CY1119220T1 - Μονοκυκλικο παραγωγο πυριδινης - Google Patents
Μονοκυκλικο παραγωγο πυριδινηςInfo
- Publication number
- CY1119220T1 CY1119220T1 CY20171100631T CY171100631T CY1119220T1 CY 1119220 T1 CY1119220 T1 CY 1119220T1 CY 20171100631 T CY20171100631 T CY 20171100631T CY 171100631 T CY171100631 T CY 171100631T CY 1119220 T1 CY1119220 T1 CY 1119220T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- atom
- hydrogen atom
- alkoxy
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Η παρούσα εφεύρεση αποκαλύπτει μια ένωση που αντιπροσωπεύεται από τον ακόλουθο τύπο (ΙΑ) ή ένα φαρμακευτικώς αποδεκτό άλας αυτής: όπου το n αντιπροσωπεύει 0 έως 2· το Α αντιπροσωπεύει μια ομάδα αρυλενίου ή μία ομάδα ετεροαρυλενίου· το G αντιπροσωπεύει έναν απλό δεσμό, ένα άτομο οξυγόνου ή -CΗ2-· το Ε αντιπροσωπεύει ένα μη-αρωματικό ετεροκυκλικό δακτύλιο που περιέχει άζωτο· το R1 αντιπροσωπεύει ομάδα αλκοξυ, μια ομάδα αλκοξυ αλκοξυ ή τα παρόμοια· το R2 αντιπροσωπεύει ένα άτομο υδρογόνου, ένα άτομο αλογόνου, μια ομάδα υδροξυλίου, μια ομάδα αλκυλίου, μια ομάδα υδροξυ αλκυλίου, μια μη-αρωματική ετεροκυκλική ομάδα που περιέχει άζωτο ή τα παρόμοια· το R3 αντιπροσωπεύει ένα άτομο υδρογόνου, μια ομάδα αλκυλίου, μια ομάδα αλκόξυ ή τα παρόμοια· και το R4 αντιπροσωπεύει μια ομάδα C1-6 αλκυλίου, υπό την προϋπόθεση ότι όταν το Ε αντιπροσωπεύει έναν δακτύλιο αζετιδίνης και το R2 ή το R3 είναι παρόν σε ένα άτομο αζώτου στον δακτύλιο αζετιδίνης, το R2 ή το R3 δεν αντιπροσωπεύει ένα άτομο υδρογόνου.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361766922P | 2013-02-20 | 2013-02-20 | |
PCT/JP2014/053819 WO2014129477A1 (ja) | 2013-02-20 | 2014-02-18 | 単環ピリジン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119220T1 true CY1119220T1 (el) | 2018-02-14 |
Family
ID=51351646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171100631T CY1119220T1 (el) | 2013-02-20 | 2017-06-15 | Μονοκυκλικο παραγωγο πυριδινης |
Country Status (35)
Country | Link |
---|---|
US (1) | US8933099B2 (el) |
EP (1) | EP2960238B1 (el) |
JP (2) | JP5600229B1 (el) |
KR (1) | KR102050128B1 (el) |
CN (1) | CN105073730B (el) |
AR (1) | AR094812A1 (el) |
AU (1) | AU2014219811B2 (el) |
BR (1) | BR112015019790B1 (el) |
CA (1) | CA2901585C (el) |
CL (1) | CL2015002311A1 (el) |
CY (1) | CY1119220T1 (el) |
DK (1) | DK2960238T3 (el) |
ES (1) | ES2628495T3 (el) |
HK (1) | HK1215949A1 (el) |
HR (1) | HRP20170873T1 (el) |
HU (1) | HUE032931T2 (el) |
IL (1) | IL240623B (el) |
JO (1) | JO3261B1 (el) |
LT (1) | LT2960238T (el) |
ME (1) | ME02755B (el) |
MX (1) | MX361870B (el) |
MY (1) | MY178760A (el) |
NZ (1) | NZ711101A (el) |
PE (1) | PE20151509A1 (el) |
PH (1) | PH12015501813A1 (el) |
PL (1) | PL2960238T3 (el) |
PT (1) | PT2960238T (el) |
RS (1) | RS56064B1 (el) |
RU (1) | RU2645352C2 (el) |
SG (1) | SG11201506488WA (el) |
SI (1) | SI2960238T1 (el) |
TW (4) | TWI641602B (el) |
UA (1) | UA116794C2 (el) |
WO (1) | WO2014129477A1 (el) |
ZA (1) | ZA201505941B (el) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9951047B2 (en) * | 2014-08-18 | 2018-04-24 | Eisai R&D Management Co., Ltd. | Salt of monocyclic pyridine derivative and crystal thereof |
RU2712222C2 (ru) * | 2015-03-25 | 2020-01-27 | Нэшнл Кэнсер Сентер | Терапевтическое средство против рака желчных протоков |
CN115177619A (zh) * | 2015-12-17 | 2022-10-14 | 卫材R&D管理有限公司 | 用于乳腺癌的治疗剂 |
CN107098884A (zh) * | 2016-02-19 | 2017-08-29 | 中国科学院上海药物研究所 | 一类取代的氨基吡啶类化合物及其制备和用途 |
BR112020003849A2 (pt) * | 2017-10-12 | 2020-09-08 | Eisai R&D Management Co., Ltd. | composição farmacêutica compreendendo inibidor seletivo de tirosina quinase fgfr |
BR112020017922A2 (pt) | 2018-03-28 | 2020-12-22 | Eisai R&D Management Co., Ltd. | Agente terapêutico para carcinoma hepatocelular |
CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
AU2020378630A1 (en) | 2019-11-08 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
US20230149381A1 (en) | 2020-04-17 | 2023-05-18 | Eisai R&D Management Co., Ltd. | Breast cancer therapeutic agent |
MX2023000060A (es) | 2020-07-31 | 2023-02-01 | Eisai R&D Man Co Ltd | Agente terapeutico para cancer de mama. |
WO2022092085A1 (ja) | 2020-10-28 | 2022-05-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍治療用医薬組成物 |
TW202328098A (zh) | 2021-08-31 | 2023-07-16 | 日商衛材R&D企管股份有限公司 | 單環吡啶衍生物的合成中間體之製造方法 |
TW202328099A (zh) | 2021-08-31 | 2023-07-16 | 日商衛材R&D企管股份有限公司 | 單環吡啶衍生物之製造方法 |
WO2023174400A1 (zh) * | 2022-03-18 | 2023-09-21 | 上海润石医药科技有限公司 | 一种取代的氨基六元氮杂环类化合物的盐及其晶型、制备方法和应用 |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10006139A1 (de) * | 2000-02-11 | 2001-08-16 | Merck Patent Gmbh | Indol-3-yl-Derivate |
DE60126997T2 (de) | 2000-10-20 | 2007-10-25 | Eisai R&D Management Co., Ltd. | Stickstoff-enthaltende aromatische ringverbindungen zur behandlung von tumorerkrankungen |
JP4071636B2 (ja) | 2001-04-03 | 2008-04-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シクロオクタノン誘導体およびシクロデカノン誘導体、およびその用途 |
US20030187026A1 (en) * | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
MXPA05001536A (es) * | 2002-08-30 | 2005-04-19 | Eisai Co Ltd | Derivados aromaticos que contienen nitrogeno. |
US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
MXPA05010765A (es) | 2003-04-10 | 2005-12-12 | Hoffmann La Roche | Compuestos pirimido. |
US20050256154A1 (en) | 2004-05-04 | 2005-11-17 | Kin-Chun Luk | 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
FR2883286B1 (fr) | 2005-03-16 | 2008-10-03 | Sanofi Aventis Sa | NOUVEAUX DERIVES D'IMIDAZO[1,5-a]PYRIDINES, INHIBITEURS DE FGFs, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT |
MX2007014782A (es) * | 2005-05-23 | 2008-02-19 | Novartis Ag | Formas cristalinas y otras formas de las sales de acido lactico de 4-amino-5-fluoro-3-[6-(4-metilpiperazin-1-il)-1h-bencimidazol-2 -il]-1h quinolin-2-ona. |
JP5153645B2 (ja) | 2005-12-21 | 2013-02-27 | ノバルティス アーゲー | Fgf阻害剤であるピリミジニルアリールウレア誘導体 |
JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
TW200811134A (en) | 2006-07-12 | 2008-03-01 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
EP1891955A1 (en) | 2006-07-24 | 2008-02-27 | Sanofi-Aventis | Use of 1,2,3-substituted indolizine derivatives, inhibitors of FGFs, for the preparation of a medicament intended for the treatment of degenerative joint diseases |
US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
US8131527B1 (en) | 2006-12-22 | 2012-03-06 | Astex Therapeutics Ltd. | FGFR pharmacophore compounds |
CA2672213C (en) | 2006-12-22 | 2016-02-16 | Astex Therapeutics Limited | Bicyclic amine derivatives as protein tyrosine kinase inhibitors |
JP5442448B2 (ja) | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | Fgfrインヒビターとしての二環式ヘテロ環式化合物 |
EP2158470A1 (en) | 2007-06-25 | 2010-03-03 | Qinetiq Limited | Preconcentrator device incorporating a polymer of intrinsic microporosity |
WO2009019518A1 (en) | 2007-08-09 | 2009-02-12 | Astrazeneca Ab | Pyrimidine compounds having a fgfr inhibitory effect |
GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
WO2009056886A1 (en) | 2007-11-01 | 2009-05-07 | Astrazeneca Ab | Pyrimidine derivatives and their use as modulators of fgfr activity |
WO2009076660A2 (en) * | 2007-12-13 | 2009-06-18 | Tyratech, Inc. | Organic absorbent material and uses thereof |
CL2008003675A1 (es) * | 2007-12-13 | 2009-03-20 | Wyeth Corp | Compuestos derivados de 5-alquil o alquenil 3-cianopiridinas, procedimiento de preparacion, composicion farmaceutica, util para reducir la actividad incrementada de una enzima en un mamifero, en donde dicha enzima es una proteina quinasa, destinado al tratamiento de la inflamacion, asma, colitis, esclerosis multiple, soriasis, artritis reumatoide. |
CN102036963B (zh) | 2008-05-23 | 2013-08-21 | 诺瓦提斯公司 | 作为蛋白酪氨酸激酶抑制剂的喹啉类和喹喔啉类衍生物 |
GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
EP2328872A1 (en) | 2008-06-19 | 2011-06-08 | AstraZeneca AB | Pyrazole compounds 436 |
CA2748174A1 (en) | 2008-12-30 | 2010-07-08 | Arqule, Inc. | Substituted 1h-pyrazolo[3,4-d]pyrimidine-6-amine compounds |
EP2379551A1 (en) | 2008-12-30 | 2011-10-26 | ArQule, Inc. | Substituted pyrazolo [3, 4-b]pyridine compounds |
JP5739820B2 (ja) | 2008-12-30 | 2015-06-24 | アークル インコーポレイテッド | 置換5,6−ジヒドロ−6−フェニルベンゾ[f]イソキノリン−2−アミン化合物 |
US9002427B2 (en) | 2009-03-30 | 2015-04-07 | Lifewave Biomedical, Inc. | Apparatus and method for continuous noninvasive measurement of respiratory function and events |
GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
EP2270043A1 (en) | 2009-07-03 | 2011-01-05 | Sanofi-Aventis | Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor |
FR2947546B1 (fr) | 2009-07-03 | 2011-07-01 | Sanofi Aventis | Derives de pyrazoles, leur preparation et leur application en therapeutique |
CN102574836B (zh) | 2009-08-07 | 2014-04-16 | 中外制药株式会社 | 氨基吡唑衍生物 |
WO2011051425A1 (en) | 2009-10-30 | 2011-05-05 | Novartis Ag | N-oxide of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea |
AR079257A1 (es) | 2009-12-07 | 2012-01-04 | Novartis Ag | Formas cristalinas de 3-(2,6-dicloro-3-5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
FR2962437B1 (fr) | 2010-07-06 | 2012-08-17 | Sanofi Aventis | Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
EP2548877A1 (en) * | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
FR2984325A1 (fr) | 2011-12-14 | 2013-06-21 | Sanofi Sa | Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique |
PT2657233E (pt) | 2012-01-19 | 2014-10-24 | Taiho Pharmaceutical Co Ltd | Composto de alcinil-benzeno substituído nas posições 3 e 5 e um seu sal |
JP5343177B1 (ja) | 2012-02-28 | 2013-11-13 | アステラス製薬株式会社 | 含窒素芳香族へテロ環化合物 |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
BR112014030812B1 (pt) | 2012-06-13 | 2022-11-08 | Incyte Holdings Corporation | Compostos tricíclicos substituídos como inibidores de fgfr, seus usos, composição farmacêutica e método para inibir uma enzima fgfr |
RU2019102203A (ru) | 2012-07-11 | 2019-03-05 | Блюпринт Медсинс Корпорейшн | Ингибиторы рецептора фактора роста фибробластов |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
WO2014044846A1 (en) | 2012-09-24 | 2014-03-27 | Evotec (Uk) Ltd. | 3-(aryl- or heteroaryl-amino)-7-(3,5-dimethoxyphenyl)isoquinoline derivatives as fgfr inhibitors useful for the treatment of proliferative disorders or dysplasia |
WO2014048878A1 (en) | 2012-09-26 | 2014-04-03 | Evotec (Uk) Ltd. | Phenyl- or pyridyl- pyrrolo[2,3b]pyrazine derivatives useful in the treatment or prevention of proliferative disorders or dysplasia |
EA031631B1 (ru) | 2012-09-27 | 2019-01-31 | Чугаи Сеияку Кабушики Каиша | Способ лечения или предупреждения злокачественного новообразования, способ отбора пациента, способ тестирования предрасположенности к злокачественному новообразованию у субъекта, гибридный полипептид и его применения |
TWI628176B (zh) | 2013-04-04 | 2018-07-01 | 奧利安公司 | 蛋白質激酶抑制劑 |
-
2014
- 2014-02-17 AR ARP140100495A patent/AR094812A1/es active IP Right Grant
- 2014-02-18 JP JP2014526292A patent/JP5600229B1/ja active Active
- 2014-02-18 MX MX2015010698A patent/MX361870B/es active IP Right Grant
- 2014-02-18 CN CN201480009370.XA patent/CN105073730B/zh active Active
- 2014-02-18 MY MYPI2015702696A patent/MY178760A/en unknown
- 2014-02-18 TW TW103105419A patent/TWI641602B/zh active
- 2014-02-18 SG SG11201506488WA patent/SG11201506488WA/en unknown
- 2014-02-18 AU AU2014219811A patent/AU2014219811B2/en active Active
- 2014-02-18 CA CA2901585A patent/CA2901585C/en active Active
- 2014-02-18 HU HUE14754294A patent/HUE032931T2/en unknown
- 2014-02-18 PL PL14754294T patent/PL2960238T3/pl unknown
- 2014-02-18 WO PCT/JP2014/053819 patent/WO2014129477A1/ja active Application Filing
- 2014-02-18 UA UAA201508149A patent/UA116794C2/uk unknown
- 2014-02-18 ME MEP-2017-130A patent/ME02755B/me unknown
- 2014-02-18 TW TW107134522A patent/TWI672296B/zh active
- 2014-02-18 DK DK14754294.8T patent/DK2960238T3/en active
- 2014-02-18 NZ NZ711101A patent/NZ711101A/en unknown
- 2014-02-18 TW TW107134526A patent/TWI672139B/zh active
- 2014-02-18 KR KR1020157022252A patent/KR102050128B1/ko active IP Right Grant
- 2014-02-18 PT PT147542948T patent/PT2960238T/pt unknown
- 2014-02-18 JO JOP/2014/0039A patent/JO3261B1/ar active
- 2014-02-18 BR BR112015019790-6A patent/BR112015019790B1/pt active IP Right Grant
- 2014-02-18 SI SI201430247A patent/SI2960238T1/sl unknown
- 2014-02-18 TW TW107134529A patent/TWI672140B/zh active
- 2014-02-18 ES ES14754294.8T patent/ES2628495T3/es active Active
- 2014-02-18 LT LTEP14754294.8T patent/LT2960238T/lt unknown
- 2014-02-18 PE PE2015001748A patent/PE20151509A1/es active IP Right Grant
- 2014-02-18 RS RS20170596A patent/RS56064B1/sr unknown
- 2014-02-18 EP EP14754294.8A patent/EP2960238B1/en active Active
- 2014-02-18 RU RU2015134558A patent/RU2645352C2/ru active
- 2014-02-19 US US14/183,864 patent/US8933099B2/en active Active
- 2014-08-14 JP JP2014165311A patent/JP2014237707A/ja active Pending
-
2015
- 2015-08-17 IL IL240623A patent/IL240623B/en active IP Right Grant
- 2015-08-18 ZA ZA2015/05941A patent/ZA201505941B/en unknown
- 2015-08-18 PH PH12015501813A patent/PH12015501813A1/en unknown
- 2015-08-18 CL CL2015002311A patent/CL2015002311A1/es unknown
-
2016
- 2016-04-06 HK HK16103911.2A patent/HK1215949A1/zh unknown
-
2017
- 2017-06-07 HR HRP20170873TT patent/HRP20170873T1/hr unknown
- 2017-06-15 CY CY20171100631T patent/CY1119220T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1119220T1 (el) | Μονοκυκλικο παραγωγο πυριδινης | |
CY1122614T1 (el) | 11-υδροξυλ-6-υποκατεστημενα-παραγωγα χολικων οξεων και συζευγματα αμινοξεων αυτων ως ρυθμιστες υποδοχεων χ φαρνεσοειδων | |
CY1119585T1 (el) | Ενωσεις τετραϋδροπυρρολοθειαζινης | |
CY1122821T1 (el) | Παραγωγα 1,3-βενζοδιοξολιου ως αναστολεις εζη1 ή/και εζη2 | |
CY1124620T1 (el) | Οξυστερολες και μεθοδοι χρησης αυτων | |
CY1121804T1 (el) | Καινοτομες ενωσεις πυριμιδινης και πυριδινης και η χρηση τους | |
CY1119422T1 (el) | Παραγωγα μπετουλινης | |
CY1121677T1 (el) | Ενωσεις διμεθυλοβενζοϊκου οξεος | |
CY1120173T1 (el) | Ενωση πυραζολο-αμιδιου και φαρμακευτικες χρησεις αυτης | |
AR099400A1 (es) | Compuesto heterocíclico fusionado | |
CR20150509A (es) | Derivados de naftiridina utiles como antagonistas de la alfa-v-beta-6 integrina | |
CY1123670T1 (el) | Κρυσταλλικο παραγωγο 6,7-ακορεστης-7-καρβαμοϋλ μορφινανης, και μεθοδος για την παραγωγη αυτου | |
CY1124537T1 (el) | Παραγωγο πυριδονης που εχει τετραϋδροπυρανυλ μεθυλ ομαδα | |
CY1123154T1 (el) | Παραγοντας ενισχυσης της επιδρασης αποκαταστασης μετα απο νευρικη βλαβη που περιλαμβανει ενα παραγωγο αλκυλαιθερα ή ενα αλας αυτου | |
UA113643C2 (xx) | N-цикліламіди як нематоциди | |
CY1121626T1 (el) | Νεο παραγωγο υδροξαμικου οξεος ή αλας αυτου | |
CY1114452T1 (el) | Ενωσεις πυρρολιου | |
EA201690019A1 (ru) | Производное аминотриазина и содержащая его фармацевтическая композиция | |
CY1119583T1 (el) | Φαινοξυαιθυλο παραγωγα κυκλικης αμινης και η δραστικοτητα τους ως τροποποιητες του ερ4 υποδοχεα | |
BR112016001979A2 (pt) | composto de tetrazolinona e uso do mesmo | |
PE20160523A1 (es) | Derivados de arilo o heteroarilo como inhibidores de moleculas pequenas de fibrosis | |
CY1119425T1 (el) | Ενωσεις φαινοξυαιθυλο πιπεριδινης | |
CY1124643T1 (el) | Νεα ενωση και φαρμακευτικα αποδεκτο αλας αυτης | |
AR095523A1 (es) | Derivados piridin-4-ilo | |
CY1119296T1 (el) | Ενωση δικαρβοξυλικου οξεος |