JO3261B1 - مشتق بيريدين أحادي الحلقة - Google Patents

مشتق بيريدين أحادي الحلقة

Info

Publication number
JO3261B1
JO3261B1 JOP/2014/0039A JOP20140039A JO3261B1 JO 3261 B1 JO3261 B1 JO 3261B1 JO P20140039 A JOP20140039 A JO P20140039A JO 3261 B1 JO3261 B1 JO 3261B1
Authority
JO
Jordan
Prior art keywords
group
hydrogen atom
present
alkoxy
pharmaceutically acceptable
Prior art date
Application number
JOP/2014/0039A
Other languages
English (en)
Inventor
Ohashi Isao
Okada Toshimi
Nagao Satoshi
Funasaka Setsuo
Tanaka Keigo
Nakatani Yusuke
Yamane Yoshinobu
Karoji Yuki
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Application granted granted Critical
Publication of JO3261B1 publication Critical patent/JO3261B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بتقديم مركب جديد له نشاط مثبط لـ FGFR أو ملح مقبول صيدلانيا منه، وتركيبة صيدلانية تتضمنه. بصفة خاصة، يقدم الاختراع الحالي مركب ممثل بالصيغة التالية (I) أو ملح مقبول صيدلانيا منه: حيث n تمثل 0 الى 2؛ A تمثل مجموعة أريلين أو مجموعة أريلين غير متجانسة؛ G تمثل رابطة فردية، ذرة أكسجين أو -CH 2 - ؛ E تمثل سيكل غير متجانسة غير عطرية تتضمن نيتروجين؛ R1 تمثل مجموعة ألكوكسي، مجموعة ألكوكسي ألكوكسي أو ما شابه ذلك؛ R2 تمثل ذرة هيدروجين، ذرة هالوجين، مجموعة هيدروكسيل، مجموعة ألكيل، مجموعة هيدروكسي ألكيل، مجموعة سيكليك غير متجانسة غير عطرية تتضمن نيتروجين أو ما شابه ذلك؛ و R3 تمثل ذرة هيدروجين، مجموعة ألكيل، مجموعة ألكوكسي أو ما شابه ذلك، بشرط أنه عندما تكون E تمثل حلقة أزيتيدين و R2 أو تكون R3 موجودة على ذرة نيتروجين على حلقة الأزيتيدين، R2 أو R3 لا تمثل ذرة هيدروجين.
JOP/2014/0039A 2013-02-20 2014-02-18 مشتق بيريدين أحادي الحلقة JO3261B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361766922P 2013-02-20 2013-02-20

Publications (1)

Publication Number Publication Date
JO3261B1 true JO3261B1 (ar) 2018-09-16

Family

ID=51351646

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2014/0039A JO3261B1 (ar) 2013-02-20 2014-02-18 مشتق بيريدين أحادي الحلقة

Country Status (35)

Country Link
US (1) US8933099B2 (ar)
EP (1) EP2960238B1 (ar)
JP (2) JP5600229B1 (ar)
KR (1) KR102050128B1 (ar)
CN (1) CN105073730B (ar)
AR (1) AR094812A1 (ar)
AU (1) AU2014219811B2 (ar)
BR (1) BR112015019790B1 (ar)
CA (1) CA2901585C (ar)
CL (1) CL2015002311A1 (ar)
CY (1) CY1119220T1 (ar)
DK (1) DK2960238T3 (ar)
ES (1) ES2628495T3 (ar)
HR (1) HRP20170873T1 (ar)
HU (1) HUE032931T2 (ar)
IL (1) IL240623B (ar)
JO (1) JO3261B1 (ar)
LT (1) LT2960238T (ar)
ME (1) ME02755B (ar)
MX (1) MX361870B (ar)
MY (1) MY178760A (ar)
NZ (1) NZ711101A (ar)
PE (1) PE20151509A1 (ar)
PH (1) PH12015501813A1 (ar)
PL (1) PL2960238T3 (ar)
PT (1) PT2960238T (ar)
RS (1) RS56064B1 (ar)
RU (1) RU2645352C2 (ar)
SG (1) SG11201506488WA (ar)
SI (1) SI2960238T1 (ar)
SM (1) SMT201700288T1 (ar)
TW (4) TWI672296B (ar)
UA (1) UA116794C2 (ar)
WO (1) WO2014129477A1 (ar)
ZA (1) ZA201505941B (ar)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5925978B1 (ja) * 2014-08-18 2016-05-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 単環ピリジン誘導体の塩およびその結晶
CA2974937C (en) * 2015-03-25 2023-09-05 National Cancer Center Therapeutic agent for bile duct cancer
KR102486722B1 (ko) * 2015-12-17 2023-01-11 에자이 알앤드디 매니지먼트 가부시키가이샤 유방암 치료제
CN107098884A (zh) * 2016-02-19 2017-08-29 中国科学院上海药物研究所 一类取代的氨基吡啶类化合物及其制备和用途
RU2020108284A (ru) * 2017-10-12 2021-11-12 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Фармацевтическая композиция, содержащая селективный ингибитор тирозинкиназы fgfr
US11219619B2 (en) 2018-03-28 2022-01-11 Eisai R&D Management Co., Ltd. Therapeutic agent for hepatocellular carcinoma
JP2022526713A (ja) 2019-03-21 2022-05-26 オンクセオ がんの処置のための、キナーゼ阻害剤と組み合わせたＤｂａｉｔ分子
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
KR20230004595A (ko) * 2020-04-17 2023-01-06 에자이 알앤드디 매니지먼트 가부시키가이샤 유방암 치료제
CA3185174A1 (en) 2020-07-31 2022-02-03 Eisai R&D Management Co., Ltd. Therapeutic agent for breast cancer
WO2022092085A1 (ja) 2020-10-28 2022-05-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍治療用医薬組成物
WO2023032873A1 (ja) 2021-08-31 2023-03-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 単環ピリジン誘導体の製造方法
EP4361139A4 (en) * 2021-08-31 2025-08-20 Eisai R&D Man Co Ltd PROCESS FOR PRODUCING SYNTHETIC INTERMEDIATE OF MONOCYCLIC PYRIDINE DERIVATIVE
EP4495109A4 (en) * 2022-03-18 2025-09-03 Shanghai Runshi Medical Tech Co Ltd SALT OF SUBSTITUTED SIX-MEMBERED AMINO NITRIC HETEROCYCLIC COMPOUND, CRYSTALLINE FORM THEREOF, PREPARATION METHOD THEREOF AND USE THEREOF
WO2025061013A1 (zh) * 2023-09-18 2025-03-27 上海润石医药科技有限公司 包含杂芳基氧基萘类化合物的药物组合物及其制备方法和应用

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10006139A1 (de) * 2000-02-11 2001-08-16 Merck Patent Gmbh Indol-3-yl-Derivate
EP1506962B1 (en) 2000-10-20 2008-07-02 Eisai R&D Management Co., Ltd. Nitrogen-containing aromatic heterocycles
EP1375465A4 (en) 2001-04-03 2006-01-11 Eisai Co Ltd CYCLOOCTANON DERIVATIVE AND CYCLODECANON DERIVATIVE AND THEIR USE
US20030187026A1 (en) * 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
CN100339376C (zh) * 2002-08-30 2007-09-26 卫材R&D管理有限公司 含氮芳环衍生物
US7098332B2 (en) 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
KR20050111636A (ko) 2003-04-10 2005-11-25 에프. 호프만-라 로슈 아게 피리미도 화합물
US20050256154A1 (en) 2004-05-04 2005-11-17 Kin-Chun Luk 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
FR2883286B1 (fr) 2005-03-16 2008-10-03 Sanofi Aventis Sa NOUVEAUX DERIVES D'IMIDAZO[1,5-a]PYRIDINES, INHIBITEURS DE FGFs, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
EP1904480A2 (en) * 2005-05-23 2008-04-02 Novartis Pharma AG Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts
WO2007071752A2 (en) 2005-12-21 2007-06-28 Novartis Ag Pyrimidinyl aryl urea derivatives being fgf inhibitors
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
TW200811134A (en) 2006-07-12 2008-03-01 Irm Llc Compounds and compositions as protein kinase inhibitors
EP1891955A1 (en) 2006-07-24 2008-02-27 Sanofi-Aventis Use of 1,2,3-substituted indolizine derivatives, inhibitors of FGFs, for the preparation of a medicament intended for the treatment of degenerative joint diseases
US7737149B2 (en) 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
US8131527B1 (en) 2006-12-22 2012-03-06 Astex Therapeutics Ltd. FGFR pharmacophore compounds
HRP20150642T1 (hr) 2006-12-22 2015-08-14 Astex Therapeutics Limited BICIKLIÄŚKE HETEROCIKLIÄŚKE TVARI KAO INHIBITORI FGFR-a
JP5442449B2 (ja) 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッド 新規化合物
WO2009001065A1 (en) 2007-06-25 2008-12-31 Qinetiq Limited Preconcentrator device incorporating a polymer of intrinsic microporosity
WO2009019518A1 (en) 2007-08-09 2009-02-12 Astrazeneca Ab Pyrimidine compounds having a fgfr inhibitory effect
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
WO2009056886A1 (en) 2007-11-01 2009-05-07 Astrazeneca Ab Pyrimidine derivatives and their use as modulators of fgfr activity
WO2009076660A2 (en) * 2007-12-13 2009-06-18 Tyratech, Inc. Organic absorbent material and uses thereof
CL2008003675A1 (es) * 2007-12-13 2009-03-20 Wyeth Corp Compuestos derivados de 5-alquil o alquenil 3-cianopiridinas, procedimiento de preparacion, composicion farmaceutica, util para reducir la actividad incrementada de una enzima en un mamifero, en donde dicha enzima es una proteina quinasa, destinado al tratamiento de la inflamacion, asma, colitis, esclerosis multiple, soriasis, artritis reumatoide.
KR101257158B1 (ko) 2008-05-23 2013-04-23 노파르티스 아게 단백질 티로신 키나제 억제제로서의 퀴놀린 및 퀴녹살린의 유도체
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
EA201100030A1 (ru) 2008-06-19 2011-08-30 Астразенека Аб Пиразольные соединения 436
TW201035098A (en) 2008-12-30 2010-10-01 Arqule Inc Substituted imidazolyl-5,6-dihydrobenzo[n] isoquinoline compounds
WO2010078421A1 (en) 2008-12-30 2010-07-08 Arqule, Inc. Substituted 5,6-dihydro-6-phenylbenzo[f] isoquinolin-2-amine compounds
CA2748174A1 (en) 2008-12-30 2010-07-08 Arqule, Inc. Substituted 1h-pyrazolo[3,4-d]pyrimidine-6-amine compounds
US9002427B2 (en) 2009-03-30 2015-04-07 Lifewave Biomedical, Inc. Apparatus and method for continuous noninvasive measurement of respiratory function and events
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
FR2947546B1 (fr) 2009-07-03 2011-07-01 Sanofi Aventis Derives de pyrazoles, leur preparation et leur application en therapeutique
EP2270043A1 (en) 2009-07-03 2011-01-05 Sanofi-Aventis Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor
TWI464160B (zh) 2009-08-07 2014-12-11 Chugai Pharmaceutical Co Ltd Amino pyrazole derivative
US20120220600A1 (en) 2009-10-30 2012-08-30 Reiner Aichholz N-Oxide of 3-(2,6-dichloro-3,5-dimethoxy-phenyl) -1--1-methyl-urea
AR079257A1 (es) 2009-12-07 2012-01-04 Novartis Ag Formas cristalinas de 3-(2,6-dicloro-3-5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
FR2962437B1 (fr) 2010-07-06 2012-08-17 Sanofi Aventis Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
EP2548877A1 (en) * 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
FR2984325A1 (fr) 2011-12-14 2013-06-21 Sanofi Sa Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique
ES2516392T3 (es) 2012-01-19 2014-10-30 Taiho Pharmaceutical Co., Ltd. Compuesto de alquinilbenceno 3,5-disustituido y sal del mismo
AU2013227139B2 (en) 2012-02-28 2017-02-16 Astellas Pharma Inc. Nitrogen-containing aromatic heterocyclic compound
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
UA125503C2 (uk) 2012-06-13 2022-04-13 Інсайт Холдинґс Корпорейшн Заміщені трициклічні сполуки як інгібітори fgfr
RU2679130C2 (ru) 2012-07-11 2019-02-06 Блюпринт Медсинс Корпорейшн Ингибиторы рецептора фактора роста фибробластов
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
WO2014044846A1 (en) 2012-09-24 2014-03-27 Evotec (Uk) Ltd. 3-(aryl- or heteroaryl-amino)-7-(3,5-dimethoxyphenyl)isoquinoline derivatives as fgfr inhibitors useful for the treatment of proliferative disorders or dysplasia
WO2014048878A1 (en) 2012-09-26 2014-04-03 Evotec (Uk) Ltd. Phenyl- or pyridyl- pyrrolo[2,3b]pyrazine derivatives useful in the treatment or prevention of proliferative disorders or dysplasia
KR101942148B1 (ko) 2012-09-27 2019-01-24 추가이 세이야쿠 가부시키가이샤 Ｆｇｆｒ３ 융합 유전자 및 그것을 표적으로 하는 의약
TWI628176B (zh) 2013-04-04 2018-07-01 奧利安公司 蛋白質激酶抑制劑

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EP2960238A4 (en) 2016-08-17
RS56064B1 (sr) 2017-10-31
EP2960238B1 (en) 2017-04-05
CA2901585C (en) 2019-09-24
KR20150118151A (ko) 2015-10-21
TWI641602B (zh) 2018-11-21
JP5600229B1 (ja) 2014-10-01
NZ711101A (en) 2018-08-31
US8933099B2 (en) 2015-01-13
HRP20170873T1 (hr) 2017-09-08
IL240623A0 (en) 2015-10-29
CL2015002311A1 (es) 2016-02-05
AR094812A1 (es) 2015-08-26
BR112015019790A2 (pt) 2017-07-18
SG11201506488WA (en) 2015-09-29
SI2960238T1 (sl) 2017-07-31
ES2628495T3 (es) 2017-08-03
TW201902889A (zh) 2019-01-16
HUE032931T2 (en) 2017-11-28
PL2960238T3 (pl) 2017-09-29
LT2960238T (lt) 2017-07-10
DK2960238T3 (en) 2017-06-26
ME02755B (me) 2018-01-20
AU2014219811A1 (en) 2015-09-03
TWI672296B (zh) 2019-09-21
PH12015501813A1 (en) 2015-12-07
PT2960238T (pt) 2017-06-05
MY178760A (en) 2020-10-20
TW201900168A (zh) 2019-01-01
EP2960238A1 (en) 2015-12-30
WO2014129477A1 (ja) 2014-08-28
AU2014219811B2 (en) 2017-09-28
KR102050128B1 (ko) 2019-11-28
CA2901585A1 (en) 2014-08-28
MX361870B (es) 2018-12-18
CN105073730B (zh) 2017-10-13
IL240623B (en) 2019-03-31
MX2015010698A (es) 2016-04-11
RU2015134558A (ru) 2017-03-24
TWI672140B (zh) 2019-09-21
US20140235614A1 (en) 2014-08-21
UA116794C2 (uk) 2018-05-10
CY1119220T1 (el) 2018-02-14
ZA201505941B (en) 2016-07-27
RU2645352C2 (ru) 2018-02-21
SMT201700288T1 (it) 2017-07-18
TWI672139B (zh) 2019-09-21
CN105073730A (zh) 2015-11-18
PE20151509A1 (es) 2015-10-18
HK1215949A1 (en) 2016-09-30
JP2014237707A (ja) 2014-12-18
TW201439085A (zh) 2014-10-16
JPWO2014129477A1 (ja) 2017-02-02
TW201900169A (zh) 2019-01-01
BR112015019790B1 (pt) 2020-12-01

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