MX2010007348A - Derivados de n-fenil-imidazo[1,2-a]piridin-2-carboxamidas, su preparacion y su aplicacion terapeutica. - Google Patents
Derivados de n-fenil-imidazo[1,2-a]piridin-2-carboxamidas, su preparacion y su aplicacion terapeutica.Info
- Publication number
- MX2010007348A MX2010007348A MX2010007348A MX2010007348A MX2010007348A MX 2010007348 A MX2010007348 A MX 2010007348A MX 2010007348 A MX2010007348 A MX 2010007348A MX 2010007348 A MX2010007348 A MX 2010007348A MX 2010007348 A MX2010007348 A MX 2010007348A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- alkyl
- alkoxy
- nrarb
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
La invención se refiere a compuestos de fórmula (I) en donde: X es un grupo fenilo sustituido; R1 es un átomo de hidrógeno, un halógeno, un grupo alcoxi de 1 a 6 átomos de carbono, un grupo alquilo de 1 a 6 átomos de carbono, un grupo NRaRb; R2 es un átomo de hidrógeno, un grupo alquilo de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono, opcionalmente sustituidos, un grupo alquenilo de 2 a 6 átomos de carbono, alquinilo de 2 a 6 átomos de carbono, CO-R5, -CO-NR6R7, -CO-O-R8, NR9-CO-R10, NR11R12, N = CH-NRaRb, un átomo de halógeno, ciano, nitro, hidroxiiminoalquilo, un grupo alcoxiiminoalquilo, alquiltio de 1 a 6 átomos de carbono, un grupo alquilsulfinilo de 1 a 5 átomos de carbono, alquilsulfonilo de 1 a 6 átomos de carbono, ((alquilo de 1 a 6 átomos de carbono) 3) sililetinilo, -SO2-NR9R10, fenilo opcionalmente sustituido por uno o más grupos seleccionados independientemente unos de otros de los siguientes átomos o grupos: halógeno, alcoxi de 1 a 6 átomos de carbono, ciano, NRaRb, -CO-R5, -CO-NR6R7, -CO-O-R8, un grupo alquilo de 1 a 6 átomos de carbono opcionalmente sustituido por uno o más hidroxi o NRaRb; R3 es un átomo de hidrógeno, un grupo alquilo de 1 a 6 átomos de carbono, grupo alcoxi de 1 a 6 átomos de carbono o un átomo de halógeno; R4 es un átomo de hidrógeno, un grupo alquilo de 1 a 4 átomos de carbono, un grupo alcoxi de 1 a 4 átomos de carbono o un átomo de flúor; tales compuestos que están en forma de base o una sal de adición de un ácido. La invención pude tener uso terapéutico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0800002A FR2925900B1 (fr) | 2008-01-02 | 2008-01-02 | DERIVES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
PCT/FR2008/001833 WO2009106748A2 (fr) | 2008-01-02 | 2008-12-31 | Dérivés de n-phenyl-imidazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010007348A true MX2010007348A (es) | 2010-08-18 |
Family
ID=39691313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010007348A MX2010007348A (es) | 2008-01-02 | 2008-12-31 | Derivados de n-fenil-imidazo[1,2-a]piridin-2-carboxamidas, su preparacion y su aplicacion terapeutica. |
Country Status (21)
Country | Link |
---|---|
US (1) | US20100317685A1 (es) |
EP (1) | EP2225241B1 (es) |
JP (1) | JP2011508758A (es) |
KR (1) | KR20100099245A (es) |
CN (1) | CN101910176A (es) |
AR (1) | AR070071A1 (es) |
AT (1) | ATE524468T1 (es) |
AU (1) | AU2008351926A1 (es) |
BR (1) | BRPI0821674A2 (es) |
CA (1) | CA2710943A1 (es) |
CL (1) | CL2008003926A1 (es) |
CO (1) | CO6321243A2 (es) |
EA (1) | EA201070816A1 (es) |
FR (1) | FR2925900B1 (es) |
IL (1) | IL206668A0 (es) |
MA (1) | MA32060B1 (es) |
MX (1) | MX2010007348A (es) |
TW (1) | TW200942539A (es) |
UY (1) | UY31586A1 (es) |
WO (1) | WO2009106748A2 (es) |
ZA (1) | ZA201004641B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2903108B1 (fr) * | 2006-07-03 | 2008-08-29 | Sanofi Aventis Sa | Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique. |
FR2925906B1 (fr) * | 2008-01-02 | 2010-08-20 | Sanofi Aventis | COMPOSES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
FR2950344B1 (fr) * | 2009-09-18 | 2011-11-25 | Sanofi Aventis | Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2638161B1 (fr) * | 1988-10-24 | 1991-01-11 | Centre Nat Rech Scient | Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
US7750160B2 (en) * | 2003-11-13 | 2010-07-06 | Ambit Biosciences Corporation | Isoxazolyl urea derivatives as kinase modulators |
CA2589773A1 (en) * | 2004-12-22 | 2006-06-29 | Astrazeneca Ab | Pyridine carboxamide derivatives for use as anticancer agents |
FR2903108B1 (fr) * | 2006-07-03 | 2008-08-29 | Sanofi Aventis Sa | Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique. |
FR2903107B1 (fr) * | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
FR2925906B1 (fr) * | 2008-01-02 | 2010-08-20 | Sanofi Aventis | COMPOSES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
-
2008
- 2008-01-02 FR FR0800002A patent/FR2925900B1/fr not_active Expired - Fee Related
- 2008-12-30 AR ARP080105776A patent/AR070071A1/es unknown
- 2008-12-30 CL CL2008003926A patent/CL2008003926A1/es unknown
- 2008-12-30 UY UY31586A patent/UY31586A1/es not_active Application Discontinuation
- 2008-12-31 MX MX2010007348A patent/MX2010007348A/es active IP Right Grant
- 2008-12-31 AU AU2008351926A patent/AU2008351926A1/en not_active Abandoned
- 2008-12-31 BR BRPI0821674-6A patent/BRPI0821674A2/pt not_active IP Right Cessation
- 2008-12-31 EA EA201070816A patent/EA201070816A1/ru unknown
- 2008-12-31 KR KR1020107014641A patent/KR20100099245A/ko not_active Application Discontinuation
- 2008-12-31 AT AT08872826T patent/ATE524468T1/de not_active IP Right Cessation
- 2008-12-31 CA CA2710943A patent/CA2710943A1/fr not_active Abandoned
- 2008-12-31 WO PCT/FR2008/001833 patent/WO2009106748A2/fr active Application Filing
- 2008-12-31 TW TW097151693A patent/TW200942539A/zh unknown
- 2008-12-31 EP EP08872826A patent/EP2225241B1/fr active Active
- 2008-12-31 JP JP2010541082A patent/JP2011508758A/ja not_active Withdrawn
- 2008-12-31 CN CN200880123840XA patent/CN101910176A/zh active Pending
-
2010
- 2010-06-28 IL IL206668A patent/IL206668A0/en unknown
- 2010-07-01 ZA ZA2010/04641A patent/ZA201004641B/en unknown
- 2010-07-01 US US12/828,369 patent/US20100317685A1/en not_active Abandoned
- 2010-07-02 CO CO10080881A patent/CO6321243A2/es not_active Application Discontinuation
- 2010-08-02 MA MA33058A patent/MA32060B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
ZA201004641B (en) | 2011-09-28 |
JP2011508758A (ja) | 2011-03-17 |
CA2710943A1 (fr) | 2009-09-03 |
IL206668A0 (en) | 2010-12-30 |
EA201070816A1 (ru) | 2010-12-30 |
CL2008003926A1 (es) | 2010-02-12 |
EP2225241B1 (fr) | 2011-09-14 |
BRPI0821674A2 (pt) | 2015-06-16 |
US20100317685A1 (en) | 2010-12-16 |
MA32060B1 (fr) | 2011-02-01 |
KR20100099245A (ko) | 2010-09-10 |
WO2009106748A2 (fr) | 2009-09-03 |
FR2925900B1 (fr) | 2011-03-04 |
CN101910176A (zh) | 2010-12-08 |
ATE524468T1 (de) | 2011-09-15 |
EP2225241A2 (fr) | 2010-09-08 |
WO2009106748A3 (fr) | 2009-12-30 |
AR070071A1 (es) | 2010-03-10 |
TW200942539A (en) | 2009-10-16 |
UY31586A1 (es) | 2009-08-03 |
FR2925900A1 (fr) | 2009-07-03 |
AU2008351926A1 (en) | 2009-09-03 |
CO6321243A2 (es) | 2011-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX344669B (es) | Agente antiplaquetas novedoso. | |
MX2008016558A (es) | Preparacion y aplicacion terapéutica de derivados de 2-benzoil-imidazopiridinas. | |
MX2010007351A (es) | Derivados de imidazo[1,2-a]piridina-2-carboxamidas, su preparacion y su aplicacion en terapeutica. | |
MY145603A (en) | 2-ARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | |
MX2009004920A (es) | Nuevos derivados de aminopirimidina como inhibidores de plk1. | |
MA32247B1 (fr) | Derives de 2-aryl-6-phenyl-imidazo[1,2-a]pyridines polysubstitues, leur préparation et leur application en thérapeutique | |
AU2010326429B2 (en) | Diphenyl-pyrazolopyridine derivatives, preparation thereof, and use thereof as nuclear receptor NOT modulators | |
TW200607808A (en) | Pyrido-pyrimidine derivatives, preparation thereof and application thereof | |
WO2009118473A3 (fr) | Composés dérivés d'azétidines, leur préparation et leur application en thérapeutique | |
MX2011012057A (es) | Derivados de ciclopenta [c] pirrolilalquilcarbamatos de heterociclos de 5 miembros, su preparación y su uso en terapéutica. | |
MX2010007349A (es) | Derivados de n-heterociclico-imidazo[1,2-a]piridina-2-carboxamidas , su preparacion y su aplicacion terapeutica. | |
MY146939A (en) | Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics | |
MY165634A (en) | Pyrazole compounds having therapeutic effect on multiple myeloma | |
WO2008003855A3 (fr) | Utilisation de 2-benzoyl-imidazopyridines en thérapeutique | |
MX2010007348A (es) | Derivados de n-fenil-imidazo[1,2-a]piridin-2-carboxamidas, su preparacion y su aplicacion terapeutica. | |
BRPI1009497A2 (pt) | Derivados de n-[(6-aza-biciclo[3.2.1] oct-5-il)-aril- metil]-heterobenzamida, o respectivo preparo e a respectiva aplicação em terapêutica | |
TW200700419A (en) | 5,6-dialkyl-7-aminoazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds | |
WO2008003858A3 (fr) | Utilisation de dérivés d'imidazo[1, 2-a]pyridine-2-carboxamides en thérapeutique | |
MX2010007353A (es) | Derivados de 6-heterociclico-imidazo[1,2-a]piridina-2-carboxamidas , su preparacion y su aplicacion terapeutica. | |
WO2009115651A3 (fr) | Composés de n-phenyl-imidazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique | |
WO2007057571A3 (fr) | Derives de 3-acylindole, leur preparation et leur application en therapeutique comme modulateurs pour les recepteurs cb2 | |
MX2010007352A (es) | Derivados de n-heterociclico-6-heterociclico-imidazo[1,2-a]piridin a-2-carboxamidas, su preparacion y su aplicacion terapeutica. | |
TW200942538A (en) | 2-benzoylimidazo[1,2-a]pyridine derivatives, preparation thereof and therapeutic use thereof | |
MY152978A (en) | Derivatives of morphine-6-glucuronide, preparation method thereof and use of same in therapeutics | |
MX2011011246A (es) | Derivados de 1-h-pirazolo [4,3-c] isoquinoleinas, su preparacion y su uso en terapeutica. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |