DE60023870D1 - Verfahren zur herstellung von 3-aryloxy-3-arylpropylamine und deren zwischenprodukte - Google Patents
Verfahren zur herstellung von 3-aryloxy-3-arylpropylamine und deren zwischenprodukteInfo
- Publication number
- DE60023870D1 DE60023870D1 DE60023870T DE60023870T DE60023870D1 DE 60023870 D1 DE60023870 D1 DE 60023870D1 DE 60023870 T DE60023870 T DE 60023870T DE 60023870 T DE60023870 T DE 60023870T DE 60023870 D1 DE60023870 D1 DE 60023870D1
- Authority
- DE
- Germany
- Prior art keywords
- aryloxy
- preparation
- arylpropylamine
- intermediate products
- arylpropylamines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 2
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical compound CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000006073 displacement reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Luminescent Compositions (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12848099P | 1999-04-09 | 1999-04-09 | |
PCT/US2000/006423 WO2000061540A1 (en) | 1999-04-09 | 2000-03-22 | Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60023870D1 true DE60023870D1 (de) | 2005-12-15 |
DE60023870T2 DE60023870T2 (de) | 2006-06-14 |
Family
ID=22435565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60023870T Expired - Lifetime DE60023870T2 (de) | 1999-04-09 | 2000-03-22 | Verfahren zur herstellung von 3-aryloxy-3-arylpropylamine und deren zwischenprodukte |
Country Status (10)
Country | Link |
---|---|
US (1) | US6541668B1 (de) |
EP (1) | EP1171417B1 (de) |
JP (1) | JP2002541235A (de) |
AT (1) | ATE309196T1 (de) |
AU (1) | AU3877500A (de) |
CA (1) | CA2362185C (de) |
DE (1) | DE60023870T2 (de) |
DK (1) | DK1171417T3 (de) |
ES (1) | ES2249256T3 (de) |
WO (1) | WO2000061540A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002070457A1 (en) | 2001-03-06 | 2002-09-12 | Eli Lilly And Company | Inhibitor of monoamine uptake |
EP1478641A1 (de) * | 2002-01-24 | 2004-11-24 | Eli Lilly And Company | Verfahren zur herstellung eines für die asymmetrische synthese von duloxetin geeigneten zwischenprodukts |
GB0229583D0 (en) | 2002-12-19 | 2003-01-22 | Cipla Ltd | A process for preparing duloxetine and intermediates for use therein |
ATE526954T1 (de) * | 2003-07-28 | 2011-10-15 | Leslie Joe Dunaway | Atomoxetin zur behandlung von allergischer rhinitis und asthma |
US20050197503A1 (en) * | 2004-03-05 | 2005-09-08 | Boehringer Ingelheim International Gmbh | Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines |
US7439399B2 (en) * | 2004-06-28 | 2008-10-21 | Teva Pharmaceutical Fine Chemicals | Processes for the preparation of atomoxetine hydrochloride |
ATE407111T1 (de) * | 2004-06-28 | 2008-09-15 | Teva Pharm Fine Chemicals Srl | Isolierte atomoxetinverunreinigung, verfahren zur herstellung von atomoxetinverunreinigungen und deren verwendung als referenzstandards |
WO2006020348A2 (en) * | 2004-07-22 | 2006-02-23 | Teva Pharmaceutical Fine Chemicals S.R.L. | Polymorphs of atomoxetine hydrochloride |
WO2006027798A2 (en) * | 2004-08-05 | 2006-03-16 | Sun Pharmaceutical Industries Limited | A process for preparation of an antidepressant compound |
EP1794112A4 (de) * | 2004-09-27 | 2009-11-04 | Reddys Lab Ltd Dr | Synthese von atomexetin-hydrochlorid |
WO2006071868A2 (en) * | 2004-12-23 | 2006-07-06 | Teva Pharmaceutical Industries Ltd. | Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof |
MX2007010931A (es) * | 2005-03-08 | 2007-10-16 | Teva Pharma | Formas cristalinas de (s)-(+)-n,n-dimetil-3-(1-naftaleniloxi)-3-(2 -tienil)propanamina oxalato y la preparacion ellas. |
US7534900B2 (en) * | 2005-03-14 | 2009-05-19 | Teva Pharmaceutical Industries Ltd | Process for the purification of duloxetine hydrochloride |
US7569729B2 (en) * | 2005-04-05 | 2009-08-04 | Teva Pharmaceutical Fine Chemicals S.R.L. | Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability |
EP1889828A1 (de) * | 2005-04-05 | 2008-02-20 | Teva Pharmaceutical Fine Chemicals S.R.L. | Stabiles Atomoxetinhydrochlorid, Herstellungsverfahren und analytische Steuerung seiner Stabilität |
US7485754B2 (en) * | 2005-07-08 | 2009-02-03 | Apotex Pharmachem Inc. | Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers |
CZ296345B6 (cs) * | 2005-07-21 | 2006-02-15 | Zentiva, A. S | Zpusob výroby hydrochloridu (R)-N-methyl-3-(2-methylfenoxy)-3-fenylpropylaminu (atomoxetinu) |
US20080207923A1 (en) * | 2005-09-22 | 2008-08-28 | Santiago Ini | Pure DNT-maleate and methods of preparation thereof |
EP1838692A2 (de) * | 2005-09-22 | 2007-10-03 | Teva Pharmaceutical Industries Ltd | Dnt-maleat und herstellungsverfahren dafür |
US7759500B2 (en) * | 2005-12-05 | 2010-07-20 | Teva Pharmaceutical Industries Ltd. | 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride |
EP1971592B1 (de) | 2005-12-12 | 2011-04-27 | Medichem, S.A. | Verbesserte synthese und zubereitungen von duloxetinsalzen |
EP1798215A1 (de) * | 2005-12-14 | 2007-06-20 | SOLMAG S.p.A. | Polymorph von Atomoxetin-hydrochloride in kristalliner Form |
US7538232B2 (en) | 2006-01-19 | 2009-05-26 | Eli Lilly And Company | Process for the asymmetric synthesis of duloxetine |
US20070173541A1 (en) * | 2006-01-23 | 2007-07-26 | Santiago Ini | DNT-succinate and methods of preparation thereof |
EP1844034A1 (de) * | 2006-01-23 | 2007-10-17 | Teva Pharmaceutical Industries Ltd | Dnt-fumarat, und verfahren zu dessem herstellung |
US20070238883A1 (en) * | 2006-02-13 | 2007-10-11 | Santiago Ini | Process for the preparation of(s)-(+)-N,N-dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thienyl)propanamine, A duloxetine intermediate |
EP1888554A2 (de) * | 2006-02-21 | 2008-02-20 | Teva Pharmaceutical Industries Ltd | Verfahren zur herstellung von (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamin, einem duloxetin-zwischenprodukt |
US20080146675A1 (en) * | 2006-04-05 | 2008-06-19 | Eugenio Castelli | Stable Atomoxetine Hydrochloride, a process for the preparation thereof, and an analytical control of its stability |
MX2008001079A (es) * | 2006-05-23 | 2008-03-19 | Teva Pharma | Polimorfos de hidrocloruro de duloxetina. |
EP1976846A2 (de) * | 2006-05-31 | 2008-10-08 | Teva Pharmaceutical Industries Ltd | Verfahren zur herstellung von duloxetin und vermittler davon |
CN100430370C (zh) * | 2006-11-03 | 2008-11-05 | 华东理工大学 | 一种丙胺衍生物及其在制备托莫西汀中的应用 |
US20080145318A1 (en) * | 2006-12-13 | 2008-06-19 | Midha Kamal K | Atomoxetine formulations and associated methods |
WO2008077645A1 (en) | 2006-12-22 | 2008-07-03 | Synthon B.V. | Process for making duloxetine and related compounds |
EP2132192B1 (de) * | 2007-03-05 | 2013-04-24 | Lupin Limited | Neues verfahren zur herstellung von duloxetinhydrochlorid |
WO2009019719A2 (en) * | 2007-08-09 | 2009-02-12 | Ind-Swift Laboratories Limited | Process for the preparation of 3-aryloxy-3-arylpropanamines |
EP2060559A1 (de) | 2007-11-19 | 2009-05-20 | Cadila Pharmaceuticals Limited | Herstellungsverfahren für enantiomerenreine 3-Hydroxy-3-Arylpropylamine und ihrer optischen Stereoisomere |
US20100267968A1 (en) * | 2007-12-26 | 2010-10-21 | Orchid Chemicals & Pharmaceuticals Limited | Method for the preparation of duloxetine hydrochloride |
JP2011510024A (ja) * | 2008-01-25 | 2011-03-31 | アルファファーム ピーティーワイ リミテッド | デュロキセチンの遅延放出医薬組成物 |
WO2009141833A2 (en) * | 2008-04-17 | 2009-11-26 | Ind-Swift Laboratories Limited | An improved process for synthesizing highly pure atomoxetine |
US8426178B2 (en) | 2008-08-27 | 2013-04-23 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
WO2010025287A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
SI2558455T1 (sl) | 2010-04-13 | 2017-12-29 | Krka, D.D., Novo Mesto | Sinteza duloksetina in/ali njegovih farmacevtsko sprejemljivih soli |
CN102863344B (zh) * | 2012-07-20 | 2015-06-03 | 葫芦岛国帝药业有限责任公司 | 一种托莫西汀药物制备方法 |
CN106916074A (zh) * | 2017-02-14 | 2017-07-04 | 万特制药(海南)有限公司 | 盐酸托莫西汀的制备 |
CN108929236A (zh) * | 2017-05-26 | 2018-12-04 | 万特制药(海南)有限公司 | 盐酸托莫西汀的制备 |
CN110294680A (zh) * | 2018-03-22 | 2019-10-01 | 北京深蓝海生物医药科技有限公司 | 一种盐酸阿托莫西汀的制备方法 |
CN111302958B (zh) * | 2020-03-24 | 2023-05-02 | 合肥医工医药股份有限公司 | 一种光学纯的(r)-n-甲基-3-苯基-3-(邻-甲苯氧基)-丙胺盐酸盐制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT73982B (en) | 1980-11-14 | 1983-11-23 | Lilly Co Eli | Process for preparing 3-aryloxy-3-phenylpropylamines |
JPS6023656A (ja) | 1983-07-20 | 1985-02-06 | Nissan Motor Co Ltd | 自動変速機の遊星歯車列 |
US4868344A (en) | 1988-03-30 | 1989-09-19 | Aldrich-Boranes, Inc. | Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein |
FI81083C (fi) * | 1989-03-03 | 1990-09-10 | Orion Yhtymae Oy | Ett foerbaettrat foerfarande foer framstaellning av n-metyl-3-(p-trifluormetylfenoxi)-3-fenylpropylamin hydroklorid. |
US5166437A (en) * | 1989-03-03 | 1992-11-24 | Orion-Yhtyma Oy | Process for the preparation of fluoxetine |
US5104899A (en) | 1990-08-13 | 1992-04-14 | Sepracor, Inc. | Methods and compositions for treating depression using optically pure fluoxetine |
US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
ES2120368B1 (es) * | 1996-06-14 | 1999-07-01 | Almirall Prodesfarma Sa | Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables. |
IT1283141B1 (it) * | 1996-07-11 | 1998-04-07 | Laporte Organics Francis S P A | Procedimento per la preparazione di n-metil-3-(p-trifluorometilfenossi)-3-fenilpropilamina e dei suoi |
TW514634B (en) | 1997-10-14 | 2002-12-21 | Lilly Co Eli | Process to make chiral compounds |
-
2000
- 2000-03-22 DK DK00917868T patent/DK1171417T3/da active
- 2000-03-22 DE DE60023870T patent/DE60023870T2/de not_active Expired - Lifetime
- 2000-03-22 ES ES00917868T patent/ES2249256T3/es not_active Expired - Lifetime
- 2000-03-22 AT AT00917868T patent/ATE309196T1/de not_active IP Right Cessation
- 2000-03-22 AU AU38775/00A patent/AU3877500A/en not_active Abandoned
- 2000-03-22 US US09/936,468 patent/US6541668B1/en not_active Expired - Lifetime
- 2000-03-22 WO PCT/US2000/006423 patent/WO2000061540A1/en active IP Right Grant
- 2000-03-22 EP EP00917868A patent/EP1171417B1/de not_active Expired - Lifetime
- 2000-03-22 JP JP2000610817A patent/JP2002541235A/ja active Pending
- 2000-03-22 CA CA002362185A patent/CA2362185C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE309196T1 (de) | 2005-11-15 |
DK1171417T3 (da) | 2006-02-20 |
EP1171417B1 (de) | 2005-11-09 |
CA2362185A1 (en) | 2000-10-19 |
EP1171417A1 (de) | 2002-01-16 |
DE60023870T2 (de) | 2006-06-14 |
US6541668B1 (en) | 2003-04-01 |
WO2000061540A1 (en) | 2000-10-19 |
ES2249256T3 (es) | 2006-04-01 |
CA2362185C (en) | 2009-06-02 |
AU3877500A (en) | 2000-11-14 |
JP2002541235A (ja) | 2002-12-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |