AU2001286996A1 - Stabilized fgf formulations containing reducing agents - Google Patents

Stabilized fgf formulations containing reducing agents

Info

Publication number
AU2001286996A1
AU2001286996A1 AU2001286996A AU8699601A AU2001286996A1 AU 2001286996 A1 AU2001286996 A1 AU 2001286996A1 AU 2001286996 A AU2001286996 A AU 2001286996A AU 8699601 A AU8699601 A AU 8699601A AU 2001286996 A1 AU2001286996 A1 AU 2001286996A1
Authority
AU
Australia
Prior art keywords
reducing agents
formulations containing
containing reducing
stabilized fgf
fgf formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001286996A
Inventor
Kamaljit K. Bajwa
Robert V. Hageman
Bret A. Shirley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of AU2001286996A1 publication Critical patent/AU2001286996A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
AU2001286996A 2000-08-31 2001-08-31 Stabilized fgf formulations containing reducing agents Abandoned AU2001286996A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22923800P 2000-08-31 2000-08-31
US60/229,238 2000-08-31
PCT/US2001/027209 WO2002017956A2 (en) 2000-08-31 2001-08-31 Stabilized fgf formulations containing reducing agents

Publications (1)

Publication Number Publication Date
AU2001286996A1 true AU2001286996A1 (en) 2002-03-13

Family

ID=22860362

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001286996A Abandoned AU2001286996A1 (en) 2000-08-31 2001-08-31 Stabilized fgf formulations containing reducing agents

Country Status (3)

Country Link
US (1) US7754686B2 (en)
AU (1) AU2001286996A1 (en)
WO (1) WO2002017956A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2046361A4 (en) * 2006-07-26 2011-06-29 Univ California Osteogenic enhancer composition
GB0710529D0 (en) * 2007-06-01 2007-07-11 Circassia Ltd Vaccine
ATE482721T1 (en) * 2007-08-15 2010-10-15 Circassia Ltd PEPTIDES FOR DESENSITIZATION TO ALLERGENS
JP2011506565A (en) * 2007-12-21 2011-03-03 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム vaccine
GB0821806D0 (en) 2008-11-28 2009-01-07 Circassia Ltd Compositions with reduced dimer formation
EP4202040A1 (en) 2010-07-01 2023-06-28 Regenerative Research Foundation Methods for culturing undifferentiated cells using sustained release compositions
TWI527590B (en) * 2011-06-17 2016-04-01 艾瑞斯貿易公司 Freeze-dried formulations of fgf-18
ES2824479T3 (en) 2015-11-27 2021-05-12 Univ Masarykova Thermostable FGF2 polypeptide, use thereof
EP4183796A1 (en) 2021-11-19 2023-05-24 Enantis s.r.o. Thermostable fgf10 polypeptide or fragment thereof use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4100150A (en) 1975-11-04 1978-07-11 G. D. Searle & Co. Stabilization of interferon against mechanical stress using thioctic acid
US4992271A (en) 1982-09-23 1991-02-12 Cetus Corporation Formulation for lipophilic IL-2 proteins
US4889919A (en) 1986-08-13 1989-12-26 Zymogenetics, Inc. Biologically active PDGF derived A-chain homodimers
US5474982A (en) 1986-08-13 1995-12-12 Zymogenetics, Inc. PDGF analogs and methods of use
US5037644A (en) 1986-10-27 1991-08-06 Cetus Corporation Pharmaceutical compositions of recombinant interleukin-2 and formulation processes
AU614137B2 (en) 1988-06-06 1991-08-22 Takeda Chemical Industries Ltd. Stabilized fgf composition and production thereof
US5175147A (en) 1988-08-19 1992-12-29 Takeda Chemical Industries, Ltd Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
US5217954A (en) 1990-04-04 1993-06-08 Scios Nova Inc. Formulations for stabilizing fibroblast growth factor
GB9015824D0 (en) 1990-07-18 1990-09-05 Erba Carlo Spa Stable pharmaceutical compositions containing a fibroblast growth factor
US5714458A (en) 1990-07-18 1998-02-03 Farmitalia Carlo Erba S.R.L. Stable pharmaceutical compositions containing a fibroblast growth factor
AU8532691A (en) 1990-08-01 1992-03-02 Chiron Ophthalmics Inc. Method for treating corneal endothelial wounds
US5348941A (en) 1992-04-01 1994-09-20 Merck & Co., Inc. Stabilizers for fibroblast growth factors
JP3552240B2 (en) 1993-02-23 2004-08-11 第一製薬株式会社 High concentration TCF preparation
GB9319104D0 (en) 1993-09-15 1993-11-03 Unilever Plc Skin care method & composition
US6165981A (en) * 1995-03-07 2000-12-26 Dade Behring Inc. Stabilizing solutions for proteins and peptides
AU6411199A (en) 1998-10-13 2000-05-01 Chiron Corporation Angiogenically effective unit dose of fgf and method of administering

Also Published As

Publication number Publication date
WO2002017956A2 (en) 2002-03-07
US20080293624A1 (en) 2008-11-27
WO2002017956A3 (en) 2003-09-12
US7754686B2 (en) 2010-07-13

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