BR0316902A - Processos para preparar (+)duloxetina e hidrocloreto de (+)duloxetina, sal de ácido quiral e (+)duloxetina, di-p-toluil tartarato de (+)duloxetina, (+)duloxetina e composição farmacêutica - Google Patents

Processos para preparar (+)duloxetina e hidrocloreto de (+)duloxetina, sal de ácido quiral e (+)duloxetina, di-p-toluil tartarato de (+)duloxetina, (+)duloxetina e composição farmacêutica

Info

Publication number
BR0316902A
BR0316902A BR0316902-2A BR0316902A BR0316902A BR 0316902 A BR0316902 A BR 0316902A BR 0316902 A BR0316902 A BR 0316902A BR 0316902 A BR0316902 A BR 0316902A
Authority
BR
Brazil
Prior art keywords
duloxetine
preparing
processes
pharmaceutical composition
acid salt
Prior art date
Application number
BR0316902-2A
Other languages
English (en)
Inventor
Dharmaraj Ramachandra Rao
Rajendra Narayanrao Kankan
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9949985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0316902(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of BR0316902A publication Critical patent/BR0316902A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"PROCESSOS PARA PREPARAR (+)DULOXETINA E HIDROCLORETO DE (+)DULOXETINA, SAL DE áCIDO QUIRAL E (+)DULOXETINA, DI-PTOLUIL TARTARATO DE (+)DULOXETINA,(+)DULOXETINA E COMPOSIçãO FARMACêUTICA". A presente invenção refere-se a um processo para preparar (+) duloxetina, ou um sal de adição ácida da mesma, compreendendo (i) resolver (<sym>) duloxetina com um ácido quiral de maneira a obter um sal do ácido quiral e (+)duloxetina, substancialmente isenta de (-)duloxetina e (ii) caso desejado, converter o sal preparado na etapa (i) em uma base ou outro sal de adição ácida, conforme seja apropriado. O processo para preparar (+)duloxetina, ou um sal de adição ácida da mesma, pode adicionalmente compreender uma etapa de processo intermediária de O-alquilação que é realizada na presença de uma base e um catalisador de transferência de fase.
BR0316902-2A 2002-12-19 2003-12-10 Processos para preparar (+)duloxetina e hidrocloreto de (+)duloxetina, sal de ácido quiral e (+)duloxetina, di-p-toluil tartarato de (+)duloxetina, (+)duloxetina e composição farmacêutica BR0316902A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0229583.0A GB0229583D0 (en) 2002-12-19 2002-12-19 A process for preparing duloxetine and intermediates for use therein
PCT/GB2003/005357 WO2004056795A1 (en) 2002-12-19 2003-12-10 A process for preparing duloxetine and intermediates for use therein

Publications (1)

Publication Number Publication Date
BR0316902A true BR0316902A (pt) 2005-10-25

Family

ID=9949985

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316902-2A BR0316902A (pt) 2002-12-19 2003-12-10 Processos para preparar (+)duloxetina e hidrocloreto de (+)duloxetina, sal de ácido quiral e (+)duloxetina, di-p-toluil tartarato de (+)duloxetina, (+)duloxetina e composição farmacêutica

Country Status (24)

Country Link
US (1) US7645890B2 (pt)
EP (2) EP1690861B1 (pt)
JP (1) JP5259048B2 (pt)
KR (1) KR100926723B1 (pt)
CN (2) CN100579975C (pt)
AT (1) ATE353081T1 (pt)
AU (2) AU2003292396B2 (pt)
BR (1) BR0316902A (pt)
CA (1) CA2510750A1 (pt)
DE (1) DE60311599T2 (pt)
ES (1) ES2279971T3 (pt)
GB (1) GB0229583D0 (pt)
HR (1) HRP20050657A2 (pt)
IL (1) IL169232A (pt)
IS (1) IS7915A (pt)
MA (1) MA27706A1 (pt)
MX (1) MXPA05006659A (pt)
NZ (2) NZ569874A (pt)
PL (1) PL377380A1 (pt)
PT (1) PT1587801E (pt)
RU (1) RU2351594C2 (pt)
TN (1) TNSN05167A1 (pt)
WO (1) WO2004056795A1 (pt)
ZA (1) ZA200505656B (pt)

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WO2006027798A2 (en) * 2004-08-05 2006-03-16 Sun Pharmaceutical Industries Limited A process for preparation of an antidepressant compound
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EP1730132A2 (en) * 2004-12-23 2006-12-13 Teva Pharmaceutical Industries Ltd Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
WO2006081515A2 (en) * 2005-01-27 2006-08-03 Teva Pharmaceutical Industries Ltd. Duloxetine hydrochloride polymorphs
EP1856087A1 (en) 2005-03-08 2007-11-21 Teva Pharmaceutical Industries Limited Crystal forms of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine oxalate and the preparation thereof
MX2007011255A (es) * 2005-03-14 2007-10-18 Teva Pharma Clohidrato de duloxetina puro.
US8093408B2 (en) * 2005-06-21 2012-01-10 The Company Wockhardt Antidepressant oral pharmaceutical compositions
US8153824B2 (en) * 2005-06-22 2012-04-10 The Wockhardt Company Antidepressant oral liquid compositions
EP1838692A2 (en) * 2005-09-22 2007-10-03 Teva Pharmaceutical Industries Ltd Dnt-maleate and methods of preparation thereof
EP2100888A3 (en) * 2005-12-05 2011-01-19 Teva Pharmaceutical Industries Ltd. Process for the preparation of duloxetine hydrochloride
PL1971592T3 (pl) * 2005-12-12 2011-09-30 Medichem Sa Ulepszona synteza i preparaty soli duloksetyny
CZ299270B6 (cs) 2006-01-04 2008-06-04 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
US8362279B2 (en) * 2006-01-06 2013-01-29 Msn Laboratories Limited Process for pure duloxetine hydrochloride
US7538232B2 (en) 2006-01-19 2009-05-26 Eli Lilly And Company Process for the asymmetric synthesis of duloxetine
MX2007014131A (es) * 2006-02-13 2008-01-11 Teva Pharma Un proceso para la preparacion de (s)-(+)-n,n-dimetil-3-(1- naftale niloxi)-3-(2-tienil)propanamina un intermedio de duloxetina.
HU228458B1 (en) * 2006-03-13 2013-03-28 Egis Gyogyszergyar Nyrt Duloxetine salts for producing pharmaceutical compositions
EP1857451B1 (en) 2006-05-05 2010-07-21 Fidia Farmaceutici S.p.A. A process for the preparation of an intermediate useful for the asymmetric synthesis of (+)duloxetine
CN101448815A (zh) * 2006-05-23 2009-06-03 特瓦制药工业有限公司 度洛西汀hci多晶型物
WO2008004191A2 (en) 2006-07-03 2008-01-10 Ranbaxy Laboratories Limited Process for the preparation of enantiomerically pure salts of n-methyl-3- ( 1-naphthaleneoxy) -3- (2-thienyl) propanamine
CZ300116B6 (cs) * 2006-12-05 2009-02-11 Zentiva, A. S. Zpusob cištení hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
ATE552250T1 (de) 2006-12-22 2012-04-15 Synthon Bv Verfahren zur herstellung von duloxetin und verwandten verbindungen
HU227730B1 (en) 2006-12-22 2012-01-30 Richter Gedeon Nyrt Process for the preparation of duloxetine and for their the intermediates
EP2132192B1 (en) 2007-03-05 2013-04-24 Lupin Limited Novel process for preparation of duloxetine hydrochloride
WO2009019719A2 (en) * 2007-08-09 2009-02-12 Ind-Swift Laboratories Limited Process for the preparation of 3-aryloxy-3-arylpropanamines
WO2009130708A2 (en) * 2008-04-22 2009-10-29 Shodhana Laboratories Limited Preparation of duloxetine and its salts
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
SI2329013T1 (sl) 2008-08-27 2016-03-31 Codexis, Inc. Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina
WO2011033366A2 (en) 2009-09-16 2011-03-24 Jubilant Life Sciences Limited Process for the preparation of duloxetine hydrochloride and its precursors
CN103360365A (zh) * 2012-04-06 2013-10-23 李晓红 一种抗抑郁症药物原料药盐酸度洛西汀的制备新工艺
CN104230882B (zh) * 2014-08-29 2017-03-08 宁波美诺华药业股份有限公司 一种度洛西汀盐酸盐杂质的制备方法
CN104829587B (zh) * 2015-05-08 2017-07-21 上海万巷制药有限公司 盐酸度洛西汀的制备
CN107382958B (zh) * 2017-07-05 2021-11-09 浙江华海药业股份有限公司 一种度洛西汀中间体的结晶方法

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Also Published As

Publication number Publication date
AU2003292396A1 (en) 2004-07-14
NZ540881A (en) 2008-09-26
AU2010200142A1 (en) 2010-02-04
HRP20050657A2 (en) 2005-10-31
MXPA05006659A (es) 2006-02-22
TNSN05167A1 (en) 2007-05-14
CN101125848A (zh) 2008-02-20
NZ569874A (en) 2009-11-27
EP1587801A1 (en) 2005-10-26
IS7915A (is) 2005-06-24
PT1587801E (pt) 2007-04-30
JP2006514030A (ja) 2006-04-27
KR100926723B1 (ko) 2009-11-16
KR20050089839A (ko) 2005-09-08
JP5259048B2 (ja) 2013-08-07
IL169232A (en) 2010-02-17
CA2510750A1 (en) 2004-07-08
AU2003292396B2 (en) 2010-05-20
EP1690861B1 (en) 2012-09-12
WO2004056795A8 (en) 2005-08-11
EP1690861A3 (en) 2006-09-06
ATE353081T1 (de) 2007-02-15
PL377380A1 (pl) 2006-02-06
DE60311599D1 (de) 2007-03-22
AU2010200142B2 (en) 2012-04-12
EP1690861A2 (en) 2006-08-16
RU2005122662A (ru) 2006-01-20
EP1587801B1 (en) 2007-01-31
MA27706A1 (fr) 2006-01-02
CN101125848B (zh) 2012-09-12
RU2351594C2 (ru) 2009-04-10
GB0229583D0 (en) 2003-01-22
WO2004056795A1 (en) 2004-07-08
US7645890B2 (en) 2010-01-12
ES2279971T3 (es) 2007-09-01
CN100579975C (zh) 2010-01-13
CN1747947A (zh) 2006-03-15
US20060205956A1 (en) 2006-09-14
ZA200505656B (en) 2006-04-26
DE60311599T2 (de) 2007-10-25

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.