BRPI0810195A2 - Moduladores de gpbar1 - Google Patents

Moduladores de gpbar1

Info

Publication number
BRPI0810195A2
BRPI0810195A2 BRPI0810195-7A2A BRPI0810195A BRPI0810195A2 BR PI0810195 A2 BRPI0810195 A2 BR PI0810195A2 BR PI0810195 A BRPI0810195 A BR PI0810195A BR PI0810195 A2 BRPI0810195 A2 BR PI0810195A2
Authority
BR
Brazil
Prior art keywords
gpbar1
modulators
gpbar1 modulators
Prior art date
Application number
BRPI0810195-7A2A
Other languages
English (en)
Inventor
Luca Arista
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0810195A2 publication Critical patent/BRPI0810195A2/pt

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    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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BRPI0810195-7A2A 2007-04-13 2008-04-11 Moduladores de gpbar1 BRPI0810195A2 (pt)

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EP07109410 2007-06-01
PCT/EP2008/054422 WO2008125627A1 (en) 2007-04-13 2008-04-11 Pyridazine-, pyridine- and pyrane-derivatives as gpbar1 agonisis

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WO2010049302A1 (en) * 2008-10-29 2010-05-06 F. Hoffmann-La Roche Ag Novel phenyl amide or pyridil amide derivatives and their use as gpbar1 agonists
US8420647B2 (en) * 2010-01-21 2013-04-16 Hoffmann-La Roche Inc. 4-phenoxy-nicotinamide or 4-phenoxy-pyrimidine-5-carboxamide compounds
US8987307B2 (en) * 2011-03-03 2015-03-24 Hoffmann-La Roche Inc. 3-amino-pyridines as GPBAR1 agonists
EP2834226B1 (en) * 2012-04-04 2016-05-25 F.Hoffmann-La Roche Ag 1,2-pyridazine, 1,6-pyridazine or pyrimidine-benzamide derivatives as gpbar1 modulators
CN104797267A (zh) 2012-06-26 2015-07-22 德玛医药 使用卫康醇、二乙酰二脱水卫矛醇、二溴卫矛醇或类似物或其衍生物治疗具有基因多型性或ahi1失调或突变患者的抗酪氨酸激酶抑制剂的恶性肿瘤的方法
JP2016519684A (ja) 2013-04-08 2016-07-07 デニス エム ブラウン 準最適に投与された薬物療法の有効性を改善するための及び／又は副作用を低減するための方法および組成物
KR101548955B1 (ko) * 2013-08-26 2015-09-02 (주)샤페론 Gpcr19 작용제를 유효성분으로 함유하는 아토피 예방 또는 치료용 조성물
US9932309B2 (en) * 2014-07-29 2018-04-03 Universite De Lille 2 Droit Et Sante 2-oxo-3,4-dihydropyridine-5-carboxylates and their use
KR101743960B1 (ko) 2015-07-06 2017-06-08 서울대학교산학협력단 G단백질 결합형 수용체19 작용제를 유효성분으로 함유하는 알츠하이머 질환 또는 치매를 예방, 치료 또는 지연하기 위한 약학적 조성물

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AU2002361429A1 (en) * 2001-12-17 2003-06-30 Novartis Ag Novel g-protein coupled receptors and dna sequences thereof
SE0302486D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
WO2005030753A2 (en) * 2003-09-22 2005-04-07 Euro-Celtique S.A. Therapeutic agents useful for treating pain
GB0328796D0 (en) * 2003-12-12 2004-01-14 Biofocus Plc Compounds which interact with the G-protein coupled receptor family
MXPA06007674A (es) * 2004-01-31 2006-09-04 Actimis Pharmaceuticals Inc Derivados del acido imidazo [1,2-c] pirimidinilacetico.
GB2418427A (en) * 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
JPWO2009038007A1 (ja) * 2007-09-19 2011-01-06 株式会社豊田自動織機 ポリウレタン及びポリウレア、並びにその製造法

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CN101679304A (zh) 2010-03-24
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WO2008125627A1 (en) 2008-10-23
CA2681311A1 (en) 2008-10-23
US20100048579A1 (en) 2010-02-25
JP2010523627A (ja) 2010-07-15
MX2009010959A (es) 2009-10-29
EA200901375A1 (ru) 2010-04-30
EP2146970A1 (en) 2010-01-27

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