CO6251269A2 - Derivados de 6- cicloamino-3-(piridin-4-il)imidazo[1,2-b]-piridazina su preparacion y aplicacion en terapeutica - Google Patents
Derivados de 6- cicloamino-3-(piridin-4-il)imidazo[1,2-b]-piridazina su preparacion y aplicacion en terapeuticaInfo
- Publication number
- CO6251269A2 CO6251269A2 CO09148262A CO09148262A CO6251269A2 CO 6251269 A2 CO6251269 A2 CO 6251269A2 CO 09148262 A CO09148262 A CO 09148262A CO 09148262 A CO09148262 A CO 09148262A CO 6251269 A2 CO6251269 A2 CO 6251269A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- alkyl
- groups
- optionally substituted
- alkylene group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1.- Compuesto que responde a la fórmula general (I):en la que - R2 representa un grupo arilo eventualmente sustituido con uno o varios sustituyentes elegidos entre átomos de halógeno y grupos alquilo(C1-C6), alcoxi(C1-C6), alquiltio(C1-C6), fluoroalquilo(C1-C6), fluoroalcoxi(C1-C6), -CN; - R3 representa un átomo de hidrógeno o un grupo alquilo(C1-C3), -NR4R5, hidroxilo o alcoxi(C1-C4); - A representa un grupo alquileno(C1-C7) eventualmente sustituido con uno o dos grupos Ra; - B representa un grupo alquileno(C1-C7) eventualmente sustituido con un grupo Rb; - L representa, o un átomo de nitrógeno eventualmente sustituido con un grupo Rc o Rd, o un átomo de carbono sustituido con un grupo Re1 y un grupo Rd o dos grupos Re2; estando los átomos de carbono de A y de B eventualmente sustituidos con uno o varios grupos Rf idénticos o diferentes uno de otro; Ra, Rb y Rc se definen de manera que: dos grupos Ra pueden formar conjuntamente un grupo alquileno(C1-C6); Ra y Rb pueden formar conjuntamente un enlace o un grupo alquileno(C1-C6); Ra y Rc pueden formar conjuntamente un enlace o un grupo alquileno(C1-C6); Rb y Rc pueden formar conjuntamente un enlace o un grupo alquileno(C1-C6); Rd representa un grupo elegido entre el átomo de hidrógeno y los grupos alquilo(C1-C6), cicloalquilo(C3-C7), cicloalquil(C3-C7)-alquilo(C1-C6), alquiltio(C3-C7) alquilo( C1-C6), alcoxi(C1-C6)-alquilo(C1-C6), fluoroalquilo(C1-C6), bencilo, acilo(C1-C6), hidroxialquilo(C1-C6); Re1 representa un grupo -NR4R5 o una monoamina ciclica que comprende eventualmente un átomo de oxígeno, estando la monoamina cíclica eventualmente sustituida con uno o varios sustituyentes elegidos entre el átomo de flúor y los grupos alquilo(C1-C6), alcoxi(C1-C6), hidroxilo: Dos Re2 forman con el átomo de carbono que los lleva una monoamina cíclica que comprende eventualmente un átomo de oxigeno, estando esta monoamina cíclica eventualmente sustituida con uno o varios grupos Rf idénticos o diferentes uno de otro; ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94678507P | 2007-06-28 | 2007-06-28 | |
| FR0704661A FR2918061B1 (fr) | 2007-06-28 | 2007-06-28 | Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6251269A2 true CO6251269A2 (es) | 2011-02-21 |
Family
ID=39203151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09148262A CO6251269A2 (es) | 2007-06-28 | 2009-12-28 | Derivados de 6- cicloamino-3-(piridin-4-il)imidazo[1,2-b]-piridazina su preparacion y aplicacion en terapeutica |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8354405B2 (es) |
| EP (1) | EP2170889B1 (es) |
| JP (1) | JP5537424B2 (es) |
| KR (1) | KR20100050492A (es) |
| CN (1) | CN101765602A (es) |
| AR (1) | AR069269A1 (es) |
| AU (1) | AU2008281662A1 (es) |
| BR (1) | BRPI0814807A2 (es) |
| CA (1) | CA2691866A1 (es) |
| CL (1) | CL2008001932A1 (es) |
| CO (1) | CO6251269A2 (es) |
| EA (1) | EA201070072A1 (es) |
| FR (1) | FR2918061B1 (es) |
| MA (1) | MA31572B1 (es) |
| MX (1) | MX2009013948A (es) |
| NZ (1) | NZ582677A (es) |
| PA (1) | PA8786101A1 (es) |
| PE (1) | PE20090556A1 (es) |
| TW (1) | TW200911812A (es) |
| UY (1) | UY31193A1 (es) |
| WO (1) | WO2009016286A2 (es) |
| ZA (1) | ZA200909186B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7868001B2 (en) * | 2007-11-02 | 2011-01-11 | Hutchison Medipharma Enterprises Limited | Cytokine inhibitors |
| KR101324804B1 (ko) | 2008-05-13 | 2013-11-01 | 아이알엠 엘엘씨 | 키나제 억제제로서의 질소 함유 융합 헤테로사이클 및 그의 조성물 |
| FR2934994B1 (fr) * | 2008-08-12 | 2010-09-17 | Sanofi Aventis | Derives de 2-alkyl-6cycloamino-3-(pyridin-4-yl)imidaz°1,2-b! pyridazine, leur preparation et leur application en therapeutique |
| FR2939134A1 (fr) * | 2008-12-01 | 2010-06-04 | Sanofi Aventis | Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique |
| FR2940284B1 (fr) * | 2008-12-19 | 2011-02-18 | Sanofi Aventis | Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique |
| FR2940285A1 (fr) * | 2008-12-19 | 2010-06-25 | Sanofi Aventis | Derives de 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo °1,2-b!-pyridazine et 6-cycloamino-2-furanyl-3- (pyridin-4-yl)imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique |
| JP5847087B2 (ja) | 2009-10-23 | 2016-01-20 | ヤンセン ファーマシューティカ エヌ．ベー． | オレキシン受容体調節因子としての縮合複素環式化合物 |
| KR101859400B1 (ko) | 2009-10-23 | 2018-05-18 | 얀센 파마슈티카 엔.브이. | 오렉신 수용체 조절제로서의 이치환된 옥타하이드로피롤로［3,4-ｃ］피롤 |
| US9062044B2 (en) | 2009-10-23 | 2015-06-23 | Janssen Pharmaceutica Nv | Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators |
| NZ599597A (en) | 2009-10-30 | 2013-05-31 | Janssen Pharmaceutica Nv | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| US9801853B2 (en) | 2010-04-06 | 2017-10-31 | Fred Hutchinson Cancer Research Center | Methods for identifying and using inhibitors of casein kinase 1 epsilon isoform for inhibiting the growth and/or proliferation of MYC-driven tumor cells |
| US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
| DK2835131T3 (en) * | 2010-12-14 | 2017-12-04 | Electrophoretics Ltd | Casein kinase 1 delta inhibitors (CK1 delta) |
| TWI617559B (zh) * | 2010-12-22 | 2018-03-11 | 江蘇恆瑞醫藥股份有限公司 | ２－芳基咪唑并［１，２－ｂ］嗒．２－苯基咪唑并［１，２－ａ］吡啶，和２－苯基咪唑并［１，２－ａ］吡衍生物 |
| US9586962B2 (en) | 2011-04-20 | 2017-03-07 | Janssen Pharmaceutica Nv | Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators |
| EA027418B1 (ru) | 2011-06-27 | 2017-07-31 | Янссен Фармацевтика Нв | ПРОИЗВОДНЫЕ 1-АРИЛ-4-МЕТИЛ[1,2,4]ТРИАЗОЛО[4,3-a]ХИНОКСАЛИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, СПОСОБЫ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ ИХ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ |
| WO2013023084A2 (en) | 2011-08-09 | 2013-02-14 | Fred Hutchinson Cancer Research Center | Methods and compositions for inhibiting the growth and/or proliferation of myc-driven tumor cells |
| RU2657540C2 (ru) | 2012-06-26 | 2018-06-14 | Янссен Фармацевтика Нв | Комбинации, содержащие ингибиторы pde 2, такие как 1-арил-4-метил-[1,2,4]триазоло[4,3-а]хиноксалиновые соединения, и ингибиторы pde 10, для применения в лечении неврологических или метаболических расстройств |
| IN2014MN02562A (es) | 2012-06-27 | 2015-07-24 | 4Sc Discovery Gmbh | |
| AU2013289284B2 (en) | 2012-07-09 | 2017-03-30 | Janssen Pharmaceutica Nv | Inhibitors of phosphodiesterase 10 enzyme |
| CZ2012538A3 (cs) * | 2012-08-08 | 2014-02-19 | Masarykova Univerzita | Inhibitory pro léčbu B-buněčné chronické lymfocytární leukémie |
| US10676746B2 (en) | 2013-11-22 | 2020-06-09 | Fred Hutchinson Cancer Research Center | Methods for identifying therapeutic targets and treating monitoring cancers |
| WO2015106158A1 (en) * | 2014-01-09 | 2015-07-16 | Intra-Cellular Therapies, Inc. | Organic compounds |
| AU2015212341A1 (en) * | 2014-02-03 | 2016-09-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Use of Casein kinase I inhibitors for depleting stem cells |
| LT3426251T (lt) | 2016-03-10 | 2022-06-27 | Janssen Pharmaceutica Nv | Depresijos gydymo būdai, panaudojant oreksino-2 receptoriaus antagonistus |
| JP7082608B2 (ja) | 2017-03-14 | 2022-06-08 | 第一三共株式会社 | ３，６－ジ置換イミダゾ［１，２－ｂ］ピリダジン誘導体の製造方法 |
| MX2018014032A (es) | 2017-03-20 | 2019-08-21 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de piruvato cinasa (pkr). |
| US10973820B2 (en) | 2017-12-13 | 2021-04-13 | Facio Intellectual Property B.V. | Compounds for treatment of diseases related to DUX4 expression |
| EP3853206B1 (en) | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Treating sickle cell disease with a pyruvate kinase r activating compound |
| CN113226356A (zh) | 2018-09-19 | 2021-08-06 | 福马治疗股份有限公司 | 活化丙酮酸激酶r |
| CN111471056B (zh) * | 2019-01-23 | 2021-07-02 | 成都先导药物开发股份有限公司 | 一种大环类免疫调节剂 |
| TW202112368A (zh) | 2019-06-13 | 2021-04-01 | 荷蘭商法西歐知識產權股份有限公司 | 用於治療有關dux4表現之疾病的抑制劑組合 |
| US11193891B2 (en) | 2019-12-20 | 2021-12-07 | Robert Bosch Gmbh | Receptors and spacers for a fluorescence-based lead ion chemosensor |
| WO2021190616A1 (en) * | 2020-03-27 | 2021-09-30 | Gritscience Biopharmaceuticals Co., Ltd. | Methods for inhibiting casein kinases |
| EP4126878A1 (en) * | 2020-03-27 | 2023-02-08 | Gritscience Biopharmaceuticals Co., Ltd. | Compounds as casein kinase inhibitors |
| US11939328B2 (en) | 2021-10-14 | 2024-03-26 | Incyte Corporation | Quinoline compounds as inhibitors of KRAS |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0103926D0 (en) * | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
| EP1388541A1 (en) * | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazines as kinase inhibitors |
| CN100439367C (zh) * | 2003-12-11 | 2008-12-03 | 安万特药物公司 | 作为酪蛋白激酶Iε抑制剂的取代的1H-吡咯并[3,2-b、3,2-c和2,3-c]吡啶-2-甲酰胺以及相关类似物 |
| JP4972804B2 (ja) * | 2004-08-31 | 2012-07-11 | Ｍｓｄ株式会社 | 新規置換イミダゾール誘導体 |
| JPWO2006070943A1 (ja) * | 2004-12-28 | 2008-06-12 | 武田薬品工業株式会社 | 縮合イミダゾール化合物およびその用途 |
| EP1910369A1 (en) * | 2005-07-29 | 2008-04-16 | Astellas Pharma Inc. | Fused heterocycles as lck inhibitors |
| EP1845098A1 (en) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands |
| EP2086979B1 (en) * | 2006-11-06 | 2015-06-03 | Tolero Pharmaceuticals, Inc. | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
| AR064420A1 (es) * | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
-
2007
- 2007-06-28 FR FR0704661A patent/FR2918061B1/fr active Active
-
2008
- 2008-06-25 TW TW097123772A patent/TW200911812A/zh unknown
- 2008-06-26 NZ NZ582677A patent/NZ582677A/en not_active IP Right Cessation
- 2008-06-26 BR BRPI0814807-4A2A patent/BRPI0814807A2/pt not_active IP Right Cessation
- 2008-06-26 WO PCT/FR2008/000902 patent/WO2009016286A2/fr active Application Filing
- 2008-06-26 MX MX2009013948A patent/MX2009013948A/es unknown
- 2008-06-26 KR KR1020107001891A patent/KR20100050492A/ko not_active Application Discontinuation
- 2008-06-26 JP JP2010514033A patent/JP5537424B2/ja not_active Expired - Fee Related
- 2008-06-26 CA CA002691866A patent/CA2691866A1/fr not_active Abandoned
- 2008-06-26 AU AU2008281662A patent/AU2008281662A1/en not_active Abandoned
- 2008-06-26 CN CN200880100885A patent/CN101765602A/zh active Pending
- 2008-06-26 EP EP08826677.0A patent/EP2170889B1/fr active Active
- 2008-06-26 PE PE2008001090A patent/PE20090556A1/es not_active Application Discontinuation
- 2008-06-26 EA EA201070072A patent/EA201070072A1/ru unknown
- 2008-06-27 UY UY31193A patent/UY31193A1/es not_active Application Discontinuation
- 2008-06-27 CL CL2008001932A patent/CL2008001932A1/es unknown
- 2008-06-27 PA PA20088786101A patent/PA8786101A1/es unknown
- 2008-06-27 AR ARP080102783A patent/AR069269A1/es unknown
-
2009
- 2009-12-23 ZA ZA2009/09186A patent/ZA200909186B/en unknown
- 2009-12-24 US US12/647,059 patent/US8354405B2/en not_active Expired - Fee Related
- 2009-12-28 CO CO09148262A patent/CO6251269A2/es not_active Application Discontinuation
-
2010
- 2010-01-26 MA MA32556A patent/MA31572B1/fr unknown
-
2012
- 2012-09-14 US US13/617,678 patent/US8846676B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200909186B (en) | 2011-02-23 |
| CL2008001932A1 (es) | 2009-09-25 |
| MX2009013948A (es) | 2010-03-09 |
| TW200911812A (en) | 2009-03-16 |
| AU2008281662A1 (en) | 2009-02-05 |
| FR2918061A1 (fr) | 2009-01-02 |
| BRPI0814807A2 (pt) | 2015-02-03 |
| PA8786101A1 (es) | 2009-01-23 |
| EP2170889A2 (fr) | 2010-04-07 |
| JP2010531342A (ja) | 2010-09-24 |
| WO2009016286A3 (fr) | 2009-04-09 |
| EP2170889B1 (fr) | 2016-08-17 |
| WO2009016286A2 (fr) | 2009-02-05 |
| NZ582677A (en) | 2011-12-22 |
| UY31193A1 (es) | 2009-01-30 |
| CA2691866A1 (fr) | 2009-02-05 |
| EA201070072A1 (ru) | 2010-08-30 |
| KR20100050492A (ko) | 2010-05-13 |
| PE20090556A1 (es) | 2009-06-01 |
| AR069269A1 (es) | 2010-01-13 |
| US20100179154A1 (en) | 2010-07-15 |
| JP5537424B2 (ja) | 2014-07-02 |
| MA31572B1 (fr) | 2010-08-02 |
| US20130012516A1 (en) | 2013-01-10 |
| US8354405B2 (en) | 2013-01-15 |
| US8846676B2 (en) | 2014-09-30 |
| CN101765602A (zh) | 2010-06-30 |
| FR2918061B1 (fr) | 2010-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO6251269A2 (es) | Derivados de 6- cicloamino-3-(piridin-4-il)imidazo[1,2-b]-piridazina su preparacion y aplicacion en terapeutica | |
| AR069272A1 (es) | Derivados de la 6-cicloamino-3-(piridazin-4-il)imidazol(1,2-b-)-piridazina su preparacion y su aplicacion en terapeutica | |
| CO6640226A2 (es) | 5-fluoro-1h-pirazolipiridinas sustituidas y su uso | |
| CO6220974A2 (es) | Derivados de indol 2-carboxamidas y de azaindol 2- carboxamidas sustituidos con un grupo silanilo su preparacion y su aplicacion en terapeutica | |
| AR081387A1 (es) | Derivados de ciclohexilamina que tienen actividad como agonistas adrenergicos beta 2 y como antagonistas muscarinicos m3, composiciones farmaceuticas y uso de los mismos. | |
| GT201200346A (es) | Derivados de imidazopiridina, su procedimiento de preparaciòn y su aplicaciòn en terapèutica | |
| CO6150146A2 (es) | Derivados de n-(amino-heteroaril)-1h-indol-2-carboxamidas su preparacion y su aplicacion en terapeutica | |
| ES2521596T3 (es) | Combinación del compuesto GlyT1 con antipsicóticos | |
| AR089774A1 (es) | Derivados de indolizina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| PE20110368A1 (es) | Moduladores de mif | |
| CR10643A (es) | DERIVADOS DE 2-ARIL-6-FENIL-IMIDAZOL[1,2-a]PIRIDINAS, SU PREPARACION Y SU APLICACION EN TERAPEUTICA | |
| AR096979A1 (es) | Derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| AR092742A1 (es) | Piridinonas antifibroticas | |
| AR098048A1 (es) | Inhibidores de fgfr4 | |
| UY35643A (es) | Nuevos compuestos útiles como nematicidas, sus composiciones y métodos de uso | |
| ECSP13012362A (es) | Derivados de indolizina, su procedimiento de preparación | |
| ECSP10010272A (es) | Derivados bis-(sulfonilamino) para uso en terapia | |
| PE20121048A1 (es) | Derivados de imidazolidin-2-ona 1,3-disustituida como inhibidores de cyp17 | |
| AR068813A1 (es) | Derivados de pirazol sustituidos como antagonistas del receptor de androgenos (ar), un agente farmaceutico que los comprende y su uso en el tratamiento del cancer de prostata | |
| AR099913A1 (es) | Derivados de indolizina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| AR083903A1 (es) | Derivados de benzooxazol y benzotiazol sulfonamidas, utiles para tratar trastornos del ritmo cardiaco y cancer, composiciones farmaceuticas que los contienen y metodo para prepararlos | |
| AR068538A1 (es) | Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido | |
| CU20090048A7 (es) | Nuevos derivados de diosmetina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| AR072932A1 (es) | Derivados de 2-alquil-6-cicloamino-3-(piridin-4-il)imidazo[1,2-b]piridazina, su preparacion, composicion farmaceutica que los comprende y su aplicacion en terapeutica de enfermedades mediadas por caseina quinasa epsilon y delta. | |
| NI201000134A (es) | Nuevos derivados dihidroindolonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |