ES8603828A1 - Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias - Google Patents

Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias

Info

Publication number
ES8603828A1
ES8603828A1 ES543794A ES543794A ES8603828A1 ES 8603828 A1 ES8603828 A1 ES 8603828A1 ES 543794 A ES543794 A ES 543794A ES 543794 A ES543794 A ES 543794A ES 8603828 A1 ES8603828 A1 ES 8603828A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
piperidine derivatives
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543794A
Other languages
English (en)
Other versions
ES543794A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES8603828A1 publication Critical patent/ES8603828A1/es
Publication of ES543794A0 publication Critical patent/ES543794A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS A-ETILBENZOL CON UN GRUPO PIPERIDINOPROPANOLICO SUSTITUIDO Y SUS SALES DE ADICION ACIDAS Y AMONICAS CUATERNARIAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA (III) PARA OBTENER DERIVADOS A-ETILBENZOL CON UN GRUPO PIPERIDINOPROPANOLICO SUSTITUIDO Y SUS SALES DE ADICION ACIDAS Y AMONICAS CUATERNARIAS DE FORMULA (I), DONDE R1 ES HALOGENO, TRIHALOMETILO Y ALQUILO C 1 A 4 O ALCOXILO C 1 A 4; Y R2 ES ALQUILO C 1 A 4. LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGLUTINANTE, BAJO CONDICIONES ANHIDRAS O EN UNA MEZCLA DE AGUA Y UN DISOLVENTE ORGANICO Y A UNA TEMPERATURA ENTRE 20JC Y LA DEL PUNTO DE EBULLICION DEL DISOLVENTE EMPLEADO, AISLANDOSE LAS SALES POR FILTRACION Y PURIFICANDOSE POR CRISTALIZACION. TIENE UTILIDAD FARMACEUTICA POR INHIBIR EL SISTEMA ENZIMATICO.
ES543794A 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias Granted ES543794A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU824185A HU186655B (en) 1982-12-28 1982-12-28 Process for producing new piperidine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
ES8603828A1 true ES8603828A1 (es) 1986-01-01
ES543794A0 ES543794A0 (es) 1986-01-01

Family

ID=10967246

Family Applications (5)

Application Number Title Priority Date Filing Date
ES528455A Expired ES8604146A1 (es) 1982-12-28 1983-12-27 Procedimiento de preparacion de nuevos derivados de piperidina y sus sales de adicion acidas y amonicas cuaternarias
ES543792A Granted ES543792A0 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias
ES543791A Expired ES8603825A1 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y sus sa- les de adicion acidas y amonicas cuaternarias
ES543793A Granted ES543793A0 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y sus sa- les de adicion acidas y amonicas cuaternarias
ES543794A Granted ES543794A0 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES528455A Expired ES8604146A1 (es) 1982-12-28 1983-12-27 Procedimiento de preparacion de nuevos derivados de piperidina y sus sales de adicion acidas y amonicas cuaternarias
ES543792A Granted ES543792A0 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias
ES543791A Expired ES8603825A1 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y sus sa- les de adicion acidas y amonicas cuaternarias
ES543793A Granted ES543793A0 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y sus sa- les de adicion acidas y amonicas cuaternarias

Country Status (14)

Country Link
US (1) US4551465A (es)
EP (1) EP0115700B1 (es)
JP (1) JPS59130867A (es)
AT (1) ATE28632T1 (es)
AU (1) AU562024B2 (es)
CA (1) CA1216293A (es)
DE (1) DE3372757D1 (es)
DK (1) DK158730C (es)
ES (5) ES8604146A1 (es)
FI (1) FI78906C (es)
GR (1) GR79153B (es)
HU (1) HU186655B (es)
IL (1) IL70553A (es)
ZA (1) ZA839611B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU187205B (en) * 1982-12-28 1985-11-28 Richter Gedeon Vegyeszet Process for preparing new derivatives of amni-ethoxy-benzyl-alcohol and salts thereof further pharmaceutical compositions containing such compounds
FR2603583B1 (fr) * 1986-09-05 1988-12-09 Andre Buzas Derives de la benzhydryloxyethyl-piperidine, procede d'obtention et compositions pharmaceutiques les contenant
US5585492A (en) * 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US6506876B1 (en) 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
EP1717235A3 (en) * 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
WO2023106973A1 (ru) * 2021-12-10 2023-06-15 Общество С Ограниченной Ответственностью "Валента-Интеллект" Новые гепатопротекторные средства

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA633816A (en) * 1962-01-02 Richardson-Merrell Inc. Substituted triphenylethanols
US3075014A (en) * 1960-06-14 1963-01-22 Richardson Merrell Inc Basic substituted alkoxy diphenylalkanols, diphenylalkenes and diphenylalkanes
US3272841A (en) * 1964-03-23 1966-09-13 Parke Davis & Co Alpha-(aminoalkoxyphenyl)-alpha'-nitrostilbene compounds
CH474515A (de) * 1966-06-24 1969-06-30 Hoffmann La Roche Verfahren zur Herstellung von aromatischen Äthern
US3647863A (en) * 1968-11-25 1972-03-07 Richardson Merrell Inc Aminoalkoxy-triphenyl ethylenes and the salts thereof
US4094908A (en) * 1973-08-15 1978-06-13 Richter Gedeon Vegyeszeti Gyar Rt. Alpha-substituted benzhydrol derivatives
HU168432B (es) * 1973-08-15 1976-04-28

Also Published As

Publication number Publication date
DK601383A (da) 1984-06-29
ZA839611B (en) 1985-02-27
FI78906C (fi) 1989-10-10
JPS59130867A (ja) 1984-07-27
IL70553A (en) 1986-12-31
GR79153B (es) 1984-10-20
ES8603827A1 (es) 1986-01-01
ES8603826A1 (es) 1986-01-01
DK158730B (da) 1990-07-09
ES543794A0 (es) 1986-01-01
IL70553A0 (en) 1984-03-30
FI78906B (fi) 1989-06-30
EP0115700A3 (en) 1984-11-21
FI834793A0 (fi) 1983-12-27
HU186655B (en) 1985-09-30
JPH0257065B2 (es) 1990-12-03
CA1216293A (en) 1987-01-06
AU562024B2 (en) 1987-05-28
AU2290883A (en) 1984-07-05
ES543792A0 (es) 1986-01-01
FI834793A (fi) 1984-06-29
EP0115700B1 (en) 1987-07-29
ES543791A0 (es) 1986-01-01
ATE28632T1 (de) 1987-08-15
US4551465A (en) 1985-11-05
EP0115700A2 (en) 1984-08-15
ES8604146A1 (es) 1986-01-16
DK601383D0 (da) 1983-12-27
ES543793A0 (es) 1986-01-01
DE3372757D1 (en) 1987-09-03
DK158730C (da) 1990-11-19
ES8603825A1 (es) 1986-01-01
ES528455A0 (es) 1986-01-16

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