BR112015023280A2 - derivados de dihidroquinolin-2-ona para utilização como inibidores da aldosterona sintase - Google Patents

derivados de dihidroquinolin-2-ona para utilização como inibidores da aldosterona sintase

Info

Publication number
BR112015023280A2
BR112015023280A2 BR112015023280A BR112015023280A BR112015023280A2 BR 112015023280 A2 BR112015023280 A2 BR 112015023280A2 BR 112015023280 A BR112015023280 A BR 112015023280A BR 112015023280 A BR112015023280 A BR 112015023280A BR 112015023280 A2 BR112015023280 A2 BR 112015023280A2
Authority
BR
Brazil
Prior art keywords
dihydroquinolin
derivatives
synthase inhibitors
aldosterone synthase
compounds
Prior art date
Application number
BR112015023280A
Other languages
English (en)
Inventor
V Mayweg Alexander
Hornsperger Benoit
Kuhn Bernd
P Maerki Hans
Aebi Johannes
Amrein Kurt
Tan Xuefei
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015023280A2 publication Critical patent/BR112015023280A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)

Abstract

1/1 resumo derivados de dihidroquinolin-2-ona para utilização como inibidores da aldosterona sintase a invenção proporciona novos compostos que possuem a fórmula geral (i) em que r, r2, r3, r4, r5, r6,1 r7, r9, r10 e r11 são tal como aqui descritos, as composições incluem os compostos e métodos de utilização dos compostos.
BR112015023280A 2013-03-14 2014-03-11 derivados de dihidroquinolin-2-ona para utilização como inibidores da aldosterona sintase BR112015023280A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2013072578 2013-03-14
PCT/EP2014/054642 WO2014139981A1 (en) 2013-03-14 2014-03-11 Dihydroquinoline-2-one derivatives for use as aldosterone synthase inhibitors

Publications (1)

Publication Number Publication Date
BR112015023280A2 true BR112015023280A2 (pt) 2017-07-18

Family

ID=50239647

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015023280A BR112015023280A2 (pt) 2013-03-14 2014-03-11 derivados de dihidroquinolin-2-ona para utilização como inibidores da aldosterona sintase

Country Status (11)

Country Link
US (1) US9593107B2 (pt)
EP (1) EP2970198B1 (pt)
JP (1) JP6117948B2 (pt)
KR (1) KR20150119207A (pt)
BR (1) BR112015023280A2 (pt)
CA (1) CA2898349A1 (pt)
ES (1) ES2822340T3 (pt)
HK (1) HK1211936A1 (pt)
MX (1) MX2015011005A (pt)
RU (1) RU2015138961A (pt)
WO (1) WO2014139981A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6622300B2 (ja) * 2014-10-31 2019-12-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規なジヒドロキノリンピラゾリル化合物
CN106660998B (zh) * 2014-10-31 2019-10-25 豪夫迈·罗氏有限公司 吡唑基-3,4-二氢喹啉-2-酮醛固酮合酶抑制剂
CN106604917B (zh) * 2014-10-31 2020-10-09 豪夫迈·罗氏有限公司 作为醛固酮合酶抑制剂的新型二氢喹啉吡唑基化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008022221A1 (de) * 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
JP6012735B2 (ja) * 2011-09-15 2016-10-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規ジヒドロキノリン−２−オン誘導体
US9353081B2 (en) * 2011-09-23 2016-05-31 Hoffmann-La Roche Inc. Bicyclic dihydroquinoline-2-one derivatives
CN105102445B (zh) 2013-03-08 2018-10-23 豪夫迈·罗氏有限公司 作为醛固酮合酶(cyp11b2或cyp11b1)抑制剂的新二氢喹啉-2-酮衍生物
MX2015010611A (es) * 2013-03-08 2015-12-16 Hoffmann La Roche Nuevos derivados de dihidroquinolin-2-ona como inhibidores de la aldosterona-sintasa (citocromo p450, familia 11, subfamilia b, polipeptido 2 (cyp11b2) o citocromo p450, familia 11, subfamilia b, polipeptido 1 (cyp11b1)).
EP3117585B1 (en) 2014-03-10 2021-10-20 Nokia Solutions and Networks Oy Distribution of popular content between user nodes of a social network community via direct proximity-based communication

Also Published As

Publication number Publication date
US20150376180A1 (en) 2015-12-31
MX2015011005A (es) 2015-10-22
HK1211936A1 (en) 2016-06-03
EP2970198B1 (en) 2020-08-05
ES2822340T3 (es) 2021-04-30
CA2898349A1 (en) 2014-09-18
JP6117948B2 (ja) 2017-04-19
EP2970198A1 (en) 2016-01-20
KR20150119207A (ko) 2015-10-23
WO2014139981A1 (en) 2014-09-18
US9593107B2 (en) 2017-03-14
JP2016510015A (ja) 2016-04-04
RU2015138961A (ru) 2017-04-18

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2505 DE 08-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.