ES2001041A6 - Un metodo para preparar 2-acil-3,4-dialcoxianilinas - Google Patents

Un metodo para preparar 2-acil-3,4-dialcoxianilinas

Info

Publication number
ES2001041A6
ES2001041A6 ES8600652A ES8600652A ES2001041A6 ES 2001041 A6 ES2001041 A6 ES 2001041A6 ES 8600652 A ES8600652 A ES 8600652A ES 8600652 A ES8600652 A ES 8600652A ES 2001041 A6 ES2001041 A6 ES 2001041A6
Authority
ES
Spain
Prior art keywords
dialkoxyanilines
acyl
preparing
quinazolinones
dialkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600652A
Other languages
English (en)
Inventor
Richard A Conley
Donald L Barton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of ES2001041A6 publication Critical patent/ES2001041A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Seasonings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Luminescent Compositions (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

UN METODO PARA PREPARAR 2-ACIL-3,4-DIALCOXIANILINAS. LOS COMPUESTOS DE FORMULA (I) SE OBTIENEN POR REACCION DE (II) CON (III) PARA DAR (IV) EL CUAL SE HACE REACCIONAR CON (V) R-LI SEGUIDO DE REACCION CON (VI) R1-CHO PARA DAR (VII) QUE SE HACE REACCIONAR CON UN AGENTE OXIDANTE PARA DAR (VIII) QUE FINALMENTE SE HIDROLIZA CON ACIDO. EN ESTOS COMPUESTOS, R1, R2 Y R3 SON ALQUILO INFERIOR, R2 Y R3 CUANDO SE TOMAN JUNTOS SON METILENDIOXI Y R4 ES N-BUTILO, S-BUTILO O T-BUTILO Y X ES CLORO, BROMO, FLUOR O OCOC(CH3)3. LAS 2-ACIL-3,4-DIALCOXIANILINAS (I) SON UTILES COMO INTERMEDIOS EN LA PREPARACION DE 5,6-DIALCOXI-4-ALQUIL-2(1H)-QUINAZOLINONAS QUE TIENEN APLICACION COMO AGENTES CARDIOTONICOS.
ES8600652A 1985-07-29 1986-07-28 Un metodo para preparar 2-acil-3,4-dialcoxianilinas Expired ES2001041A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75997385A 1985-07-29 1985-07-29

Publications (1)

Publication Number Publication Date
ES2001041A6 true ES2001041A6 (es) 1988-04-16

Family

ID=25057649

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600652A Expired ES2001041A6 (es) 1985-07-29 1986-07-28 Un metodo para preparar 2-acil-3,4-dialcoxianilinas

Country Status (15)

Country Link
EP (1) EP0212868B1 (es)
JP (1) JPS6253949A (es)
KR (1) KR900003529B1 (es)
AT (1) ATE48592T1 (es)
AU (1) AU585379B2 (es)
DE (1) DE3667464D1 (es)
DK (1) DK358486A (es)
ES (1) ES2001041A6 (es)
FI (1) FI863084A (es)
GR (1) GR861976B (es)
HK (1) HK41390A (es)
HU (1) HUT44763A (es)
NO (1) NO165835C (es)
SG (1) SG27990G (es)
ZA (1) ZA865626B (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH194648A (de) * 1934-11-20 1937-12-15 Ig Farbenindustrie Ag Verfahren zur Darstellung eines 4,5-alkylsubstituierten 2-Aminodiarylketons.
FR1601M (fr) * 1961-10-18 1962-12-10 Ile De France Nouveaux médicaments analgésiques.
GB1040163A (en) * 1963-03-01 1966-08-24 Warner Lambert Pharmaceutical Derivatives of benzophenone and benzhydrol
US4490374A (en) 1982-09-30 1984-12-25 Ortho Pharmaceutical Corporation 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use
US4556739A (en) * 1983-09-29 1985-12-03 Ortho Pharmaceutical Corporation 3,4-Dialkoxy-2-alkylcarbonyl analino compounds

Also Published As

Publication number Publication date
ATE48592T1 (de) 1989-12-15
KR870001146A (ko) 1987-03-11
HUT44763A (en) 1988-04-28
NO165835B (no) 1991-01-07
KR900003529B1 (ko) 1990-05-21
FI863084A (fi) 1987-01-30
GR861976B (en) 1986-12-22
NO863043L (no) 1987-01-30
EP0212868A1 (en) 1987-03-04
DE3667464D1 (de) 1990-01-18
FI863084A0 (fi) 1986-07-28
DK358486A (da) 1987-01-30
AU585379B2 (en) 1989-06-15
DK358486D0 (da) 1986-07-28
HK41390A (en) 1990-06-08
NO863043D0 (no) 1986-07-28
EP0212868B1 (en) 1989-12-13
SG27990G (en) 1990-07-13
JPS6253949A (ja) 1987-03-09
AU6063286A (en) 1987-02-05
ZA865626B (en) 1988-03-30
NO165835C (no) 1991-04-17

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-07-28