SG11201506488WA - Monocyclic pyridine derivative - Google Patents

Monocyclic pyridine derivative

Info

Publication number
SG11201506488WA
SG11201506488WA SG11201506488WA SG11201506488WA SG11201506488WA SG 11201506488W A SG11201506488W A SG 11201506488WA SG 11201506488W A SG11201506488W A SG 11201506488WA SG 11201506488W A SG11201506488W A SG 11201506488WA SG 11201506488W A SG11201506488W A SG 11201506488WA
Authority
SG
Singapore
Prior art keywords
pyridine derivative
monocyclic pyridine
monocyclic
derivative
pyridine
Prior art date
Application number
SG11201506488WA
Inventor
Setsuo Funasaka
Toshimi Okada
Keigo Tanaka
Satoshi Nagao
Isao Ohashi
Yoshinobu Yamane
Yusuke Nakatani
Yuki KAROJI
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of SG11201506488WA publication Critical patent/SG11201506488WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
SG11201506488WA 2013-02-20 2014-02-18 Monocyclic pyridine derivative SG11201506488WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361766922P 2013-02-20 2013-02-20
PCT/JP2014/053819 WO2014129477A1 (en) 2013-02-20 2014-02-18 Monocyclic pyridine derivative

Publications (1)

Publication Number Publication Date
SG11201506488WA true SG11201506488WA (en) 2015-09-29

Family

ID=51351646

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201506488WA SG11201506488WA (en) 2013-02-20 2014-02-18 Monocyclic pyridine derivative

Country Status (35)

Country Link
US (1) US8933099B2 (en)
EP (1) EP2960238B1 (en)
JP (2) JP5600229B1 (en)
KR (1) KR102050128B1 (en)
CN (1) CN105073730B (en)
AR (1) AR094812A1 (en)
AU (1) AU2014219811B2 (en)
BR (1) BR112015019790B1 (en)
CA (1) CA2901585C (en)
CL (1) CL2015002311A1 (en)
CY (1) CY1119220T1 (en)
DK (1) DK2960238T3 (en)
ES (1) ES2628495T3 (en)
HK (1) HK1215949A1 (en)
HR (1) HRP20170873T1 (en)
HU (1) HUE032931T2 (en)
IL (1) IL240623B (en)
JO (1) JO3261B1 (en)
LT (1) LT2960238T (en)
ME (1) ME02755B (en)
MX (1) MX361870B (en)
MY (1) MY178760A (en)
NZ (1) NZ711101A (en)
PE (1) PE20151509A1 (en)
PH (1) PH12015501813A1 (en)
PL (1) PL2960238T3 (en)
PT (1) PT2960238T (en)
RS (1) RS56064B1 (en)
RU (1) RU2645352C2 (en)
SG (1) SG11201506488WA (en)
SI (1) SI2960238T1 (en)
TW (4) TWI672139B (en)
UA (1) UA116794C2 (en)
WO (1) WO2014129477A1 (en)
ZA (1) ZA201505941B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2658821C1 (en) * 2014-08-18 2018-06-25 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Salt of monocyclic derivative of pyridine and crystal thereof
SG11201706143SA (en) * 2015-03-25 2017-09-28 Nat Cancer Ct Therapeutic agent for bile duct cancer
CN115177619A (en) * 2015-12-17 2022-10-14 卫材R&D管理有限公司 Therapeutic agent for breast cancer
CN107098884A (en) * 2016-02-19 2017-08-29 中国科学院上海药物研究所 The aminopyridines and its preparation and use of one class substitution
US20200297711A1 (en) * 2017-10-12 2020-09-24 Eisai R&D Management Co., Ltd. Pharmaceutical composition comprising fgfr selective tyrosine kinase inhibitor
EP3777860A4 (en) 2018-03-28 2021-12-15 Eisai R&D Management Co., Ltd. Therapeutic agent for hepatocellular carcinoma
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
JPWO2021210636A1 (en) * 2020-04-17 2021-10-21
AU2021315234A1 (en) 2020-07-31 2023-01-19 Eisai R&D Management Co., Ltd. Therapeutic agent for breast cancer
US20230330081A1 (en) 2020-10-28 2023-10-19 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumors
IL310338A (en) 2021-08-31 2024-03-01 Eisai R&D Man Co Ltd Production method for synthetic intermediate of monocyclic pyridine derivative
JP7315806B1 (en) 2021-08-31 2023-07-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 Method for producing monocyclic pyridine derivative
WO2023174400A1 (en) * 2022-03-18 2023-09-21 上海润石医药科技有限公司 Salt of substituted amino six-membered nitric heterocyclic compound, crystal form thereof, method for preparing same, and use thereof

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10006139A1 (en) * 2000-02-11 2001-08-16 Merck Patent Gmbh Indol-3-yl derivatives
ES2318649T3 (en) 2000-10-20 2009-05-01 EISAI R&D MANAGEMENT CO., LTD. PROCEDURE FOR PREPARATION OF DERIVATIVES OF 4-FENOXI QUINOLINAS.
WO2002081420A1 (en) 2001-04-03 2002-10-17 Eisai Co., Ltd. Cyclooctanone derivative and cyclodecanone derivative, and use thereof
US20030187026A1 (en) * 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
WO2004020434A1 (en) * 2002-08-30 2004-03-11 Eisai Co., Ltd. Azaarene derivatives
US7098332B2 (en) 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
BRPI0409366A (en) 2003-04-10 2006-04-25 Hoffmann La Roche pyrimidine compounds
US20050256154A1 (en) 2004-05-04 2005-11-17 Kin-Chun Luk 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
FR2883286B1 (en) 2005-03-16 2008-10-03 Sanofi Aventis Sa NOVEL IMIDAZO [1,5-a] PYRIDINE DERIVATIVES, INHIBITORS OF FGFs, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
KR101368519B1 (en) * 2005-05-23 2014-02-27 노파르티스 아게 Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts
SMP200800041B (en) 2005-12-21 2009-07-14 Novartis Ag Active pyrimidinyl-aryl-urea derivatives such as fgf-inhibitors
JP2009184924A (en) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd Compound for biological reagent
TW200811134A (en) 2006-07-12 2008-03-01 Irm Llc Compounds and compositions as protein kinase inhibitors
EP1891955A1 (en) 2006-07-24 2008-02-27 Sanofi-Aventis Use of 1,2,3-substituted indolizine derivatives, inhibitors of FGFs, for the preparation of a medicament intended for the treatment of degenerative joint diseases
US7737149B2 (en) 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
JP5442448B2 (en) 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッド Bicyclic heterocyclic compounds as FGFR inhibitors
US8131527B1 (en) 2006-12-22 2012-03-06 Astex Therapeutics Ltd. FGFR pharmacophore compounds
PL2121687T3 (en) 2006-12-22 2016-03-31 Astex Therapeutics Ltd Tricyclic amine derivatives as protein tyrosine kinase inhibitors
EP2158470A1 (en) 2007-06-25 2010-03-03 Qinetiq Limited Preconcentrator device incorporating a polymer of intrinsic microporosity
WO2009019518A1 (en) 2007-08-09 2009-02-12 Astrazeneca Ab Pyrimidine compounds having a fgfr inhibitory effect
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
WO2009056886A1 (en) 2007-11-01 2009-05-07 Astrazeneca Ab Pyrimidine derivatives and their use as modulators of fgfr activity
CL2008003675A1 (en) * 2007-12-13 2009-03-20 Wyeth Corp Compounds derived from 5-alkyl or alkenyl 3-cyanopyridines, preparation process, pharmaceutical composition, useful to reduce the increased activity of an enzyme in a mammal, wherein said enzyme is a protein kinase, intended for the treatment of inflammation, asthma, colitis, multiple sclerosis, psoriasis, rheumatoid arthritis.
WO2009076660A2 (en) * 2007-12-13 2009-06-18 Tyratech, Inc. Organic absorbent material and uses thereof
CA2725185C (en) 2008-05-23 2016-10-25 Novartis Ag Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
JP2011524888A (en) 2008-06-19 2011-09-08 アストラゼネカ アクチボラグ Pyrazole compound 436
WO2010078427A1 (en) 2008-12-30 2010-07-08 Arqule, Inc. Substituted pyrazolo [3, 4-b] pyridine compounds
WO2010078421A1 (en) 2008-12-30 2010-07-08 Arqule, Inc. Substituted 5,6-dihydro-6-phenylbenzo[f] isoquinolin-2-amine compounds
US8273754B2 (en) 2008-12-30 2012-09-25 Arqule, Inc. Substituted 1H-pyrazolo[3,4-D]pyrimidine-6-amine compounds
US9002427B2 (en) 2009-03-30 2015-04-07 Lifewave Biomedical, Inc. Apparatus and method for continuous noninvasive measurement of respiratory function and events
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
FR2947546B1 (en) 2009-07-03 2011-07-01 Sanofi Aventis PYRAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
EP2270043A1 (en) 2009-07-03 2011-01-05 Sanofi-Aventis Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor
ES2561659T3 (en) 2009-08-07 2016-02-29 Chugai Seiyaku Kabushiki Kaisha Aminopyrazole derivatives
IN2012DN03180A (en) 2009-10-30 2015-09-25 Novartis Ag
AR079257A1 (en) 2009-12-07 2012-01-04 Novartis Ag CRYSTAL FORMS OF 3- (2,6-DICLORO-3-5-DIMETOXI-PHENYL) -1- {6- [4- (4-ETIL-PIPERAZIN-1-IL) -PENYL-AMINO] -PIRIMIDIN-4- IL} -1-METHYL-UREA AND SALTS OF THE SAME
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
FR2962437B1 (en) 2010-07-06 2012-08-17 Sanofi Aventis IMIDAZOPYRIDINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
EP2548877A1 (en) * 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
FR2984325A1 (en) 2011-12-14 2013-06-21 Sanofi Sa PYRAZOLOPYRIDINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION
ES2516392T3 (en) 2012-01-19 2014-10-30 Taiho Pharmaceutical Co., Ltd. 3,5-disubstituted alkynylbenzene compound and salt thereof
JP5343177B1 (en) 2012-02-28 2013-11-13 アステラス製薬株式会社 Nitrogen-containing aromatic heterocyclic compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
UA117347C2 (en) 2012-06-13 2018-07-25 Інсайт Холдинґс Корпорейшн Substituted tricyclic compounds as fgfr inhibitors
CN109627239B (en) 2012-07-11 2021-10-12 缆图药品公司 Inhibitors of fibroblast growth factor receptors
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
WO2014044846A1 (en) 2012-09-24 2014-03-27 Evotec (Uk) Ltd. 3-(aryl- or heteroaryl-amino)-7-(3,5-dimethoxyphenyl)isoquinoline derivatives as fgfr inhibitors useful for the treatment of proliferative disorders or dysplasia
WO2014048878A1 (en) 2012-09-26 2014-04-03 Evotec (Uk) Ltd. Phenyl- or pyridyl- pyrrolo[2,3b]pyrazine derivatives useful in the treatment or prevention of proliferative disorders or dysplasia
US10689705B2 (en) 2012-09-27 2020-06-23 Chugai Seiyaku Kabushiki Kaisha FGFR3 fusion gene and pharmaceutical drug targeting same
TWI628176B (en) 2013-04-04 2018-07-01 奧利安公司 Protein kinase inhibitors

Also Published As

Publication number Publication date
LT2960238T (en) 2017-07-10
JPWO2014129477A1 (en) 2017-02-02
CA2901585C (en) 2019-09-24
WO2014129477A1 (en) 2014-08-28
JP2014237707A (en) 2014-12-18
AU2014219811B2 (en) 2017-09-28
TW201439085A (en) 2014-10-16
MY178760A (en) 2020-10-20
CL2015002311A1 (en) 2016-02-05
DK2960238T3 (en) 2017-06-26
ME02755B (en) 2018-01-20
BR112015019790A2 (en) 2017-07-18
CN105073730B (en) 2017-10-13
CN105073730A (en) 2015-11-18
PT2960238T (en) 2017-06-05
MX2015010698A (en) 2016-04-11
TW201900168A (en) 2019-01-01
RU2645352C2 (en) 2018-02-21
US8933099B2 (en) 2015-01-13
PL2960238T3 (en) 2017-09-29
NZ711101A (en) 2018-08-31
TWI672139B (en) 2019-09-21
PE20151509A1 (en) 2015-10-18
IL240623A0 (en) 2015-10-29
TW201902889A (en) 2019-01-16
SI2960238T1 (en) 2017-07-31
CA2901585A1 (en) 2014-08-28
RU2015134558A (en) 2017-03-24
CY1119220T1 (en) 2018-02-14
EP2960238A1 (en) 2015-12-30
BR112015019790B1 (en) 2020-12-01
AU2014219811A1 (en) 2015-09-03
RS56064B1 (en) 2017-10-31
HRP20170873T1 (en) 2017-09-08
TWI672296B (en) 2019-09-21
ZA201505941B (en) 2016-07-27
JO3261B1 (en) 2018-09-16
JP5600229B1 (en) 2014-10-01
HK1215949A1 (en) 2016-09-30
EP2960238A4 (en) 2016-08-17
UA116794C2 (en) 2018-05-10
TW201900169A (en) 2019-01-01
KR20150118151A (en) 2015-10-21
PH12015501813A1 (en) 2015-12-07
AR094812A1 (en) 2015-08-26
ES2628495T3 (en) 2017-08-03
MX361870B (en) 2018-12-18
EP2960238B1 (en) 2017-04-05
HUE032931T2 (en) 2017-11-28
IL240623B (en) 2019-03-31
KR102050128B1 (en) 2019-11-28
TWI641602B (en) 2018-11-21
TWI672140B (en) 2019-09-21
US20140235614A1 (en) 2014-08-21

Similar Documents

Publication Publication Date Title
HK1215949A1 (en) Monocyclic pyridine derivative
HK1215795A1 (en) Amatoxin derivatives
LT2953944T (en) Pyridazinone-amides derivatives
HK1211938A1 (en) Novel pyridine derivatives
HK1220454A1 (en) Pyridin-4-yl derivatives -4-
LT3027598T (en) Oxoquinazolinyl-butanamide derivatives
HK1220200A1 (en) Ethynyl derivatives
HUE037606T2 (en) Imidazopyrazinone derivatives
EP2966074A4 (en) Morphinan derivative
EP3009444A4 (en) Alpha-oxoacyl amino-caprolactam derivative