EA200200016A1 - Способ получения чистого циталопрама - Google Patents

Способ получения чистого циталопрама

Info

Publication number
EA200200016A1
EA200200016A1 EA200200016A EA200200016A EA200200016A1 EA 200200016 A1 EA200200016 A1 EA 200200016A1 EA 200200016 A EA200200016 A EA 200200016A EA 200200016 A EA200200016 A EA 200200016A EA 200200016 A1 EA200200016 A1 EA 200200016A1
Authority
EA
Eurasian Patent Office
Prior art keywords
citalopram
cyanide
subjected
formula
cytaloprama
Prior art date
Application number
EA200200016A
Other languages
English (en)
Other versions
EA003459B1 (ru
Inventor
Андреа Кастеллин
Джулио Вольпе
Федерико Сброджо
Original Assignee
Х.Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х.Лундбекк А/С filed Critical Х.Лундбекк А/С
Publication of EA200200016A1 publication Critical patent/EA200200016A1/ru
Publication of EA003459B1 publication Critical patent/EA003459B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Описывается способ получения циталопрама формулы (I), по которому соединение формулы (II), в которой Z означает иод, бром, хлор или CF-(CF)-SO-O-, n равно 0, 1, 2, 3, 4, 5, 6, 7 или 8, подвергают реакции цианидного обмена, по которой группа Z обменивается с цианидной группой по реакции с цианидным источником; полученный сырой продукт - циталопрам, необязательно, подвергают некоторой первоначальной очистке и сырое основание циталопрама впоследствии подвергают процессу пленочной дистилляции; полученный продукт - циталопрам затем, необязательно, дополнительно очищают и обрабатывают и выделяют в виде основания или его фармацевтически приемлемой соли.Отчет о международном поиске был опубликован 2001.12.27.
EA200200016A 2000-12-28 2001-03-07 Способ получения чистого циталопрама EA003459B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001943 2000-12-28
PCT/DK2001/000148 WO2001047877A2 (en) 2000-12-28 2001-03-07 Process for the preparation of pure citalopram

Publications (2)

Publication Number Publication Date
EA200200016A1 true EA200200016A1 (ru) 2002-04-25
EA003459B1 EA003459B1 (ru) 2003-06-26

Family

ID=8159933

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200016A EA003459B1 (ru) 2000-12-28 2001-03-07 Способ получения чистого циталопрама

Country Status (41)

Country Link
US (2) US6855834B2 (ru)
EP (1) EP1181272B1 (ru)
JP (1) JP2003519121A (ru)
KR (1) KR100430746B1 (ru)
CN (1) CN1366526A (ru)
AR (1) AR029898A1 (ru)
AT (2) ATE222899T1 (ru)
AU (3) AU3920201A (ru)
BE (2) BE1013417A6 (ru)
BG (1) BG106219A (ru)
BR (1) BR0106271A (ru)
CA (1) CA2359810C (ru)
CH (1) CH691536A5 (ru)
CZ (1) CZ293140B6 (ru)
DE (1) DE60100016T2 (ru)
DK (1) DK1181272T3 (ru)
EA (1) EA003459B1 (ru)
ES (2) ES2181663T3 (ru)
FI (2) FI108640B (ru)
FR (1) FR2818977B1 (ru)
GB (2) GB2356199B (ru)
GR (1) GR20010100131A (ru)
HK (1) HK1049332A1 (ru)
HR (1) HRP20020005A2 (ru)
HU (2) HU0101028D0 (ru)
IE (2) IES20010253A2 (ru)
IL (1) IL147162A0 (ru)
IS (1) IS5884A (ru)
IT (1) ITMI20010604A1 (ru)
MX (1) MXPA01013336A (ru)
NL (1) NL1017534C1 (ru)
NO (1) NO313047B1 (ru)
NZ (1) NZ516299A (ru)
PL (1) PL353369A1 (ru)
PT (1) PT1181272E (ru)
SE (1) SE0103044L (ru)
SK (1) SK284418B6 (ru)
TR (1) TR200200018T1 (ru)
UA (1) UA71635C2 (ru)
WO (1) WO2001047877A2 (ru)
ZA (1) ZA200110133B (ru)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
DK1298124T3 (da) 1999-10-25 2007-07-09 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
SI1246812T1 (en) 1999-12-28 2004-08-31 H. Lundbeck A/S Method for the preparation of citalopram
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
EA005134B1 (ru) 2000-01-14 2004-12-30 Х.Лундбекк А/С Способ получения 5-цианофталида
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NZ521201A (en) 2000-03-13 2004-02-27 H Method for the preparation of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CN1427835A (zh) * 2000-03-13 2003-07-02 H·隆德贝克有限公司 5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化
ATE257832T1 (de) 2000-03-14 2004-01-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
WO2001068632A1 (en) * 2000-03-16 2001-09-20 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
EP1181713B1 (en) 2000-12-22 2004-09-29 H. Lundbeck A/S Method for the preparation of pure citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro
GB2376945A (en) * 2001-06-27 2002-12-31 Cipla Ltd Citalopram preparation
WO2003057132A2 (en) 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1486492A3 (en) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

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DE19626659A1 (de) * 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) * 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
PT1015416E (pt) * 1997-07-08 2002-03-28 Lundbeck & Co As H Metodo para a producao de citalopram
DE19734673A1 (de) * 1997-08-11 1999-02-18 Rwe Dea Ag Verfahren zur Herstellung von metallfreien Guerbetalkoholen
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
AU738359B2 (en) 1997-11-11 2001-09-13 H. Lundbeck A/S Method for the preparation of citalopram
EP0965593B2 (en) * 1998-06-19 2008-12-03 Shin-Etsu Chemical Co., Ltd. Distillation of (meth)acryloxybearing alkoxysilane
HU228576B1 (en) * 1998-10-20 2013-04-29 Lundbeck & Co As H Method for the preparation of citalopram
CA2356188C (en) 1998-12-23 2006-05-23 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
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GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
EP1181713B1 (en) 2000-12-22 2004-09-29 H. Lundbeck A/S Method for the preparation of pure citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram

Also Published As

Publication number Publication date
AT4368U1 (de) 2001-06-25
GR20010100131A (el) 2002-10-09
SK284418B6 (sk) 2005-04-01
MXPA01013336A (es) 2002-07-09
TR200200018T1 (tr) 2002-06-21
IES20010632A2 (en) 2002-03-06
CZ293140B6 (cs) 2004-02-18
GB2361697A (en) 2001-10-31
ITMI20010604A0 (it) 2001-03-22
US20030178295A1 (en) 2003-09-25
HUP0102818A2 (hu) 2001-12-28
ES2170733A1 (es) 2002-08-01
BR0106271A (pt) 2002-05-21
EP1181272B1 (en) 2002-08-28
NO20011272D0 (no) 2001-03-13
UA71635C2 (ru) 2004-12-15
SK18472001A3 (sk) 2002-05-09
NL1017534C1 (nl) 2001-04-26
AU750006B1 (en) 2002-07-11
JP2003519121A (ja) 2003-06-17
HUP0102818A3 (en) 2003-07-28
WO2001047877A3 (en) 2001-12-27
ES2181663T3 (es) 2003-03-01
DE60100016T2 (de) 2003-04-17
IES20010253A2 (en) 2002-03-06
ITMI20010604A1 (it) 2002-09-22
BE1013417A6 (fr) 2001-12-04
EA003459B1 (ru) 2003-06-26
PT1181272E (pt) 2003-01-31
IS5884A (is) 2002-06-28
US20020087012A1 (en) 2002-07-04
KR100430746B1 (ko) 2004-05-10
US6855834B2 (en) 2005-02-15
CA2359810C (en) 2002-11-05
WO2001047877A2 (en) 2001-07-05
GB2356199B (en) 2001-10-03
NO20011272L (no) 2002-07-01
ES2170733B1 (es) 2003-12-16
FI20011578A0 (fi) 2001-07-26
AU2001100399A4 (en) 2001-11-01
NO313047B1 (no) 2002-08-05
GB0105981D0 (en) 2001-05-02
KR20020073379A (ko) 2002-09-26
HU0102818D0 (en) 2001-09-28
FI108640B (fi) 2002-02-28
HRP20020005A2 (en) 2003-04-30
AU3920201A (en) 2001-07-09
CZ2001891A3 (cs) 2002-08-14
BG106219A (en) 2002-08-30
FR2818977B1 (fr) 2003-12-05
HU0101028D0 (en) 2001-05-28
AU2001100399B4 (en) 2002-03-21
ZA200110133B (en) 2003-01-13
AR029898A1 (es) 2003-07-23
ATE222899T1 (de) 2002-09-15
SE0103044L (sv) 2002-06-29
GB0117095D0 (en) 2001-09-05
PL353369A1 (en) 2003-11-17
EP1181272A2 (en) 2002-02-27
HK1049332A1 (zh) 2003-05-09
CA2359810A1 (en) 2001-07-05
FI20010501A0 (fi) 2001-03-13
GB2356199A (en) 2001-05-16
FR2818977A1 (fr) 2002-07-05
CH691536A5 (de) 2001-08-15
DE60100016D1 (de) 2002-10-02
DK1181272T3 (da) 2002-12-30
IL147162A0 (en) 2002-08-14
CN1366526A (zh) 2002-08-28
BE1013316A6 (fr) 2001-11-06
NZ516299A (en) 2002-12-20
SE0103044D0 (sv) 2001-09-14

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM