ES2195644T3 - Metodo para la preparacion de 5-cianoftalida. - Google Patents

Metodo para la preparacion de 5-cianoftalida.

Info

Publication number
ES2195644T3
ES2195644T3 ES99960958T ES99960958T ES2195644T3 ES 2195644 T3 ES2195644 T3 ES 2195644T3 ES 99960958 T ES99960958 T ES 99960958T ES 99960958 T ES99960958 T ES 99960958T ES 2195644 T3 ES2195644 T3 ES 2195644T3
Authority
ES
Spain
Prior art keywords
cyanoftalide
formula
preparation
amide
carboxyphthalide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99960958T
Other languages
English (en)
Inventor
Hans Petersen
Nielsen Poul Dahlberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Application granted granted Critical
Publication of ES2195644T3 publication Critical patent/ES2195644T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Abstract

Un método para preparar 5-cianoftalida que comprende; a) convertir 5-carboxiftalida en una amida de Fórmula IV **(Fórmula)** en la cual R es hidrógeno o alquilo C1-6, y b) hacer reaccionar luego la amida de Fórmula IV con un agente deshidratante obteniéndose de ese modo la 5-cianoftalida **(Fórmula)**
ES99960958T 1998-12-23 1999-12-22 Metodo para la preparacion de 5-cianoftalida. Expired - Lifetime ES2195644T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA199801718 1998-12-23

Publications (1)

Publication Number Publication Date
ES2195644T3 true ES2195644T3 (es) 2003-12-01

Family

ID=8107494

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99960958T Expired - Lifetime ES2195644T3 (es) 1998-12-23 1999-12-22 Metodo para la preparacion de 5-cianoftalida.

Country Status (31)

Country Link
US (1) US6392060B2 (es)
EP (1) EP1140886B1 (es)
JP (1) JP2002533450A (es)
KR (1) KR100454008B1 (es)
CN (1) CN1149208C (es)
AR (1) AR019791A1 (es)
AT (1) ATE236145T1 (es)
AU (1) AU764161B2 (es)
BG (1) BG64986B1 (es)
BR (1) BR9916955A (es)
CA (1) CA2356188C (es)
CZ (1) CZ300408B6 (es)
DE (1) DE69906580T2 (es)
DK (1) DK1140886T3 (es)
EA (1) EA003057B1 (es)
ES (1) ES2195644T3 (es)
HK (1) HK1043130B (es)
HU (1) HUP0104856A3 (es)
IL (1) IL143422A0 (es)
IS (1) IS2261B (es)
IT (1) IT1315269B1 (es)
NO (1) NO326516B1 (es)
NZ (1) NZ512073A (es)
PL (1) PL203275B1 (es)
PT (1) PT1140886E (es)
SI (1) SI1140886T1 (es)
SK (1) SK285530B6 (es)
TR (1) TR200101796T2 (es)
UA (1) UA70979C2 (es)
WO (1) WO2000039112A1 (es)
ZA (1) ZA200104262B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA002977B1 (ru) 1998-10-20 2002-12-26 Х.Лундбекк А/С Способ получения циталопрама
CN1149208C (zh) 1998-12-23 2004-05-12 H.隆德贝克有限公司 制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
CN1142926C (zh) 1999-04-14 2004-03-24 H·隆德贝克有限公司 制备西酞普兰的方法
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
NZ512406A (en) 1999-10-25 2004-01-30 H Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
CZ20022213A3 (cs) 1999-12-28 2002-09-11 H. Lundbeck A/S Způsob výroby citalopramu
SI1246813T1 (en) 1999-12-30 2004-08-31 H. Lundbeck A/S Method for the preparation of citalopram
CZ20022601A3 (cs) 2000-01-14 2002-10-16 H. Lundbeck A/S Způsob výroby 5-kyanoftalidu
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
MXPA02008869A (es) 2000-03-13 2003-02-10 Lundbeck & Co As H Metodo para la preparacion de citalopram.
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
EA200200968A1 (ru) * 2000-03-13 2003-02-27 Х.Лундбекк А/С Поэтапное алкилирование 5-замещенных 1-(4-фторфенил)-1,3-дигидроизобензофуранов
JP2003527386A (ja) 2000-03-14 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
AU2001244086A1 (en) * 2000-03-16 2001-09-24 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) * 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
ES2228824T3 (es) 2000-12-22 2005-04-16 H. Lundbeck A/S Metodo de preparacion de citalopram puro.
IL147162A0 (en) 2000-12-28 2002-08-14 Lundbeck & Co As H Process for the preparation of pure citalopram
EP1321464A1 (en) * 2001-12-21 2003-06-25 ICROM S.p.A. Process for the preparation of 5-cyanophthalide and intermediates useful therein
EP1611118A2 (en) * 2003-03-21 2006-01-04 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
EP1777221A1 (en) 2005-10-14 2007-04-25 Adorkem Technology SpA Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (es) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
EP1015416B1 (en) * 1997-07-08 2001-09-19 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
DE69714480T2 (de) 1997-11-11 2003-03-06 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram
EA002977B1 (ru) 1998-10-20 2002-12-26 Х.Лундбекк А/С Способ получения циталопрама
CN1149208C (zh) 1998-12-23 2004-05-12 H.隆德贝克有限公司 制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
CN1142926C (zh) 1999-04-14 2004-03-24 H·隆德贝克有限公司 制备西酞普兰的方法
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate

Also Published As

Publication number Publication date
JP2002533450A (ja) 2002-10-08
AR019791A1 (es) 2002-03-13
DE69906580D1 (de) 2003-05-08
UA70979C2 (uk) 2004-11-15
HUP0104856A2 (hu) 2002-04-29
KR20010082370A (ko) 2001-08-29
IS2261B (is) 2007-06-15
WO2000039112A1 (en) 2000-07-06
ZA200104262B (en) 2001-12-11
HUP0104856A3 (en) 2003-01-28
PL203275B1 (pl) 2009-09-30
AU1774200A (en) 2000-07-31
NO20013150L (no) 2001-08-20
CN1331686A (zh) 2002-01-16
BR9916955A (pt) 2001-09-11
CA2356188A1 (en) 2000-07-06
US6392060B2 (en) 2002-05-21
CZ20012335A3 (cs) 2001-12-12
BG105655A (en) 2002-01-31
SK8962001A3 (en) 2003-03-04
NO20013150D0 (no) 2001-06-22
DK1140886T3 (da) 2003-07-28
CA2356188C (en) 2006-05-23
IL143422A0 (en) 2002-04-21
US20020019546A1 (en) 2002-02-14
PT1140886E (pt) 2003-08-29
ITMI992696A1 (it) 2001-06-23
SK285530B6 (sk) 2007-03-01
CN1149208C (zh) 2004-05-12
AU764161B2 (en) 2003-08-14
EP1140886A1 (en) 2001-10-10
NZ512073A (en) 2003-10-31
SI1140886T1 (en) 2003-08-31
CZ300408B6 (cs) 2009-05-13
DE69906580T2 (de) 2004-02-12
IS5952A (is) 2001-05-22
NO326516B1 (no) 2008-12-22
EA200100696A1 (ru) 2001-12-24
HK1043130B (zh) 2005-03-04
EA003057B1 (ru) 2002-12-26
ATE236145T1 (de) 2003-04-15
EP1140886B1 (en) 2003-04-02
PL348608A1 (en) 2002-06-03
KR100454008B1 (ko) 2004-10-20
BG64986B1 (bg) 2006-11-30
HK1043130A1 (en) 2002-09-06
TR200101796T2 (tr) 2001-11-21
ITMI992696A0 (it) 1999-12-23
IT1315269B1 (it) 2003-02-03

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