CO6220974A2 - Derivados de indol 2-carboxamidas y de azaindol 2- carboxamidas sustituidos con un grupo silanilo su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de indol 2-carboxamidas y de azaindol 2- carboxamidas sustituidos con un grupo silanilo su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- CO6220974A2 CO6220974A2 CO10089495A CO10089495A CO6220974A2 CO 6220974 A2 CO6220974 A2 CO 6220974A2 CO 10089495 A CO10089495 A CO 10089495A CO 10089495 A CO10089495 A CO 10089495A CO 6220974 A2 CO6220974 A2 CO 6220974A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- cycloalkyl
- carboxamids
- alkyl
- aryl
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- -1 C3-C7-C1-C6 alkylene Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004428 fluoroalkoxy group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La invención se refiere a los compuestos de fórmula general (I) en la que G1, G2, G3 y G4 representan, independientemente entre sí, un grupo C-X o un átomo de nitrógeno; uno de G1, G2, G3 y G4 y como máximo uno de G1, G2, G3 y G4 representa un grupo C- X en el que X es un grupo Si(X1)(X2)(X3); n es igual a 0, 1 2 ó 3; Y representa un arilo o un heteroarilo opcionalmente sustituido; Z1, Z2, Z3, Z4 representan, independientemente entre si un átomo de nitrógeno o un grupo C(R6), correspondiendo uno al menos a un átomo de nitrógeno y correspondiendo uno al menos a un grupo C(R6). 1.- Compuesto que responde a la fórmula (I)en la que G1, G2, G3 y G4 representan, independientemente el uno del otro, un grupo C-X o un átomo de nitrógeno; X se elige entre un átomo de hidrógeno, de halógeno o un grupo alquilo-C1-C6, cicloalquilo-C3-C7, cicloalquil-C3-C7-alquileno-C1-C3, fluoroalquilo-C1-C6, alcoxilo-C1-C6, cicloalcoxilo-C3-C7, cicloalquil-C3-C7-alquileno-C1-C6-O-, fluoroalcoxilo-C1-C6, ciano, tioalquilo-C1-C6, NR1R2, aril-alquileno-C1-C6-O, arilo, heteroarilo o -Si(X1)(X2)(X3); estando los grupos alquilo-C1-C6, cicloalquilo-C3-C7, cicloalquil-C3-C7alquileno-C1-C3, fluoroalquilo-C1-C6, alcoxilo-C1-C6, cicloalcoxilo-C3-C7, cicloalquil-C3-C7-alquileno-C1-C6-O-sustituidos opcionalmente con un grupo hidroxi, alcoxilo-C1-C6 o NR4R5; estando el arilo y el heteroarilo sustituidos opcionalmente con uno o varios sustituyentes elegidos entre un halógeno, un grupo alquilo- C1-C6, cicloalquilo- C3-C7, cicloalquilo-C3-C7-alquileno-C1-C6, fluoroalquilo-C1-C6, alcoxilo-C1-C6, fluoroalcoxilo-C1-C6, nitro o ciano; uno de G1, G2, G3 y G4 y como máximo uno de G1, G2, G3 y G4 representa un grupo C-X en el que X es un grupo - Si(X1)(X2)(X3); X1, X2, X3 representan, independientemente el uno del otro, un grupo alquilo-C1-C6, cicloalquilo-C1-C6, cicloalquil-C3-C7alquilo-C1-C6, hidroxilo, arilo o heteroarilo; estando los grupos arilo o heteroarilo de X1, X2, X3 sustituidos opcionalmente con uno o varios sustituyentes elegidos entre un halógeno, un grupo alquilo-C1-C6, cicloalquilo-C3-C7, cicloalquilo-C3-C7-alquileno-C1-C6, fluoroalquilo-C1-C6, alcoxilo-C1-C6, fluoroalcoxilo- C1-C6, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800343A FR2926553B1 (fr) | 2008-01-23 | 2008-01-23 | Derives d'indole-2-carboxamides et d'azaindole-2- carboxamides substitues par un groupe silanyle, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6220974A2 true CO6220974A2 (es) | 2010-11-19 |
Family
ID=39671700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10089495A CO6220974A2 (es) | 2008-01-23 | 2010-07-22 | Derivados de indol 2-carboxamidas y de azaindol 2- carboxamidas sustituidos con un grupo silanilo su preparacion y su aplicacion en terapeutica |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8399491B2 (es) |
| EP (1) | EP2235003B1 (es) |
| JP (1) | JP5508287B2 (es) |
| KR (1) | KR20100115358A (es) |
| CN (1) | CN102143956B (es) |
| AR (1) | AR070214A1 (es) |
| AU (1) | AU2009221032B2 (es) |
| BR (1) | BRPI0906634A2 (es) |
| CA (1) | CA2712921C (es) |
| CL (1) | CL2009000127A1 (es) |
| CO (1) | CO6220974A2 (es) |
| EA (1) | EA201070874A1 (es) |
| FR (1) | FR2926553B1 (es) |
| IL (1) | IL207079A0 (es) |
| MA (1) | MA32087B1 (es) |
| MX (1) | MX2010008101A (es) |
| MY (1) | MY150289A (es) |
| NZ (1) | NZ586964A (es) |
| PE (1) | PE20091307A1 (es) |
| TW (1) | TW200936578A (es) |
| UY (1) | UY31612A1 (es) |
| WO (1) | WO2009109710A1 (es) |
| ZA (1) | ZA201005242B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2926554B1 (fr) * | 2008-01-22 | 2010-03-12 | Sanofi Aventis | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| KR101699822B1 (ko) | 2011-12-21 | 2017-01-25 | 노비라 테라퓨틱스, 인코포레이티드 | B형 간염의 항바이러스성 제제 |
| AR092270A1 (es) | 2012-08-28 | 2015-04-08 | Janssen R&D Ireland | Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b |
| PT2961732T (pt) | 2013-02-28 | 2017-06-26 | Janssen Sciences Ireland Uc | Sulfamoil-arilamidas e utilização das mesmas como medicamentos para o tratamento de hepatite b |
| EA027068B1 (ru) | 2013-04-03 | 2017-06-30 | Янссен Сайенсиз Айрлэнд Юси | Производные n-фенилкарбоксамида и их применение в качестве лекарственных препаратов для лечения гепатита b |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| JP6441315B2 (ja) | 2013-05-17 | 2018-12-19 | ヤンセン・サイエンシズ・アイルランド・ユーシー | スルファモイルチオフェンアミド誘導体およびｂ型肝炎を治療するための医薬品としてのその使用 |
| US10450270B2 (en) | 2013-07-25 | 2019-10-22 | Janssen Sciences Ireland Uc | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| MX368158B (es) | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| MX2016009449A (es) | 2014-02-05 | 2016-10-13 | Novira Therapeutics Inc | Terapia de combinacion para el tratamiento de infecciones por virus de la hepatitis b (vhb). |
| EA035848B1 (ru) | 2014-02-06 | 2020-08-20 | Янссен Сайенсиз Айрлэнд Юси | Производные сульфамоилпирроламида и их применение в качестве медикаментов для лечения гепатита b |
| WO2016149581A1 (en) | 2015-03-19 | 2016-09-22 | Novira Therapeutics, Inc. | Azocane and azonane derivatives and methods of treating hepatitis b infections |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| RS62639B1 (sr) | 2015-07-06 | 2021-12-31 | Alkermes Inc | Hetero-halo inhibitori histonskih deacetilaza |
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| AU2016330964B2 (en) | 2015-09-29 | 2021-04-01 | Novira Therapeutics, Inc. | Crystalline forms of a hepatitis B antiviral agent |
| CN105820104B (zh) * | 2016-03-10 | 2018-12-11 | 温州医科大学 | 一种具有抗炎作用的吲哚-2-酰胺类化合物及其在制备抗炎药物中的应用 |
| SG11201808949SA (en) | 2016-04-15 | 2018-11-29 | Novira Therapeutics Inc | Combinations and methods comprising a capsid assembly inhibitor |
| RS62959B1 (sr) | 2017-01-11 | 2022-03-31 | Alkermes Inc | Biciklični inhibitori histon-deacetilaze |
| MD3664802T2 (ro) | 2017-08-07 | 2022-07-31 | Alkermes Inc | Inhibitori biciclici ai deacetilazei histonei |
| CA3090125A1 (en) | 2018-03-14 | 2019-09-19 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
| AU2019203034B1 (en) | 2018-07-25 | 2019-09-26 | Hanmi Pharm. Co., Ltd. | Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same |
| KR101954370B1 (ko) | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| US11096931B2 (en) | 2019-02-22 | 2021-08-24 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases |
| EP3966205A1 (en) | 2019-05-06 | 2022-03-16 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200403223A (en) * | 2002-02-15 | 2004-03-01 | Glaxo Group Ltd | Novel compounds |
| US20050197364A1 (en) * | 2003-10-07 | 2005-09-08 | Kelly Michael G. | Amide compounds as ion channel ligands and uses thereof |
| WO2005072681A2 (en) * | 2004-01-23 | 2005-08-11 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments of inflammatory and neurotic pain. |
| FR2888847B1 (fr) * | 2005-07-22 | 2007-08-31 | Sanofi Aventis Sa | Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique |
| FR2897061B1 (fr) * | 2006-02-03 | 2010-09-03 | Sanofi Aventis | Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique. |
| FR2903985B1 (fr) * | 2006-07-24 | 2008-09-05 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2904316B1 (fr) * | 2006-07-31 | 2008-09-05 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique. |
| FR2910473B1 (fr) * | 2006-12-26 | 2009-02-13 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique. |
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2008
- 2008-01-23 FR FR0800343A patent/FR2926553B1/fr not_active Expired - Fee Related
-
2009
- 2009-01-20 AU AU2009221032A patent/AU2009221032B2/en not_active Ceased
- 2009-01-20 MY MYPI2010003446A patent/MY150289A/en unknown
- 2009-01-20 CA CA2712921A patent/CA2712921C/fr not_active Expired - Fee Related
- 2009-01-20 KR KR1020107018568A patent/KR20100115358A/ko not_active Application Discontinuation
- 2009-01-20 BR BRPI0906634-9A patent/BRPI0906634A2/pt not_active IP Right Cessation
- 2009-01-20 JP JP2010543541A patent/JP5508287B2/ja not_active Expired - Fee Related
- 2009-01-20 WO PCT/FR2009/000054 patent/WO2009109710A1/fr active Application Filing
- 2009-01-20 CN CN200980109255.9A patent/CN102143956B/zh not_active Expired - Fee Related
- 2009-01-20 EP EP09718226A patent/EP2235003B1/fr active Active
- 2009-01-20 MX MX2010008101A patent/MX2010008101A/es active IP Right Grant
- 2009-01-20 NZ NZ586964A patent/NZ586964A/en not_active IP Right Cessation
- 2009-01-20 EA EA201070874A patent/EA201070874A1/ru unknown
- 2009-01-21 PE PE2009000067A patent/PE20091307A1/es not_active Application Discontinuation
- 2009-01-21 AR ARP090100176A patent/AR070214A1/es not_active Application Discontinuation
- 2009-01-22 CL CL2009000127A patent/CL2009000127A1/es unknown
- 2009-01-22 TW TW098102666A patent/TW200936578A/zh unknown
- 2009-01-23 UY UY031612A patent/UY31612A1/es not_active Application Discontinuation
-
2010
- 2010-07-19 IL IL207079A patent/IL207079A0/en unknown
- 2010-07-21 US US12/840,665 patent/US8399491B2/en not_active Expired - Fee Related
- 2010-07-22 ZA ZA2010/05242A patent/ZA201005242B/en unknown
- 2010-07-22 CO CO10089495A patent/CO6220974A2/es not_active Application Discontinuation
- 2010-08-17 MA MA33095A patent/MA32087B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2926553A1 (fr) | 2009-07-24 |
| CL2009000127A1 (es) | 2010-02-12 |
| CA2712921C (fr) | 2016-08-02 |
| UY31612A1 (es) | 2009-08-31 |
| IL207079A0 (en) | 2010-12-30 |
| AU2009221032A1 (en) | 2009-09-11 |
| US8399491B2 (en) | 2013-03-19 |
| CN102143956A (zh) | 2011-08-03 |
| KR20100115358A (ko) | 2010-10-27 |
| ZA201005242B (en) | 2011-09-28 |
| CA2712921A1 (fr) | 2009-09-11 |
| JP2011510052A (ja) | 2011-03-31 |
| EA201070874A1 (ru) | 2011-02-28 |
| MY150289A (en) | 2013-12-31 |
| EP2235003B1 (fr) | 2012-12-19 |
| TW200936578A (en) | 2009-09-01 |
| AU2009221032B2 (en) | 2013-09-26 |
| PE20091307A1 (es) | 2009-09-21 |
| NZ586964A (en) | 2012-06-29 |
| FR2926553B1 (fr) | 2010-02-19 |
| BRPI0906634A2 (pt) | 2015-07-14 |
| CN102143956B (zh) | 2014-04-23 |
| WO2009109710A1 (fr) | 2009-09-11 |
| EP2235003A1 (fr) | 2010-10-06 |
| MA32087B1 (fr) | 2011-02-01 |
| MX2010008101A (es) | 2010-08-04 |
| US20110009365A1 (en) | 2011-01-13 |
| AR070214A1 (es) | 2010-03-25 |
| JP5508287B2 (ja) | 2014-05-28 |
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