ES8607313A1 - Un metodo de preparar espiro-(benzofuran-azalcanos) - Google Patents
Un metodo de preparar espiro-(benzofuran-azalcanos)Info
- Publication number
- ES8607313A1 ES8607313A1 ES535357A ES535357A ES8607313A1 ES 8607313 A1 ES8607313 A1 ES 8607313A1 ES 535357 A ES535357 A ES 535357A ES 535357 A ES535357 A ES 535357A ES 8607313 A1 ES8607313 A1 ES 8607313A1
- Authority
- ES
- Spain
- Prior art keywords
- spiro
- azalkanes
- benzofuran
- medicaments
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS ESPIRO-BENZOFURAN-ALCANOS, DE FORMULA GENERAL (I), EN LA QUE X ES HIDROGENO O HALOGENO; M Y N SON CADA UNO DE ELLOS 0, 1 O 2 CON LA CONDICION DE QUE LA SUMA DE M Y N ES 1 O 2; Y R ES UN RADICAL, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES DEL MISMO. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA GENERAL (III), EN LA QUE Y ES HIDROGENO O HALOGENO; Y HAL ES CLORO O BROMO. DE APLICACION COMO AGENTES UTILES COMO AGENTES ANTIHIPERTENSIVOS DEBIDO A SU CAPACIDAD PARA REBAJAR LA PRESION SANGUINEA EN MAMIFEROS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/526,193 US4452802A (en) | 1983-08-25 | 1983-08-25 | Antihypertensive spiro[benzofuran-azalkanes] |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8607313A1 true ES8607313A1 (es) | 1986-05-16 |
ES535357A0 ES535357A0 (es) | 1986-05-16 |
Family
ID=24096310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535357A Expired ES8607313A1 (es) | 1983-08-25 | 1984-08-23 | Un metodo de preparar espiro-(benzofuran-azalcanos) |
Country Status (8)
Country | Link |
---|---|
US (1) | US4452802A (es) |
EP (1) | EP0139138B1 (es) |
JP (1) | JPS6072892A (es) |
AT (1) | ATE28200T1 (es) |
DE (1) | DE3464609D1 (es) |
DK (1) | DK405884A (es) |
ES (1) | ES8607313A1 (es) |
GR (1) | GR80173B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4788201A (en) * | 1987-01-22 | 1988-11-29 | Hoechst-Roussel Pharmaceuticals Inc. | 3-methylenespiro (benzofuranpiperidines) |
IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
DK78692D0 (da) * | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
DK0681571T3 (da) * | 1993-01-28 | 1998-11-23 | Merck & Co Inc | Spiro-substituerede azacykliske forbindelser som tachykininreceptorantagonister |
JP2009507800A (ja) * | 2005-09-09 | 2009-02-26 | ユーロ−セルティーク エス.エイ. | 縮合およびスピロ環化合物ならびにその使用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3962259A (en) * | 1973-12-12 | 1976-06-08 | American Hoechst Corporation | 1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof |
US4166120A (en) * | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines |
US4166119A (en) * | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines |
-
1983
- 1983-08-25 US US06/526,193 patent/US4452802A/en not_active Expired - Fee Related
-
1984
- 1984-08-14 DE DE8484109647T patent/DE3464609D1/de not_active Expired
- 1984-08-14 EP EP84109647A patent/EP0139138B1/en not_active Expired
- 1984-08-14 AT AT84109647T patent/ATE28200T1/de not_active IP Right Cessation
- 1984-08-23 ES ES535357A patent/ES8607313A1/es not_active Expired
- 1984-08-23 GR GR80173A patent/GR80173B/el unknown
- 1984-08-24 JP JP59175334A patent/JPS6072892A/ja active Pending
- 1984-08-24 DK DK405884A patent/DK405884A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0139138B1 (en) | 1987-07-08 |
US4452802A (en) | 1984-06-05 |
JPS6072892A (ja) | 1985-04-24 |
DK405884A (da) | 1985-02-26 |
ATE28200T1 (de) | 1987-07-15 |
DE3464609D1 (en) | 1987-08-13 |
ES535357A0 (es) | 1986-05-16 |
DK405884D0 (da) | 1984-08-24 |
EP0139138A1 (en) | 1985-05-02 |
GR80173B (en) | 1985-01-02 |
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