組合 |
US11193891B2 (en) | 2019-12-20 | 2021-12-07 | Robert Bosch Gmbh | Receptors and spacers for a fluorescence-based lead ion chemosensor |
WO2021190616A1 (en) * | 2020-03-27 | 2021-09-30 | Gritscience Biopharmaceuticals Co., Ltd. | Methods for inhibiting casein kinases |
EP4126878A1 (en) * | 2020-03-27 | 2023-02-08 | Gritscience Biopharmaceuticals Co., Ltd. | Compounds as casein kinase inhibitors |
AU2022367432A1 (en) | 2021-10-14 | 2024-05-02 | Incyte Corporation | Quinoline compounds as inhibitors of kras |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0103926D0 (en) * | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
EP1388541A1 (en) * | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazines as kinase inhibitors |
WO2005061498A1 (en) | 2003-12-11 | 2005-07-07 | Aventis Pharmaceuticals Inc. | Substituted 1h-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase i epsilon |
US7718801B2 (en) * | 2004-08-31 | 2010-05-18 | Banyu Pharmaceutical Co., Ltd. | Substituted imidazole derivative |
WO2006070943A1 (ja) * | 2004-12-28 | 2006-07-06 | Takeda Pharmaceutical Company Limited | 縮合イミダゾール化合物およびその用途 |
US20100216798A1 (en) * | 2005-07-29 | 2010-08-26 | Astellas Pharma Inc | Fused heterocycles as lck inhibitors |
EP1845098A1 (en) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands |
KR101546493B1 (ko) * | 2006-11-06 | 2015-08-21 | 톨레로 파마수티컬스, 인크. | 이미다조[1,2-b]피리다진 및 피라졸로[1,5-a]피리미딘 유도체 및 단백질 키나제 억제제로서의 이의 용도 |
AR064420A1 (es) * | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
-
2007
- 2007-06-28 FR FR0704661A patent/FR2918061B1/fr active Active
-
2008
- 2008-06-25 TW TW097123772A patent/TW200911812A/zh unknown
- 2008-06-26 NZ NZ582677A patent/NZ582677A/en not_active IP Right Cessation
- 2008-06-26 KR KR1020107001891A patent/KR20100050492A/ko not_active Application Discontinuation
- 2008-06-26 JP JP2010514033A patent/JP5537424B2/ja not_active Expired - Fee Related
- 2008-06-26 BR BRPI0814807-4A2A patent/BRPI0814807A2/pt not_active IP Right Cessation
- 2008-06-26 CN CN200880100885A patent/CN101765602A/zh active Pending
- 2008-06-26 CA CA002691866A patent/CA2691866A1/fr not_active Abandoned
- 2008-06-26 PE PE2008001090A patent/PE20090556A1/es not_active Application Discontinuation
- 2008-06-26 WO PCT/FR2008/000902 patent/WO2009016286A2/fr active Application Filing
- 2008-06-26 EP EP08826677.0A patent/EP2170889B1/fr active Active
- 2008-06-26 AU AU2008281662A patent/AU2008281662A1/en not_active Abandoned
- 2008-06-26 MX MX2009013948A patent/MX2009013948A/es unknown
- 2008-06-26 EA EA201070072A patent/EA201070072A1/ru unknown
- 2008-06-27 CL CL2008001932A patent/CL2008001932A1/es unknown
- 2008-06-27 UY UY31193A patent/UY31193A1/es not_active Application Discontinuation
- 2008-06-27 PA PA20088786101A patent/PA8786101A1/es unknown
- 2008-06-27 AR ARP080102783A patent/AR069269A1/es unknown
-
2009
- 2009-12-23 ZA ZA2009/09186A patent/ZA200909186B/en unknown
- 2009-12-24 US US12/647,059 patent/US8354405B2/en not_active Expired - Fee Related
- 2009-12-28 CO CO09148262A patent/CO6251269A2/es not_active Application Discontinuation
-
2010
- 2010-01-26 MA MA32556A patent/MA31572B1/fr unknown
-
2012
- 2012-09-14 US US13/617,678 patent/US8846676B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2170889B1 (fr) | 2016-08-17 |
EP2170889A2 (fr) | 2010-04-07 |
ZA200909186B (en) | 2011-02-23 |
PE20090556A1 (es) | 2009-06-01 |
US8846676B2 (en) | 2014-09-30 |
AR069269A1 (es) | 2010-01-13 |
TW200911812A (en) | 2009-03-16 |
FR2918061A1 (fr) | 2009-01-02 |
FR2918061B1 (fr) | 2010-10-22 |
WO2009016286A3 (fr) | 2009-04-09 |
JP2010531342A (ja) | 2010-09-24 |
MX2009013948A (es) | 2010-03-09 |
CL2008001932A1 (es) | 2009-09-25 |
US8354405B2 (en) | 2013-01-15 |
CA2691866A1 (fr) | 2009-02-05 |
CO6251269A2 (es) | 2011-02-21 |
CN101765602A (zh) | 2010-06-30 |
PA8786101A1 (es) | 2009-01-23 |
US20130012516A1 (en) | 2013-01-10 |
KR20100050492A (ko) | 2010-05-13 |
WO2009016286A2 (fr) | 2009-02-05 |
BRPI0814807A2 (pt) | 2015-02-03 |
MA31572B1 (fr) | 2010-08-02 |
EA201070072A1 (ru) | 2010-08-30 |
JP5537424B2 (ja) | 2014-07-02 |
NZ582677A (en) | 2011-12-22 |
US20100179154A1 (en) | 2010-07-15 |
AU2008281662A1 (en) | 2009-02-05 |
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Legal Events
Date | Code | Title | Description |
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109 | Application deemed to be withdrawn |
Effective date: 20140729 |