DK1181272T3 - Fremgangsmåde til fremstilling af rent citalopram - Google Patents

Fremgangsmåde til fremstilling af rent citalopram

Info

Publication number
DK1181272T3
DK1181272T3 DK01913727T DK01913727T DK1181272T3 DK 1181272 T3 DK1181272 T3 DK 1181272T3 DK 01913727 T DK01913727 T DK 01913727T DK 01913727 T DK01913727 T DK 01913727T DK 1181272 T3 DK1181272 T3 DK 1181272T3
Authority
DK
Denmark
Prior art keywords
preparation
pure citalopram
citalopram
pure
Prior art date
Application number
DK01913727T
Other languages
English (en)
Inventor
Andrea Castellin
Giulio Volpe
Federico Sbrogio
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of DK1181272T3 publication Critical patent/DK1181272T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
DK01913727T 2000-12-28 2001-03-07 Fremgangsmåde til fremstilling af rent citalopram DK1181272T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001943 2000-12-28
PCT/DK2001/000148 WO2001047877A2 (en) 2000-12-28 2001-03-07 Process for the preparation of pure citalopram

Publications (1)

Publication Number Publication Date
DK1181272T3 true DK1181272T3 (da) 2002-12-30

Family

ID=8159933

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01913727T DK1181272T3 (da) 2000-12-28 2001-03-07 Fremgangsmåde til fremstilling af rent citalopram

Country Status (41)

Country Link
US (2) US6855834B2 (da)
EP (1) EP1181272B1 (da)
JP (1) JP2003519121A (da)
KR (1) KR100430746B1 (da)
CN (1) CN1366526A (da)
AR (1) AR029898A1 (da)
AT (2) ATE222899T1 (da)
AU (3) AU2001100399B4 (da)
BE (2) BE1013417A6 (da)
BG (1) BG106219A (da)
BR (1) BR0106271A (da)
CA (1) CA2359810C (da)
CH (1) CH691536A5 (da)
CZ (1) CZ293140B6 (da)
DE (1) DE60100016T2 (da)
DK (1) DK1181272T3 (da)
EA (1) EA003459B1 (da)
ES (2) ES2181663T3 (da)
FI (2) FI108640B (da)
FR (1) FR2818977B1 (da)
GB (2) GB2356199B (da)
GR (1) GR20010100131A (da)
HK (1) HK1049332A1 (da)
HR (1) HRP20020005A2 (da)
HU (2) HU0101028D0 (da)
IE (2) IES20010253A2 (da)
IL (1) IL147162A0 (da)
IS (1) IS5884A (da)
IT (1) ITMI20010604A1 (da)
MX (1) MXPA01013336A (da)
NL (1) NL1017534C1 (da)
NO (1) NO313047B1 (da)
NZ (1) NZ516299A (da)
PL (1) PL353369A1 (da)
PT (1) PT1181272E (da)
SE (1) SE0103044L (da)
SK (1) SK284418B6 (da)
TR (1) TR200200018T1 (da)
UA (1) UA71635C2 (da)
WO (1) WO2001047877A2 (da)
ZA (1) ZA200110133B (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) * 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
DE69935355T2 (de) 1999-10-25 2007-11-08 H. Lundbeck A/S, Valby Verfahren zur Herstellung von Citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
MXPA02006503A (es) 1999-12-28 2002-12-09 Lundbeck & Co As H Metodo para la preparacion de citalopram.
EA004055B1 (ru) 1999-12-30 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
ATE252570T1 (de) 2000-01-14 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von 5-cyanophthalid
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
WO2001068629A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AU2001242298A1 (en) 2000-03-13 2001-09-24 H Lunbeck A/S Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
MXPA02008653A (es) 2000-03-14 2003-02-24 Lundbeck & Co As H Metodo para la preparacion de citalopram.
CN1418206A (zh) * 2000-03-16 2003-05-14 H·隆德贝克有限公司 5－氰基－1－(4－氟苯基)－1,3－二氢异苯并呋喃的制备方法
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
SI1181713T1 (en) 2000-12-22 2005-02-28 H. Lundbeck A/S Method for the preparation of pure citalopram
TR200200018T1 (tr) 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.
GB2376945A (en) * 2001-06-27 2002-12-31 Cipla Ltd Citalopram preparation
US7148364B2 (en) 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB0204607D0 (en) 2002-02-27 2002-04-10 Matrix Lab Ltd Process
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1486492A3 (en) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

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NL135959C (da) 1964-12-23
GB1143702A (da) 1965-03-18
DE1619713A1 (de) * 1967-03-29 1970-12-17 Leybold Heraeus Gmbh & Co Kg Vorrichtung zur Vakuum- und Kurzwegdestillation
DE2135085C3 (de) 1971-07-14 1981-12-03 Basf Ag, 6700 Ludwigshafen Verfahren zur Wiedergewinnung von Caprolactam aus einem Gemisch, das Caprolactam und dessen Oligomere enthält
DE2442426C2 (de) 1974-09-05 1983-04-07 Bayer Ag, 5090 Leverkusen Diisocyanatodiketene, Verfahren zu deren Herstellung und deren Verwendung
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
IT8020902A0 (it) 1980-03-25 1980-03-25 Snia Viscosa Procedimento ed apparecchiatura per la separazione continua per via termica di miscele liquide dicomposti termolabili.
JPS6082101A (ja) 1983-10-13 1985-05-10 Mitsui Toatsu Chem Inc 高沸点重合性化合物の薄膜蒸留による精製方法
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
FR2656305B1 (fr) 1989-12-22 1992-04-10 Norsolor Sa Procede de purification du (meth)acrylate de glycidyle.
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
US5582692A (en) 1994-10-07 1996-12-10 Artisan Industries, Inc. Method for the purification of vitamin E
US6136991A (en) * 1996-05-21 2000-10-24 Exxon Chemical Patents Inc. Glycidyl ester adducts having increased glass transition temperatures
AU723333B2 (en) 1996-05-21 2000-08-24 Resolution Specialty Materials Llc Process for the purification of glycidyl esters from epihalohydrin and carboxylic acids
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ATE205824T1 (de) 1997-07-08 2001-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
DE19734673A1 (de) 1997-08-11 1999-02-18 Rwe Dea Ag Verfahren zur Herstellung von metallfreien Guerbetalkoholen
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
TR200001341T2 (tr) 1997-11-11 2000-11-21 H. Lundbeck A/S Sitalopramın hazırlandığı metot
EP0965593B2 (en) 1998-06-19 2008-12-03 Shin-Etsu Chemical Co., Ltd. Distillation of (meth)acryloxybearing alkoxysilane
WO2000023431A1 (en) * 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
ES2195644T3 (es) 1998-12-23 2003-12-01 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida.
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
SI1181713T1 (en) 2000-12-22 2005-02-28 H. Lundbeck A/S Method for the preparation of pure citalopram
TR200200018T1 (tr) 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram

Also Published As

Publication number Publication date
SE0103044L (sv) 2002-06-29
NO20011272D0 (no) 2001-03-13
UA71635C2 (uk) 2004-12-15
ES2181663T3 (es) 2003-03-01
FI20011578A0 (fi) 2001-07-26
EA200200016A1 (ru) 2002-04-25
ITMI20010604A1 (it) 2002-09-22
MXPA01013336A (es) 2002-07-09
BE1013316A6 (fr) 2001-11-06
KR100430746B1 (ko) 2004-05-10
CA2359810A1 (en) 2001-07-05
GB0117095D0 (en) 2001-09-05
DE60100016T2 (de) 2003-04-17
IS5884A (is) 2002-06-28
ITMI20010604A0 (it) 2001-03-22
JP2003519121A (ja) 2003-06-17
BE1013417A6 (fr) 2001-12-04
HU0102818D0 (en) 2001-09-28
AU750006B1 (en) 2002-07-11
US20020087012A1 (en) 2002-07-04
CZ293140B6 (cs) 2004-02-18
EA003459B1 (ru) 2003-06-26
CH691536A5 (de) 2001-08-15
AU2001100399A4 (en) 2001-11-01
GB2361697A (en) 2001-10-31
IES20010253A2 (en) 2002-03-06
CZ2001891A3 (cs) 2002-08-14
ATE222899T1 (de) 2002-09-15
HUP0102818A2 (hu) 2001-12-28
WO2001047877A2 (en) 2001-07-05
NO313047B1 (no) 2002-08-05
US20030178295A1 (en) 2003-09-25
KR20020073379A (ko) 2002-09-26
FR2818977A1 (fr) 2002-07-05
NZ516299A (en) 2002-12-20
CA2359810C (en) 2002-11-05
GB0105981D0 (en) 2001-05-02
DE60100016D1 (de) 2002-10-02
NO20011272L (no) 2002-07-01
AU3920201A (en) 2001-07-09
AU2001100399B4 (en) 2002-03-21
EP1181272B1 (en) 2002-08-28
PL353369A1 (en) 2003-11-17
HRP20020005A2 (en) 2003-04-30
BG106219A (en) 2002-08-30
WO2001047877A3 (en) 2001-12-27
ES2170733A1 (es) 2002-08-01
AR029898A1 (es) 2003-07-23
SK284418B6 (sk) 2005-04-01
AT4368U1 (de) 2001-06-25
US6855834B2 (en) 2005-02-15
HUP0102818A3 (en) 2003-07-28
CN1366526A (zh) 2002-08-28
FI108640B (fi) 2002-02-28
HK1049332A1 (zh) 2003-05-09
HU0101028D0 (en) 2001-05-28
IL147162A0 (en) 2002-08-14
SE0103044D0 (sv) 2001-09-14
ZA200110133B (en) 2003-01-13
NL1017534C1 (nl) 2001-04-26
IES20010632A2 (en) 2002-03-06
EP1181272A2 (en) 2002-02-27
GR20010100131A (el) 2002-10-09
GB2356199B (en) 2001-10-03
FI20010501A0 (fi) 2001-03-13
GB2356199A (en) 2001-05-16
TR200200018T1 (tr) 2002-06-21
ES2170733B1 (es) 2003-12-16
FR2818977B1 (fr) 2003-12-05
PT1181272E (pt) 2003-01-31
BR0106271A (pt) 2002-05-21
SK18472001A3 (sk) 2002-05-09

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