ATE353081T1 - Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten - Google Patents
Verfahren zur herstellung von duloxetin und deren verwendeten zwischenproduktenInfo
- Publication number
- ATE353081T1 ATE353081T1 AT03767973T AT03767973T ATE353081T1 AT E353081 T1 ATE353081 T1 AT E353081T1 AT 03767973 T AT03767973 T AT 03767973T AT 03767973 T AT03767973 T AT 03767973T AT E353081 T1 ATE353081 T1 AT E353081T1
- Authority
- AT
- Austria
- Prior art keywords
- duloxetine
- acid addition
- addition salt
- intermediate products
- products used
- Prior art date
Links
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 title 1
- 229960002866 duloxetine Drugs 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- ZEUITGRIYCTCEM-UHFFFAOYSA-N duloxetine Chemical compound C=1C=CC2=CC=CC=C2C=1OC(CCNC)C1=CC=CS1 ZEUITGRIYCTCEM-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- ZEUITGRIYCTCEM-QGZVFWFLSA-N (R)-duloxetine Chemical compound C1([C@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-QGZVFWFLSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0229583.0A GB0229583D0 (en) | 2002-12-19 | 2002-12-19 | A process for preparing duloxetine and intermediates for use therein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353081T1 true ATE353081T1 (de) | 2007-02-15 |
Family
ID=9949985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03767973T ATE353081T1 (de) | 2002-12-19 | 2003-12-10 | Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7645890B2 (de) |
| EP (2) | EP1690861B1 (de) |
| JP (1) | JP5259048B2 (de) |
| KR (1) | KR100926723B1 (de) |
| CN (2) | CN100579975C (de) |
| AT (1) | ATE353081T1 (de) |
| AU (2) | AU2003292396B2 (de) |
| BR (1) | BR0316902A (de) |
| CA (1) | CA2510750A1 (de) |
| DE (1) | DE60311599T2 (de) |
| ES (1) | ES2279971T3 (de) |
| GB (1) | GB0229583D0 (de) |
| HR (1) | HRP20050657A2 (de) |
| IL (1) | IL169232A (de) |
| IS (1) | IS7915A (de) |
| MA (1) | MA27706A1 (de) |
| MX (1) | MXPA05006659A (de) |
| NZ (2) | NZ569874A (de) |
| PL (1) | PL377380A1 (de) |
| PT (1) | PT1587801E (de) |
| RU (1) | RU2351594C2 (de) |
| TN (1) | TNSN05167A1 (de) |
| WO (1) | WO2004056795A1 (de) |
| ZA (1) | ZA200505656B (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7550605B2 (en) * | 2004-08-05 | 2009-06-23 | Sun Pharmaceutical Industries Ltd. | Process for preparation of an anitdepressant compound |
| CZ297560B6 (cs) * | 2004-10-26 | 2007-02-07 | Zentiva, A. S. | Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu) |
| WO2006071868A2 (en) * | 2004-12-23 | 2006-07-06 | Teva Pharmaceutical Industries Ltd. | Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof |
| US20060270859A1 (en) * | 2005-01-27 | 2006-11-30 | Santiago Ini | Duloxetine HCl polymorphs |
| WO2006096809A1 (en) | 2005-03-08 | 2006-09-14 | Teva Pharmaceutical Industries Ltd. | Crystal forms of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine oxalate and the preparation thereof |
| EP1858859A1 (de) | 2005-03-14 | 2007-11-28 | Teva Pharmaceutical Industries Ltd. | Verfahren zur herstellung von optisch aktivem (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propanamin |
| US8093408B2 (en) * | 2005-06-21 | 2012-01-10 | The Company Wockhardt | Antidepressant oral pharmaceutical compositions |
| US8153824B2 (en) * | 2005-06-22 | 2012-04-10 | The Wockhardt Company | Antidepressant oral liquid compositions |
| US7842717B2 (en) | 2005-09-22 | 2010-11-30 | Teva Pharmaceutical Industries Ltd. | DNT-maleate and methods of preparation thereof |
| US7759500B2 (en) * | 2005-12-05 | 2010-07-20 | Teva Pharmaceutical Industries Ltd. | 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride |
| ATE507215T1 (de) * | 2005-12-12 | 2011-05-15 | Medichem Sa | Verbesserte synthese und zubereitungen von duloxetinsalzen |
| CZ299270B6 (cs) | 2006-01-04 | 2008-06-04 | Zentiva, A. S. | Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu |
| WO2007077580A2 (en) * | 2006-01-06 | 2007-07-12 | Msn Laboratories Limited | Improved process for pure duloxetine hydrochloride |
| US7538232B2 (en) | 2006-01-19 | 2009-05-26 | Eli Lilly And Company | Process for the asymmetric synthesis of duloxetine |
| EP1976845A2 (de) * | 2006-02-13 | 2008-10-08 | Teva Pharmaceutical Industries Ltd | Verfahren zur herstellung von (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propanamin, einem duloxetin-zwischenprodukt |
| HU228458B1 (en) * | 2006-03-13 | 2013-03-28 | Egis Gyogyszergyar Nyrt | Duloxetine salts for producing pharmaceutical compositions |
| DE602006015617D1 (de) | 2006-05-05 | 2010-09-02 | Fidia Farmaceutici | Verfahren zur Herstellung eines Zwischenprodukts für die asymmetrische Synthese von (+)Duloxetine |
| MX2008001079A (es) * | 2006-05-23 | 2008-03-19 | Teva Pharma | Polimorfos de hidrocloruro de duloxetina. |
| WO2008004191A2 (en) | 2006-07-03 | 2008-01-10 | Ranbaxy Laboratories Limited | Process for the preparation of enantiomerically pure salts of n-methyl-3- ( 1-naphthaleneoxy) -3- (2-thienyl) propanamine |
| CZ300116B6 (cs) * | 2006-12-05 | 2009-02-11 | Zentiva, A. S. | Zpusob cištení hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu |
| CN101657438A (zh) | 2006-12-22 | 2010-02-24 | 斯索恩有限公司 | 制备度洛西汀和相关化合物的方法 |
| HU227730B1 (en) | 2006-12-22 | 2012-01-30 | Richter Gedeon Nyrt | Process for the preparation of duloxetine and for their the intermediates |
| WO2008107911A2 (en) | 2007-03-05 | 2008-09-12 | Lupin Limited | Novel process for preparation of duloxetine hydrochloride |
| WO2009019719A2 (en) * | 2007-08-09 | 2009-02-12 | Ind-Swift Laboratories Limited | Process for the preparation of 3-aryloxy-3-arylpropanamines |
| WO2009130708A2 (en) * | 2008-04-22 | 2009-10-29 | Shodhana Laboratories Limited | Preparation of duloxetine and its salts |
| US8426178B2 (en) | 2008-08-27 | 2013-04-23 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| US8288141B2 (en) | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2011033366A2 (en) | 2009-09-16 | 2011-03-24 | Jubilant Life Sciences Limited | Process for the preparation of duloxetine hydrochloride and its precursors |
| CN103360365A (zh) * | 2012-04-06 | 2013-10-23 | 李晓红 | 一种抗抑郁症药物原料药盐酸度洛西汀的制备新工艺 |
| CN104230882B (zh) * | 2014-08-29 | 2017-03-08 | 宁波美诺华药业股份有限公司 | 一种度洛西汀盐酸盐杂质的制备方法 |
| CN104829587B (zh) * | 2015-05-08 | 2017-07-21 | 上海万巷制药有限公司 | 盐酸度洛西汀的制备 |
| CN107382958B (zh) * | 2017-07-05 | 2021-11-09 | 浙江华海药业股份有限公司 | 一种度洛西汀中间体的结晶方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH578532A5 (de) * | 1971-08-03 | 1976-08-13 | Cassella Farbwerke Mainkur Ag | |
| FI77018C (fi) | 1980-11-14 | 1989-01-10 | Lilly Co Eli | Analogifoerfarande foer framstaellning av antidepressivt aktiv (-)-enantiomer av n-metyl-n-/3-(2-metylfenoxi) -3-fenylpropyl/amin och dess farmaceutiskt godtagbara salt. |
| US4777291A (en) * | 1985-02-27 | 1988-10-11 | Eli Lilly And Company | Racemization process |
| JPS62286959A (ja) * | 1986-06-05 | 1987-12-12 | Seitetsu Kagaku Co Ltd | 光学活性シアノカルニチン塩の製造方法 |
| KR880007433A (ko) * | 1986-12-22 | 1988-08-27 | 메리 앤 터커 | 3-아릴옥시-3-치환된 프로판아민 |
| US4956388A (en) * | 1986-12-22 | 1990-09-11 | Eli Lilly And Company | 3-aryloxy-3-substituted propanamines |
| IL98108A0 (en) * | 1990-05-17 | 1992-06-21 | Lilly Co Eli | Chiral synthesis of 1-aryl-3-aminopropan-1-ols |
| JPH09176157A (ja) * | 1992-12-09 | 1997-07-08 | Takeda Chem Ind Ltd | 光学活性アミノクマラン誘導体 |
| US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
| US6162949A (en) * | 1994-12-16 | 2000-12-19 | Uop Llc | Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers |
| US6458955B1 (en) * | 1994-12-16 | 2002-10-01 | Uop Llc | Process for preparation of pharmaceutically desired enantiomers |
| EP0792649A1 (de) * | 1996-02-29 | 1997-09-03 | Eli Lilly And Company | Behandlung von Schlafstörungen |
| UA78181C2 (en) * | 1998-05-22 | 2007-03-15 | Lilly Co Eli | Combined therapy for treating refractory depressive states |
| DE69905938T2 (de) * | 1998-11-13 | 2003-11-13 | Eli Lilly And Co., Indianapolis | Kombination von duloxetin mit nichtsteroid-entzündungshemmern für die behandlung von schmerz |
| JP2002541235A (ja) * | 1999-04-09 | 2002-12-03 | イーライ・リリー・アンド・カンパニー | ３−アリールオキシ−３−アリールプロピルアミン及びその中間体の製造方法 |
| US6677485B2 (en) * | 1999-12-17 | 2004-01-13 | Ranbaxy Laboratories Limited | Process for the preparation of fluoxetine hydrochloride |
| WO2003062219A1 (en) * | 2002-01-24 | 2003-07-31 | Eli Lilly And Company | Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine |
-
2002
- 2002-12-19 GB GBGB0229583.0A patent/GB0229583D0/en not_active Ceased
-
2003
- 2003-12-10 NZ NZ569874A patent/NZ569874A/en not_active IP Right Cessation
- 2003-12-10 AU AU2003292396A patent/AU2003292396B2/en not_active Ceased
- 2003-12-10 JP JP2004561607A patent/JP5259048B2/ja not_active Expired - Fee Related
- 2003-12-10 WO PCT/GB2003/005357 patent/WO2004056795A1/en not_active Ceased
- 2003-12-10 KR KR1020057011506A patent/KR100926723B1/ko not_active Expired - Fee Related
- 2003-12-10 CN CN200380109793A patent/CN100579975C/zh not_active Expired - Fee Related
- 2003-12-10 AT AT03767973T patent/ATE353081T1/de not_active IP Right Cessation
- 2003-12-10 HR HR20050657A patent/HRP20050657A2/hr not_active Application Discontinuation
- 2003-12-10 EP EP06075798A patent/EP1690861B1/de not_active Expired - Lifetime
- 2003-12-10 NZ NZ540881A patent/NZ540881A/en not_active IP Right Cessation
- 2003-12-10 RU RU2005122662/04A patent/RU2351594C2/ru not_active IP Right Cessation
- 2003-12-10 ES ES03767973T patent/ES2279971T3/es not_active Expired - Lifetime
- 2003-12-10 EP EP03767973A patent/EP1587801B1/de not_active Revoked
- 2003-12-10 CA CA002510750A patent/CA2510750A1/en not_active Abandoned
- 2003-12-10 DE DE60311599T patent/DE60311599T2/de not_active Revoked
- 2003-12-10 PL PL377380A patent/PL377380A1/pl unknown
- 2003-12-10 MX MXPA05006659A patent/MXPA05006659A/es active IP Right Grant
- 2003-12-10 CN CN2007101531328A patent/CN101125848B/zh not_active Expired - Fee Related
- 2003-12-10 BR BR0316902-2A patent/BR0316902A/pt not_active IP Right Cessation
- 2003-12-10 US US10/539,415 patent/US7645890B2/en not_active Expired - Fee Related
- 2003-12-10 PT PT03767973T patent/PT1587801E/pt unknown
-
2005
- 2005-06-16 IL IL169232A patent/IL169232A/en not_active IP Right Cessation
- 2005-06-17 TN TNP2005000167A patent/TNSN05167A1/en unknown
- 2005-06-24 IS IS7915A patent/IS7915A/is unknown
- 2005-07-14 ZA ZA200505656A patent/ZA200505656B/en unknown
- 2005-07-18 MA MA28400A patent/MA27706A1/fr unknown
-
2010
- 2010-01-14 AU AU2010200142A patent/AU2010200142B2/en not_active Ceased
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |