EA200901375A1 - Производные пиридазина, пиридина и пирана в качестве агонистов рецептора gpbar1 - Google Patents
Производные пиридазина, пиридина и пирана в качестве агонистов рецептора gpbar1Info
- Publication number
- EA200901375A1 EA200901375A1 EA200901375A EA200901375A EA200901375A1 EA 200901375 A1 EA200901375 A1 EA 200901375A1 EA 200901375 A EA200901375 A EA 200901375A EA 200901375 A EA200901375 A EA 200901375A EA 200901375 A1 EA200901375 A1 EA 200901375A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- piran
- pyridazin
- pyridin
- agonists
- Prior art date
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- C07—ORGANIC CHEMISTRY
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- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
Abstract
В настоящем изобретении предлагается соединение формулыгде заместители имеют различное значение, необязательно в форме соли и/или сольвата, и его применение в качестве фармацевтического препарата.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07106151 | 2007-04-13 | ||
EP07109410 | 2007-06-01 | ||
PCT/EP2008/054422 WO2008125627A1 (en) | 2007-04-13 | 2008-04-11 | Pyridazine-, pyridine- and pyrane-derivatives as gpbar1 agonisis |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200901375A1 true EA200901375A1 (ru) | 2010-04-30 |
Family
ID=39432919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200901375A EA200901375A1 (ru) | 2007-04-13 | 2008-04-11 | Производные пиридазина, пиридина и пирана в качестве агонистов рецептора gpbar1 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20100048579A1 (ru) |
EP (1) | EP2146970A1 (ru) |
JP (1) | JP2010523627A (ru) |
KR (1) | KR20100015499A (ru) |
CN (1) | CN101679304A (ru) |
AU (1) | AU2008237944A1 (ru) |
BR (1) | BRPI0810195A2 (ru) |
CA (1) | CA2681311A1 (ru) |
EA (1) | EA200901375A1 (ru) |
MX (1) | MX2009010959A (ru) |
WO (1) | WO2008125627A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0919648A2 (pt) | 2008-10-29 | 2015-12-08 | Hoffmann La Roche | novos derivados de fenil amida ou piridil amida e seu uso como agonistas de gpbar1 |
US8420647B2 (en) | 2010-01-21 | 2013-04-16 | Hoffmann-La Roche Inc. | 4-phenoxy-nicotinamide or 4-phenoxy-pyrimidine-5-carboxamide compounds |
US8987307B2 (en) * | 2011-03-03 | 2015-03-24 | Hoffmann-La Roche Inc. | 3-amino-pyridines as GPBAR1 agonists |
RU2014142971A (ru) * | 2012-04-04 | 2016-05-27 | Ф.Хоффманн-Ля Рош Аг | Производные 1,2-пиридазина, 1,6-пиридазина или пиримидин-бензамида в качестве модуляторов сопряженного с белком g рецептора желчных кислот 1 (gpbar1) |
SG11201408679XA (en) | 2012-06-26 | 2015-01-29 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
KR20160061911A (ko) | 2013-04-08 | 2016-06-01 | 데니스 엠. 브라운 | 최적하 투여된 화학 화합물의 치료 효과 |
KR101548955B1 (ko) * | 2013-08-26 | 2015-09-02 | (주)샤페론 | Gpcr19 작용제를 유효성분으로 함유하는 아토피 예방 또는 치료용 조성물 |
EP3174872A1 (en) * | 2014-07-29 | 2017-06-07 | Université de Lille 2 Droit et Santé | 2-oxo-3,4-dihydropyridine-5-carboxylates and their use |
KR101743960B1 (ko) | 2015-07-06 | 2017-06-08 | 서울대학교산학협력단 | G단백질 결합형 수용체19 작용제를 유효성분으로 함유하는 알츠하이머 질환 또는 치매를 예방, 치료 또는 지연하기 위한 약학적 조성물 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003051923A2 (en) * | 2001-12-17 | 2003-06-26 | Novartis Ag | Novel g-protein coupled receptors and dna sequences thereof |
SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
WO2005030753A2 (en) * | 2003-09-22 | 2005-04-07 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
GB0328796D0 (en) * | 2003-12-12 | 2004-01-14 | Biofocus Plc | Compounds which interact with the G-protein coupled receptor family |
WO2005073234A2 (en) * | 2004-01-31 | 2005-08-11 | Actimis Pharmaceuticals, Inc. | Imidazo[1,2-c]pyrimidinylacetic acid derivatives |
GB2418427A (en) * | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
EP2192137A4 (en) * | 2007-09-19 | 2012-08-29 | Toyota Jidoshokki Kk | POLYURETHANE AND POLYUREA, AND PROCESS FOR PRODUCING THEM |
-
2008
- 2008-04-11 KR KR1020097021233A patent/KR20100015499A/ko not_active Application Discontinuation
- 2008-04-11 MX MX2009010959A patent/MX2009010959A/es not_active Application Discontinuation
- 2008-04-11 EP EP08736133A patent/EP2146970A1/en not_active Withdrawn
- 2008-04-11 CA CA002681311A patent/CA2681311A1/en not_active Abandoned
- 2008-04-11 AU AU2008237944A patent/AU2008237944A1/en not_active Abandoned
- 2008-04-11 JP JP2010502524A patent/JP2010523627A/ja active Pending
- 2008-04-11 US US12/595,532 patent/US20100048579A1/en not_active Abandoned
- 2008-04-11 CN CN200880019598A patent/CN101679304A/zh active Pending
- 2008-04-11 EA EA200901375A patent/EA200901375A1/ru unknown
- 2008-04-11 BR BRPI0810195-7A2A patent/BRPI0810195A2/pt not_active Application Discontinuation
- 2008-04-11 WO PCT/EP2008/054422 patent/WO2008125627A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
BRPI0810195A2 (pt) | 2014-12-30 |
CN101679304A (zh) | 2010-03-24 |
AU2008237944A1 (en) | 2008-10-23 |
KR20100015499A (ko) | 2010-02-12 |
MX2009010959A (es) | 2009-10-29 |
WO2008125627A1 (en) | 2008-10-23 |
US20100048579A1 (en) | 2010-02-25 |
EP2146970A1 (en) | 2010-01-27 |
JP2010523627A (ja) | 2010-07-15 |
CA2681311A1 (en) | 2008-10-23 |
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