CZ20013658A3 - Syntéza a krystalizace sloučenin obsahujících piperazinový kruh - Google Patents

Syntéza a krystalizace sloučenin obsahujících piperazinový kruh Download PDF

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Publication number
CZ20013658A3
CZ20013658A3 CZ20013658A CZ20013658A CZ20013658A3 CZ 20013658 A3 CZ20013658 A3 CZ 20013658A3 CZ 20013658 A CZ20013658 A CZ 20013658A CZ 20013658 A CZ20013658 A CZ 20013658A CZ 20013658 A3 CZ20013658 A3 CZ 20013658A3
Authority
CZ
Czechia
Prior art keywords
mirtazapine
methyl
phenylpiperazine
cyanopyridyl
base
Prior art date
Application number
CZ20013658A
Other languages
Czech (cs)
English (en)
Inventor
Claude Singer
Anita Liberman
Nina Finkelstein
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of CZ20013658A3 publication Critical patent/CZ20013658A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
CZ20013658A 1999-04-19 2000-04-18 Syntéza a krystalizace sloučenin obsahujících piperazinový kruh CZ20013658A3 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13004799P 1999-04-19 1999-04-19

Publications (1)

Publication Number Publication Date
CZ20013658A3 true CZ20013658A3 (cs) 2002-08-14

Family

ID=22442814

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20013658A CZ20013658A3 (cs) 1999-04-19 2000-04-18 Syntéza a krystalizace sloučenin obsahujících piperazinový kruh

Country Status (16)

Country Link
JP (1) JP2004500324A (tr)
KR (1) KR20020019902A (tr)
CN (4) CN1679586A (tr)
CA (1) CA2368815A1 (tr)
CZ (1) CZ20013658A3 (tr)
HK (1) HK1044116A1 (tr)
HR (1) HRP20010747A2 (tr)
HU (1) HUP0200839A3 (tr)
IL (1) IL146023A0 (tr)
PL (1) PL366289A1 (tr)
RU (1) RU2001128229A (tr)
SK (1) SK14672001A3 (tr)
TR (1) TR200103028T2 (tr)
WO (1) WO2000062782A1 (tr)
YU (1) YU74101A (tr)
ZA (1) ZA200108220B (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038329A1 (fr) * 1999-11-24 2001-05-31 Sumika Fine Chemicals Co., Ltd. Cristaux de mirtazapine anhydre et leur procede d'obtention
WO2001042239A1 (fr) * 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Procede de preparation d'un compose pyridinemethanol
US6660730B2 (en) * 2000-11-27 2003-12-09 Sumika Fine Chemicals Co., Ltd. Anhydrous mirtazapine and process for preparing the same
UA83666C2 (ru) 2003-07-10 2008-08-11 Н.В. Органон Способ получения энантиомерно чистого миртазапина
ES2246161B1 (es) * 2004-07-22 2007-04-01 Medichem, S.A. Proceso mejorado para la fabricacion de mirtazapina.
JP4848704B2 (ja) * 2004-08-24 2011-12-28 住友化学株式会社 ２−（４−メチル−２−フェニルピペラジン−１−イル）−３−シアノピリジンの製造方法
JP5192707B2 (ja) 2007-03-22 2013-05-08 住友化学株式会社 ミルタザピンの製造方法
CA2684021A1 (en) 2007-04-11 2008-10-23 N.V. Organon A method for the preparation of an enantiomer of a tetracyclic benzazepine
US7994314B2 (en) 2007-04-11 2011-08-09 N.V. Organon Method for the preparation of an enantiomerically pure benzazepine
KR101485418B1 (ko) 2013-05-29 2015-01-26 주식회사 메디켐코리아 고순도 미르타자핀의 제조방법
JP2017088564A (ja) * 2015-11-13 2017-05-25 株式会社トクヤマ ミルタザピンの製造方法
JP6571497B2 (ja) * 2015-11-13 2019-09-04 株式会社トクヤマ ミルタザピンの製造方法
CN108191873B (zh) * 2018-01-08 2021-09-24 山东省食品药品检验研究院 一种盐酸米安色林的纯化方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.

Also Published As

Publication number Publication date
CA2368815A1 (en) 2000-10-26
CN1679586A (zh) 2005-10-12
ZA200108220B (en) 2006-02-26
CN1680365A (zh) 2005-10-12
HRP20010747A2 (en) 2002-12-31
HK1044116A1 (zh) 2002-10-11
SK14672001A3 (sk) 2002-11-06
HUP0200839A3 (en) 2003-05-28
KR20020019902A (ko) 2002-03-13
JP2004500324A (ja) 2004-01-08
YU74101A (sh) 2004-09-03
CN1356903A (zh) 2002-07-03
IL146023A0 (en) 2002-07-25
CN1680374A (zh) 2005-10-12
PL366289A1 (en) 2005-01-24
HUP0200839A2 (en) 2002-08-28
WO2000062782A1 (en) 2000-10-26
RU2001128229A (ru) 2003-07-10
TR200103028T2 (tr) 2002-01-21

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