ES8801895A1 - Procedimiento para la obtencion de benzamidas - Google Patents

Procedimiento para la obtencion de benzamidas

Info

Publication number
ES8801895A1
ES8801895A1 ES557540A ES557540A ES8801895A1 ES 8801895 A1 ES8801895 A1 ES 8801895A1 ES 557540 A ES557540 A ES 557540A ES 557540 A ES557540 A ES 557540A ES 8801895 A1 ES8801895 A1 ES 8801895A1
Authority
ES
Spain
Prior art keywords
benzamides
salts
lower alkoxy
cycloalkoxy
alkenyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557540A
Other languages
English (en)
Other versions
ES557540A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8801895A1 publication Critical patent/ES8801895A1/es
Publication of ES557540A0 publication Critical patent/ES557540A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE BENZAMIDAS. BENZAMIDAS (I) DONDE R1 Y R2 SON ALQUILO INFERIOR, R3 ES ALCOXI INFERIOR U OTROS, R4 ES HALOGENO Y R5 ES CIANO Y SUS SALES, SE PREPARAN POR CALENTAMIENTO, CON CIANURO CUPROSO-I, DE UN COMPUESTO (II) CONDE X5 ES HALOGENO. TIENEN EFECTOS QUE INDICAN BLOQUEO DE LOS RECEPTORES DE DOPAMINA (DA), SIN QUE SE APRECIEN EFECTOS SECUNDARIOS EXTRAPIRIMIDALES, POR LO QUE SE PUEDEN EMPLEAR COMO ANTIDEPRESIVOS ESTIMULADORES DOPAMINERGICOS Y COMO TERAPEUTICO NEUROLEPTICO EN EL TRATAMIENTO DE LA ESQUIZOFRENIA Y ESTADOS DEPRESIVOS.
ES557540A 1984-11-23 1987-05-14 Procedimiento para la obtencion de benzamidas Expired ES8801895A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH560884 1984-11-23
CH236385 1985-06-04

Publications (2)

Publication Number Publication Date
ES8801895A1 true ES8801895A1 (es) 1988-03-01
ES557540A0 ES557540A0 (es) 1988-03-01

Family

ID=25690263

Family Applications (3)

Application Number Title Priority Date Filing Date
ES549154A Expired ES8707923A1 (es) 1984-11-23 1985-11-21 Procedimiento para la obtencion de benzamidas
ES557539A Expired ES8802489A1 (es) 1984-11-23 1987-05-14 Procedimiento para la obtencion de benzamidas
ES557540A Expired ES8801895A1 (es) 1984-11-23 1987-05-14 Procedimiento para la obtencion de benzamidas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES549154A Expired ES8707923A1 (es) 1984-11-23 1985-11-21 Procedimiento para la obtencion de benzamidas
ES557539A Expired ES8802489A1 (es) 1984-11-23 1987-05-14 Procedimiento para la obtencion de benzamidas

Country Status (20)

Country Link
US (1) US4772630A (es)
EP (1) EP0183190B1 (es)
KR (1) KR900008133B1 (es)
AU (1) AU589921B2 (es)
CA (1) CA1330347C (es)
DE (1) DE3567016D1 (es)
DK (1) DK541085A (es)
ES (3) ES8707923A1 (es)
FI (1) FI86846C (es)
GR (1) GR852814B (es)
HK (1) HK103091A (es)
HU (1) HU196054B (es)
IE (1) IE58166B1 (es)
IL (1) IL77105A (es)
MX (1) MX9203367A (es)
NO (1) NO170012C (es)
NZ (1) NZ214284A (es)
PH (1) PH22807A (es)
PT (1) PT81534B (es)
SG (1) SG83691G (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772630A (en) * 1984-11-23 1988-09-20 Ciba-Geigy Corp. Benzamides and their salts
JP3933244B2 (ja) * 1997-04-04 2007-06-20 株式会社資生堂 アルキレンジアミン誘導体及び抗潰瘍剤、抗菌剤
TW402591B (en) 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
WO2013175316A2 (en) 2012-05-25 2013-11-28 Rhenovia Pharma Treatment for huntington's disease
WO2014155184A1 (en) 2013-03-28 2014-10-02 Rhenovia Pharma Treatment for parkinson's disease
US11377421B2 (en) 2016-11-28 2022-07-05 Lb Pharmaceuticals Inc. Psychotropic agents and uses thereof
US10259786B2 (en) * 2016-11-28 2019-04-16 Lb Pharmaceuticals Inc. Psychotropic agents and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1525M (fr) * 1961-07-25 1962-11-16 Ile De France Médicaments antiémétiques nouveaux.
NL281394A (es) * 1961-07-25
FR85707E (fr) * 1964-02-07 1965-10-01 Ile De France Nouveaux benzamides substitués et leur procédé de préparation
CH653670A5 (de) * 1983-03-03 1986-01-15 Hoffmann La Roche Benzamid-derivate.
DK159420C (da) * 1983-03-09 1991-03-11 Ciba Geigy Ag N-(piperidinyl-alkyl)-carboxamider og salte deraf, farmaceutiske praeparater indeholdende disse forbindelser samt anvendelsen af forbindelserne til fremstilling af antipsykotiske farmaceutiske praeparater
US4808624A (en) * 1984-06-28 1989-02-28 Bristol-Myers Company Pharmacologically active substituted benzamides
US4772630A (en) * 1984-11-23 1988-09-20 Ciba-Geigy Corp. Benzamides and their salts

Also Published As

Publication number Publication date
DE3567016D1 (en) 1989-02-02
PT81534A (en) 1985-12-01
ES8802489A1 (es) 1988-07-01
AU589921B2 (en) 1989-10-26
ES8707923A1 (es) 1987-09-01
CA1330347C (en) 1994-06-21
ES549154A0 (es) 1987-09-01
FI86846C (fi) 1992-10-26
IL77105A (en) 1990-08-31
NO170012B (no) 1992-05-25
PH22807A (en) 1988-12-27
HUT38898A (en) 1986-07-28
KR900008133B1 (ko) 1990-10-31
GR852814B (es) 1986-03-21
SG83691G (en) 1991-11-22
DK541085A (da) 1986-05-24
AU5035285A (en) 1986-05-29
IE852939L (en) 1986-05-23
DK541085D0 (da) 1985-11-22
NZ214284A (en) 1989-07-27
KR860004012A (ko) 1986-06-16
PT81534B (pt) 1988-03-03
IL77105A0 (en) 1986-04-29
FI854588A (fi) 1986-05-24
HK103091A (en) 1991-12-27
ES557539A0 (es) 1988-07-01
HU196054B (en) 1988-09-28
EP0183190B1 (de) 1988-12-28
US4772630A (en) 1988-09-20
ES557540A0 (es) 1988-03-01
NO854685L (no) 1986-05-26
NO170012C (no) 1992-09-02
FI86846B (fi) 1992-07-15
EP0183190A1 (de) 1986-06-04
MX9203367A (es) 1992-09-01
IE58166B1 (en) 1993-07-28
FI854588A0 (fi) 1985-11-20

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20011110