MX2010007351A - Derivados de imidazo[1,2-a]piridina-2-carboxamidas, su preparacion y su aplicacion en terapeutica. - Google Patents
Derivados de imidazo[1,2-a]piridina-2-carboxamidas, su preparacion y su aplicacion en terapeutica.Info
- Publication number
- MX2010007351A MX2010007351A MX2010007351A MX2010007351A MX2010007351A MX 2010007351 A MX2010007351 A MX 2010007351A MX 2010007351 A MX2010007351 A MX 2010007351A MX 2010007351 A MX2010007351 A MX 2010007351A MX 2010007351 A MX2010007351 A MX 2010007351A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- optionally substituted
- alkyl
- alkoxy
- atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención se refiere a compuestos de fórmula (I) en la cual: X e Y definen, junto con el átomo nitrógeno llevado por los mismos, un amino monocíclico o bicíclico saturado o parcialmente saturado con 5 a 10 enlaces que opcionalmente incluyen 1 a 2 heteroátomos adicionales seleccionados de O, S, N y opcionalmente sustituidos por un átomo de halógeno, un grupo alquilo de 1 a 6 átomos de carbono, un grupo alcoxi de 1 a 6 átomos de carbono, ciano, NRaRb, COOR8, los grupos alquilo de 1 a 6 átomos de carbono y alcoxi de 1 a 6 átomos de carbono se sustituyen opcionalmente por uno o más átomos de halógeno; R1 es un átomo de hidrógeno, un átomo de halógeno, un grupo alcoxi de 1 a 6 átomos de carbono, un grupo alquilo de 1 a 6 átomos de carbono; R2 es un átomo de hidrógeno o un grupo alquilo de 1 a 6 átomos de carbono opcionalmente sustituido, un grupo alcoxi de 1 a 6 átomos de carbono opcionalmente sustituido, un grupo alquenilo de 2 a 6 átomos de carbono, un grupo alquinilo de 2 a 6 átomos de carbono, un grupo -CO-R5, un grupo -CO-NR6R7, un grupo CO-O-R8, un grupo -NR9-CO-R10, un grupo -N=CH-NraRb, un átomo de halógeno, un grupo ciano, nitro, hidroxiiminoalquilo, alcoxiiminoalquilo, un grupo alquiltio de 1 a 6 átomos de carbono, un grupo alquilsulfinilo de 1 a 6 átomos de carbono, un grupo alquilsulfonilo de 1 a 6 átomos de carbono, un grupo ((alquilo de 1 a 6 átomos de carbono)3)sililetinilo, un grupo -SO2-NR9R10, un grupo fenilo opcionalmente sustituido, un grupo heterocíclico opcionalmente sustituido; R3 es un átomo de hidrógeno, un grupo alquilo de 2 a 6 átomos de carbono, un grupo alcoxi de 1 a 6 átomos de carbono o un átomo de halógeno; R4 es un átomo de hidrógeno, un grupo alquilo de 1 a 4 átomos de carbono, un grupo alcoxi de 1 a 4 átomos de carbono o un átomo flúor; en donde los compuestos están en la forma de una base o una sal de adición a un ácido. La invención puede utilizarse en terapéutica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0800004A FR2925902B1 (fr) | 2008-01-02 | 2008-01-02 | DERIVES D'IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
PCT/FR2008/001835 WO2009112651A1 (fr) | 2008-01-02 | 2008-12-31 | Dérivés d'mtoazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010007351A true MX2010007351A (es) | 2010-10-05 |
Family
ID=39739369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010007351A MX2010007351A (es) | 2008-01-02 | 2008-12-31 | Derivados de imidazo[1,2-a]piridina-2-carboxamidas, su preparacion y su aplicacion en terapeutica. |
Country Status (21)
Country | Link |
---|---|
US (1) | US20100317656A1 (es) |
EP (1) | EP2225244A1 (es) |
JP (1) | JP2011508759A (es) |
KR (1) | KR20100109941A (es) |
CN (1) | CN101959886A (es) |
AR (1) | AR070073A1 (es) |
AU (1) | AU2008352728A1 (es) |
BR (1) | BRPI0822223A2 (es) |
CA (1) | CA2710797A1 (es) |
CL (1) | CL2008003927A1 (es) |
CO (1) | CO6331307A2 (es) |
EA (1) | EA201070817A1 (es) |
FR (1) | FR2925902B1 (es) |
IL (1) | IL206673A0 (es) |
MA (1) | MA32057B1 (es) |
MX (1) | MX2010007351A (es) |
PA (1) | PA8810101A1 (es) |
PE (1) | PE20091182A1 (es) |
TW (1) | TW200932746A (es) |
UY (1) | UY31588A1 (es) |
WO (1) | WO2009112651A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2925907B1 (fr) * | 2008-01-02 | 2010-10-15 | Sanofi Aventis | DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
KR101477156B1 (ko) * | 2010-08-25 | 2014-12-29 | (주)네오팜 | 신규한 헤테로고리 화합물 및 이를 이용한 염증성 질환 치료용 조성물 |
WO2016133838A1 (en) | 2015-02-20 | 2016-08-25 | Rigel Pharmaceuticals, Inc. | Gdf-8 inhibitors |
CA3073656C (en) | 2017-09-22 | 2024-03-05 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
CN111225915B (zh) | 2017-10-18 | 2023-03-07 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的咪唑并吡啶化合物 |
EP3707135A1 (en) | 2017-11-06 | 2020-09-16 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation |
CN107915752B (zh) * | 2017-11-14 | 2018-09-18 | 牡丹江医学院 | 一种治疗白内障的药物及其制备方法 |
BR112020010322A2 (pt) | 2017-11-24 | 2020-11-17 | Jubilant Episcribe Llc | composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer |
SG11202008950PA (en) | 2018-03-13 | 2020-10-29 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8827189D0 (en) * | 1988-11-21 | 1988-12-29 | Fujisawa Pharmaceutical Co | 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same |
US5716964A (en) * | 1989-12-04 | 1998-02-10 | G.D. Searle & Co. | Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury |
FR2696177B1 (fr) * | 1992-09-28 | 1995-05-12 | Synthelabo | Dérivés de pipéridine, leur préparation et leur application en thérapeutique. |
GB0420519D0 (en) * | 2004-09-15 | 2004-10-20 | Novartis Ag | Organic compounds |
AU2008287421A1 (en) * | 2007-08-10 | 2009-02-19 | Glaxosmithkline Llc | Nitrogen containing bicyclic chemical entities for treating viral infections |
JP2011507910A (ja) * | 2007-12-21 | 2011-03-10 | ユニバーシティー オブ ロチェスター | 真核生物の寿命を変更するための方法 |
-
2008
- 2008-01-02 FR FR0800004A patent/FR2925902B1/fr not_active Expired - Fee Related
- 2008-12-23 PA PA20088810101A patent/PA8810101A1/es unknown
- 2008-12-30 UY UY31588A patent/UY31588A1/es not_active Application Discontinuation
- 2008-12-30 CL CL2008003927A patent/CL2008003927A1/es unknown
- 2008-12-30 AR ARP080105778A patent/AR070073A1/es unknown
- 2008-12-30 PE PE2008002195A patent/PE20091182A1/es not_active Application Discontinuation
- 2008-12-31 EP EP08873283A patent/EP2225244A1/fr not_active Ceased
- 2008-12-31 EA EA201070817A patent/EA201070817A1/ru unknown
- 2008-12-31 BR BRPI0822223-1A patent/BRPI0822223A2/pt not_active IP Right Cessation
- 2008-12-31 CN CN2008801277688A patent/CN101959886A/zh active Pending
- 2008-12-31 MX MX2010007351A patent/MX2010007351A/es not_active Application Discontinuation
- 2008-12-31 CA CA2710797A patent/CA2710797A1/fr not_active Abandoned
- 2008-12-31 AU AU2008352728A patent/AU2008352728A1/en not_active Abandoned
- 2008-12-31 KR KR1020107017147A patent/KR20100109941A/ko not_active Application Discontinuation
- 2008-12-31 WO PCT/FR2008/001835 patent/WO2009112651A1/fr active Application Filing
- 2008-12-31 JP JP2010541084A patent/JP2011508759A/ja not_active Withdrawn
- 2008-12-31 TW TW097151675A patent/TW200932746A/zh unknown
-
2010
- 2010-06-28 IL IL206673A patent/IL206673A0/en unknown
- 2010-07-01 US US12/828,372 patent/US20100317656A1/en not_active Abandoned
- 2010-07-02 CO CO10080876A patent/CO6331307A2/es not_active Application Discontinuation
- 2010-08-02 MA MA33055A patent/MA32057B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
MA32057B1 (fr) | 2011-02-01 |
WO2009112651A1 (fr) | 2009-09-17 |
CL2008003927A1 (es) | 2010-02-12 |
UY31588A1 (es) | 2009-08-03 |
CA2710797A1 (fr) | 2009-09-17 |
FR2925902A1 (fr) | 2009-07-03 |
AU2008352728A1 (en) | 2009-09-17 |
AR070073A1 (es) | 2010-03-10 |
EP2225244A1 (fr) | 2010-09-08 |
US20100317656A1 (en) | 2010-12-16 |
TW200932746A (en) | 2009-08-01 |
KR20100109941A (ko) | 2010-10-11 |
EA201070817A1 (ru) | 2011-02-28 |
JP2011508759A (ja) | 2011-03-17 |
CN101959886A (zh) | 2011-01-26 |
PA8810101A1 (es) | 2009-08-26 |
FR2925902B1 (fr) | 2011-01-07 |
IL206673A0 (en) | 2010-12-30 |
BRPI0822223A2 (pt) | 2015-06-23 |
PE20091182A1 (es) | 2009-08-31 |
CO6331307A2 (es) | 2011-10-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |