ATE353081T1 - Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten - Google Patents
Verfahren zur herstellung von duloxetin und deren verwendeten zwischenproduktenInfo
- Publication number
- ATE353081T1 ATE353081T1 AT03767973T AT03767973T ATE353081T1 AT E353081 T1 ATE353081 T1 AT E353081T1 AT 03767973 T AT03767973 T AT 03767973T AT 03767973 T AT03767973 T AT 03767973T AT E353081 T1 ATE353081 T1 AT E353081T1
- Authority
- AT
- Austria
- Prior art keywords
- duloxetine
- acid addition
- addition salt
- intermediate products
- products used
- Prior art date
Links
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 title 1
- 229960002866 duloxetine Drugs 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- ZEUITGRIYCTCEM-UHFFFAOYSA-N duloxetine Chemical compound C=1C=CC2=CC=CC=C2C=1OC(CCNC)C1=CC=CS1 ZEUITGRIYCTCEM-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- ZEUITGRIYCTCEM-QGZVFWFLSA-N (R)-duloxetine Chemical compound C1([C@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-QGZVFWFLSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0229583.0A GB0229583D0 (en) | 2002-12-19 | 2002-12-19 | A process for preparing duloxetine and intermediates for use therein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353081T1 true ATE353081T1 (de) | 2007-02-15 |
Family
ID=9949985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03767973T ATE353081T1 (de) | 2002-12-19 | 2003-12-10 | Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7645890B2 (de) |
| EP (2) | EP1587801B1 (de) |
| JP (1) | JP5259048B2 (de) |
| KR (1) | KR100926723B1 (de) |
| CN (2) | CN101125848B (de) |
| AT (1) | ATE353081T1 (de) |
| AU (2) | AU2003292396B2 (de) |
| BR (1) | BR0316902A (de) |
| CA (1) | CA2510750A1 (de) |
| DE (1) | DE60311599T2 (de) |
| ES (1) | ES2279971T3 (de) |
| GB (1) | GB0229583D0 (de) |
| HR (1) | HRP20050657A2 (de) |
| IL (1) | IL169232A (de) |
| IS (1) | IS7915A (de) |
| MA (1) | MA27706A1 (de) |
| MX (1) | MXPA05006659A (de) |
| NZ (2) | NZ569874A (de) |
| PL (1) | PL377380A1 (de) |
| PT (1) | PT1587801E (de) |
| RU (1) | RU2351594C2 (de) |
| TN (1) | TNSN05167A1 (de) |
| WO (1) | WO2004056795A1 (de) |
| ZA (1) | ZA200505656B (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7550605B2 (en) * | 2004-08-05 | 2009-06-23 | Sun Pharmaceutical Industries Ltd. | Process for preparation of an anitdepressant compound |
| CZ297560B6 (cs) * | 2004-10-26 | 2007-02-07 | Zentiva, A. S. | Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu) |
| JP2007523213A (ja) * | 2004-12-23 | 2007-08-16 | テバ ファーマシューティカル インダストリーズ リミティド | 医薬的に許容できるデュロキセチンの塩及びその中間体の調製方法 |
| US20060270859A1 (en) * | 2005-01-27 | 2006-11-30 | Santiago Ini | Duloxetine HCl polymorphs |
| EP1856087A1 (de) | 2005-03-08 | 2007-11-21 | Teva Pharmaceutical Industries Limited | Kristallformen von (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamin-oxalat und deren herstellung |
| US7534900B2 (en) * | 2005-03-14 | 2009-05-19 | Teva Pharmaceutical Industries Ltd | Process for the purification of duloxetine hydrochloride |
| US8093408B2 (en) * | 2005-06-21 | 2012-01-10 | The Company Wockhardt | Antidepressant oral pharmaceutical compositions |
| US8153824B2 (en) * | 2005-06-22 | 2012-04-10 | The Wockhardt Company | Antidepressant oral liquid compositions |
| WO2007038253A2 (en) * | 2005-09-22 | 2007-04-05 | Teva Pharmaceutical Industries Ltd. | Dnt-maleate and methods of preparation thereof |
| EP1863782A1 (de) * | 2005-12-05 | 2007-12-12 | Teva Pharmaceutical Industries Ltd. | 2-(n-methyl-propanamin)-3-(2-naphthol) thiophen, eine verunreinigung von duloxetin hydrochlorid |
| WO2007119114A2 (en) * | 2005-12-12 | 2007-10-25 | Medichem, S.A. | Improved synthesis and preparations of duloxetine salts |
| CZ299270B6 (cs) | 2006-01-04 | 2008-06-04 | Zentiva, A. S. | Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu |
| EP1976844A4 (de) * | 2006-01-06 | 2010-11-03 | Msn Lab Ltd | Verbessertes verfahren für reines duloxetin-hydrochlorid |
| US7538232B2 (en) | 2006-01-19 | 2009-05-26 | Eli Lilly And Company | Process for the asymmetric synthesis of duloxetine |
| EP1976845A2 (de) * | 2006-02-13 | 2008-10-08 | Teva Pharmaceutical Industries Ltd | Verfahren zur herstellung von (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propanamin, einem duloxetin-zwischenprodukt |
| HU228458B1 (en) * | 2006-03-13 | 2013-03-28 | Egis Gyogyszergyar Nyrt | Duloxetine salts for producing pharmaceutical compositions |
| PT1857451E (pt) | 2006-05-05 | 2010-10-25 | Fidia Farmaceutici | Processo para a preparação de uma substância intermédia útil para a síntese assimétrica da (+)duloxetina |
| CN101448815A (zh) * | 2006-05-23 | 2009-06-03 | 特瓦制药工业有限公司 | 度洛西汀hci多晶型物 |
| EP2044049A2 (de) | 2006-07-03 | 2009-04-08 | Ranbaxy Laboratories Limited | Verfahren zur herstellung von enantiomerenreinen salzen von n-methyl-3 -( 1-naph-thaleneoxy)- 3 - (-2-thienyl)-propanamin |
| CZ300116B6 (cs) * | 2006-12-05 | 2009-02-11 | Zentiva, A. S. | Zpusob cištení hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu |
| HU227730B1 (en) | 2006-12-22 | 2012-01-30 | Richter Gedeon Nyrt | Process for the preparation of duloxetine and for their the intermediates |
| EP2114912B1 (de) | 2006-12-22 | 2012-04-04 | Synthon B.V. | Verfahren zur herstellung von duloxetin und verwandten verbindungen |
| EP2132192B1 (de) | 2007-03-05 | 2013-04-24 | Lupin Limited | Neues verfahren zur herstellung von duloxetinhydrochlorid |
| WO2009019719A2 (en) * | 2007-08-09 | 2009-02-12 | Ind-Swift Laboratories Limited | Process for the preparation of 3-aryloxy-3-arylpropanamines |
| WO2009130708A2 (en) * | 2008-04-22 | 2009-10-29 | Shodhana Laboratories Limited | Preparation of duloxetine and its salts |
| WO2010025287A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010025238A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2011033366A2 (en) | 2009-09-16 | 2011-03-24 | Jubilant Life Sciences Limited | Process for the preparation of duloxetine hydrochloride and its precursors |
| CN103360365A (zh) * | 2012-04-06 | 2013-10-23 | 李晓红 | 一种抗抑郁症药物原料药盐酸度洛西汀的制备新工艺 |
| CN104230882B (zh) * | 2014-08-29 | 2017-03-08 | 宁波美诺华药业股份有限公司 | 一种度洛西汀盐酸盐杂质的制备方法 |
| CN104829587B (zh) * | 2015-05-08 | 2017-07-21 | 上海万巷制药有限公司 | 盐酸度洛西汀的制备 |
| CN107382958B (zh) * | 2017-07-05 | 2021-11-09 | 浙江华海药业股份有限公司 | 一种度洛西汀中间体的结晶方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH578532A5 (de) * | 1971-08-03 | 1976-08-13 | Cassella Farbwerke Mainkur Ag | |
| GR75395B (de) | 1980-11-14 | 1984-07-13 | Lilly Co Eli | |
| US4777291A (en) * | 1985-02-27 | 1988-10-11 | Eli Lilly And Company | Racemization process |
| JPS62286959A (ja) * | 1986-06-05 | 1987-12-12 | Seitetsu Kagaku Co Ltd | 光学活性シアノカルニチン塩の製造方法 |
| US4956388A (en) * | 1986-12-22 | 1990-09-11 | Eli Lilly And Company | 3-aryloxy-3-substituted propanamines |
| KR880007433A (ko) * | 1986-12-22 | 1988-08-27 | 메리 앤 터커 | 3-아릴옥시-3-치환된 프로판아민 |
| IL98108A0 (en) * | 1990-05-17 | 1992-06-21 | Lilly Co Eli | Chiral synthesis of 1-aryl-3-aminopropan-1-ols |
| JPH09176157A (ja) * | 1992-12-09 | 1997-07-08 | Takeda Chem Ind Ltd | 光学活性アミノクマラン誘導体 |
| US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
| US6458955B1 (en) * | 1994-12-16 | 2002-10-01 | Uop Llc | Process for preparation of pharmaceutically desired enantiomers |
| US6162949A (en) * | 1994-12-16 | 2000-12-19 | Uop Llc | Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers |
| EP0792649A1 (de) * | 1996-02-29 | 1997-09-03 | Eli Lilly And Company | Behandlung von Schlafstörungen |
| HK1040055B (zh) * | 1998-05-22 | 2005-04-01 | 伊莱利利公司 | 奥氮平和氟西汀在制备治疗对抗治疗的严重抑郁症的药物中的应用 |
| ES2194536T3 (es) * | 1998-11-13 | 2003-11-16 | Lilly Co Eli | Combinacion de duloxetina con farmacos antiinflamatorios no esteroideos. |
| AU3877500A (en) * | 1999-04-09 | 2000-11-14 | Eli Lilly And Company | Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof |
| EP1242362A4 (de) * | 1999-12-17 | 2003-07-09 | Ranbaxy Lab Ltd | Verfahren zur herstellung von fluoxetinhydrochlorid |
| US20040249170A1 (en) | 2002-01-24 | 2004-12-09 | Alfio Borghese | Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine |
-
2002
- 2002-12-19 GB GBGB0229583.0A patent/GB0229583D0/en not_active Ceased
-
2003
- 2003-12-10 EP EP03767973A patent/EP1587801B1/de not_active Revoked
- 2003-12-10 MX MXPA05006659A patent/MXPA05006659A/es active IP Right Grant
- 2003-12-10 NZ NZ569874A patent/NZ569874A/en not_active IP Right Cessation
- 2003-12-10 NZ NZ540881A patent/NZ540881A/en not_active IP Right Cessation
- 2003-12-10 CA CA002510750A patent/CA2510750A1/en not_active Abandoned
- 2003-12-10 DE DE60311599T patent/DE60311599T2/de not_active Revoked
- 2003-12-10 WO PCT/GB2003/005357 patent/WO2004056795A1/en not_active Ceased
- 2003-12-10 PL PL377380A patent/PL377380A1/pl unknown
- 2003-12-10 AT AT03767973T patent/ATE353081T1/de not_active IP Right Cessation
- 2003-12-10 HR HR20050657A patent/HRP20050657A2/hr not_active Application Discontinuation
- 2003-12-10 RU RU2005122662/04A patent/RU2351594C2/ru not_active IP Right Cessation
- 2003-12-10 JP JP2004561607A patent/JP5259048B2/ja not_active Expired - Fee Related
- 2003-12-10 KR KR1020057011506A patent/KR100926723B1/ko not_active Expired - Fee Related
- 2003-12-10 CN CN2007101531328A patent/CN101125848B/zh not_active Expired - Fee Related
- 2003-12-10 US US10/539,415 patent/US7645890B2/en not_active Expired - Fee Related
- 2003-12-10 PT PT03767973T patent/PT1587801E/pt unknown
- 2003-12-10 BR BR0316902-2A patent/BR0316902A/pt not_active IP Right Cessation
- 2003-12-10 EP EP06075798A patent/EP1690861B1/de not_active Expired - Lifetime
- 2003-12-10 ES ES03767973T patent/ES2279971T3/es not_active Expired - Lifetime
- 2003-12-10 CN CN200380109793A patent/CN100579975C/zh not_active Expired - Fee Related
- 2003-12-10 AU AU2003292396A patent/AU2003292396B2/en not_active Ceased
-
2005
- 2005-06-16 IL IL169232A patent/IL169232A/en not_active IP Right Cessation
- 2005-06-17 TN TNP2005000167A patent/TNSN05167A1/en unknown
- 2005-06-24 IS IS7915A patent/IS7915A/is unknown
- 2005-07-14 ZA ZA200505656A patent/ZA200505656B/en unknown
- 2005-07-18 MA MA28400A patent/MA27706A1/fr unknown
-
2010
- 2010-01-14 AU AU2010200142A patent/AU2010200142B2/en not_active Ceased
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |