BR9916955A - Método para preparação de 5-cianoftalida - Google Patents

Método para preparação de 5-cianoftalida

Info

Publication number
BR9916955A
BR9916955A BR9916955-0A BR9916955A BR9916955A BR 9916955 A BR9916955 A BR 9916955A BR 9916955 A BR9916955 A BR 9916955A BR 9916955 A BR9916955 A BR 9916955A
Authority
BR
Brazil
Prior art keywords
cyanophthalide
formula
preparing
carboxyphthalide
alkyl
Prior art date
Application number
BR9916955-0A
Other languages
English (en)
Inventor
Hans Petersen
Poul Nielsen Dahlberg
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BR9916955A publication Critical patent/BR9916955A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

<B>"MéTODO PARA PREPARAçãO DE 5-CIANOFTALIDA"<D> Provê-se um método para a preparação de 5-cianoftalida, no qual 5-carboxiftalida é convertido na amida correspondente de Fórmula (IV), na qual R é hidrogênio ou C1-6 alcil, que é então reagida com um agente de desidratação, deste modo obtendo-se 5-cianoftalida. A conversão de 5-carboxiftalida na amida correspondente de Fórmula (IV) pode ser conduzida através de um éster de C1-6 alcil ou fenil ou de cloreto de ácido, o qual é convertido na amida de Fórmula (IV) por amidação com amónia ou C1-6 alcilamina. Através do processo, 5-cianoftalida, um intermediário importante utilizado na preparação do conhecido medicamento antidepressivo citalopram, é preparado em rendimentos altos através de um procedimento conveniente, eficaz e não oneroso.
BR9916955-0A 1998-12-23 1999-12-22 Método para preparação de 5-cianoftalida BR9916955A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199801718 1998-12-23
PCT/DK1999/000728 WO2000039112A1 (en) 1998-12-23 1999-12-22 Method for the preparation of 5-cyanophthalide

Publications (1)

Publication Number Publication Date
BR9916955A true BR9916955A (pt) 2001-09-11

Family

ID=8107494

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916955-0A BR9916955A (pt) 1998-12-23 1999-12-22 Método para preparação de 5-cianoftalida

Country Status (31)

Country Link
US (1) US6392060B2 (pt)
EP (1) EP1140886B1 (pt)
JP (1) JP2002533450A (pt)
KR (1) KR100454008B1 (pt)
CN (1) CN1149208C (pt)
AR (1) AR019791A1 (pt)
AT (1) ATE236145T1 (pt)
AU (1) AU764161B2 (pt)
BG (1) BG64986B1 (pt)
BR (1) BR9916955A (pt)
CA (1) CA2356188C (pt)
CZ (1) CZ300408B6 (pt)
DE (1) DE69906580T2 (pt)
DK (1) DK1140886T3 (pt)
EA (1) EA003057B1 (pt)
ES (1) ES2195644T3 (pt)
HK (1) HK1043130B (pt)
HU (1) HUP0104856A3 (pt)
IL (1) IL143422A0 (pt)
IS (1) IS2261B (pt)
IT (1) IT1315269B1 (pt)
NO (1) NO326516B1 (pt)
NZ (1) NZ512073A (pt)
PL (1) PL203275B1 (pt)
PT (1) PT1140886E (pt)
SI (1) SI1140886T1 (pt)
SK (1) SK285530B6 (pt)
TR (1) TR200101796T2 (pt)
UA (1) UA70979C2 (pt)
WO (1) WO2000039112A1 (pt)
ZA (1) ZA200104262B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL142346A0 (en) 1998-10-20 2002-03-10 Lundbeck & Co As H Method for the preparation of citalopram
CZ300408B6 (cs) 1998-12-23 2009-05-13 H. Lundbeck A/S Zpusob výroby 5-kyanoftalidu
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
DK1298124T3 (da) 1999-10-25 2007-07-09 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
IL150335A0 (en) 1999-12-28 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
KR100660802B1 (ko) 2000-01-14 2006-12-26 하. 룬트벡 아크티에 셀스카브 5-시아노프탈리드의 제조 방법
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
HUP0300274A2 (hu) 2000-03-13 2003-06-28 H. Lundbeck A/S Eljárás citalopram előállítására
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
JP2003527385A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
PL360107A1 (en) 2000-03-14 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
ES2159271B1 (es) * 2000-03-16 2002-05-01 Lundbeck & Co As H Metodo para la preparacion de 5-ciano-1-(4-fluorofenil)-1,3-dihidroisobenzofuranos
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) * 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
KR100439329B1 (ko) 2000-12-22 2004-07-07 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법
PL353369A1 (en) 2000-12-28 2003-11-17 H.Lundbeck A/S Process for the preparation of pure citalopram
EP1321464A1 (en) * 2001-12-21 2003-06-25 ICROM S.p.A. Process for the preparation of 5-cyanophthalide and intermediates useful therein
WO2004083197A2 (en) * 2003-03-21 2004-09-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
EP1777221A1 (en) * 2005-10-14 2007-04-25 Adorkem Technology SpA Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (pt) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
CA2291067C (en) 1997-07-08 2002-07-30 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
WO1998019512A2 (en) 1997-11-11 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
IL142346A0 (en) 1998-10-20 2002-03-10 Lundbeck & Co As H Method for the preparation of citalopram
CZ300408B6 (cs) 1998-12-23 2009-05-13 H. Lundbeck A/S Zpusob výroby 5-kyanoftalidu
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate

Also Published As

Publication number Publication date
PT1140886E (pt) 2003-08-29
CN1149208C (zh) 2004-05-12
UA70979C2 (uk) 2004-11-15
CA2356188C (en) 2006-05-23
IT1315269B1 (it) 2003-02-03
HUP0104856A3 (en) 2003-01-28
NO20013150D0 (no) 2001-06-22
NO20013150L (no) 2001-08-20
ITMI992696A1 (it) 2001-06-23
NZ512073A (en) 2003-10-31
ZA200104262B (en) 2001-12-11
NO326516B1 (no) 2008-12-22
ATE236145T1 (de) 2003-04-15
CA2356188A1 (en) 2000-07-06
ES2195644T3 (es) 2003-12-01
JP2002533450A (ja) 2002-10-08
CZ20012335A3 (cs) 2001-12-12
PL203275B1 (pl) 2009-09-30
AR019791A1 (es) 2002-03-13
DE69906580T2 (de) 2004-02-12
HK1043130B (zh) 2005-03-04
DK1140886T3 (da) 2003-07-28
CZ300408B6 (cs) 2009-05-13
HUP0104856A2 (hu) 2002-04-29
WO2000039112A1 (en) 2000-07-06
SI1140886T1 (en) 2003-08-31
IS5952A (is) 2001-05-22
EP1140886A1 (en) 2001-10-10
SK8962001A3 (en) 2003-03-04
BG105655A (en) 2002-01-31
CN1331686A (zh) 2002-01-16
KR100454008B1 (ko) 2004-10-20
PL348608A1 (en) 2002-06-03
DE69906580D1 (de) 2003-05-08
US6392060B2 (en) 2002-05-21
AU1774200A (en) 2000-07-31
IS2261B (is) 2007-06-15
HK1043130A1 (en) 2002-09-06
KR20010082370A (ko) 2001-08-29
TR200101796T2 (tr) 2001-11-21
EP1140886B1 (en) 2003-04-02
US20020019546A1 (en) 2002-02-14
EA003057B1 (ru) 2002-12-26
ITMI992696A0 (it) 1999-12-23
SK285530B6 (sk) 2007-03-01
IL143422A0 (en) 2002-04-21
AU764161B2 (en) 2003-08-14
BG64986B1 (bg) 2006-11-30
EA200100696A1 (ru) 2001-12-24

Similar Documents

Publication Publication Date Title
BR9916955A (pt) Método para preparação de 5-cianoftalida
BR0008978A (pt) Método para preparação de 5-cianoftalida
ATE63553T1 (de) Chinazolindione und pyridopyrimidindione.
FR2682388B1 (fr) Procede de preparation d&#39;un oligoside par depolymerisation d&#39;un polyoside issu d&#39;un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal.
ES512381A0 (es) &#34;procedimiento de preparacion de disacaridos&#34;.
BR0015471A (pt) Método para preparação de 5-carboxiftalida
MY101132A (en) An optically pure pipecoloxylidide hydrochloride and a process for its preparation
PT759921E (pt) Processo para a preparacao de derivados azabiciclicos
IT1292130B1 (it) Processo per la preparazione dell&#39;acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
FR2583414B1 (fr) Procede de fabrication de (meth)acrylates d&#39;alkyles fluores.
BR0009518A (pt) Processo para a preparação de um éster do ácido 2-hidroxi-4-metiltiobutìrico
ES2053471T3 (es) Empleo de dihidropiridinas condensadas carbociclica y heterociclicamente para la preparacion de agentes cardioprotectores, asi como nuevas dihidropiridinas condensadas heterociclica y carbociclicamente, procedimiento para su preparacion y etapas intermedias para su preparacion.
IT1190987B (it) Tioesteri dell&#39;acido acetilsalicilico,procedimento per la loro preparazione e composizioni farmaceutiche che li conttengono
PT80688B (en) Process for the preparation of new 3-aminocarbonylmethoxy-5-phenylpyrazol compounds as well as medicament containing said compounds
ES2020926B3 (es) Procedimiento para la obtencion de compuestos de carbonilo.
DE69707603D1 (de) Verfahren zur Herstellung von N2-Arylsulfonyl-L-Argininamiden
BR9908899A (pt) Processos para preparar lactamas e um catalisador, e, processo de utilização de oligofosfatos de metal ou misturas de oligofosfatos de metal e sais de metal
JPS55118456A (en) Method of collecting optically active d-alpha-methyl-beta- benzoyl-thiopropionic acid
BR0312773A (pt) Método para produzir um composto altamente puro
JPS5479269A (en) Preparation of optically active 5-oxo-2-pyrrolidinecarboxy anilide
PT1104397E (pt) Processo para a preparacao de ester de etilo do acido atropico
ATE77091T1 (de) Verfahren zur herstellung von alphaaminoalkylphosphons|uren.
BR9707558A (pt) Preparacao de compostos ativos superficialmente com base em lactose.
JPS5379856A (en) Preparation of optical active 1-methyl-2-(beta-hydroxyethyl)pyrrplidive
JPS574955A (en) Reducing method of benzenediazonium sulfate

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2159 DE 22/05/2012.