IS5883A - Aðferð til framleiðslu á hreinu sítalóprami - Google Patents

Aðferð til framleiðslu á hreinu sítalóprami

Info

Publication number
IS5883A
IS5883A IS5883A IS5883A IS5883A IS 5883 A IS5883 A IS 5883A IS 5883 A IS5883 A IS 5883A IS 5883 A IS5883 A IS 5883A IS 5883 A IS5883 A IS 5883A
Authority
IS
Iceland
Prior art keywords
citalopram
amide
subjecting
base
optionally
Prior art date
Application number
IS5883A
Other languages
English (en)
Other versions
IS2060B (is
Inventor
Villa Marco
Sbrogio Federico
Dancer Robert
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of IS5883A publication Critical patent/IS5883A/is
Publication of IS2060B publication Critical patent/IS2060B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IS5883A 2000-12-22 2001-03-09 Aðferð til framleiðslu á hreinu sítalóprami IS2060B (is)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001929 2000-12-22

Publications (2)

Publication Number Publication Date
IS5883A true IS5883A (is) 2001-06-20
IS2060B IS2060B (is) 2005-11-15

Family

ID=8159922

Family Applications (1)

Application Number Title Priority Date Filing Date
IS5883A IS2060B (is) 2000-12-22 2001-03-09 Aðferð til framleiðslu á hreinu sítalóprami

Country Status (43)

Country Link
US (1) US6455710B1 (is)
EP (2) EP1181713B1 (is)
JP (1) JP3798982B2 (is)
KR (1) KR100439329B1 (is)
CN (1) CN1282648C (is)
AR (1) AR030056A1 (is)
AT (2) ATE277920T1 (is)
AU (2) AU2001100405B4 (is)
BE (2) BE1013212A6 (is)
BG (1) BG65131B1 (is)
BR (1) BR0106272A (is)
CA (1) CA2360303C (is)
CH (1) CH691535A5 (is)
CZ (1) CZ292200B6 (is)
DE (2) DE60105926T2 (is)
DK (1) DK1181713T3 (is)
EA (1) EA003581B1 (is)
ES (2) ES2228824T3 (is)
FI (2) FI108639B (is)
FR (1) FR2812877B1 (is)
GB (1) GB2357763B (is)
GR (1) GR1003874B (is)
HK (1) HK1048812B (is)
HR (1) HRP20020004A2 (is)
HU (2) HU0101029D0 (is)
IE (1) IES20010254A2 (is)
IL (1) IL147226A (is)
IS (1) IS2060B (is)
IT (1) ITMI20010602A1 (is)
MX (1) MXPA01013151A (is)
NL (2) NL1017525C1 (is)
NO (1) NO312462B1 (is)
NZ (1) NZ516298A (is)
PL (1) PL205724B1 (is)
PT (1) PT1181713E (is)
SE (1) SE517623C2 (is)
SG (1) SG167655A1 (is)
SI (1) SI1181713T1 (is)
SK (2) SK284428B6 (is)
TR (1) TR200201166T1 (is)
UA (1) UA71634C2 (is)
WO (1) WO2001045483A2 (is)
ZA (1) ZA200110179B (is)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
IL150335A0 (en) 1999-12-28 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
KR100660802B1 (ko) 2000-01-14 2006-12-26 하. 룬트벡 아크티에 셀스카브 5-시아노프탈리드의 제조 방법
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
JP2003527385A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
HUP0300274A2 (hu) 2000-03-13 2003-06-28 H. Lundbeck A/S Eljárás citalopram előállítására
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
PL360107A1 (en) 2000-03-14 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
ES2159271B1 (es) * 2000-03-16 2002-05-01 Lundbeck & Co As H Metodo para la preparacion de 5-ciano-1-(4-fluorofenil)-1,3-dihidroisobenzofuranos
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
PL353369A1 (en) 2000-12-28 2003-11-17 H.Lundbeck A/S Process for the preparation of pure citalopram
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
CZ20032567A3 (en) * 2001-03-09 2004-04-14 Ranbaxy Laboratories Limited Process for the preparation of citalopram
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
RU2004117211A (ru) * 2001-11-08 2005-03-27 Сепракор, Инк. (Us) Способы лечения депресии и других рассстройств цнс с использованием энантиомерно обогащшенных десметил-и дидесметилметаболитов циталопрама
AU2003222435A1 (en) * 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
KR20050086560A (ko) * 2002-11-15 2005-08-30 아크조 노벨 엔.브이. 지방 니트릴용 정제/탈색 처리 방법
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
EP1486492A3 (en) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
CA2546422A1 (en) * 2003-10-28 2005-05-12 Wockhardt Limited Improved process for the manufacture of citalopram hydrobromide
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
CN114763343A (zh) * 2021-01-14 2022-07-19 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE536169C (de) * 1926-08-21 1931-10-20 British Dyestuffs Corp Ltd Verfahren zur Gewinnung von tertiaeren aromatischen Aminen aus ihren Gemischen mit sekundaeren und primaeren aromatischen Aminen
US1992111A (en) * 1931-06-20 1935-02-19 Du Pont Separation of secondary and tertiary amines
DE1032261B (de) * 1955-03-08 1958-06-19 Leda Chemicals Ltd Verfahren zur Abtrennung sekundaerer Amine aus einer primaeres und sekundaeres Amin enthaltenden Mischung
GB1143703A (is) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
US4302399A (en) * 1978-09-28 1981-11-24 Dynapol Acetylation of crude reaction products containing polymeric colorants
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
US4943591A (en) 1984-10-17 1990-07-24 Glaxo Group Limited Dichloroaniline derivatives
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DE69717317T2 (de) * 1997-06-30 2003-10-02 Beloit Technologies Inc Verfahren und vorrichtung zum auftragen einer beschichtung auf eine bei hoher geschwindigkeit laufende papierbahn
CA2291067C (en) 1997-07-08 2002-07-30 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
WO1998019512A2 (en) 1997-11-11 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
IL142346A0 (en) * 1998-10-20 2002-03-10 Lundbeck & Co As H Method for the preparation of citalopram
CZ300408B6 (cs) 1998-12-23 2009-05-13 H. Lundbeck A/S Zpusob výroby 5-kyanoftalidu
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
PL353369A1 (en) 2000-12-28 2003-11-17 H.Lundbeck A/S Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
ITMI20010602A1 (it) 2002-09-22
CN1366525A (zh) 2002-08-28
CA2360303A1 (en) 2001-06-28
AU2001100405B4 (en) 2002-03-21
AU2001100405A4 (en) 2001-11-01
NL1017525C1 (nl) 2001-04-26
AT4367U1 (de) 2001-06-25
PL205724B1 (pl) 2010-05-31
WO2001045483A2 (en) 2001-06-28
BG106203A (en) 2002-08-30
JP3798982B2 (ja) 2006-07-19
CA2360303C (en) 2003-08-12
DE60105926D1 (de) 2004-11-04
HUP0102817A2 (hu) 2001-12-28
BR0106272A (pt) 2004-06-15
SG167655A1 (en) 2011-01-28
HUP0102817A3 (en) 2003-07-28
IL147226A (en) 2006-04-10
FI108639B (fi) 2002-02-28
US6455710B1 (en) 2002-09-24
EA003581B1 (ru) 2003-06-26
SK286283B6 (sk) 2008-06-06
PT1181713E (pt) 2005-02-28
US20020120005A1 (en) 2002-08-29
TR200201166T1 (tr) 2002-10-21
EP1462447A2 (en) 2004-09-29
DE60105926T2 (de) 2005-11-24
SK284428B6 (sk) 2005-04-01
HU0102817D0 (en) 2001-09-28
EA200200018A1 (ru) 2002-04-25
ES2170732A1 (es) 2002-08-01
SE0103045L (sv) 2002-06-23
AU3920101A (en) 2001-07-03
ATE277920T1 (de) 2004-10-15
ITMI20010602A0 (it) 2001-03-22
DK1181713T3 (da) 2005-01-31
BE1013212A6 (fr) 2001-10-02
HK1048812B (zh) 2007-06-01
UA71634C2 (uk) 2004-12-15
GB2357763A (en) 2001-07-04
IL147226A0 (en) 2002-08-14
NO20011271A (no) 2002-05-13
GB2357763B (en) 2002-01-16
BG65131B1 (bg) 2007-03-30
KR20020065345A (ko) 2002-08-13
FI20010500A0 (fi) 2001-03-13
EP1181713B1 (en) 2004-09-29
SI1181713T1 (en) 2005-02-28
CN1282648C (zh) 2006-11-01
HU0101029D0 (en) 2001-05-28
GB0105983D0 (en) 2001-05-02
CZ292200B6 (cs) 2003-08-13
CH691535A5 (de) 2001-08-15
KR100439329B1 (ko) 2004-07-07
FR2812877B1 (fr) 2003-04-04
EP1181713A2 (en) 2002-02-27
WO2001045483A3 (en) 2001-12-27
DE10112829C1 (de) 2002-07-25
HRP20020004A2 (en) 2003-04-30
CZ2001890A3 (cs) 2002-08-14
BE1013213A6 (fr) 2001-10-02
ES2170732B2 (es) 2003-09-16
MXPA01013151A (es) 2002-08-12
NL1018360C1 (nl) 2001-10-04
SE0103045D0 (sv) 2001-09-14
ZA200110179B (en) 2002-12-11
AR030056A1 (es) 2003-08-13
IS2060B (is) 2005-11-15
SE517623C2 (sv) 2002-06-25
NO20011271D0 (no) 2001-03-13
FR2812877A1 (fr) 2002-02-15
NZ516298A (en) 2002-12-20
NO312462B1 (no) 2002-05-13
JP2003517484A (ja) 2003-05-27
IES20010254A2 (en) 2002-03-06
HK1048812A1 (en) 2003-04-17
GR1003874B (el) 2002-04-24
SK18482001A3 (sk) 2002-05-09
PL353398A1 (en) 2003-11-17
ES2228824T3 (es) 2005-04-16
FI20011577A0 (fi) 2001-07-26
EP1462447A3 (en) 2004-11-17

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