YU46216B - Karbociklicno in heterociklicno anelirani dihidropiridini - Google Patents

Karbociklicno in heterociklicno anelirani dihidropiridini

Info

Publication number
YU46216B
YU46216B YU119887A YU119887A YU46216B YU 46216 B YU46216 B YU 46216B YU 119887 A YU119887 A YU 119887A YU 119887 A YU119887 A YU 119887A YU 46216 B YU46216 B YU 46216B
Authority
YU
Yugoslavia
Prior art keywords
hydrogen
methoxy
analyled
dihydropyridines
carbocyclic
Prior art date
Application number
YU119887A
Other languages
English (en)
Other versions
YU119887A (en
Inventor
W. Loesel
G. Schnorrenberg
O. Ropos
D. Arndts
I. Streller
W. Traunecker
Original Assignee
Boehringer Ingelheim Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg. filed Critical Boehringer Ingelheim Kg.
Publication of YU119887A publication Critical patent/YU119887A/xx
Publication of YU46216B publication Critical patent/YU46216B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

kjer stoje X za OR1, NHR2 ali NR3R4 in A za anelirane obročne sisteme kjer R1 pomeni alkil z 1 do 4 atomi ogljika, R2 pomeni alkil z 2 do 4 atomi ogljika, ki je lahko substituiren s fenilom, s fenilom, substituiranim z OH in/ali OCH3, ali s fenilom, ki vsebuje vicinalno vezano skupino -O-CH2-O; s R3 in R4 skupaj z atomom dušika, na katerega sta vezana, pomenita R6 in R7 pomenita neodvisno drug od drugega vodik, hidroksi, amino ali metansulfonilamino ali skupaj -O-CH2-O-, R8 pomeni vodik ali metoksi, pri čemer, če je A kjer R6 in R7 neodvisno drug od drugega pomenita vodik, hidroksi, metoksi ali skupaj -O-CH2-O in R8 pomeni vodik ali metoksi, je lahko XIe OR1. Prijava vsebuje še 2 neovisna zahtevka + 4 ovisna.
YU119887A 1986-06-26 1987-06-25 Karbociklicno in heterociklicno anelirani dihidropiridini YU46216B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863621413 DE3621413A1 (de) 1986-06-26 1986-06-26 Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung

Publications (2)

Publication Number Publication Date
YU119887A YU119887A (en) 1988-10-31
YU46216B true YU46216B (sh) 1993-05-28

Family

ID=6303756

Family Applications (1)

Application Number Title Priority Date Filing Date
YU119887A YU46216B (sh) 1986-06-26 1987-06-25 Karbociklicno in heterociklicno anelirani dihidropiridini

Country Status (18)

Country Link
EP (1) EP0251194B1 (sh)
JP (1) JPS63258458A (sh)
KR (2) KR890000480A (sh)
AU (1) AU598558B2 (sh)
DD (1) DD264429A5 (sh)
DE (2) DE3621413A1 (sh)
DK (1) DK323887A (sh)
ES (1) ES2053471T3 (sh)
FI (1) FI872827A (sh)
GR (1) GR3007545T3 (sh)
HU (1) HU203752B (sh)
IE (1) IE59546B1 (sh)
IL (1) IL82995A0 (sh)
NO (1) NO872672L (sh)
PL (1) PL159840B1 (sh)
PT (1) PT85169B (sh)
YU (1) YU46216B (sh)
ZA (1) ZA874587B (sh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
IL86131A0 (en) * 1987-04-24 1988-11-15 Boehringer Ingelheim Kg Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
DE3827727A1 (de) * 1988-08-16 1990-02-22 Boehringer Ingelheim Kg Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion
GB8921304D0 (en) * 1989-09-20 1989-11-08 Wyeth John & Brother Ltd New method of treatment and heterocyclic compounds used therein
DE4041482A1 (de) * 1990-12-22 1992-06-25 Boehringer Ingelheim Kg Neue pharmazeutische verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine
CN1056832C (zh) * 1992-06-22 2000-09-27 贝林格尔·英格海姆公司 稠合二氢吡啶衍生物及其制法和含有其的药物组合物
EP0957092A1 (de) * 1992-06-22 1999-11-17 Boehringer Ingelheim Pharma KG Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
DE4343683A1 (de) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
FR2724384B1 (fr) * 1994-09-14 1999-04-16 Cemaf Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2417512A1 (fr) * 1978-02-17 1979-09-14 Parcor Thieno (3,2-c) et thieno (2,3-c) pyridines, leur procede de preparation et leur application en therapeutique
DE3013906A1 (de) * 1980-04-11 1981-10-15 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung
DE3309596A1 (de) * 1982-08-05 1984-04-05 Basf Ag, 6700 Ludwigshafen 2-substituierte 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-ss-carboline, ihre herstellung und verwendung als arzneimittel

Also Published As

Publication number Publication date
DK323887D0 (da) 1987-06-25
HU203752B (en) 1991-09-30
DK323887A (da) 1987-12-27
FI872827A0 (fi) 1987-06-26
EP0251194A1 (de) 1988-01-07
KR930006639B1 (ko) 1993-07-22
IE871689L (en) 1987-12-26
JPS63258458A (ja) 1988-10-25
PT85169A (de) 1987-07-01
AU598558B2 (en) 1990-06-28
HUT47932A (en) 1989-04-28
AU7477587A (en) 1988-01-07
PL159840B1 (pl) 1993-01-29
KR890002144A (ko) 1989-04-08
DE3621413A1 (de) 1988-01-07
EP0251194B1 (de) 1993-03-31
NO872672D0 (no) 1987-06-25
IE59546B1 (en) 1994-03-09
GR3007545T3 (sh) 1993-08-31
ZA874587B (en) 1989-02-22
ES2053471T3 (es) 1994-08-01
PL266416A1 (en) 1988-09-01
DE3785093D1 (de) 1993-05-06
KR890000480A (ko) 1989-03-14
IL82995A0 (en) 1987-12-20
FI872827A (fi) 1987-12-27
DD264429A5 (de) 1989-02-01
YU119887A (en) 1988-10-31
PT85169B (pt) 1990-03-30
NO872672L (no) 1987-12-28

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