EA201070816A1 - Производные n-фенилимидазо[1,2-a]пиридин-2-карбоксамидов, их получение и их применение в терапии - Google Patents

Производные n-фенилимидазо[1,2-a]пиридин-2-карбоксамидов, их получение и их применение в терапии

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Publication number
EA201070816A1
EA201070816A1 EA201070816A EA201070816A EA201070816A1 EA 201070816 A1 EA201070816 A1 EA 201070816A1 EA 201070816 A EA201070816 A EA 201070816A EA 201070816 A EA201070816 A EA 201070816A EA 201070816 A1 EA201070816 A1 EA 201070816A1
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EA
Eurasian Patent Office
Prior art keywords
group
alkyl
alkoxy
nrr
nrarb
Prior art date
Application number
EA201070816A
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English (en)
Inventor
Жан-Франсуа Пэронель
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Санофи-Авентис
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Publication date
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Publication of EA201070816A1 publication Critical patent/EA201070816A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P37/08—Antiallergic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Соединения формулы (I), в которой Х означает замещенную фенильную группу; Rозначает атом водорода, галоген, (C-С)алкоксигруппу, (C-С)алкильную группу, группу NRaRb; Rозначает атом водорода, (C-С)алкильную группу, возможно замещенную, (C-С)алкоксигруппу, возможно замещенную, (С-С)алкенильную группу, (C-С)алкинильную группу, группу -CO-R, группу -CO-NRR, группу -CO-O-R, группу -NR-CO-R, группу -NRR, группу -N=CH-NRaRb, атом галогена, циано-, нитро-, гидроксииминоалкильную группу, алкоксииминоалкильную группу, (C-С)алкилтиогруппу, (C-С)алкилсульфинильную группу, (C-С)алкилсульфонильную группу, (((C-С)алкил))силилэтинильную группу, группу -SO-NRR, фенильную группу, возможно замещенную одной или несколькими группами, выбранными независимо друг от друга из следующих атомов или групп: галоген, (C-С) алкокси, циано, NRaRb, -CO-R, -CO-NRR, -CO-O-R, (C-С)алкильная группа, возможно замещенная одним или несколькими гидрокси или NRaRb, Rозначает атом водорода, (C-С)алкильную группу, (C-С)алкоксигруппу или атом галогена, R4 означает атом водорода, (C-С)алкильную группу, (C-С)алкоксигруппу или атом фтора, в форме основания или кислотно-аддитивной соли. Применение в терапии.
EA201070816A 2008-01-02 2008-12-31 Производные n-фенилимидазо[1,2-a]пиридин-2-карбоксамидов, их получение и их применение в терапии EA201070816A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0800002A FR2925900B1 (fr) 2008-01-02 2008-01-02 DERIVES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
PCT/FR2008/001833 WO2009106748A2 (fr) 2008-01-02 2008-12-31 Dérivés de n-phenyl-imidazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
EA201070816A1 true EA201070816A1 (ru) 2010-12-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070816A EA201070816A1 (ru) 2008-01-02 2008-12-31 Производные n-фенилимидазо[1,2-a]пиридин-2-карбоксамидов, их получение и их применение в терапии

Country Status (21)

Country Link
US (1) US20100317685A1 (ru)
EP (1) EP2225241B1 (ru)
JP (1) JP2011508758A (ru)
KR (1) KR20100099245A (ru)
CN (1) CN101910176A (ru)
AR (1) AR070071A1 (ru)
AT (1) ATE524468T1 (ru)
AU (1) AU2008351926A1 (ru)
BR (1) BRPI0821674A2 (ru)
CA (1) CA2710943A1 (ru)
CL (1) CL2008003926A1 (ru)
CO (1) CO6321243A2 (ru)
EA (1) EA201070816A1 (ru)
FR (1) FR2925900B1 (ru)
IL (1) IL206668A0 (ru)
MA (1) MA32060B1 (ru)
MX (1) MX2010007348A (ru)
TW (1) TW200942539A (ru)
UY (1) UY31586A1 (ru)
WO (1) WO2009106748A2 (ru)
ZA (1) ZA201004641B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2903108B1 (fr) * 2006-07-03 2008-08-29 Sanofi Aventis Sa Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique.
FR2925906B1 (fr) * 2008-01-02 2010-08-20 Sanofi Aventis COMPOSES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2950344B1 (fr) 2009-09-18 2011-11-25 Sanofi Aventis Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2638161B1 (fr) * 1988-10-24 1991-01-11 Centre Nat Rech Scient Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US7767670B2 (en) * 2003-11-13 2010-08-03 Ambit Biosciences Corporation Substituted 3-carboxamido isoxazoles as kinase modulators
ATE427946T1 (de) * 2004-12-22 2009-04-15 Astrazeneca Ab Pyridincarbonsaureamidderivate zur verwendung als antikrebsmittel
FR2903107B1 (fr) * 2006-07-03 2008-08-22 Sanofi Aventis Sa Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique
FR2903108B1 (fr) * 2006-07-03 2008-08-29 Sanofi Aventis Sa Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique.
FR2925906B1 (fr) * 2008-01-02 2010-08-20 Sanofi Aventis COMPOSES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Also Published As

Publication number Publication date
EP2225241A2 (fr) 2010-09-08
UY31586A1 (es) 2009-08-03
ZA201004641B (en) 2011-09-28
MX2010007348A (es) 2010-08-18
ATE524468T1 (de) 2011-09-15
IL206668A0 (en) 2010-12-30
EP2225241B1 (fr) 2011-09-14
KR20100099245A (ko) 2010-09-10
AR070071A1 (es) 2010-03-10
WO2009106748A3 (fr) 2009-12-30
CO6321243A2 (es) 2011-09-20
JP2011508758A (ja) 2011-03-17
CL2008003926A1 (es) 2010-02-12
US20100317685A1 (en) 2010-12-16
BRPI0821674A2 (pt) 2015-06-16
MA32060B1 (fr) 2011-02-01
CN101910176A (zh) 2010-12-08
WO2009106748A2 (fr) 2009-09-03
FR2925900B1 (fr) 2011-03-04
AU2008351926A1 (en) 2009-09-03
CA2710943A1 (fr) 2009-09-03
FR2925900A1 (fr) 2009-07-03
TW200942539A (en) 2009-10-16

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