ES543792A0 - Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias - Google Patents
Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternariasInfo
- Publication number
- ES543792A0 ES543792A0 ES543792A ES543792A ES543792A0 ES 543792 A0 ES543792 A0 ES 543792A0 ES 543792 A ES543792 A ES 543792A ES 543792 A ES543792 A ES 543792A ES 543792 A0 ES543792 A0 ES 543792A0
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- sub
- new
- derivatives
- quaternary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000511343 Chondrostoma nasus Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 230000003228 microsomal effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU824185A HU186655B (en) | 1982-12-28 | 1982-12-28 | Process for producing new piperidine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8603826A1 ES8603826A1 (es) | 1986-01-01 |
| ES543792A0 true ES543792A0 (es) | 1986-01-01 |
Family
ID=10967246
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES528455A Expired ES8604146A1 (es) | 1982-12-28 | 1983-12-27 | Procedimiento de preparacion de nuevos derivados de piperidina y sus sales de adicion acidas y amonicas cuaternarias |
| ES543791A Expired ES8603825A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y sus sa- les de adicion acidas y amonicas cuaternarias |
| ES543792A Granted ES543792A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias |
| ES543793A Expired ES8603827A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y sus sa- les de adicion acidas y amonicas cuaternarias |
| ES543794A Granted ES543794A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES528455A Expired ES8604146A1 (es) | 1982-12-28 | 1983-12-27 | Procedimiento de preparacion de nuevos derivados de piperidina y sus sales de adicion acidas y amonicas cuaternarias |
| ES543791A Expired ES8603825A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y sus sa- les de adicion acidas y amonicas cuaternarias |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES543793A Expired ES8603827A1 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y sus sa- les de adicion acidas y amonicas cuaternarias |
| ES543794A Granted ES543794A0 (es) | 1982-12-28 | 1985-06-01 | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4551465A (es) |
| EP (1) | EP0115700B1 (es) |
| JP (1) | JPS59130867A (es) |
| AT (1) | ATE28632T1 (es) |
| AU (1) | AU562024B2 (es) |
| CA (1) | CA1216293A (es) |
| DE (1) | DE3372757D1 (es) |
| DK (1) | DK158730C (es) |
| ES (5) | ES8604146A1 (es) |
| FI (1) | FI78906C (es) |
| GR (1) | GR79153B (es) |
| HU (1) | HU186655B (es) |
| IL (1) | IL70553A (es) |
| ZA (1) | ZA839611B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU187205B (en) * | 1982-12-28 | 1985-11-28 | Richter Gedeon Vegyeszet | Process for preparing new derivatives of amni-ethoxy-benzyl-alcohol and salts thereof further pharmaceutical compositions containing such compounds |
| FR2603583B1 (fr) * | 1986-09-05 | 1988-12-09 | Andre Buzas | Derives de la benzhydryloxyethyl-piperidine, procede d'obtention et compositions pharmaceutiques les contenant |
| US5585492A (en) * | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
| US6506876B1 (en) | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
| EP1717235A3 (en) * | 2005-04-29 | 2007-02-28 | Bioprojet | Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands |
| WO2023106973A1 (ru) * | 2021-12-10 | 2023-06-15 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Новые гепатопротекторные средства |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA633816A (en) * | 1962-01-02 | Richardson-Merrell Inc. | Substituted triphenylethanols | |
| US3075014A (en) * | 1960-06-14 | 1963-01-22 | Richardson Merrell Inc | Basic substituted alkoxy diphenylalkanols, diphenylalkenes and diphenylalkanes |
| US3272841A (en) * | 1964-03-23 | 1966-09-13 | Parke Davis & Co | Alpha-(aminoalkoxyphenyl)-alpha'-nitrostilbene compounds |
| CH474515A (de) * | 1966-06-24 | 1969-06-30 | Hoffmann La Roche | Verfahren zur Herstellung von aromatischen Äthern |
| US3647863A (en) * | 1968-11-25 | 1972-03-07 | Richardson Merrell Inc | Aminoalkoxy-triphenyl ethylenes and the salts thereof |
| HU168432B (es) * | 1973-08-15 | 1976-04-28 | ||
| US4094908A (en) * | 1973-08-15 | 1978-06-13 | Richter Gedeon Vegyeszeti Gyar Rt. | Alpha-substituted benzhydrol derivatives |
-
1982
- 1982-12-28 HU HU824185A patent/HU186655B/hu not_active IP Right Cessation
-
1983
- 1983-12-23 EP EP83307964A patent/EP0115700B1/en not_active Expired
- 1983-12-23 DE DE8383307964T patent/DE3372757D1/de not_active Expired
- 1983-12-23 CA CA000444205A patent/CA1216293A/en not_active Expired
- 1983-12-23 AU AU22908/83A patent/AU562024B2/en not_active Ceased
- 1983-12-23 AT AT83307964T patent/ATE28632T1/de not_active IP Right Cessation
- 1983-12-27 JP JP58244945A patent/JPS59130867A/ja active Granted
- 1983-12-27 ES ES528455A patent/ES8604146A1/es not_active Expired
- 1983-12-27 ZA ZA839611A patent/ZA839611B/xx unknown
- 1983-12-27 DK DK601383A patent/DK158730C/da not_active IP Right Cessation
- 1983-12-27 IL IL70553A patent/IL70553A/xx unknown
- 1983-12-27 US US06/565,902 patent/US4551465A/en not_active Expired - Fee Related
- 1983-12-27 FI FI834793A patent/FI78906C/fi not_active IP Right Cessation
- 1983-12-28 GR GR73367A patent/GR79153B/el unknown
-
1985
- 1985-06-01 ES ES543791A patent/ES8603825A1/es not_active Expired
- 1985-06-01 ES ES543792A patent/ES543792A0/es active Granted
- 1985-06-01 ES ES543793A patent/ES8603827A1/es not_active Expired
- 1985-06-01 ES ES543794A patent/ES543794A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DK601383A (da) | 1984-06-29 |
| ES8603826A1 (es) | 1986-01-01 |
| ES8603828A1 (es) | 1986-01-01 |
| ES543791A0 (es) | 1986-01-01 |
| CA1216293A (en) | 1987-01-06 |
| ES543793A0 (es) | 1986-01-01 |
| ZA839611B (en) | 1985-02-27 |
| ATE28632T1 (de) | 1987-08-15 |
| DK601383D0 (da) | 1983-12-27 |
| IL70553A0 (en) | 1984-03-30 |
| DK158730B (da) | 1990-07-09 |
| ES543794A0 (es) | 1986-01-01 |
| EP0115700B1 (en) | 1987-07-29 |
| FI834793A0 (fi) | 1983-12-27 |
| DK158730C (da) | 1990-11-19 |
| FI78906C (fi) | 1989-10-10 |
| FI78906B (fi) | 1989-06-30 |
| IL70553A (en) | 1986-12-31 |
| FI834793L (fi) | 1984-06-29 |
| DE3372757D1 (en) | 1987-09-03 |
| ES8603827A1 (es) | 1986-01-01 |
| US4551465A (en) | 1985-11-05 |
| GR79153B (es) | 1984-10-20 |
| EP0115700A2 (en) | 1984-08-15 |
| AU562024B2 (en) | 1987-05-28 |
| ES8603825A1 (es) | 1986-01-01 |
| AU2290883A (en) | 1984-07-05 |
| JPH0257065B2 (es) | 1990-12-03 |
| ES8604146A1 (es) | 1986-01-16 |
| JPS59130867A (ja) | 1984-07-27 |
| EP0115700A3 (en) | 1984-11-21 |
| ES528455A0 (es) | 1986-01-16 |
| HU186655B (en) | 1985-09-30 |
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| ES543792A0 (es) | Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piperidinopropanolico sustituido y de sus sales de adicion acidas y amonicas cuaternarias | |
| DK160495C (da) | Benzhydrylpiperazinderivater, en fremgangsmaade til fremstilling af disse, farmaceutiske praeparater der indeholder disse, samt en fremgangsmaade til fremst illing af saadanne farmaceutiske praeparater | |
| ES543790A0 (es) | Procedimiento de preparacion de nuevos derivados a-etilami- noetoxibencilalcoholicos con un grupo fenil sustituido en situacion a y de sus sales de adicion acidas y amonicas cua-ternarias | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |