CL2011000296A1 - Proceso de preparación del ester metílico del ácido 4-oxo-octahidro-indol-1-carboxílico y compuestos intermediarios utilizados. - Google Patents

Proceso de preparación del ester metílico del ácido 4-oxo-octahidro-indol-1-carboxílico y compuestos intermediarios utilizados.

Info

Publication number
CL2011000296A1
CL2011000296A1 CL2011000296A CL2011000296A CL2011000296A1 CL 2011000296 A1 CL2011000296 A1 CL 2011000296A1 CL 2011000296 A CL2011000296 A CL 2011000296A CL 2011000296 A CL2011000296 A CL 2011000296A CL 2011000296 A1 CL2011000296 A1 CL 2011000296A1
Authority
CL
Chile
Prior art keywords
octahydro
indole
oxo
carboxylic acid
methyl ester
Prior art date
Application number
CL2011000296A
Other languages
English (en)
Inventor
Gottfried Sedelmeier
Murat Acemoglu
Philipp Lustenberger
Ernst Kuesters
Beast Schmidt
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US8815608P priority Critical
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2011000296A1 publication Critical patent/CL2011000296A1/es
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41278189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011000296(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D203/00Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Abstract

Proceso para la producción de un compuesto derivado de éster metílico del ácido 4-oxo-octahidro-indol-1-carboxílico; compuestos intermediarios y procesos para prepararlos.
CL2011000296A 2008-08-12 2011-02-11 Proceso de preparación del ester metílico del ácido 4-oxo-octahidro-indol-1-carboxílico y compuestos intermediarios utilizados. CL2011000296A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US8815608P true 2008-08-12 2008-08-12

Publications (1)

Publication Number Publication Date
CL2011000296A1 true CL2011000296A1 (es) 2011-11-04

Family

ID=41278189

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011000296A CL2011000296A1 (es) 2008-08-12 2011-02-11 Proceso de preparación del ester metílico del ácido 4-oxo-octahidro-indol-1-carboxílico y compuestos intermediarios utilizados.

Country Status (22)

Country Link
US (1) US8084487B2 (es)
EP (1) EP2315748B1 (es)
JP (1) JP5468608B2 (es)
KR (1) KR101673634B1 (es)
CN (1) CN102119151A (es)
AU (1) AU2009281218B2 (es)
BR (1) BRPI0917492A8 (es)
CA (1) CA2732095C (es)
CL (1) CL2011000296A1 (es)
CO (1) CO6341608A2 (es)
EC (1) ECSP11010883A (es)
ES (1) ES2547269T3 (es)
HK (1) HK1155733A1 (es)
IL (1) IL210835A (es)
MA (1) MA32618B1 (es)
MX (1) MX2011001664A (es)
MY (1) MY151183A (es)
NZ (1) NZ590753A (es)
PE (1) PE20110415A1 (es)
RU (1) RU2513856C2 (es)
WO (1) WO2010018154A1 (es)
ZA (1) ZA201100558B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130274294A1 (en) * 2010-12-20 2013-10-17 David Carcache 4-(Hetero)Aryl-Ethynyl-Octahydro-Indole-1-Esters
WO2012101058A1 (en) 2011-01-24 2012-08-02 Novartis Ag 4-tolyl-ethynyl-octahydro-indole-1-ester derivatives
EP2650284A1 (en) 2012-04-10 2013-10-16 Merz Pharma GmbH & Co. KGaA Heterocyclic derivatives as metabotropic glutamate receptor modulators
CA3067688A1 (en) 2017-07-31 2019-02-07 Novartis Ag Use of mavoglurant in the reduction of alcohol use or in preventing relapse into alcohol use
KR20200035035A (ko) 2017-07-31 2020-04-01 노파르티스 아게 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도
WO2020157640A1 (en) 2019-01-29 2020-08-06 Novartis Ag The use of an mglur5 antagonist for treating opioid analgesic tolerance
WO2022013809A2 (en) 2020-07-17 2022-01-20 Novartis Ag USE OF mGluR5 ANTAGONISTS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0128996D0 (en) * 2001-12-04 2002-01-23 Novartis Ag Organic compounds
GB0514296D0 (en) * 2005-07-12 2005-08-17 Novartis Ag Organic compounds
AU2007296964B2 (en) * 2006-09-11 2012-05-31 Novartis Ag Nicotinic acid derivatives as modulators of metabotropic glutanate receptors
NZ584856A (en) * 2007-10-12 2012-12-21 Novartis Ag Metabotropic glutamate receptor modulators for the treatment of parkinson's disease
EP2320892A2 (en) * 2008-06-30 2011-05-18 Novartis AG Combination products

Also Published As

Publication number Publication date
WO2010018154A1 (en) 2010-02-18
MA32618B1 (fr) 2011-09-01
RU2011108663A (ru) 2012-09-20
EP2315748B1 (en) 2015-06-24
AU2009281218B2 (en) 2013-05-16
AU2009281218A1 (en) 2010-02-18
CO6341608A2 (es) 2011-11-21
KR20110042222A (ko) 2011-04-25
HK1155733A1 (en) 2012-05-25
IL210835D0 (en) 2011-04-28
BRPI0917492A2 (pt) 2015-08-04
MY151183A (en) 2014-04-30
CA2732095C (en) 2017-04-25
US8084487B2 (en) 2011-12-27
JP2011530566A (ja) 2011-12-22
ZA201100558B (en) 2011-10-26
PE20110415A1 (es) 2011-07-04
CA2732095A1 (en) 2010-02-18
CN102119151A (zh) 2011-07-06
EP2315748A1 (en) 2011-05-04
BRPI0917492A8 (pt) 2016-07-05
ECSP11010883A (es) 2011-04-29
MX2011001664A (es) 2011-03-25
US20110144352A1 (en) 2011-06-16
IL210835A (en) 2016-05-31
KR101673634B1 (ko) 2016-11-07
NZ590753A (en) 2012-06-29
JP5468608B2 (ja) 2014-04-09
ES2547269T3 (es) 2015-10-05
RU2513856C2 (ru) 2014-04-20

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