EA201170093A1 - Замещенные n-оксидпиразиновые производные - Google Patents

Замещенные n-оксидпиразиновые производные

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Publication number
EA201170093A1
EA201170093A1 EA201170093A EA201170093A EA201170093A1 EA 201170093 A1 EA201170093 A1 EA 201170093A1 EA 201170093 A EA201170093 A EA 201170093A EA 201170093 A EA201170093 A EA 201170093A EA 201170093 A1 EA201170093 A1 EA 201170093A1
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EA
Eurasian Patent Office
Prior art keywords
hydrogen atom
derivatives
substituted
oxydpyrazine
group
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EA201170093A
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English (en)
Inventor
Алистер Локхед
Мурад Саади
Филипп Иэш
Original Assignee
Мицубиси Танабе Фарма Корпорейшн
Санофи-Авентис
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Application filed by Мицубиси Танабе Фарма Корпорейшн, Санофи-Авентис filed Critical Мицубиси Танабе Фарма Корпорейшн
Publication of EA201170093A1 publication Critical patent/EA201170093A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

N-оксидпиразиновые производные формулы (I) или их соли, их сольваты или гидратыгде R1 представляет 4-пиридиновое кольцо, атом галогена; R2 представляет атом водорода; R3 представляет атом водорода; R4 представляет фенил-С-алкильную группу, причем эта группа может быть необязательно замещенной; R5 представляет атом водорода; в форме свободного основания или соли с присоединением кислоты. Применение для терапии.
EA201170093A 2008-06-26 2009-06-25 Замещенные n-оксидпиразиновые производные EA201170093A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08290619A EP2138485A1 (en) 2008-06-26 2008-06-26 Substituted N-Oxide pyrazine derivatives
PCT/IB2009/006445 WO2009156857A1 (en) 2008-06-26 2009-06-25 Substituted n-oxide pyrazine derivatives

Publications (1)

Publication Number Publication Date
EA201170093A1 true EA201170093A1 (ru) 2011-06-30

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ID=39820921

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170093A EA201170093A1 (ru) 2008-06-26 2009-06-25 Замещенные n-оксидпиразиновые производные

Country Status (22)

Country Link
US (1) US8202874B2 (ru)
EP (2) EP2138485A1 (ru)
JP (1) JP5409783B2 (ru)
KR (1) KR20110028367A (ru)
CN (1) CN102076669A (ru)
AR (1) AR072229A1 (ru)
AT (1) ATE545635T1 (ru)
AU (1) AU2009263843A1 (ru)
BR (1) BRPI0914676A2 (ru)
CA (1) CA2728680A1 (ru)
DK (1) DK2321286T3 (ru)
EA (1) EA201170093A1 (ru)
ES (1) ES2382677T3 (ru)
IL (1) IL210170A0 (ru)
MX (1) MX2010013939A (ru)
NZ (1) NZ590047A (ru)
PL (1) PL2321286T3 (ru)
PT (1) PT2321286E (ru)
SI (1) SI2321286T1 (ru)
TW (1) TW201006814A (ru)
WO (1) WO2009156857A1 (ru)
ZA (1) ZA201009267B (ru)

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EP2138492A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidin-4-one derivatives
EP2138494A1 (en) 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
EP2138498A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted tricyclic derivatives against neurodegenerative diseases
EP2138488A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
EP2138495A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
EP2138493A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidone derivatives
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2014106606A1 (en) * 2013-01-05 2014-07-10 F. Hoffmann-La Roche Ag Nove phenyl/pyridine series substitued by hydroxyethylamino for the treatment of cancer

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EP2138495A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted pyrimido[2,1-a]isoquinolin-4-one derivatives
EP2138494A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
EP2138488A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
EP2138493A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted pyrimidone derivatives

Also Published As

Publication number Publication date
AR072229A1 (es) 2010-08-11
IL210170A0 (en) 2011-03-31
NZ590047A (en) 2011-11-25
DK2321286T3 (da) 2012-06-11
KR20110028367A (ko) 2011-03-17
US20110136828A1 (en) 2011-06-09
PT2321286E (pt) 2012-05-02
EP2321286A1 (en) 2011-05-18
EP2138485A1 (en) 2009-12-30
CA2728680A1 (en) 2009-12-30
JP2011525903A (ja) 2011-09-29
PL2321286T3 (pl) 2012-07-31
EP2321286B1 (en) 2012-02-15
AU2009263843A1 (en) 2009-12-30
JP5409783B2 (ja) 2014-02-05
TW201006814A (en) 2010-02-16
ZA201009267B (en) 2012-03-28
CN102076669A (zh) 2011-05-25
MX2010013939A (es) 2011-09-27
ES2382677T3 (es) 2012-06-12
BRPI0914676A2 (pt) 2015-10-20
SI2321286T1 (sl) 2012-06-29
US8202874B2 (en) 2012-06-19
ATE545635T1 (de) 2012-03-15
WO2009156857A1 (en) 2009-12-30

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