ES8603834A1 - Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternarias - Google Patents

Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternarias

Info

Publication number
ES8603834A1
ES8603834A1 ES543787A ES543787A ES8603834A1 ES 8603834 A1 ES8603834 A1 ES 8603834A1 ES 543787 A ES543787 A ES 543787A ES 543787 A ES543787 A ES 543787A ES 8603834 A1 ES8603834 A1 ES 8603834A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
pyridine derivatives
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543787A
Other languages
English (en)
Other versions
ES543787A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES543787A0 publication Critical patent/ES543787A0/es
Publication of ES8603834A1 publication Critical patent/ES8603834A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Decoration By Transfer Pictures (AREA)
  • Control Of Electric Motors In General (AREA)
  • Emergency Protection Circuit Devices (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS AP07-ETILBENZOL CON UN GRUPO PIRIDINOMETOXI SUSTITUIDO Y DE SUS SALES DE ADICION ACIDAS Y CUATERNARIAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER NUEVOS DERIVADOS A-ETILBENZOL CON UN GRUPO PIRIDINOMETOXI SUSTITUIDO Y SUS SALES DE ADICION ACIDAS Y CUATERNARIAS DE FORMULA (I) DONDE R1 Y R2 REPRESENTAN INDEPENDIENTEMENTE H, HALOGENO, TRIHALOMETILO, ALQUILO DE C 1 A 4 O ALCOXILO DE C 1 A 4. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UN AGENTE AGLUTINANTE DE ACIDOS, BAJO CONDICIONES ANHIDRAS O EN UNA MEZCLA DE AGUA Y UN DISOLVENTE ORGANICO TAL COMO ESTERES Y A UNA TEMPERATURA ENTRE 20JC Y LA DEL PUNTO DE EBULLICION DEL DISOLVENTE EMPLEADO. TIENEN UTILIDAD FARMACEUTICA POR INHIBIR EL SISTEMA ENZIMATICO DE LA MONOOXIGENASA MICROSOMATICA DEL HIGADO.
ES543787A 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternarias Expired ES8603834A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU824183A HU186654B (en) 1982-12-28 1982-12-28 Process for producing new pyridine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
ES543787A0 ES543787A0 (es) 1986-01-01
ES8603834A1 true ES8603834A1 (es) 1986-01-01

Family

ID=10967238

Family Applications (3)

Application Number Title Priority Date Filing Date
ES528453A Expired ES8600244A1 (es) 1982-12-28 1983-12-27 Procedimiento de preparacion de nuevos derivados piridinicos y de sus sales de adicion acidas y cuaternarias
ES543787A Expired ES8603834A1 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternarias
ES543788A Expired ES8603835A1 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternarias

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES528453A Expired ES8600244A1 (es) 1982-12-28 1983-12-27 Procedimiento de preparacion de nuevos derivados piridinicos y de sus sales de adicion acidas y cuaternarias

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES543788A Expired ES8603835A1 (es) 1982-12-28 1985-06-01 Procedimiento de preparacion de nuevos derivados a-etilben- zol con un grupo piridinometoxi sustituido y de sus sales deadicion acidas y cuaternarias

Country Status (14)

Country Link
US (1) US4598080A (es)
EP (1) EP0113587B1 (es)
JP (1) JPS59130868A (es)
AT (1) ATE23995T1 (es)
AU (1) AU560420B2 (es)
CA (1) CA1210010A (es)
DE (1) DE3368050D1 (es)
DK (1) DK158663C (es)
ES (3) ES8600244A1 (es)
FI (1) FI78907C (es)
GR (1) GR79148B (es)
HU (1) HU186654B (es)
IL (1) IL70551A (es)
ZA (1) ZA839612B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
US4778931A (en) * 1982-12-01 1988-10-18 Usv Pharmaceutical Corporation Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity
US4794188A (en) * 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
JPS61110675U (es) * 1984-12-25 1986-07-12
DE3617183A1 (de) * 1985-11-16 1987-05-27 Bayer Ag Substituierte benzylether
GB8603475D0 (en) * 1986-02-12 1986-03-19 Glaxo Group Ltd Chemical compounds
GB8711802D0 (en) * 1987-05-19 1987-06-24 Fujisawa Pharmaceutical Co Dithioacetal compounds
ATE123278T1 (de) * 1991-03-25 1995-06-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von ethern.
CA2666686A1 (en) * 2006-09-01 2008-03-13 Merck & Co., Inc. Inhibitors of 5-lipoxygenase activating protein (flap)
AU2008266960A1 (en) * 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. Diphenyl substituted alkanes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3360526A (en) * 1964-01-15 1967-12-26 Bristol Myers Co Heterocyclicamino methylene ethers of benzylphenols
US4094908A (en) * 1973-08-15 1978-06-13 Richter Gedeon Vegyeszeti Gyar Rt. Alpha-substituted benzhydrol derivatives
DE2516331A1 (de) * 1974-04-18 1975-11-06 Ciba Geigy Ag Phenylaralkyl-aether und -thioaether

Also Published As

Publication number Publication date
FI834791A0 (fi) 1983-12-27
DE3368050D1 (en) 1987-01-15
FI78907B (fi) 1989-06-30
IL70551A0 (en) 1984-03-30
JPS59130868A (ja) 1984-07-27
DK601283D0 (da) 1983-12-27
JPH0130821B2 (es) 1989-06-22
ATE23995T1 (de) 1986-12-15
GR79148B (es) 1984-10-02
DK158663B (da) 1990-07-02
AU2290683A (en) 1984-07-05
ES543787A0 (es) 1986-01-01
ES528453A0 (es) 1985-10-01
HU186654B (en) 1985-09-30
DK158663C (da) 1990-11-19
ES543788A0 (es) 1986-01-01
IL70551A (en) 1987-02-27
DK601283A (da) 1984-06-29
FI78907C (fi) 1989-10-10
ZA839612B (en) 1984-08-29
EP0113587A1 (en) 1984-07-18
FI834791A (fi) 1984-06-29
ES8600244A1 (es) 1985-10-01
US4598080A (en) 1986-07-01
CA1210010A (en) 1986-08-19
EP0113587B1 (en) 1986-12-03
ES8603835A1 (es) 1986-01-01
AU560420B2 (en) 1987-04-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401