ES8506301A1 - Un procedimiento para preparar 2-alcoxi-5-(piridinil) piridinas - Google Patents

Un procedimiento para preparar 2-alcoxi-5-(piridinil) piridinas

Info

Publication number
ES8506301A1
ES8506301A1 ES527108A ES527108A ES8506301A1 ES 8506301 A1 ES8506301 A1 ES 8506301A1 ES 527108 A ES527108 A ES 527108A ES 527108 A ES527108 A ES 527108A ES 8506301 A1 ES8506301 A1 ES 8506301A1
Authority
ES
Spain
Prior art keywords
preparation
composition containing
pyridine derivatives
hydrogen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527108A
Other languages
English (en)
Other versions
ES527108A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES8506301A1 publication Critical patent/ES8506301A1/es
Publication of ES527108A0 publication Critical patent/ES527108A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 2-ALCOXI-5-(PIRIDINIL)PIRIDINAS, DE FORMULA (I), EN LA QUE R1 ES METILO O ETILO; R ES HIDROGENO O ALQUILO INFERIOR; Q ES HIDROGENO, BROMO O CLORO; Y PI ES 4 O 3-PIRIDINILO, Y SUS SALES ACIDAS DE ADICION FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN CALENTAR 2-BROMO O CLORO-3-Q-5-PI-6-R-PIRIDINA CON UN METOXIDO O UN ETOXIDO ALCALINO-METALICO.DE APLICACION EN LA PREPARACION DE COMPOSICIONES CARDIOTONICAS CAPACES DE AUMENTAR LA CONTRACTICILIDAD CARDIACA.
ES527108A 1982-11-10 1983-11-08 Un procedimiento para preparar 2-alcoxi-5-(piridinil) piridinas Granted ES527108A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/440,505 US4463008A (en) 1982-11-10 1982-11-10 2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof

Publications (2)

Publication Number Publication Date
ES8506301A1 true ES8506301A1 (es) 1985-07-01
ES527108A0 ES527108A0 (es) 1985-07-01

Family

ID=23749024

Family Applications (1)

Application Number Title Priority Date Filing Date
ES527108A Granted ES527108A0 (es) 1982-11-10 1983-11-08 Un procedimiento para preparar 2-alcoxi-5-(piridinil) piridinas

Country Status (16)

Country Link
US (1) US4463008A (es)
EP (1) EP0109027A1 (es)
JP (1) JPS59101466A (es)
KR (1) KR840006642A (es)
AU (1) AU2102683A (es)
CA (1) CA1198113A (es)
DK (1) DK512283A (es)
ES (1) ES527108A0 (es)
FI (1) FI834084A (es)
GR (1) GR79718B (es)
IL (1) IL70084A0 (es)
NO (1) NO834084L (es)
NZ (1) NZ206136A (es)
PH (1) PH19458A (es)
PT (1) PT77633B (es)
ZA (1) ZA838143B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0200024B1 (de) 1985-04-30 1992-07-01 ARZNEIMITTELWERK DRESDEN GmbH 3-Cyan-pyridine, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
DD298781A5 (de) * 1990-03-09 1992-03-12 Inst Wirkstofforschung Verfahren zur herstellung von 5,4'-bipyridin-1'-oxiden
WO2009081872A1 (ja) * 2007-12-21 2009-07-02 Kuraray Co., Ltd. ６－ハロゲノ－３－アリールピリジン誘導体の製造方法
US11958832B1 (en) 2023-10-12 2024-04-16 King Faisal University 2-alkoxy[4,3:6,3-terpyridine]-3-carbonitriles as antimicrobial compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655679A (en) * 1969-06-25 1972-04-11 Merck & Co Inc Certain aryl pyridine carboxylic acid derivatives
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones
US4225601A (en) * 1979-09-10 1980-09-30 Sterling Drug Inc. 3-Hydroxy or hydroxymethyl-5-(4-pyridinyl)2(1H)-pyridinones, useful as cardiotonic agents and their preparation
US4313951A (en) * 1979-11-26 1982-02-02 Sterling Drug Inc. 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor
US4297360A (en) * 1980-03-28 1981-10-27 Sterling Drug Inc. 5-(Pyridinyl)pyridine-2,3-diamines, preparation thereof and their cardiotonic use
US4347363A (en) * 1981-09-17 1982-08-31 Sterling Drug Inc. Process for preparing 1,2-dihydro-6-methyl-2-oxo-5-(pyridinyl)nicotinonitriles

Also Published As

Publication number Publication date
US4463008A (en) 1984-07-31
PT77633B (en) 1986-03-19
PH19458A (en) 1986-04-18
GR79718B (es) 1984-10-31
DK512283A (da) 1984-05-11
FI834084A0 (fi) 1983-11-08
FI834084A (fi) 1984-05-11
NZ206136A (en) 1986-03-14
CA1198113A (en) 1985-12-17
JPS59101466A (ja) 1984-06-12
AU2102683A (en) 1984-05-17
KR840006642A (ko) 1984-12-01
EP0109027A1 (en) 1984-05-23
PT77633A (en) 1983-12-01
ES527108A0 (es) 1985-07-01
IL70084A0 (en) 1984-01-31
DK512283D0 (da) 1983-11-09
ZA838143B (en) 1984-06-27
NO834084L (no) 1984-05-11

Similar Documents

Publication Publication Date Title
AU560028B2 (en) Pyridine-n-oxide derivatives
CA1251209A (en) DISHYDROPYRIDAZINONE DERIVATIVES
ES8607934A1 (es) Procedimiento para preparar nuevos compuestos de 3-piridilo
AU551066B2 (en) Pyridyl substituted pyridylalkyleneamino pyrimidones
MY102475A (en) 2 (1h)-pyridin-ones useful as intermediates.
ES8506301A1 (es) Un procedimiento para preparar 2-alcoxi-5-(piridinil) piridinas
ES8604520A1 (es) Procedimiento para preparar derivados de 2(1h)-piridona
ES8303398A1 (es) Un procedimiento para la preparacion de un derivado de 2-piridincarboxamida.
ES8603458A1 (es) Un procedimiento para preparar una 3-r1-4-r2-5-q-6-r-2(1h)-piridinona
IE780982L (en) 4-hydroxythiazoline-2-thiones.
JPS5344587A (en) Novel urazol derivatives and herbicide containing the same
ES446325A1 (es) Procedimiento para preparar tieno-(3,2-c)-piridina y deriva-dos de la misma.
JPS51138670A (en) Process for preparing phthalimide derivatives
IE802682L (en) Oxazoline derivatives
JPS56120686A (en) Tetrahydrothiopyrano 3,2-b indole derivative
JPS53144585A (en) Novel uracil derivative and process for its preparation
JPS55147279A (en) Preparation of 2,3-dipyridylquinazolinone derivative
JPS5242888A (en) Preparation of quinazoline derivatives
JPS5515455A (en) 2-substituted-methyl-1,4-benzodioxane
JPS5283850A (en) Heterocyclic compounds
JPS5359673A (en) Pyridine derivatives and anticocciciosis agents containig the same as anactive constituent
JPS53101328A (en) Succinic acid anhydride derivatives and process for their preparation
JPS5384991A (en) Novel nitrogen-containing heterocyclic compound and its preparation
JPS5398977A (en) 5-fluorouracil derivatives and process for their preparation
JPS525778A (en) N-substituted-1-oxo-1,2,3,4-tetrahydro-isoqvinoline derivatives