ES8604146A1 - Procedimiento de preparacion de nuevos derivados de piperidina y sus sales de adicion acidas y amonicas cuaternarias - Google Patents
Procedimiento de preparacion de nuevos derivados de piperidina y sus sales de adicion acidas y amonicas cuaternariasInfo
- Publication number
- ES8604146A1 ES8604146A1 ES528455A ES528455A ES8604146A1 ES 8604146 A1 ES8604146 A1 ES 8604146A1 ES 528455 A ES528455 A ES 528455A ES 528455 A ES528455 A ES 528455A ES 8604146 A1 ES8604146 A1 ES 8604146A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- piperidine derivatives
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS 1-ETILBENZOL CON UN GRUPO PIPERIDINOPROPANOLICO SUSTITUIDO Y DE SUS SALES DE ADICION ACIDAS Y AMONICAS CUATERNARIAS, DE FORMULA (I), EN LA QUE R2 REPRESENTA ALQUILO DE 1 A 4 ATOMOS DE CARBONO Y R1 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UNA PROPIOFENONA DE FORMULA (II) CON UN COMPUESTO ORGANOMETALICO DE FORMULA (III), EN LAS QUE R1 Y R2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), Y M ES UN METAL ALCALINO O UN GRUPO MGX, DONDE X ES UN ATOMO DE HALOGENO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE ANHIDRO, A UNA TEMPERATURA COMPRENDIDA ENTRE C60JC Y EL PUNTO DE EBULLICION DEL DISOLVENTE ELEGIDO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA INHIBIR O REDUCIR EL EFECTO TOXICO DE SUSTANCIAS XENOBIOTICAS EXOGENAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU824185A HU186655B (en) | 1982-12-28 | 1982-12-28 | Process for producing new piperidine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8604146A1 true ES8604146A1 (es) | 1986-01-16 |
ES528455A0 ES528455A0 (es) | 1986-01-16 |
Family
ID=10967246
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES528455A Expired ES8604146A1 (es) | 1982-12-28 | 1983-12-27 | Procedimiento de preparacion de nuevos derivados de piperidina y sus sales de adicion acidas y amonicas cuaternarias |
ES543793A Expired ES8603827A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y sus sa- les de adicion acidas y amonicas cuaternarias |
ES543791A Expired ES8603825A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y sus sa- les de adicion acidas y amonicas cuaternarias |
ES543794A Granted ES543794A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias |
ES543792A Granted ES543792A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES543793A Expired ES8603827A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y sus sa- les de adicion acidas y amonicas cuaternarias |
ES543791A Expired ES8603825A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y sus sa- les de adicion acidas y amonicas cuaternarias |
ES543794A Granted ES543794A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias |
ES543792A Granted ES543792A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias |
Country Status (14)
Country | Link |
---|---|
US (1) | US4551465A (es) |
EP (1) | EP0115700B1 (es) |
JP (1) | JPS59130867A (es) |
AT (1) | ATE28632T1 (es) |
AU (1) | AU562024B2 (es) |
CA (1) | CA1216293A (es) |
DE (1) | DE3372757D1 (es) |
DK (1) | DK158730C (es) |
ES (5) | ES8604146A1 (es) |
FI (1) | FI78906C (es) |
GR (1) | GR79153B (es) |
HU (1) | HU186655B (es) |
IL (1) | IL70553A (es) |
ZA (1) | ZA839611B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU187205B (en) * | 1982-12-28 | 1985-11-28 | Richter Gedeon Vegyeszet | Process for preparing new derivatives of amni-ethoxy-benzyl-alcohol and salts thereof further pharmaceutical compositions containing such compounds |
FR2603583B1 (fr) * | 1986-09-05 | 1988-12-09 | Andre Buzas | Derives de la benzhydryloxyethyl-piperidine, procede d'obtention et compositions pharmaceutiques les contenant |
US5585492A (en) * | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
US6506876B1 (en) * | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
EP1717235A3 (en) * | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands |
WO2023106973A1 (ru) * | 2021-12-10 | 2023-06-15 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Новые гепатопротекторные средства |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA633816A (en) * | 1962-01-02 | Richardson-Merrell Inc. | Substituted triphenylethanols | |
US3075014A (en) * | 1960-06-14 | 1963-01-22 | Richardson Merrell Inc | Basic substituted alkoxy diphenylalkanols, diphenylalkenes and diphenylalkanes |
US3272841A (en) * | 1964-03-23 | 1966-09-13 | Parke Davis & Co | Alpha-(aminoalkoxyphenyl)-alpha'-nitrostilbene compounds |
CH474515A (de) * | 1966-06-24 | 1969-06-30 | Hoffmann La Roche | Verfahren zur Herstellung von aromatischen Äthern |
US3647863A (en) * | 1968-11-25 | 1972-03-07 | Richardson Merrell Inc | Aminoalkoxy-triphenyl ethylenes and the salts thereof |
US4094908A (en) * | 1973-08-15 | 1978-06-13 | Richter Gedeon Vegyeszeti Gyar Rt. | Alpha-substituted benzhydrol derivatives |
HU168432B (es) * | 1973-08-15 | 1976-04-28 |
-
1982
- 1982-12-28 HU HU824185A patent/HU186655B/hu not_active IP Right Cessation
-
1983
- 1983-12-23 CA CA000444205A patent/CA1216293A/en not_active Expired
- 1983-12-23 AU AU22908/83A patent/AU562024B2/en not_active Ceased
- 1983-12-23 AT AT83307964T patent/ATE28632T1/de not_active IP Right Cessation
- 1983-12-23 DE DE8383307964T patent/DE3372757D1/de not_active Expired
- 1983-12-23 EP EP83307964A patent/EP0115700B1/en not_active Expired
- 1983-12-27 JP JP58244945A patent/JPS59130867A/ja active Granted
- 1983-12-27 US US06/565,902 patent/US4551465A/en not_active Expired - Fee Related
- 1983-12-27 ZA ZA839611A patent/ZA839611B/xx unknown
- 1983-12-27 DK DK601383A patent/DK158730C/da not_active IP Right Cessation
- 1983-12-27 ES ES528455A patent/ES8604146A1/es not_active Expired
- 1983-12-27 IL IL70553A patent/IL70553A/xx unknown
- 1983-12-27 FI FI834793A patent/FI78906C/fi not_active IP Right Cessation
- 1983-12-28 GR GR73367A patent/GR79153B/el unknown
-
1985
- 1985-06-01 ES ES543793A patent/ES8603827A1/es not_active Expired
- 1985-06-01 ES ES543791A patent/ES8603825A1/es not_active Expired
- 1985-06-01 ES ES543794A patent/ES543794A0/es active Granted
- 1985-06-01 ES ES543792A patent/ES543792A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
DK601383A (da) | 1984-06-29 |
ZA839611B (en) | 1985-02-27 |
AU2290883A (en) | 1984-07-05 |
ES8603828A1 (es) | 1986-01-01 |
AU562024B2 (en) | 1987-05-28 |
EP0115700A3 (en) | 1984-11-21 |
FI834793A0 (fi) | 1983-12-27 |
DE3372757D1 (en) | 1987-09-03 |
ES528455A0 (es) | 1986-01-16 |
EP0115700B1 (en) | 1987-07-29 |
ES543791A0 (es) | 1986-01-01 |
US4551465A (en) | 1985-11-05 |
ES543793A0 (es) | 1986-01-01 |
DK158730C (da) | 1990-11-19 |
FI78906C (fi) | 1989-10-10 |
CA1216293A (en) | 1987-01-06 |
GR79153B (es) | 1984-10-20 |
ES8603827A1 (es) | 1986-01-01 |
DK158730B (da) | 1990-07-09 |
JPS59130867A (ja) | 1984-07-27 |
IL70553A0 (en) | 1984-03-30 |
IL70553A (en) | 1986-12-31 |
FI834793A (fi) | 1984-06-29 |
EP0115700A2 (en) | 1984-08-15 |
ATE28632T1 (de) | 1987-08-15 |
ES8603826A1 (es) | 1986-01-01 |
ES543794A0 (es) | 1986-01-01 |
FI78906B (fi) | 1989-06-30 |
DK601383D0 (da) | 1983-12-27 |
ES543792A0 (es) | 1986-01-01 |
ES8603825A1 (es) | 1986-01-01 |
HU186655B (en) | 1985-09-30 |
JPH0257065B2 (es) | 1990-12-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL57577A0 (en) | 1,2-dihydroquinolin-2-one derivatives,process for their preparation and pharmaceutical compositions containing the same | |
ES8500264A1 (es) | Procedimiento para la fabricacion de 4-(3-trifluorometilfenil)-1,2,3,6-tetrahidropiridinas | |
ES8407471A1 (es) | Procedimiento para preparar derivados de prolina disustituidos | |
PT75074B (en) | Process for preparing certain pyrimidone derivatives and compositions containing them | |
DK153545C (da) | Analogifremgangsmaade til fremstilling af n-substituerede derivater af 3,4,5-trihydroxy-2-hydroxymethyl-piperidin | |
ES2000481A6 (es) | Procecimiento de preparacion de nuevos derivados del dihidro-2,3 benzofurano | |
ES8604146A1 (es) | Procedimiento de preparacion de nuevos derivados de piperidina y sus sales de adicion acidas y amonicas cuaternarias | |
ES8603834A1 (es) | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternarias | |
ATE37533T1 (de) | Derivate der 4-phenyl-4-oxo-buten-2-saeure, verfahren zu ihrer herstellung, medikamente und mischungen mit diesen derivaten. | |
CS402491A3 (en) | Heterocyclic amino compounds, process for their preparation andpharmaceutical compositions containing thereof | |
ES2004467A6 (es) | Procedimiento de preparacion de nuevos derivados de 1,4 dihidro-piridina | |
ES8802489A1 (es) | Procedimiento para la obtencion de benzamidas | |
ES464013A1 (es) | Procedimiento para preparar derivados sustituidos de orto- fenilendiamina. | |
ES8103081A1 (es) | Procedimiento para la obtencion de diazatriciclos | |
ES8203843A1 (es) | Procedimiento para la obtencion de amidas de acido 1,4-dihi-dropiridin-4-carboxilico | |
IL75285A (en) | 4-acyl resorcinol ethers,method for their preparation and pharmaceutical compositions containing them | |
ZA881384B (en) | Acetamides derived from 2,3-dihydro-3-phenyl-2-benzofuranone,processes for preparing them and the pharmaceutical compositions which contain them | |
ES8601141A1 (es) | Un procedimiento para la produccion de derivados de isoquinolina sustituidos | |
ES439180A1 (es) | Procedimiento para la preparacion de derivados de piperido- na. | |
ES8506310A1 (es) | N-oxidos de derivados aminociclicos | |
ES8600271A1 (es) | Procedimiento para la obtencion de derivados de benzodioxol | |
ES8800666A1 (es) | Procedimiento para la obtencion de derivados de 1,4-dihidropiridina |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970401 |