ES2053471T3 - Empleo de dihidropiridinas condensadas carbociclica y heterociclicamente para la preparacion de agentes cardioprotectores, asi como nuevas dihidropiridinas condensadas heterociclica y carbociclicamente, procedimiento para su preparacion y etapas intermedias para su preparacion. - Google Patents

Empleo de dihidropiridinas condensadas carbociclica y heterociclicamente para la preparacion de agentes cardioprotectores, asi como nuevas dihidropiridinas condensadas heterociclica y carbociclicamente, procedimiento para su preparacion y etapas intermedias para su preparacion.

Info

Publication number
ES2053471T3
ES2053471T3 ES87109110T ES87109110T ES2053471T3 ES 2053471 T3 ES2053471 T3 ES 2053471T3 ES 87109110 T ES87109110 T ES 87109110T ES 87109110 T ES87109110 T ES 87109110T ES 2053471 T3 ES2053471 T3 ES 2053471T3
Authority
ES
Spain
Prior art keywords
preparation
hetero
dihydropyridine
cyclic
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87109110T
Other languages
English (en)
Inventor
Walter Dr Losel
Gerd Dr Schnorrenberg
Otto Dr Roos
Dietrich Dr Arndts
Ilse Dr Streller
Werner Dr Traunecker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim GmbH
Application granted granted Critical
Publication of ES2053471T3 publication Critical patent/ES2053471T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A LA APLICACION DE DIHIDROPIRIDINAS ANILLADAS CARBOCICLICAS Y HETEROCICLICAS DE FORMULA I, ASI COMO SUS TAUTOMEROS DE FORMULA II, DONDE A ES III Y X ES OR1, NHR2 O NR3R4, PARA OBTENCION DE AGENTES CARDIOPROTECTORES. ADEMAS SE REFIERE LA INVENCION A NUEVOS COMPUESTOS DE FORMULA (I), PROCEDIMIENTOS PARA SU OBTENCION Y ETAPAS INTERMEDIAS DEL PROCESO.
ES87109110T 1986-06-26 1987-06-24 Empleo de dihidropiridinas condensadas carbociclica y heterociclicamente para la preparacion de agentes cardioprotectores, asi como nuevas dihidropiridinas condensadas heterociclica y carbociclicamente, procedimiento para su preparacion y etapas intermedias para su preparacion. Expired - Lifetime ES2053471T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863621413 DE3621413A1 (de) 1986-06-26 1986-06-26 Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung

Publications (1)

Publication Number Publication Date
ES2053471T3 true ES2053471T3 (es) 1994-08-01

Family

ID=6303756

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87109110T Expired - Lifetime ES2053471T3 (es) 1986-06-26 1987-06-24 Empleo de dihidropiridinas condensadas carbociclica y heterociclicamente para la preparacion de agentes cardioprotectores, asi como nuevas dihidropiridinas condensadas heterociclica y carbociclicamente, procedimiento para su preparacion y etapas intermedias para su preparacion.

Country Status (18)

Country Link
EP (1) EP0251194B1 (es)
JP (1) JPS63258458A (es)
KR (2) KR890000480A (es)
AU (1) AU598558B2 (es)
DD (1) DD264429A5 (es)
DE (2) DE3621413A1 (es)
DK (1) DK323887A (es)
ES (1) ES2053471T3 (es)
FI (1) FI872827A (es)
GR (1) GR3007545T3 (es)
HU (1) HU203752B (es)
IE (1) IE59546B1 (es)
IL (1) IL82995A0 (es)
NO (1) NO872672L (es)
PL (1) PL159840B1 (es)
PT (1) PT85169B (es)
YU (1) YU46216B (es)
ZA (1) ZA874587B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
IL86131A0 (en) * 1987-04-24 1988-11-15 Boehringer Ingelheim Kg Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
DE3827727A1 (de) * 1988-08-16 1990-02-22 Boehringer Ingelheim Kg Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion
GB8921304D0 (en) * 1989-09-20 1989-11-08 Wyeth John & Brother Ltd New method of treatment and heterocyclic compounds used therein
DE9017900U1 (es) * 1990-12-22 1993-01-28 Boehringer Ingelheim Kg, 6507 Ingelheim, De
CA2138788A1 (en) * 1992-06-22 1994-01-06 Dietrich Arndts Ring-closed dihydropyridines and their use in the preparation of pharmaceutical compositions
CN1056832C (zh) * 1992-06-22 2000-09-27 贝林格尔·英格海姆公司 稠合二氢吡啶衍生物及其制法和含有其的药物组合物
DE4343683A1 (de) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
FR2724384B1 (fr) * 1994-09-14 1999-04-16 Cemaf Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2417512A1 (fr) * 1978-02-17 1979-09-14 Parcor Thieno (3,2-c) et thieno (2,3-c) pyridines, leur procede de preparation et leur application en therapeutique
DE3013906A1 (de) * 1980-04-11 1981-10-15 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung
DE3309596A1 (de) * 1982-08-05 1984-04-05 Basf Ag, 6700 Ludwigshafen 2-substituierte 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-ss-carboline, ihre herstellung und verwendung als arzneimittel

Also Published As

Publication number Publication date
KR930006639B1 (ko) 1993-07-22
FI872827A0 (fi) 1987-06-26
DD264429A5 (de) 1989-02-01
DK323887D0 (da) 1987-06-25
AU7477587A (en) 1988-01-07
KR890002144A (ko) 1989-04-08
IE871689L (en) 1987-12-26
PL159840B1 (pl) 1993-01-29
EP0251194B1 (de) 1993-03-31
IE59546B1 (en) 1994-03-09
NO872672L (no) 1987-12-28
NO872672D0 (no) 1987-06-25
KR890000480A (ko) 1989-03-14
DE3621413A1 (de) 1988-01-07
DK323887A (da) 1987-12-27
IL82995A0 (en) 1987-12-20
PL266416A1 (en) 1988-09-01
JPS63258458A (ja) 1988-10-25
PT85169B (pt) 1990-03-30
FI872827A (fi) 1987-12-27
PT85169A (de) 1987-07-01
EP0251194A1 (de) 1988-01-07
AU598558B2 (en) 1990-06-28
YU46216B (sh) 1993-05-28
ZA874587B (en) 1989-02-22
DE3785093D1 (de) 1993-05-06
GR3007545T3 (es) 1993-08-31
HU203752B (en) 1991-09-30
YU119887A (en) 1988-10-31
HUT47932A (en) 1989-04-28

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