ES8707722A1 - Un procedimiento para la preparacion de quinazolinonas - Google Patents
Un procedimiento para la preparacion de quinazolinonasInfo
- Publication number
- ES8707722A1 ES8707722A1 ES554608A ES554608A ES8707722A1 ES 8707722 A1 ES8707722 A1 ES 8707722A1 ES 554608 A ES554608 A ES 554608A ES 554608 A ES554608 A ES 554608A ES 8707722 A1 ES8707722 A1 ES 8707722A1
- Authority
- ES
- Spain
- Prior art keywords
- quinazolinones
- dialkoxy
- alkyl
- preparing
- cardiotonic agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
METODO DE PREPARAR QUINAZOLINONAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN ACIDO MINERAL Y TRATAR EL PRODUCTO FORMADO CON UNA BASE, OBTENIENDOSE QUINAZOLINONAS DE FORMULA (I) DONDE R1 Y R2 SON GRUPOS ALQUILO INFERIOR IGUALES O DIFERENTES CON C 1 A 4; Y R3 ES HIDROGENO O ALQUILO INFERIOR CON C 1 A 4. LA REACCION SE LLEVA A CABO A TEMPERATURA AMNBIENTE, EN UN DISOLVENTE ADECUADO TAL COMO CLORURO DE METILENO, CLOROFORMO O ETER Y LA BASE EMPLEADA ES HIDROXIDO SODICO O HIDROXIDO POTASICO. TIENEN APLICACIONES FARMACEUTICAS COMO AGENTES CARDIOTONICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/654,820 US4751304A (en) | 1984-09-26 | 1984-09-26 | Process for preparing 5,6-dialkoxy-4-alkyl-2(1H)-quinazolinones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8707722A1 true ES8707722A1 (es) | 1987-08-16 |
| ES554608A0 ES554608A0 (es) | 1987-08-16 |
Family
ID=24626374
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES547266A Expired ES8700852A1 (es) | 1984-09-26 | 1985-09-25 | Un procedimiento para la preparacion de un compuesto |
| ES554607A Expired ES8801640A1 (es) | 1984-09-26 | 1986-04-30 | Un procedimiento para la preparacion de quinazolinonas |
| ES554608A Expired ES8707722A1 (es) | 1984-09-26 | 1986-04-30 | Un procedimiento para la preparacion de quinazolinonas |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES547266A Expired ES8700852A1 (es) | 1984-09-26 | 1985-09-25 | Un procedimiento para la preparacion de un compuesto |
| ES554607A Expired ES8801640A1 (es) | 1984-09-26 | 1986-04-30 | Un procedimiento para la preparacion de quinazolinonas |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4751304A (es) |
| EP (1) | EP0177256A3 (es) |
| KR (1) | KR870000498B1 (es) |
| AU (1) | AU574841B2 (es) |
| DK (1) | DK435085A (es) |
| ES (3) | ES8700852A1 (es) |
| FI (1) | FI853679L (es) |
| GR (1) | GR852323B (es) |
| HU (1) | HU196380B (es) |
| IL (1) | IL76489A0 (es) |
| NO (1) | NO853767L (es) |
| NZ (1) | NZ213472A (es) |
| PL (3) | PL261848A1 (es) |
| PT (1) | PT81197B (es) |
| RO (1) | RO92582B (es) |
| YU (1) | YU149985A (es) |
| ZA (1) | ZA857399B (es) |
| ZW (1) | ZW17285A1 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3759920A (en) * | 1971-06-24 | 1973-09-18 | Sandoz Ag | Process for the preparation of 1-substituted-phenyl-2(1h)-quinazolinones |
| AU533427B2 (en) * | 1978-12-07 | 1983-11-24 | Ortho Pharmaceutical Corporation | Substituted 2(1h) quinazolinones |
| US4656267A (en) * | 1983-09-29 | 1987-04-07 | Ortho Pharmaceutical Corporation | Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters |
-
1984
- 1984-09-26 US US06/654,820 patent/US4751304A/en not_active Expired - Lifetime
-
1985
- 1985-09-13 NZ NZ213472A patent/NZ213472A/xx unknown
- 1985-09-23 RO RO120182A patent/RO92582B/ro unknown
- 1985-09-23 YU YU01499/85A patent/YU149985A/xx unknown
- 1985-09-23 GR GR852323A patent/GR852323B/el unknown
- 1985-09-24 IL IL76489A patent/IL76489A0/xx unknown
- 1985-09-25 AU AU47897/85A patent/AU574841B2/en not_active Ceased
- 1985-09-25 ZW ZW172/85A patent/ZW17285A1/xx unknown
- 1985-09-25 NO NO853767A patent/NO853767L/no unknown
- 1985-09-25 EP EP85306811A patent/EP0177256A3/en not_active Withdrawn
- 1985-09-25 DK DK435085A patent/DK435085A/da not_active Application Discontinuation
- 1985-09-25 ZA ZA857399A patent/ZA857399B/xx unknown
- 1985-09-25 ES ES547266A patent/ES8700852A1/es not_active Expired
- 1985-09-25 KR KR1019850007044A patent/KR870000498B1/ko active
- 1985-09-25 FI FI853679A patent/FI853679L/fi not_active IP Right Cessation
- 1985-09-25 HU HU853641A patent/HU196380B/hu unknown
- 1985-09-26 PL PL1985261848A patent/PL261848A1/xx unknown
- 1985-09-26 PL PL1985261847A patent/PL261847A1/xx unknown
- 1985-09-26 PL PL25552685A patent/PL255526A1/xx unknown
- 1985-09-26 PT PT81197A patent/PT81197B/pt unknown
-
1986
- 1986-04-30 ES ES554607A patent/ES8801640A1/es not_active Expired
- 1986-04-30 ES ES554608A patent/ES8707722A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| PT81197B (en) | 1987-03-30 |
| PT81197A (en) | 1985-10-01 |
| RO92582A (ro) | 1987-11-30 |
| HUT40086A (en) | 1986-11-28 |
| ES547266A0 (es) | 1986-11-16 |
| YU149985A (en) | 1988-04-30 |
| KR870000498B1 (ko) | 1987-03-12 |
| HU196380B (en) | 1988-11-28 |
| ES8801640A1 (es) | 1988-01-01 |
| AU574841B2 (en) | 1988-07-14 |
| ES8700852A1 (es) | 1986-11-16 |
| EP0177256A3 (en) | 1987-04-15 |
| PL261848A1 (en) | 1987-09-07 |
| AU4789785A (en) | 1986-04-10 |
| PL261847A1 (en) | 1987-09-07 |
| NZ213472A (en) | 1988-06-30 |
| RO92582B (ro) | 1987-12-01 |
| ES554608A0 (es) | 1987-08-16 |
| US4751304A (en) | 1988-06-14 |
| EP0177256A2 (en) | 1986-04-09 |
| IL76489A0 (en) | 1986-01-31 |
| GR852323B (es) | 1986-01-24 |
| FI853679L (fi) | 1986-03-27 |
| PL255526A1 (en) | 1987-02-09 |
| ZW17285A1 (en) | 1987-04-15 |
| DK435085A (da) | 1986-03-27 |
| FI853679A0 (fi) | 1985-09-25 |
| NO853767L (no) | 1986-04-01 |
| KR860002477A (ko) | 1986-04-26 |
| DK435085D0 (da) | 1985-09-25 |
| ES554607A0 (es) | 1988-01-01 |
| ZA857399B (en) | 1987-05-27 |
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