MX2009013948A - Derivados de 6-cicloamino-3-(piridin-4-il)imidazo[1,2-b] piridazina, su preparacion y uso terapéutico. - Google Patents

Derivados de 6-cicloamino-3-(piridin-4-il)imidazo[1,2-b] piridazina, su preparacion y uso terapéutico.

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Publication number
MX2009013948A
MX2009013948A MX2009013948A MX2009013948A MX2009013948A MX 2009013948 A MX2009013948 A MX 2009013948A MX 2009013948 A MX2009013948 A MX 2009013948A MX 2009013948 A MX2009013948 A MX 2009013948A MX 2009013948 A MX2009013948 A MX 2009013948A
Authority
MX
Mexico
Prior art keywords
group
groups
optionally substituted
cycloamino
imidazo
Prior art date
Application number
MX2009013948A
Other languages
English (en)
Inventor
Antonio Almario Garcia
Pascal George
Philippe Burnier
Frederic Puech
Adrien Tak Li
Matthieu Barrague
Cecile Enguehard
Zhongli Gao
Alain Gueiffier
Roy Vaz
Qiuxia Zhao
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2009013948A publication Critical patent/MX2009013948A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se refiere a derivados de 6-cicloamino-3-(piridin-4-il)imidazo[1,2-b]piridazina que corresponden a la fórmula general de (I), en el cual cuya fórmula (I) R2 es un grupo arilo opcionalmente substituido por uno o más substituyentes seleccionados de los átomos de halógeno, y C1-6 alquilo, C1-6 alquiloxi, C1-6 alquiltio, C1-6 fluoroalquilo, C1-6 fluoroalquiloxi y grupos -CN; R3 es un átomo de hidrógeno o un C1-3 alquilo, -NR4R5, hidroxilo o un grupo C1-4 alquiloxi; -A es un grupo C1-7 alquileno opcionalmente substituido por uno o dos grupos Ra; B es un grupo C1-7 alquileno opcionalmente substituido por un grupo Ra; L es cualquiera de un átomo de nitrógeno opcionalmente substituido por un grupo R, o Ra o un átomo de carbono substituido por un grupo R y un grupo Ra o dos grupos Re2; los átomos de carbono de A y de B o de los grupos Re2 son opcionalmente substituidos por uno o más grupos Rf los cuales pueden ser idénticos o diferentes entre ellos; R7 y Ra son, independientemente entre ellos, un átomo de hidrógeno o un grupo C1-6-alquilo. Método de preparación y uso terapéutico.
MX2009013948A 2007-06-28 2008-06-26 Derivados de 6-cicloamino-3-(piridin-4-il)imidazo[1,2-b] piridazina, su preparacion y uso terapéutico. MX2009013948A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94678507P 2007-06-28 2007-06-28
FR0704661A FR2918061B1 (fr) 2007-06-28 2007-06-28 Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
PCT/FR2008/000902 WO2009016286A2 (fr) 2007-06-28 2008-06-26 Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo[1, 2-b]-pyridazine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
MX2009013948A true MX2009013948A (es) 2010-03-09

Family

ID=39203151

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013948A MX2009013948A (es) 2007-06-28 2008-06-26 Derivados de 6-cicloamino-3-(piridin-4-il)imidazo[1,2-b] piridazina, su preparacion y uso terapéutico.

Country Status (22)

Country Link
US (2) US8354405B2 (es)
EP (1) EP2170889B1 (es)
JP (1) JP5537424B2 (es)
KR (1) KR20100050492A (es)
CN (1) CN101765602A (es)
AR (1) AR069269A1 (es)
AU (1) AU2008281662A1 (es)
BR (1) BRPI0814807A2 (es)
CA (1) CA2691866A1 (es)
CL (1) CL2008001932A1 (es)
CO (1) CO6251269A2 (es)
EA (1) EA201070072A1 (es)
FR (1) FR2918061B1 (es)
MA (1) MA31572B1 (es)
MX (1) MX2009013948A (es)
NZ (1) NZ582677A (es)
PA (1) PA8786101A1 (es)
PE (1) PE20090556A1 (es)
TW (1) TW200911812A (es)
UY (1) UY31193A1 (es)
WO (1) WO2009016286A2 (es)
ZA (1) ZA200909186B (es)

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FR2939134A1 (fr) * 2008-12-01 2010-06-04 Sanofi Aventis Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
FR2940285A1 (fr) * 2008-12-19 2010-06-25 Sanofi Aventis Derives de 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo °1,2-b!-pyridazine et 6-cycloamino-2-furanyl-3- (pyridin-4-yl)imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
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JP6426603B2 (ja) 2012-06-26 2018-11-21 ヤンセン ファーマシューティカ エヌ．ベー． 神経障害または代謝障害の治療に使用するための、１−アリール−４−メチル−［１，２，４］トリアゾロ［４，３−ａ］−キノキサリン化合物などのＰＤＥ２阻害剤とＰＤＥ１０阻害剤との組合せ
UA116541C2 (uk) 2012-06-27 2018-04-10 4Ск Діскавері Гмбх Біфтордіоксаланамінобензімідазольні інгібітори кінази для лікування злоякісного новоутворення, аутоімунного запалення і порушень цнс
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Also Published As

Publication number Publication date
AR069269A1 (es) 2010-01-13
CA2691866A1 (fr) 2009-02-05
US20130012516A1 (en) 2013-01-10
WO2009016286A2 (fr) 2009-02-05
WO2009016286A3 (fr) 2009-04-09
PA8786101A1 (es) 2009-01-23
ZA200909186B (en) 2011-02-23
NZ582677A (en) 2011-12-22
CL2008001932A1 (es) 2009-09-25
JP2010531342A (ja) 2010-09-24
MA31572B1 (fr) 2010-08-02
FR2918061B1 (fr) 2010-10-22
US8354405B2 (en) 2013-01-15
FR2918061A1 (fr) 2009-01-02
CN101765602A (zh) 2010-06-30
US8846676B2 (en) 2014-09-30
EP2170889A2 (fr) 2010-04-07
BRPI0814807A2 (pt) 2015-02-03
US20100179154A1 (en) 2010-07-15
EA201070072A1 (ru) 2010-08-30
KR20100050492A (ko) 2010-05-13
EP2170889B1 (fr) 2016-08-17
PE20090556A1 (es) 2009-06-01
AU2008281662A1 (en) 2009-02-05
TW200911812A (en) 2009-03-16
CO6251269A2 (es) 2011-02-21
UY31193A1 (es) 2009-01-30
JP5537424B2 (ja) 2014-07-02

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