ATE309196T1 - Verfahren zur herstellung von 3-aryloxy-3- arylpropylamine und deren zwischenprodukte - Google Patents

Verfahren zur herstellung von 3-aryloxy-3- arylpropylamine und deren zwischenprodukte

Info

Publication number
ATE309196T1
ATE309196T1 AT00917868T AT00917868T ATE309196T1 AT E309196 T1 ATE309196 T1 AT E309196T1 AT 00917868 T AT00917868 T AT 00917868T AT 00917868 T AT00917868 T AT 00917868T AT E309196 T1 ATE309196 T1 AT E309196T1
Authority
AT
Austria
Prior art keywords
arylpropylamines
aryloxy
producing
intermediate products
methylpyrrolidinone
Prior art date
Application number
AT00917868T
Other languages
English (en)
Inventor
Douglas Patton Kjell
Kurt Thomas Lorenz
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE309196T1 publication Critical patent/ATE309196T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Pyrrole Compounds (AREA)
AT00917868T 1999-04-09 2000-03-22 Verfahren zur herstellung von 3-aryloxy-3- arylpropylamine und deren zwischenprodukte ATE309196T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12848099P 1999-04-09 1999-04-09
PCT/US2000/006423 WO2000061540A1 (en) 1999-04-09 2000-03-22 Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof

Publications (1)

Publication Number Publication Date
ATE309196T1 true ATE309196T1 (de) 2005-11-15

Family

ID=22435565

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00917868T ATE309196T1 (de) 1999-04-09 2000-03-22 Verfahren zur herstellung von 3-aryloxy-3- arylpropylamine und deren zwischenprodukte

Country Status (10)

Country Link
US (1) US6541668B1 (de)
EP (1) EP1171417B1 (de)
JP (1) JP2002541235A (de)
AT (1) ATE309196T1 (de)
AU (1) AU3877500A (de)
CA (1) CA2362185C (de)
DE (1) DE60023870T2 (de)
DK (1) DK1171417T3 (de)
ES (1) ES2249256T3 (de)
WO (1) WO2000061540A1 (de)

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EA005768B1 (ru) 2001-03-06 2005-06-30 Эли Лилли Энд Компани Ингибирование поглощения моноамина
EP1478641A1 (de) * 2002-01-24 2004-11-24 Eli Lilly And Company Verfahren zur herstellung eines für die asymmetrische synthese von duloxetin geeigneten zwischenprodukts
GB0229583D0 (en) * 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
ATE526954T1 (de) * 2003-07-28 2011-10-15 Leslie Joe Dunaway Atomoxetin zur behandlung von allergischer rhinitis und asthma
US20050197503A1 (en) * 2004-03-05 2005-09-08 Boehringer Ingelheim International Gmbh Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines
CA2561015A1 (en) * 2004-06-28 2006-06-29 Teva Pharmaceutical Fine Chemicals S.R.L. Processes for the preparation of tomoxetine
US7439399B2 (en) * 2004-06-28 2008-10-21 Teva Pharmaceutical Fine Chemicals Processes for the preparation of atomoxetine hydrochloride
CA2568629A1 (en) * 2004-07-22 2006-02-23 Teva Pharmaceutical Fine Chemicals S.R.L. Polymorphs of atomoxetine hydrochloride
WO2006027798A2 (en) * 2004-08-05 2006-03-16 Sun Pharmaceutical Industries Limited A process for preparation of an antidepressant compound
US20080004470A1 (en) * 2004-09-27 2008-01-03 Mathad Vijayavitthal T Synthesis of Atomoxetine Hydrochloride
JP2007523213A (ja) * 2004-12-23 2007-08-16 テバ ファーマシューティカル インダストリーズ リミティド 医薬的に許容できるデュロキセチンの塩及びその中間体の調製方法
WO2006096809A1 (en) * 2005-03-08 2006-09-14 Teva Pharmaceutical Industries Ltd. Crystal forms of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine oxalate and the preparation thereof
US7534900B2 (en) * 2005-03-14 2009-05-19 Teva Pharmaceutical Industries Ltd Process for the purification of duloxetine hydrochloride
EP1751085A1 (de) * 2005-04-05 2007-02-14 Teva Pharmaceutical Fine Chemicals S.R.L. Stabiles atomoxetinhydrochlorid, herstellungsverfahren und analytische steuerung seiner stabilität
EP1889828A1 (de) * 2005-04-05 2008-02-20 Teva Pharmaceutical Fine Chemicals S.R.L. Stabiles Atomoxetinhydrochlorid, Herstellungsverfahren und analytische Steuerung seiner Stabilität
US7485754B2 (en) * 2005-07-08 2009-02-03 Apotex Pharmachem Inc. Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers
CZ2005473A3 (cs) * 2005-07-21 2006-02-15 Zentiva, A. S Zpusob výroby hydrochloridu (R)-N-methyl-3-(2-methylfenoxy)-3-fenylpropylaminu (atomoxetinu)
US20080207923A1 (en) * 2005-09-22 2008-08-28 Santiago Ini Pure DNT-maleate and methods of preparation thereof
EP1838692A2 (de) * 2005-09-22 2007-10-03 Teva Pharmaceutical Industries Ltd Dnt-maleat und herstellungsverfahren dafür
WO2007067581A1 (en) 2005-12-05 2007-06-14 Teva Pharmaceutical Industries Ltd. 2-(n-methyl-propanamine)-3-(2-naphthol) thiophene, an impurity of duloxetine hydrochloride
DE602006021628D1 (de) 2005-12-12 2011-06-09 Medichem Sa Verbesserte synthese und zubereitungen von duloxetinsalzen
EP1798215A1 (de) * 2005-12-14 2007-06-20 SOLMAG S.p.A. Polymorph von Atomoxetin-hydrochloride in kristalliner Form
US7538232B2 (en) 2006-01-19 2009-05-26 Eli Lilly And Company Process for the asymmetric synthesis of duloxetine
WO2007086948A1 (en) * 2006-01-23 2007-08-02 Teva Pharmaceutical Industries Ltd. Dnt-fumarate and methods of preparation thereof
MX2007011727A (es) * 2006-01-23 2007-11-15 Teva Pharma Dnt-succinato y metodos de preparacion de el.
BRPI0707724A2 (pt) * 2006-02-13 2011-05-10 Teva Pharma um novo processo para preparaÇço de (s)-(+)-n, n-dimetil-3-(1-naftaleniloxi)-3-(2-tienil)propanamina), um intermediÁrio de duloxetina
EP1888554A2 (de) * 2006-02-21 2008-02-20 Teva Pharmaceutical Industries Ltd Verfahren zur herstellung von (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamin, einem duloxetin-zwischenprodukt
US20080146675A1 (en) * 2006-04-05 2008-06-19 Eugenio Castelli Stable Atomoxetine Hydrochloride, a process for the preparation thereof, and an analytical control of its stability
US20080027128A1 (en) * 2006-05-23 2008-01-31 Santiago Ini Duloxetine HCL polymorphs
WO2007143065A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Process for preparing duloxetine and intermediates thereof
CN100430370C (zh) * 2006-11-03 2008-11-05 华东理工大学 一种丙胺衍生物及其在制备托莫西汀中的应用
US20080145318A1 (en) * 2006-12-13 2008-06-19 Midha Kamal K Atomoxetine formulations and associated methods
CN101657438A (zh) 2006-12-22 2010-02-24 斯索恩有限公司 制备度洛西汀和相关化合物的方法
EP2132192B1 (de) * 2007-03-05 2013-04-24 Lupin Limited Neues verfahren zur herstellung von duloxetinhydrochlorid
WO2009019719A2 (en) * 2007-08-09 2009-02-12 Ind-Swift Laboratories Limited Process for the preparation of 3-aryloxy-3-arylpropanamines
EP2060559A1 (de) 2007-11-19 2009-05-20 Cadila Pharmaceuticals Limited Herstellungsverfahren für enantiomerenreine 3-Hydroxy-3-Arylpropylamine und ihrer optischen Stereoisomere
US20100267968A1 (en) * 2007-12-26 2010-10-21 Orchid Chemicals & Pharmaceuticals Limited Method for the preparation of duloxetine hydrochloride
WO2009092129A1 (en) * 2008-01-25 2009-07-30 Alpharma Pty Ltd Delayed release pharmaceutical composition of duloxetine
WO2009141833A2 (en) * 2008-04-17 2009-11-26 Ind-Swift Laboratories Limited An improved process for synthesizing highly pure atomoxetine
US8426178B2 (en) 2008-08-27 2013-04-23 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2558455B1 (de) 2010-04-13 2017-08-09 KRKA, D.D., Novo Mesto Synthese von duloxetin- und/oder pharmazeutisch akzeptablen salzen daraus
CN102863344B (zh) * 2012-07-20 2015-06-03 葫芦岛国帝药业有限责任公司 一种托莫西汀药物制备方法
CN106916074A (zh) * 2017-02-14 2017-07-04 万特制药(海南)有限公司 盐酸托莫西汀的制备
CN108929236A (zh) * 2017-05-26 2018-12-04 万特制药(海南)有限公司 盐酸托莫西汀的制备
CN110294680A (zh) * 2018-03-22 2019-10-01 北京深蓝海生物医药科技有限公司 一种盐酸阿托莫西汀的制备方法
CN111302958B (zh) * 2020-03-24 2023-05-02 合肥医工医药股份有限公司 一种光学纯的（r）-n-甲基-3-苯基-3-（邻-甲苯氧基）-丙胺盐酸盐制备方法

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RO83309B (ro) 1980-11-14 1984-02-28 Eli Lilly And Co Procedeu pentru prepararea (-)-n-metil-3-(2-metil-fenoxi)-3-fenilpropilaminei
JPS6023656A (ja) 1983-07-20 1985-02-06 Nissan Motor Co Ltd 自動変速機の遊星歯車列
US4868344A (en) 1988-03-30 1989-09-19 Aldrich-Boranes, Inc. Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein
US5166437A (en) 1989-03-03 1992-11-24 Orion-Yhtyma Oy Process for the preparation of fluoxetine
FI81083C (fi) * 1989-03-03 1990-09-10 Orion Yhtymae Oy Ett foerbaettrat foerfarande foer framstaellning av n-metyl-3-(p-trifluormetylfenoxi)-3-fenylpropylamin hydroklorid.
US5104899A (en) 1990-08-13 1992-04-14 Sepracor, Inc. Methods and compositions for treating depression using optically pure fluoxetine
US5362886A (en) 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
ES2120368B1 (es) * 1996-06-14 1999-07-01 Almirall Prodesfarma Sa Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables.
IT1283141B1 (it) * 1996-07-11 1998-04-07 Laporte Organics Francis S P A Procedimento per la preparazione di n-metil-3-(p-trifluorometilfenossi)-3-fenilpropilamina e dei suoi
TW514634B (en) 1997-10-14 2002-12-21 Lilly Co Eli Process to make chiral compounds

Also Published As

Publication number Publication date
DE60023870T2 (de) 2006-06-14
EP1171417B1 (de) 2005-11-09
EP1171417A1 (de) 2002-01-16
ES2249256T3 (es) 2006-04-01
WO2000061540A1 (en) 2000-10-19
CA2362185C (en) 2009-06-02
DK1171417T3 (da) 2006-02-20
US6541668B1 (en) 2003-04-01
DE60023870D1 (de) 2005-12-15
AU3877500A (en) 2000-11-14
JP2002541235A (ja) 2002-12-03
CA2362185A1 (en) 2000-10-19

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